Fig. 2

NLRP3 inflammasome is activated in the peripheral blood of PD patients. A Scatter plots of NLRP3 relative mRNA expression level in the PBMCs of HC (n = 226) and PD (n = 224). The effects of B disease severity (H-Y staging), C disease course (duration of PD) and D medication on the expression level of NLRP3 in PBMCs of PD patients. E Scatter plots of the cleaved form of IL-1β concentration in the plasma of HC (n = 112) and PD (n = 116). The effects of F H-Y staging, G duration of disease and H medication on IL-1β concentration in the plasma of PD patients. Horizontal bars represent mean and SEM values. **p < 0.01, ***p < 0.01, and ****p < 0.0001 by unpaired Student T test. Rho, correlation coefficient by Spearman correlation analysis. DR DA receptor agonists monotherapy, l-dopa l-dopa monotherapy, l-dopa + DR the combination of DA agonists and l-dopa