Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease

Fig. 7

Nurr1 deficiency upregulates NLRP3 expression by attenuating miR-30e-5p expression. A Relative luciferase activity of shNurr1-BV2 cells transfected with 3ʹUTR-NLRP3-WT or 3ʹUTR-NLRP3-Mut, along with miR-NC or miR-30e-mimic. ****p < 0.0001, Two-way ANOVA Tukey test. B ShNurr1-BV2 and ShNC-BV2 cells treated with miR-30e-5p mimic or miR-NC, respectively. Representative immunoblots (B) and quantitative analysis of NLRP3, Caspase-1, Cleaved-caspase-1, ASC, and IL-1β protein levels (D) and relative mRNA levels of NLRP3, Caspase-1, ASC, and IL-1β (C) are shown. Gapdh was used as a loading control. Data are presented as mean ± SD. **p < 0.01, ***p < 0.001, and ****p < 0.0001, One-way ANOVA Tukey test

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094