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Table 3 Baseline clinical characteristics of the study subjects

From: TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy

Patient group

Characteristics

All patients

Survivors

Nonsurvivors

Demographics and underlying conditions

 Number of patients

47

36

11

 Males, number (%)

37 (78.7%)

31 (86.1%)

6 (54.5%)

 Age (years)

73 [60.25,81.75]

70 [59,79]

82 [65.5,88.5]

 Cardiac functional insuffificiency, number (%)

10 (21.3%)

8 (22.2%)

2 (18.1%)

 Renal functional insuffificiency, number (%)

14 (27.8%)

10 (27.8%)

4 (36.4%)

 Hypertension, number (%)

27 (57.4%)

18 (50%)

9 (81.8%)

 Diabetes mellitus, number (%)

24 (51.1%)

17 (47.2%)

7 (63.6%)

Disease severity, number (%)

 Septic shock

23 (48.9%)

14 (38.9%)

9 (81.8%)

Baseline parameters

 APACHE II score

23.11 ± 0.975

22.7 ± 1.165

24.46 ± 1.686

 SOFA score

8.21 ± 0.515

8.23 ± 0.612

8.15 ± 0.946

Site of infection, number (%)

 Lung

21 (44.7%)

14 (38.9%)

7 (63.6%)

 Abdomen

20 (42.6%)

16 (44.4%)

4 (36.3%)

 Urinary tract

3 (6.4%)

3 (8.3%)

0

 Other

3 (6.4%)

3 (8.3%)

0

Intervention, number (%)

 Mechanical ventilation

34 (723%)

23 (63.9%)

11 (100%)

 Renal-replacement therapy

22 (46.8%)

16 (44.4%)

6 (54.5%)

 Length of stay

 In the ICU (days)

23.5 [12,40.25]

20 [12, 33]

38 [16, 55]

  1. Data are presented as median [interquartile range] or mean ± SEM or n (%)