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Table 3 Structural equation model of sTREM2 and GFAP-induced synaptic damage

From: 14-3-3 \(\upzeta /\updelta\)-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Effectors

Mediators

Effect

SE

z-value

P-value

St. estimate

sTREM2 + GFAP

[18F]MK6240 + [18F]AZD4694

Combined

0.15

5.35

< 0.001

0.78

GFAP

[18F]AZD4694

Indirect

0.08

0.64

0.52

0.05

sTREM2

[18F]AZD4694

Indirect

0.01

-0.24

0.81

− 0.003

GFAP

[18F]MK6240

Indirect

0.08

2.2

0.03

0.17

sTREM2

[18F]MK6240

Indirect

0.04

0.67

0.5

0.03

  1. SE = standard error, st. estimate = standardized estimate, GFAP = glial fibrillary acid protein, sTREM2 = soluble triggering receptor expressed in myeloid cells 2 (sTREM2)
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Journal of Neuroinflammation

ISSN: 1742-2094