Fig. 6

Knockout of YKL-40 in astrocytes attenuates cognitive deficits of 5xFAD mice. All mice were IP injected with 20 mg/mL tamoxifen in corn oil (100 µl per mice/per day) for 7 consecutive days before experiments. Experiments were carried out 7 days after last tamoxifen injection. Spatial memory and learning ability were tested using Morris Water Maze. A-C Quantified escape latency at day 0 (visible platform), day 1, and day 4. D–G Quantified total length, mean speed, escape latency, and number of entries at day 5 (probe trial). Data are mean ± SEM. One-way ANOVA with Tukey’s post hoc comparisons. *p < 0.05, **p < 0.01, ***p < 0.001. H Schematic representation of Morris water maze. I Quantified escape latency from day 1 to day 4 (training trials). Data are mean ± SEM. n = 23 ~ 25. One-way ANOVA with Tukey’s post hoc comparisons. *p < 0.05, **p < 0.01, ***p < 0.001