Fig. 3
From: Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Partial microglia depletion by low-dose PLX5622 prevents acute and long-term microgliosis after polymicobial sepsis. A Representative confocal images of microglia in the CA1 region of the hippocampus at day 38. Scale bar 200 µm, zoom-in 20 µm. B Quantitative analysis of Iba1-positive microglia in the CA1 region of the hippocampus following AIN or low-dose PLX5622 pretreatment and systemic inflammation by PCI at day 3 (AIN-sham: n = 7, AIN-PCI: n = 6; PLX5622-sham: n = 7, PLX5622-PCI: n = 6; n = 3 images/animal, Two-way ANOVA with post hoc Tukey test). C Quantitative analysis of Iba1-positive microglia in the CA1 region of the hippocampus at day 38 following AIN or low-dose PLX5622 pretreatment and systemic inflammation by PCI (n = 5 animals/group, n = 4 images/animal, Two-way ANOVA with post hoc Tukey test). Data are presented as mean ± SEM. Individual values are presented as small dots and each circle represents an average of one mouse; individual values and averages are color coded.