Fig. 4
From: Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Partial microglia depletion by low-dose PLX5622 prevents acute astrogliosis after polymicobial sepsis. A Representative confocal images of astrocytes in the CA1 region of the hippocampus at day 3. Scale bar 200 µm, zoom-in 20 µm. B Quantitative analysis of GFAP-positive astrocytes in the CA1 region of the hippocampus following AIN or low-dose PLX5622 pretreatment and systemic inflammation by PCI at day 3 (n = 5 animals/group, n = 3 images/animal, Two-way ANOVA with post hoc Tukey test). C Quantitative analysis of GFAP-positive astrocytes in the CA1 region of the hippocampus at day 38 following AIN or low-dose PLX5622 pretreatment and systemic inflammation by (n = 5 animals/group, n = 2 images/animal, Two-way ANOVA with post hoc Tukey test). Data are presented as mean ± SEM. Individual values are presented as small dots and each circle represents an average of one mouse; individual values and averages are color coded