Fig. 6

Partial microglia depletion by low-dose PLX5622 rescues from long-term neurocognitive deficits. A Schematic NOR test procedure: Mice were familiarized with two identical objects during familiarization. After 6 h intersession interval one object was replaced by the novel object and the exploration time of the novel object was investigated. B, C NOR test was performed at day 10 (AIN-sham: n = 7, AIN-PCI: n = 11; PLX5622-sham: n = 7, PLX5622-PCI: n = 10, Two-way ANOVA with post hoc Tukey test) and day 30 (AIN-sham: n = 6, AIN-PCI: n = 9; PLX5622-sham: n = 7, PLX5622-PCI: n = 10, Two-way ANOVA with post hoc Tukey test). D Schematic OF test procedure: Mice explored the OF freely and mean velocity has been measeured. E, F Open field was performed to analyze the locomotor activity at day 9 (AIN-sham: n = 6, AIN-PCI: n = 10; PLX5622-sham: n = 5, PLX5622-PCI: n = 8, Two-way ANOVA with post hoc Tukey test) and day 29 (AIN-sham: n = 7, AIN-PCI: n = 11; PLX5622-sham: n = 7, PLX5622-PCI: n = 10, Two-way ANOVA with post hoc Tukey test). Data are presented as mean ± SEM. Each circle represents one mouse