Fig. 4

Human OM-ALI cells from healthy individuals exhibit variant-specific susceptibility to SARS-CoV-2 infection. Quantification of the of viral NP-positive OM-ALIs at 72 hpi with WT-SARS-CoV-2 (1 × 105 PFU), delta variant (1 × 105 PFU’s), omicron variant (1 × 105 PFU’s), and inhibition of WT infection with pre-treatment of Nafamostat (25 µM). Graph shows mean with SD of n = 3 for cognitively healthy controls (total of 5 images were analyzed, each dot represents percentage of positive cell in single image). One-way ANOVA with Dunnett’s multiple comparisons tests; *indicates p-values ≤ 0.05 and **indicates p-values ≤ 0.01