Fig. 5

AD alters OM-ALI cell response to SARS-CoV-2 via transcriptomic changes. a–d Volcano plots showing differentially expressed genes (DEGs) between a control mock and AD mock, genes with Log2 fc of ≤ -3 or ≥ 3 and FDR ≤ 0.01 are highlighted; b control mock and control infected, genes with Log2 fc of ≤ -2 or ≥ 2 and FDR ≤ 0.01 are highlighted; c AD mock and AD infected, genes with Log2 fc of ≤ − 2 or ≥ 2 and FDR ≤ 0.01 are highlighted; d control infected and AD infected, genes with Log2 fc of ≤ − 5 or ≥ 5 and FDR ≤ 0.01 are highlighted. The red dot indicates Log2 fc cutoff 1 and FDR cutoff 0.05. e, f Heatmaps showing Alzheimer’s disease KEGG pathway (hsa05010) associated top 20 DEGs in; e control mock and AD mock; f control infected vs AD infected. g, h Heatmaps showing KEGG human coronavirus disease pathway (hsa05171) associated DEGs in g control mock and control infected and in h AD mock and AD infected. fc fold change, FDR false discovery rate