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Table 1 Animal monitoring sheet for GVHD

From: CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice

Criteria

0

0.5

1.0

1.5

2.0

Skin integrity

Normal

Minor scaling of paws OR tail OR ears only

Scaling of paws and tail

Areas of hair loss with skin thickening

Obvious areas of denuded skin

Posture

(hunching)

Normal

Very minor hunching, apparent at rest only

Clear hunching apparent at rest only

Clear hunching, apparent with movement

Severe hunching, impairs movement

Fur texture

Normal

Minor/partial ruffling over ventral surface only

Mild to moderate ruffling over ventral surface

Moderate/complete ruffling over ventral surface and partial ruffling over dorsal surface

Severe/complete ruffling over ventral and dorsal surface, poor grooming

Activity

Normal

Minor reduction only

Mild to moderate reduction

Moderate to severe reduction

Stationary unless stimulated

Weight loss

 < 10%

 

10–25%

 

25%