Table 2 Grading criteria for pathology in peripheral tissues
Grade | Skin | Liver | Lung | Gut |
|---|---|---|---|---|
0 | No visible pathology | No visible pathology | No visible pathology | No visible pathology |
I | Low degree of apoptosis, lymphocyte infiltration | Punctate infiltration of mononuclear cells | Punctate infiltration of mononuclear cells | Single cell necrosis of epithelial cells |
II | Focal separation of the dermis and epidermis | Sporadic perivascular infiltration of mononuclear cells | Sporadic clustering of mononuclear cells, particularly clustering around bronchi | Necrosis and loss of glands |
III | Widespread separation of the dermis and epidermis | Sporadic perivascular infiltration of mononuclear cells with infiltration into the parenchyma | Clustering of mononuclear cells, some loss of eosin staining on bronchi | Focal microscopic mucosal denudation |
IV | Complete or near complete separation of the dermis and epidermis | Widespread perivascular infiltration of mononuclear cells with spread into the parenchyma | Clustering of mononuclear cells with infiltration into the parenchyma, loss of structural integrity in bronchi | Diffuse mucosal denudation |