Fig. 7

Effects of experimental interventions on brain pathology and amyloidosis in the brain. A HE staining of the whole brain (n = 3 mice/group, scale bar = 100/20 μm); B immunohistochemical staining of Aβ in the cerebral cortex (n = 3 mice/group, scale bar = 100/20 μm), black arrows: Aβ deposition; C immunofluorescent double staining of Aβ and SAA in the hippocampus (n = 3 mice/group, scale bar = 100 μm), nucleus, Aβ and SAA were represented in blue, green and red, respectively; D, E Aβ and SAA relative intensity of fluorescence; F–I the mRNA and protein expression of APP and SAA in the brain (n = 6 mice/group); J Western blot results. All data are presented as mean ± SD. *p < 0.05. **p < 0.01. ***p < 0.001