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TableĀ 3 Comparison of serum oxysterols and Th17-related cytokines between MCI and control participants

From: 27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice

Ā 

MCI (nā€‰=ā€‰48)

Control (nā€‰=ā€‰52)

t/Z

p value

Oxysterols

Ā 27-OHC, Ī¼mol/L

1.343 (0.650, 2.238)

0.961 (0.275, 1.485)

āˆ’ā€‰2.164

0.030*

Ā 24S-OHC, Ī¼mol/L

4.007ā€‰Ā±ā€‰1.103

4.102ā€‰Ā±ā€‰0.881

āˆ’ā€‰0.469

0.641

Ā 27-CA, Ī¼mol/L

0.147 (0.105, 0.192)

0.146 (0.086, 0.193)

āˆ’ā€‰0.267

0.790

Ā 7-HOCA, Ī¼mol/L

0.034 (0.025, 0.046)

0.036 (0.025, 0.047)

āˆ’ā€‰0.441

0.659

Ā 27-OHC/24S-OHC

0.374 (0.165, 0.645)

0.249 (0.070, 0.382)

āˆ’ā€‰2.421

0.015*

Ā 27-OHC/7-HOCA

40.018 (16.364, 64.046)

28.821 (9.203, 42.739)

āˆ’ā€‰1.508

0.132

Th17-related cytokines

Ā IL-17A

3.662 (2.575,5.359)

3.191 (2.154,3.992)

āˆ’ā€‰2.360

0.018*

Ā IL-12p70

0.530 (0.277,0.742)

0.365 (0.249,0.522)

āˆ’ā€‰2.791

0.005*

Ā IL-23

79.220 (46.325,109.336)

57.645 (29.665,82.986)

āˆ’ā€‰2.632

0.008*

Ā GM-CSF

5.626 (4.360, 7.702)

5.596 (3.396,6.703)

āˆ’ā€‰1.979

0.048*

Ā MIP-3Ī±

10.607 (3.590,30.401)

6.840 (2.515,16.891)

āˆ’ā€‰2.212

0.027*

Ā TNF-Ī±

13.931 (8.822,18.382)

11.019 (7.840,15.733)

āˆ’ā€‰2.308

0.021*

Ā IL-13

1.699ā€‰Ā±ā€‰0.973

2.369ā€‰Ā±ā€‰1.622

āˆ’ā€‰2.484

0.017*

Ā IL-28A

0.000 (0.000,0.175)

0.000 (0.000,11.357)

āˆ’ā€‰2.004

0.045*

Ā TGF-Ī²1

193.192 (79.751,301.129)

245.234 (141.176,401.015)

āˆ’ā€‰2.201

0.028*

Ā IFN-Ī³

8.525ā€‰Ā±ā€‰3.047

8.659ā€‰Ā±ā€‰5.537

āˆ’ā€‰0.140

0.889

Ā IL-2

10.676ā€‰Ā±ā€‰5.527

11.212ā€‰Ā±ā€‰8.925

āˆ’ā€‰0.346

0.731

Ā IL-5

5.492ā€‰Ā±ā€‰2.378

6.252ā€‰Ā±ā€‰3.477

āˆ’ā€‰1.225

0.227

Ā TNF-Ī²

9.430ā€‰Ā±ā€‰10.378

6.639ā€‰Ā±ā€‰2.468

1.958

0.056

Ā IL-6

9.302 (6.199, 14.979)

8.357 (5.483, 13.092)

āˆ’ā€‰0.967

0.334

Ā IL-10

0.821 (0.598,1.034)

0.720 (0.594, 0.931)

āˆ’ā€‰0.921

0.357

Ā IL-17F

0.231 (0.065,0.786)

0.117 (0.008,0.569)

āˆ’ā€‰1.398

0.162

Ā IL-1Ī²

1.039 (0.376,2.286)

1.414 (0.758,2.342)

āˆ’ā€‰0.603

0.546

Ā IL-4

10.122 (6.701,16.334)

11.388 (9.142,12.783)

āˆ’ā€‰0.525

0.600

Ā IL-21

316.160 (257.939,425.695)

320.318 (254.223,434.132)

āˆ’ā€‰0.582

0.561

Ā IL-22

0.000(0.000,83.291)

0.000(0.000,90.544)

āˆ’ā€‰0.299

0.765

  1. *pā€‰<ā€‰0.05. 27-OHC: 27-hydroxycholesterol; 24S-OHC: 24S-hydroxycholesterol; 27-CA: 3Ī²-hydroxy-5-cholestenoic acid; 7-HOCA: 7Ī±-hydroxy-3-oxo-4-cholestenoic acid; IL: Interleukin; GM-CSF: granulocyteā€“macrophage colony-stimulating factor; MIP-3Ī±: macrophage inflammatory protein 3Ī±; TNF-Ī±: tumor necrosis factor-Ī±; TGF-Ī²1: transforming growth factor Ī²1; IFN-Ī³: Interferon-Ī³; TNF-Ī²: tumor necrosis factor-Ī²
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Journal of Neuroinflammation

ISSN: 1742-2094