Fig. 5

In vivo genetic silencing of FGF14 mitigates altered plasticity of hippocampal neurons in eCM. A Left: timeline of stereotaxic surgery, P. chabaudi infection, and field recordings. Right: schematic of HFS protocol used in D. B fEPSP slope plotted as a function of stimulation intensity to assess basic synaptic responses in slices from the indicated experimental groups. C Comparison of PPF among the indicated experimental groups. D Comparison of activity-dependent plasticity among the indicated experimental groups. Data are mean ± SEM (n = 9–14 slices/group; slices from N = 4 mice per group). Statistical significance was assessed using a one-way ANOVA with post hoc Tukey’s multiple comparisons test. In (C, right and D, bottom right): ns not significant; ***p < 0.001; ****p < 0.0001