Fig. 6

In vivo genetic silencing of FGF14 in the hippocampus ameliorates sickness behavior and controls thermoregulation in eCM. A Timeline for evaluation of sickness behavior and other consequences of P. chabaudi infection. eCM was measured by B modified SHIRPA behavioral scores, C predicted survival based upon SHIRPA scores day 7 p.i., D parasite load (%iRBC/RBC), E hypothermia, and F weight loss for mice of the indicated groups. Data shown as mean ± SEM (n = 15 mice/group). In B–F, statistical significance was determined via a 2-way ANOVA with post hoc Tukey’s multiple comparisons test: ns not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001