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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity

Fig. 8

Neurotoxic insult causes astrogliosis in the ACx. A, B Representative images of brain coronal sections stained with GFAP (red fluorescence) showing the auditory cortex (ACx) of control (A, Ctrl) and styrene treated animals (B). Scale bar: 50 μm. a1, b1 Schematic representation of a camera lucida drawing of a single GFAP-positive astrocyte from control (a1) and styrene-treated animal (b1) analyzed with Sholl analysis. C–F Bar graphs (mean ± SEM) indicate differences in total dendritic length (C, Student’s t test, p = 0.03), average of total surface area (D, Student’s t test, p = 0.03), number of bifurcating nodes (E, Student’s t test, p = 0.002) and number of total intersections (F, Student’s t test, p = 0.02) of astrocytes marked with GFAP in both experimental groups. Asterisks indicate significant differences between groups (**p < 0.01; ***p < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094