Fig. 7
Analysis of gene expression profiles between control and succinate (1 mM for 48 h) groups in Mφs. A Heatmap of different genes in the two groups. B Log2-fold change for succinate treatment compared to the control. C KEGG pathway enrichment analysis of the top 20 differentially expressed pathways. D GO analysis of the top 10 differentially expressed pathways in the BP, CC and MF categories. E Heatmap of significantly different secreted genes. F Relative mRNA expression of RBP4 in succinate-treated Mφs (n = 3). G RBP4 concentration in Mφ supernatant after succinate intervention (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001