Fig. 4
From: Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia
Upregulation of cytokine signaling in the immune system and downregulation of tube morphogenesis in the kidney following LPS challenge. a Volcano plot of differentially expressed genes (adjusted p < 0.05) for LPS (n = 4) versus control saline (n = 6) showed numerous differentially expressed genes. b Downregulated and upregulated pathways showed enrichment for cytokine signaling in the immune system, response to virus, tube morphogenesis, and kidney development, among others. c–g Heatmaps showing gene expression, log2 counts per million (CPM), for the top upregulated genes, sorted by greatest to least log2FC, within selected enrichment functions reveals potential gene targets and the corresponding pathway(s). h–l Heatmaps showing gene expression for the top downregulated genes within selected enrichment functions