Fig. 6

Nestin-Cre-mediated Hamp knockout mice exhibited pathological changes similar to Hamp^GFAP cKO mice. A The weights of total brain, and unilateral cortex and hippocampus of 3-month-old Hamp^Nes cKO mice and control mice. B, C Immunofluorescence staining of NeuN⁺ cells (B) and quantification (C) in the hippocampus of Hamp^Nes cKO mice and control mice (scale bar: 50 μm). D, E Immunofluorescence staining (D) and quantification (E) of DCX⁺ cells in the DG region of the control and Hamp^Nes cKO mice (scale bar: 50 μm). F, G qRT-PCR detection of the mRNA levels of TNF-α (F) and BDNF (G) in the hippocampus of Hamp^Nes cKO mice and control mice. Data were expressed as mean ± SEM, n = 4 or 6 per group. *p < 0.05 and ***p < 0.001