Fig. 5
From: Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
AMD patients present a systemic overactivation of RAS. A Schematic of the renin–angiotensin system. B Age and sex of the 13 controls (Ctl) and 24 AMD patients study participants. C Quantifications of plasma renin activity (PRA), eqANGI, and eqANGII measured after 1 h at 37 °C incubation of frozen plasma samples by LC–MS/MS (Mann–Whitney test; PRA, *p = 0.0160; eqANGII, *p = 0.0214). ATR1: angiotensin II receptor type 1; PRA: plasma renin activity; eqANG1: equilibrium angiotensin 1; eqANG2: equilibrium angiotensin II