Fig. 6

Proteomic analyses of microglial cells sorted from the ipsilateral hemisphere of P13 rats subjected to HI at P11 without and with various neuroprotective treatments (n = 5 in each experimental group). Principal component analysis of the experimental groups (A), comparisons between Sham and HI-injured animals and effect of hypothermia alone (HT), Sildenafil ip alone (Sild), and the combined treatment (Sild + HT) (B–D). For group comparison (Heat maps and volcano-plots), 2-side unpaired t-test were done and a p-value < 0.01 threshold were used to consider protein differentially significantly expressed