Fig. 2

Acetate reduces arterial blood pressure (ABP) in SHRs. A, schematic diagram for implant operation and acetate treatment. B-C, increased acetate levels in feces, serum and cerebrospinal fluid of WKY rats and SHRs after 1 week of acetate treatment. n = 5 for each group. D, fluorescent signals detected in brain tissues after intravenous injection of Cy5-labeled acetate in WKY rats. E-G, acetate treatment reduces SBP and diastolic blood pressure (DBP) without altering heart rate (HR) in SHRs. n = 7 for each group. H-J, effects of acetate treatment for 1 week on 24-h ambulatory blood pressure in SHR rats. n = 10 for each group. K, 1-week acetate treatment reduced serum norepinephrine levels in SHRs. n = 8 for each group. L, tachycardic response induced by intraperitoneal injection of atropine; M, propranolol-induced bradycardia response; N, hypotensive effect induced by hexamethonium. n = 5 for each group. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001