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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway

Fig. 1

Schematic diagram of the construction of mouse glaucoma model and analysis of retinal samples. (A) The overview of in vivo H-IOP mouse model construction. (B) The schematic diagram of episcleral vein cautery. Image from Ruiz-Ederra et al., 2005 [23]. The illustration of the mouse eye depicts episcleral veins (red) relative to extraocular muscles, with three veins marked by cauterization interruptions. Pre- and post-cauterization (EVC-treated) images of these veins are provided, with arrows pointing to cauterization sites. (C) The overview of ex vivo retinal explants Pressure 60 mmHg model construction and inhibition of gp91ds-tat. (D) The overview of the retina sample preparation and the imaging and analysis of the retinal flat mount and cryosection. Abbreviations: EVC, episcleral vein occlusion; IO, inferior oblique; IR, inferior rectus; LR, lateral rectus; MR, medial rectus; SO, superior oblique; SR, superior rectus

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Journal of Neuroinflammation

ISSN: 1742-2094