Fig. 7
From: Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
sCD27 in post-mortem MS cases reflects the degree of lesion activity. Histograms reported levels of sCD27 in different groups defined by degree of lesion activity (A), number of meningeal follicles (B), degree of CP (choroid plexus) inflammation (C), degree of perivascular inflammation (D), degree of meningeal inflammation (E), number of early active lesions (F), number of active lesions (G), number of chronic active lesions (H), number of inactive lesions (I). The data represent mean ± SD of 30 post-mortem MS cases. Statistical analyses were performed by using one-way non-parametric ANOVA and Mann-Whitney U test (F). Principal component analysis of cytokines detected in the matched CSF of 30 post-mortem MS cases (J). Histograms report the features stratified for importance for degree of lesion activity (K) and number of early active lesions (I) obtained from Random Forest (RF)-recursive feature elimination (RFE) algorithm