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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro

Fig. 1

Neurogranin (Nrgn) is dysregulated in PWH at the mRNA and protein levels. Representative images of postmortem frontal cortex (FC) neurons stained for Nrgn (Cy3, red) and DAPI (blue) in (A) control and (B) people with HIV-1. The images are z-projections of image stacks acquired at ×60 magnification; scale bar is 10 μm. (C) Quantification of Nrgn levels in whole frontal cortex lysates from people with HIV-1 (N = 13) in comparison with control individuals (N = 15). (D) Relative expression of Nrgn mRNA in FC brain samples from HIV-1 positive individuals (N = 49) compared to control individuals (N = 22) as assessed by RT-qPCR. (E) Quantification of Nrgn mRNA copy number in FC samples of HIV-1 positive individuals compared to control individuals. (F) Comparison of Nrgn expression across different clinical stages of HAND

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Journal of Neuroinflammation

ISSN: 1742-2094