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  1. Research

    Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function

    Stroke induces immune alterations such as impaired oxidative burst and reduced release of neutrophil extracellular traps (NETs). We hypothesised that key enzymes of these defence mechanisms may be altered in i...

    Antje Vogelgesang, Claudia Lange, Lara Blümke, Georg Laage, Sarah Rümpel, Sönke Langner, Barbara M. Bröker, Alexander Dressel and Johanna Ruhnau

    Journal of Neuroinflammation 2017 14:140

    Published on: 21 July 2017

  2. Research

    Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

    Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke. However, the role of heparanase in neuroinflammatory response...

    Benjarat Changyaleket, Zhao Zhong Chong, Randal O. Dull, Danop Nanegrungsunk and Haoliang Xu

    Journal of Neuroinflammation 2017 14:137

    Published on: 18 July 2017

  3. Research

    MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis

    Controversy exists regarding which cell types are responsible for autoantigen presentation in the retina during experimental autoimmune uveitis (EAU) development. In this study, we aimed to identify and charac...

    Deborah A. Lipski, Rémi Dewispelaere, Vincent Foucart, Laure E. Caspers, Matthieu Defrance, Catherine Bruyns and François Willermain

    Journal of Neuroinflammation 2017 14:136

    Published on: 18 July 2017

  4. Research

    The role of microglial P2X7: modulation of cell death and cytokine release

    ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflamma...

    Yingbo He, Natalie Taylor, Lawrence Fourgeaud and Anindya Bhattacharya

    Journal of Neuroinflammation 2017 14:135

    Published on: 17 July 2017

  5. Research

    Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

    During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in t...

    Stephanie M. Krasnow, J. Gabriel Knoll, Santhosh Chakkaramakkil Verghese, Peter R. Levasseur and Daniel L. Marks

    Journal of Neuroinflammation 2017 14:133

    Published on: 1 July 2017

  6. Research

    Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

    Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial act...

    Min Yin, Zhiying Chen, Yetong Ouyang, Huiyan Zhang, Zhigang Wan, Han Wang, Wei Wu and Xiaoping Yin

    Journal of Neuroinflammation 2017 14:132

    Published on: 29 June 2017

  7. Research

    The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

    The endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding infl...

    Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Carlos C. Romao, Nils Schallner, Ulrich Goebel and Julia Biermann

    Journal of Neuroinflammation 2017 14:130

    Published on: 27 June 2017

  8. Research

    Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

    The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets...

    Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner and Avindra Nath

    Journal of Neuroinflammation 2017 14:131

    Published on: 27 June 2017

  9. Research

    Evidence for an early innate immune response in the motor cortex of ALS

    Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC ...

    Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller and P. Hande Özdinler

    Journal of Neuroinflammation 2017 14:129

    Published on: 26 June 2017

  10. Research

    A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

    Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the mo...

    Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried and Allan I. Levey

    Journal of Neuroinflammation 2017 14:128

    Published on: 26 June 2017

  11. Research

    The increased concentration of macrophage migration inhibitory factor in serum and cerebrospinal fluid of patients with tick-borne encephalitis

    Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into cent...

    Sambor Grygorczuk, Miłosz Parczewski, Renata Świerzbińska, Piotr Czupryna, Anna Moniuszko, Justyna Dunaj, Maciej Kondrusik and Sławomir Pancewicz

    Journal of Neuroinflammation 2017 14:126

    Published on: 24 June 2017

  12. Short Report

    Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination

    Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating path...

    Carsten Tue Berg, Reza Khorooshi, Nasrin Asgari and Trevor Owens

    Journal of Neuroinflammation 2017 14:127

    Published on: 24 June 2017

  13. Research

    Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

    Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight ...

    Haiying Zhang, Joon Ha Park, Sony Maharjan, Jeong Ae Park, Kyu-Sung Choi, Hyojin Park, Yoonjeong Jeong, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Jeong Hwi Cho, In-Kyu Lee, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Young-Ger Suh…

    Journal of Neuroinflammation 2017 14:122

    Published on: 23 June 2017

  14. Research

    Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis

    Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers in the differential diagnosis of demyelination. Here, we report on discovery of autoanti...

    S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. P. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. vom Dahl, T. Kümpfel, P. Eichhorn, H. Gold, F. Paul…

    Journal of Neuroinflammation 2017 14:123

    Published on: 23 June 2017

  15. Research

    Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130

    Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL...

    Xinlei Wang, Eric B. Miller, Mayank Goswami, Pengfei Zhang, Kaitryn E. Ronning, Sarah J. Karlen, Robert J. Zawadzki, Edward N. Pugh Jr. and Marie E. Burns

    Journal of Neuroinflammation 2017 14:121

    Published on: 23 June 2017

  16. Research

    Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain

    All known biological functions of the pro-inflammatory cytokine interleukin-1β (IL-1β) are mediated by type 1 interleukin receptor (IL-1R1). IL-1β–IL-1R1 signaling modulates various neuronal functions includin...

    Krisztina Holló, László Ducza, Zoltán Hegyi, Klaudia Dócs, Krisztina Hegedűs, Erzsébet Bakk, Ildikó Papp, Gréta Kis, Zoltán Mészár, Zsuzsanna Bardóczi and Miklós Antal

    Journal of Neuroinflammation 2017 14:125

    Published on: 23 June 2017

  17. Research

    Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells

    Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) ...

    Chandra M. Menendez and Daniel J. J. Carr

    Journal of Neuroinflammation 2017 14:124

    Published on: 23 June 2017

  18. Research

    Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

    Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (...

    Aarti Narang, Fei Qiao, Carl Atkinson, Hong Zhu, Xiaofeng Yang, Liudmila Kulik, V. Michael Holers and Stephen Tomlinson

    Journal of Neuroinflammation 2017 14:120

    Published on: 19 June 2017

  19. Research

    Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

    Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid...

    Jun Zeng, Yizhao Chen, Rui Ding, Liang Feng, Zhenghao Fu, Shuo Yang, Xinqing Deng, Zhichong Xie and Shizhong Zheng

    Journal of Neuroinflammation 2017 14:119

    Published on: 13 June 2017

  20. Review

    Regulatory T cells in multiple sclerosis and myasthenia gravis

    Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the ...

    K. M. Danikowski, S. Jayaraman and B. S. Prabhakar

    Journal of Neuroinflammation 2017 14:117

    Published on: 9 June 2017

  21. Research

    YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

    The innate immune system is known to be involved early in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be meas...

    Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Carla San Martín-Paniello, Jordi Clarimon, Olivia Belbin, Juan Fortea and Alberto Lleó

    Journal of Neuroinflammation 2017 14:118

    Published on: 9 June 2017

  22. Research

    Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

    Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 s...

    Nádia Pereira Gonçalves, João Moreira, Diana Martins, Paulo Vieira, Laura Obici, Giampaolo Merlini, Margarida Saraiva and Maria João Saraiva

    Journal of Neuroinflammation 2017 14:115

    Published on: 6 June 2017

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