Skip to main content

Articles

Page 2 of 65

  1. Past experiments studying innate immunity in the central nervous system (CNS) utilized microglia obtained from neonatal mouse brain, which differ developmentally from adult microglia. These differences might i...

    Authors: James A. Carroll, Brent Race, Katie Williams, James F. Striebel and Bruce Chesebro

    Citation: Journal of Neuroinflammation 2021 18:194

    Content type: Research

    Published on:

  2. Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure. In the hippocampus, so...

    Authors: Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso and Eliana P. Araujo

    Citation: Journal of Neuroinflammation 2021 18:192

    Content type: Research

    Published on:

  3. Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD). Here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal ...

    Authors: Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang and Dong Soo Lee

    Citation: Journal of Neuroinflammation 2021 18:190

    Content type: Research

    Published on:

  4. Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antago...

    Authors: Sharmony B. Kelly, Vanesa Stojanovska, Valerie A. Zahra, Alison Moxham, Suzanne L. Miller, Timothy J. M. Moss, Stuart B. Hooper, Marcel F. Nold, Claudia A. Nold-Petry, Justin M. Dean, Laura Bennet, Graeme R. Polglase, Alistair J. Gunn and Robert Galinsky

    Citation: Journal of Neuroinflammation 2021 18:189

    Content type: Research

    Published on:

  5. Innate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate extracellular immune responses by promoting secretion ...

    Authors: Pengfei Xu, Chunrong Tao, Yuyou Zhu, Guoping Wang, Lingqi Kong, Wenyu Li, Rui Li, Juanji Li, Chao Zhang, Li Wang, Xinfeng Liu, Wen Sun and Wei Hu

    Citation: Journal of Neuroinflammation 2021 18:188

    Content type: Research

    Published on:

  6. Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation ...

    Authors: Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He and Dandan Sun

    Citation: Journal of Neuroinflammation 2021 18:187

    Content type: Research

    Published on:

  7. Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammat...

    Authors: Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng-mao Lin, Dejuan Kong, Heather Hager, Xuwen Liu and David A. Antonetti

    Citation: Journal of Neuroinflammation 2021 18:186

    Content type: Research

    Published on:

  8. Efforts to understand genetic variability involved in an individual’s susceptibility to chronic pain support a role for upstream regulation by epigenetic mechanisms.

    Authors: Kimberly E. Stephens, Weiqiang Zhou, Zachary Renfro, Zhicheng Ji, Hongkai Ji, Yun Guan and Sean D. Taverna

    Citation: Journal of Neuroinflammation 2021 18:185

    Content type: Research

    Published on:

  9. White matter injury (WMI) is a major neuropathological event associated with intracerebral hemorrhage (ICH). P2X purinoreceptor 4 (P2X4R) is a member of the P2X purine receptor family, which plays a crucial ro...

    Authors: Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang and Feng Yan

    Citation: Journal of Neuroinflammation 2021 18:184

    Content type: Research

    Published on:

  10. Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, par...

    Authors: Nada El Mahmoudi, Guillaume Rastoldo, Emna Marouane, David Péricat, Isabelle Watabe, Alain Tonetto, Charlotte Hautefort, Christian Chabbert, Francesca Sargolini and Brahim Tighilet

    Citation: Journal of Neuroinflammation 2021 18:183

    Content type: Research

    Published on:

  11. Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here...

    Authors: Shuo Cheng, Hong-Ning Wang, Lin-Jie Xu, Fang Li, Yanying Miao, Bo Lei, Xinghuai Sun and Zhongfeng Wang

    Citation: Journal of Neuroinflammation 2021 18:182

    Content type: Research

    Published on:

  12. Intractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of NMOSD pain remains to be elucidated. In this study, we focused on ATP, w...

    Authors: Teruyuki Ishikura, Makoto Kinoshita, Mikito Shimizu, Yoshiaki Yasumizu, Daisuke Motooka, Daisuke Okuzaki, Kazuya Yamashita, Hisashi Murata, Shohei Beppu, Toru Koda, Satoru Tada, Naoyuki Shiraishi, Yasuko Sugiyama, Katsuichi Miyamoto, Susumu Kusunoki, Tomoyuki Sugimoto…

    Citation: Journal of Neuroinflammation 2021 18:181

    Content type: Research

    Published on:

  13. Exposure to general anesthesia (GA) during the postnatal period is associated with neuroinflammation and long-term neurocognitive impairment in preclinical and clinical settings. Pyroptosis is a novel type of ...

    Authors: Jing Dai, Xue Li, Cai Wang, Shuxin Gu, Lei Dai, Jingyun Zhang, Yunxia Fan and Jing Wu

    Citation: Journal of Neuroinflammation 2021 18:180

    Content type: Research

    Published on:

  14. Intracerebral hemorrhage (ICH) results in a cascade of inflammatory cell activation with recruitment of peripheral leukocytes to the brain parenchyma and surrounding the hematoma. We hypothesized that in patie...

    Authors: Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley and Wendy C. Ziai

    Citation: Journal of Neuroinflammation 2021 18:179

    Content type: Research

    Published on:

  15. Zika virus (ZIKV) has been associated with several neurological complications in adult patients.

    Authors: William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay and Guy Boivin

    Citation: Journal of Neuroinflammation 2021 18:178

    Content type: Research

    Published on:

  16. Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has p...

    Authors: Emil Gregersen, Cristine Betzer, Woojin S. Kim, Gergo Kovacs, Lasse Reimer, Glenda M. Halliday, Steffen Thiel and Poul Henning Jensen

    Citation: Journal of Neuroinflammation 2021 18:177

    Content type: Research

    Published on:

  17. Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells including dendritic cells, macrophages, and microglia. We ...

    Authors: Junjun Ni, Juan Zhao, Xinwen Zhang, Thomas Reinheckel, Vito Turk and Hiroshi Nakanishi

    Citation: Journal of Neuroinflammation 2021 18:176

    Content type: Research

    Published on:

  18. Diabetes has been recognized as a risk factor contributing to the incidence and progression of Parkinson’s disease (PD). Although several hypotheses suggest a number of different mechanisms underlying the aggr...

    Authors: Osama F. Elabi, João Paulo M. C. M. Cunha, Abderahim Gaceb, Malin Fex and Gesine Paul

    Citation: Journal of Neuroinflammation 2021 18:175

    Content type: Research

    Published on:

  19. Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained the bioactivity of the parent compound, the ta...

    Authors: Dan-Dan Liu, Piao Luo, Liwei Gu, Qian Zhang, Peng Gao, Yongping Zhu, Xiao Chen, Qiuyan Guo, Junzhe Zhang, Nan Ma and Jigang Wang

    Citation: Journal of Neuroinflammation 2021 18:174

    Content type: Research

    Published on:

  20. Traumatic brain injury (TBI) is a significant cause of death and disability worldwide. The TLR4-NFκB signaling cascade is the critical pro-inflammatory activation pathway of leukocytes after TBI, and modulatin...

    Authors: Ning Liu, Jinrui Han, Yadan Li, Yinghua Jiang, Samuel X. Shi, Josephine Lok, Michael Whalen, Aaron S. Dumont and Xiaoying Wang

    Citation: Journal of Neuroinflammation 2021 18:173

    Content type: Research

    Published on:

  21. Traumatic spinal cord injury (SCI) is a severely disabling disease that leads to loss of sensation, motor, and autonomic function. As exosomes have great potential in diagnosis, prognosis, and treatment of SCI...

    Authors: Dayu Pan, Yongjin Li, Fuhan Yang, Zenghui Lv, Shibo Zhu, Yixin Shao, Ying Huang, Guangzhi Ning and Shiqing Feng

    Citation: Journal of Neuroinflammation 2021 18:172

    Content type: Research

    Published on:

  22. Anti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), a major component of Panax ginseng, can inhibit inflammatory cascade and alleviate...

    Authors: Lijuan Zhang, Minmin Tang, Xiaofang Xie, Qiuying Zhao, Nan Hu, Hui He, Gangcai Liu, Shiqi Huang, Cheng Peng, Ying Xiao and Zili You

    Citation: Journal of Neuroinflammation 2021 18:171

    Content type: Research

    Published on:

  23. Astrocyte over-activation and extensive neuron loss are the main characteristic pathological features of spinal cord ischemia–reperfusion injury (SCII). Prior studies have placed substantial emphasis on the ro...

    Authors: Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu and Xin Ge

    Citation: Journal of Neuroinflammation 2021 18:170

    Content type: Research

    Published on:

  24. Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 interferon-stimulated gene (ISG) expression signatu...

    Authors: Xinfeng Guo, Clayton A. Wiley, Richard A. Steinman, Yi Sheng, Beihong Ji, Junmei Wang, Liyong Zhang, Tony Wang, Mazen Zenatai, Timothy R. Billiar and Qingde Wang

    Citation: Journal of Neuroinflammation 2021 18:169

    Content type: Research

    Published on:

  25. Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological function and in treatment-induced improvements in functi...

    Authors: Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Richard J. Woodman, Hakan Muyderman and Neil R. Sims

    Citation: Journal of Neuroinflammation 2021 18:168

    Content type: Research

    Published on:

  26. Neurological complications are common in patients affected by COVID-19 due to the ability of SARS-CoV-2 to infect brains. While the mechanisms of this process are not fully understood, it has been proposed tha...

    Authors: Silvia Torices, Rosalba Cabrera, Michael Stangis, Oandy Naranjo, Nikolai Fattakhov, Timea Teglas, Daniel Adesse and Michal Toborek

    Citation: Journal of Neuroinflammation 2021 18:167

    Content type: Research

    Published on:

  27. Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘micro...

    Authors: Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer and Nicholas J. C. King

    Citation: Journal of Neuroinflammation 2021 18:166

    Content type: Research

    Published on:

  28. Malignant glioma, especially glioblastoma, is a highly aggressive disease with a dismal prognosis. Vacuole membrane protein 1 (VMP1) is a critical autophagy-associated protein with roles in oncogenesis and tum...

    Authors: Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong and Jiade J. Lu

    Citation: Journal of Neuroinflammation 2021 18:165

    Content type: Research

    Published on:

  29. Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudat...

    Authors: Kei Takahashi, Shinsuke Nakamura, Wataru Otsu, Masamitsu Shimazawa and Hideaki Hara

    Citation: Journal of Neuroinflammation 2021 18:164

    Content type: Research

    Published on:

  30. The NLRP3 inflammasome is a critical mediator of several vascular diseases through positive regulation of proinflammatory pathways. In this study, we defined the role of NLRP3 in both the acute and delayed pha...

    Authors: William S. Dodd, Imaray Noda, Melanie Martinez, Koji Hosaka and Brian L. Hoh

    Citation: Journal of Neuroinflammation 2021 18:163

    Content type: Research

    Published on:

  31. Colony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previous...

    Authors: Ishani De, Vilena Maklakova, Suzanne Litscher, Michelle M. Boyd, Lucas C. Klemm, Ziyue Wang, Christina Kendziorski and Lara S. Collier

    Citation: Journal of Neuroinflammation 2021 18:162

    Content type: Research

    Published on:

  32. The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of i...

    Authors: Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie and Kiran Bhaskar

    Citation: Journal of Neuroinflammation 2021 18:161

    Content type: Research

    Published on:

  33. Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal zone and the cerebral lateral ventricles. The co...

    Authors: Jie Xiao, Tao Cai, Yuanjian Fang, Rui Liu, Jerry J. Flores, Wenna Wang, Ling Gao, Yu Liu, Qin Lu, Lihui Tang, John H. Zhang, Hongwei Lu and Jiping Tang

    Citation: Journal of Neuroinflammation 2021 18:160

    Content type: Research

    Published on:

  34. C1qTNF-related protein 4 (CTRP4) acts in the hypothalamus to modulate food intake in diet-induced obese mice and has been shown to exert an anti-inflammatory effect on macrophages. Since high-fat diet-induced ...

    Authors: Liu Ye, Gongwei Jia, Yuejie Li, Ying Wang, Hong Chen, Lehua Yu and Dandong Wu

    Citation: Journal of Neuroinflammation 2021 18:159

    Content type: Research

    Published on:

  35. Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed tha...

    Authors: Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi and Lilly Schwieler

    Citation: Journal of Neuroinflammation 2021 18:158

    Content type: Research

    Published on:

  36. Repetitive mild traumatic brain injury (mTBI) can result in chronic visual dysfunction. G-protein receptor 110 (GPR110, ADGRF1) is the target receptor of N-docosahexaenoylethanolamine (synaptamide) mediating the ...

    Authors: Huazhen Chen, Karl Kevala, Elma Aflaki, Juan Marugan and Hee-Yong Kim

    Citation: Journal of Neuroinflammation 2021 18:157

    Content type: Research

    Published on:

  37. Inflammation is considered a key factor in the development of postoperative cognitive dysfunction (POCD). Therefore, we hypothesized that pre-operative anti-inflammatory treatment with ibuprofen would inhibit ...

    Authors: Klaske Oberman, Iris Hovens, Jacco de Haan, Joana Falcao-Salles, Barbara van Leeuwen and Regien Schoemaker

    Citation: Journal of Neuroinflammation 2021 18:156

    Content type: Research

    Published on:

  38. CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the CDKL5 gene. Evidence in a...

    Authors: Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Claudia Fuchs, Elisabetta Ciani and Stefania Trazzi

    Citation: Journal of Neuroinflammation 2021 18:155

    Content type: Research

    Published on:

  39. Complex changes in the brain microenvironment following traumatic brain injury (TBI) can cause neurological impairments for which there are few efficacious therapeutic interventions. The reactivity of astrocyt...

    Authors: Hang Zhou, Libin Hu, Jianru Li, Wu Ruan, Yang Cao, Jianfeng Zhuang, Hangzhe Xu, Yucong Peng, Zhongyuan Zhang, Chaoran Xu, Qian Yu, Yin Li, Zhangqi Dou, Junwen Hu, Xinyan Wu, Xiaobo Yu…

    Citation: Journal of Neuroinflammation 2021 18:154

    Content type: Research

    Published on:

  40. Neuroinflammation is a major driver of age-related brain degeneration and concomitant functional impairment. In patients with Alzheimer’s disease, the most common form of age-related dementia, factors that enh...

    Authors: Xiao-fei He, Li-li Li, Wen-biao Xian, Ming-yue Li, Li-ying Zhang, Jing-hui Xu, Zhong Pei, Hai-qing Zheng and Xi-quan Hu

    Citation: Journal of Neuroinflammation 2021 18:153

    Content type: Research

    Published on:

  41. The immune pathways in Alzheimer’s disease (AD) remain incompletely understood. Our recent study indicates that tissue-resident group 2 innate lymphoid cells (ILC2) accumulate in the brain barriers of aged mic...

    Authors: Ivan Ting Hin Fung, Yuanyue Zhang, Damian S. Shin, Poornima Sankar, Xiangwan Sun, Shanti S. D’Souza, Renjie Song, Marcy L. Kuentzel, Sridar V. Chittur, Kristen L. Zuloaga and Qi Yang

    Citation: Journal of Neuroinflammation 2021 18:152

    Content type: Research

    Published on:

  42. Traumatic brain injury (TBI) is a leading cause of death and disability that lacks neuroprotective therapies. Following a TBI, secondary injury response pathways are activated and contribute to ongoing neurode...

    Authors: Brittany P. Todd, Michael S. Chimenti, Zili Luo, Polly J. Ferguson, Alexander G. Bassuk and Elizabeth A. Newell

    Citation: Journal of Neuroinflammation 2021 18:151

    Content type: Research

    Published on:

  43. Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokin...

    Authors: Hao-Nan Li, Qing-Qing Yang, Wen-Tao Wang, Xue Tian, Fan Feng, Shu-Ting Zhang, Yu-Tong Xia, Jia-Xue Wang, Yuan-Wu Zou, Jun-Yang Wang and Xiao-Yan Zeng

    Citation: Journal of Neuroinflammation 2021 18:150

    Content type: Research

    Published on:

  44. Microglia are key regulators of the inflammatory response in the brain. Adenosine in RNAs can be converted to m6A (N6-methyladenosine), which regulates RNA metabolism and functions as a key epitranscriptomic modi...

    Authors: Qi Li, Shaohong Wen, Weizhen Ye, Shunying Zhao and Xiangrong Liu

    Citation: Journal of Neuroinflammation 2021 18:149

    Content type: Research

    Published on:

  45. Macrophages play a dual role in neuroinflammatory disorders such as multiple sclerosis (MS). They are involved in lesion onset and progression but can also promote the resolution of inflammation and repair of ...

    Authors: Tess Dierckx, Mansour Haidar, Elien Grajchen, Elien Wouters, Sam Vanherle, Melanie Loix, Annick Boeykens, Dany Bylemans, Kévin Hardonnière, Saadia Kerdine-Römer, Jeroen F. J. Bogie and Jerome J. A. Hendriks

    Citation: Journal of Neuroinflammation 2021 18:148

    Content type: Research

    Published on:

  46. Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid dep...

    Authors: Lisi Flores-Aguilar, M. Florencia Iulita, Chiara Orciani, Neil Tanna, Jingyun Yang, David A. Bennett and A. Claudio Cuello

    Citation: Journal of Neuroinflammation 2021 18:147

    Content type: Research

    Published on:

  47. Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells. While its effects in multiple organs and diseases are be...

    Authors: Meng Wang, Li-Rong Feng, Zi-Long Li, Kai-Ge Ma, Ke-Wei Chang, Xin-Lin Chen, Peng-Bo Yang, Sheng-Feng Ji, Yan-Bing Ma, Hua Han, John Bosco Ruganzua, Wei-Na Yang and Yi-Hua Qian

    Citation: Journal of Neuroinflammation 2021 18:146

    Content type: Research

    Published on:

  48. Experimental autoimmune encephalomyelitis (EAE) is an animal disease model of multiple sclerosis (MS) that involves the immune system and central nervous system (CNS). However, it is unclear how genetic predis...

    Authors: Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang, Wen-Jie Sun, Xi Li, Jiang-Xia Li, Chuan-Zhu Yan and Qi-Ji Liu

    Citation: Journal of Neuroinflammation 2021 18:145

    Content type: Research

    Published on:

  49. Minocycline is a clinically available synthetic tetracycline derivative with anti-inflammatory and antibiotic properties. The majority of studies show that minocycline can reduce tissue damage and improve func...

    Authors: Emma K. A. Schmidt, Pamela J. F. Raposo, Abel Torres-Espin, Keith K. Fenrich and Karim Fouad

    Citation: Journal of Neuroinflammation 2021 18:144

    Content type: Research

    Published on:

Annual Journal Metrics