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  1. Glaucoma is a blinding degenerative neuropathy in which the death of retinal ganglion cells (RGCs) causes progressive loss of visual field and eventually vision. Neuroinflammation appears to be a key event in ...

    Authors: Élodie Reboussin, Juliette Buffault, Françoise Brignole-Baudouin, Annabelle Réaux-Le Goazigo, Luisa Riancho, Céline Olmiere, José-Alain Sahel, Stéphane Mélik Parsadaniantz and Christophe Baudouin
    Citation: Journal of Neuroinflammation 2022 19:63
  2. Neuromyelitis optica spectrum disorder (NMOSD) attacks require an urgent probabilistic anti-inflammatory therapeutic strategy. As inadequately treated attacks result in disability, there is a need to identify ...

    Authors: Stanislas Demuth, Maxime Guillaume, Bertrand Bourre, Jonathan Ciron, Hélène Zephir, Yoann Sirejacob, Anne Kerbrat, Christine Lebrun-Frenay, Caroline Papeix, Laure Michel, David Laplaud, Sandra Vukusic, Elisabeth Maillart, Mikael Cohen, Bertrand Audoin, Romain Marignier…
    Citation: Journal of Neuroinflammation 2022 19:62
  3. We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve segment are the most common type of traumatic injury to nervous systems. Segmental-loss PNIs have a poor prognosis ...

    Authors: George D. Bittner, Jared S. Bushman, Cameron L. Ghergherehchi, Kelly C. S. Roballo, Jaimie T. Shores and Tyler A. Smith
    Citation: Journal of Neuroinflammation 2022 19:60
  4. The transcription factor Sox2 plays important roles in the developmental processes of multiple organs and tissues. However, whether Sox2 can protect mature or terminally differentiated cells against injury is ...

    Authors: Diyan Chen, Gaogan Jia, Yanping Zhang, Huanyu Mao, Liping Zhao, Wenyan Li, Yan Chen and Yusu Ni
    Citation: Journal of Neuroinflammation 2022 19:59
  5. Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflammation mediated by mi...

    Authors: Hazel Quek, Carla Cuní-López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Tara L. Roberts, Yi Chieh Lim, Lotta E. Oikari, Vincenzo La Bella and Anthony R. White
    Citation: Journal of Neuroinflammation 2022 19:58
  6. Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegener...

    Authors: Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt and Virginie Mansuy-Aubert
    Citation: Journal of Neuroinflammation 2022 19:57
  7. Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-c...

    Authors: Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu and Tz-Chuen Ju
    Citation: Journal of Neuroinflammation 2022 19:56
  8. Classical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process. However, treatments that target inflammatory mediators or immune cell...

    Authors: Huan Cui, Fan Liu, Yehong Fang, Tao Wang, Bo Yuan and Chao Ma
    Citation: Journal of Neuroinflammation 2022 19:55
  9. In the field of autoimmune demyelinating diseases, visual impairments have extensively been studied using the experimental autoimmune encephalomyelitis (EAE) mouse model, which is classically induced by immuni...

    Authors: Sandrine Joly, Julius Baya Mdzomba, Léa Rodriguez, Françoise Morin, Luc Vallières and Vincent Pernet
    Citation: Journal of Neuroinflammation 2022 19:54
  10. Immune system dysfunction, including higher levels of peripheral monocytes and inflammatory cytokines, is an important feature of Parkinson’s disease (PD) pathogenesis, although the mechanism underlying the pr...

    Authors: Zongran Liu, Robin Barry Chan, Zhijian Cai, Xiaodan Liu, Yufeng Wu, Zhenwei Yu, Tao Feng, Ying Yang and Jing Zhang
    Citation: Journal of Neuroinflammation 2022 19:53
  11. Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeu...

    Authors: Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal and Jiang-fan Chen
    Citation: Journal of Neuroinflammation 2022 19:52
  12. Traumatic brain injury (TBI) is a kind of acquired brain injury, which is caused by external mechanical forces. Moreover, the neuroprotective role of sevoflurane (Sevo) has been identified in TBI. Therefore, t...

    Authors: Zhongyu Wang, Zhaoyang Wang, Anqi Wang, Juan Li, Junmin Wang, Jingjing Yuan, Xin Wei, Fei Xing, Wei Zhang and Na Xing
    Citation: Journal of Neuroinflammation 2022 19:51
  13. Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. Degenerating ...

    Authors: Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis and Luigi Bubacco
    Citation: Journal of Neuroinflammation 2022 19:50
  14. Intracerebral hemorrhage (ICH) is a significant cause of death and disabilities. Recently, cell therapies using mesenchymal stem cells have been shown to improve ICH-induced neurobehavioral deficits. Based on ...

    Authors: Yoji Kuramoto, Mitsugu Fujita, Toshinori Takagi, Yuki Takeda, Nobutaka Doe, Kenichi Yamahara and Shinichi Yoshimura
    Citation: Journal of Neuroinflammation 2022 19:48
  15. Ischemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain through multiple routes, either by penetrating blood–brain barrier or ...

    Authors: Aditya Rayasam, Amin Mottahedin, Joel Faustino, Carina Mallard and Zinaida S. Vexler
    Citation: Journal of Neuroinflammation 2022 19:47
  16. Traumatic brain injury (TBI) remains one of the main causes for disability and death worldwide. While the primary mechanical injury cannot be avoided, the prevention of secondary injury is the focus of TBI res...

    Authors: Zhimin Zou, Li Li, Qin Li, Peng Zhao, Kun Zhang, Chengyong Liu, Daozhang Cai, Marc Maegele, Zhengtao Gu and Qiaobing Huang
    Citation: Journal of Neuroinflammation 2022 19:46
  17. There are over 15 disease-modifying drugs that have been approved over the last 20 years for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited treatment options available for ...

    Authors: Emily Kamma, Wendy Lasisi, Cole Libner, Huah Shin Ng and Jason R. Plemel
    Citation: Journal of Neuroinflammation 2022 19:45
  18. Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the simila...

    Authors: Ivan L. Salazar, Ana S. T. Lourenço, Bruno Manadas, Inês Baldeiras, Cláudia Ferreira, Anabela Claro Teixeira, Vera M. Mendes, Ana Margarida Novo, Rita Machado, Sónia Batista, Maria do Carmo Macário, Mário Grãos, Lívia Sousa, Maria João Saraiva, Alberto A. C. C. Pais and Carlos B. Duarte
    Citation: Journal of Neuroinflammation 2022 19:44
  19. Tissue damage and cellular destruction are the major events in traumatic brain injury (TBI), which trigger sterile neuroimmune and neuroinflammatory responses in the brain. While appropriate acute and transien...

    Authors: Xiang Gao, Wei Li, Fahim Syed, Fang Yuan, Ping Li and Qigui Yu
    Citation: Journal of Neuroinflammation 2022 19:43
  20. Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There is increasing evidence that environmental factors are important in the developm...

    Authors: Solenne Vigne, Donovan Duc, Benjamin Peter, Jessica Rebeaud, Yannick Yersin, Florian Ruiz, Valentine Bressoud, Tinh-Hai Collet and Caroline Pot
    Citation: Journal of Neuroinflammation 2022 19:42
  21. The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including...

    Authors: Ruozhi Dang, Mingyang Wang, Xinhui Li, Haiyang Wang, Lanxiang Liu, Qingyuan Wu, Jianting Zhao, Ping Ji, Lianmei Zhong, Julio Licinio and Peng Xie
    Citation: Journal of Neuroinflammation 2022 19:41
  22. Zika virus (ZIKV) is a mosquito-transmitted flavivirus that affects many regions of the world. Infection, in utero, causes microcephaly and later developmental and neurologic impairments. The impact of ZIKV in...

    Authors: Denise C. Hsu, Kesara Chumpolkulwong, Michael J. Corley, Taweewun Hunsawong, Dutsadee Inthawong, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Panupat Nadee, Jumpol Sopanaporn, Yuwadee Phuang-Ngern, Chonticha Klungthong, Matthew Reed, Stefan Fernandez, Lishomwa C. Ndhlovu, Robert Paul…
    Citation: Journal of Neuroinflammation 2022 19:40
  23. Mounting evidences indicate that oxidative stress, neuroinflammation, and dysregulation of gut microbiota are related to neurodegenerative disorders (NDs). Butyrolactone I (BTL-I), a marine fungal metabolite, ...

    Authors: Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan V. Kalueff, Cai Song and Yi Zhang
    Citation: Journal of Neuroinflammation 2022 19:39
  24. Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and rece...

    Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion
    Citation: Journal of Neuroinflammation 2022 19:38
  25. Neuroinflammation and apoptosis are involved in the pathogenesis of ischaemic stroke. Alisol A 24-acetate (24A) exerts a strong inhibitory effect on inflammation and cell apoptosis. The neuroprotective effect ...

    Authors: Taotao Lu, Huihong Li, Yangjie Zhou, Wei Wei, Linlin Ding, Zengtu Zhan, Weilin Liu, Jing Tao and Xiehua Xue
    Citation: Journal of Neuroinflammation 2022 19:37
  26. Paediatric traumatic brain injury (TBI) is recognised to have significant longer-term neurocognitive effects. Childhood is a time of high risk for head injury. Functional recovery is variable with a combinatio...

    Authors: Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger and Eleanor J. Molloy
    Citation: Journal of Neuroinflammation 2022 19:36
  27. Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive ability. Exosomes derived from bone-marrow mesenchymal stem cells (BMSC-exos) are extracellular vesic...

    Authors: Sen Liu, Min Fan, Jing-Xian Xu, Long-Jun Yang, Cong-Cong Qi, Qing-Rong Xia and Jin-Fang Ge
    Citation: Journal of Neuroinflammation 2022 19:35
  28. The role of physical exercise in the prevention of Alzheimer’s disease (AD) has been widely studied. Microglia play an important role in AD. Triggering receptor expressed in myeloid cells 2 (TREM2) is expresse...

    Authors: Shan-shan Zhang, Lin Zhu, Yan Peng, Lei Zhang, Feng-lei Chao, Lin Jiang, Qian Xiao, Xin Liang, Jing Tang, Hao Yang, Qi He, Yi-jing Guo, Chun-ni Zhou and Yong Tang
    Citation: Journal of Neuroinflammation 2022 19:34
  29. Previous studies have shown that vagus nerve stimulation (VNS) can attenuate inflammatory responses in peripheral tissues and also improve some neurological disorders and cognitive function in the brain. Howev...

    Authors: Uk Namgung, Ki-Joong Kim, Byung-Gon Jo and Jong Min Park
    Citation: Journal of Neuroinflammation 2022 19:33
  30. Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective treatments for PNI are still limited...

    Authors: Jinhuan Wei, Wenfeng Su, Yayu Zhao, Zhongya Wei, Yuchen Hua, Peng Xue, Xiang Zhu, Ying Chen and Gang Chen
    Citation: Journal of Neuroinflammation 2022 19:32
  31. The neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson’s disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger–W...

    Authors: Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi and Balázs Gaszner
    Citation: Journal of Neuroinflammation 2022 19:31
  32. Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpop...

    Authors: Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman and Alberto Serrano-Pozo
    Citation: Journal of Neuroinflammation 2022 19:30
  33. Systemic inflammation is a potent contributor to increased seizure susceptibility. However, information regarding the effects of systemic inflammation on cerebral vascular integrity that influence neuron excit...

    Authors: Wan-Yu Huang, Yen-Ling Lai, Ko-Hung Liu, Shankung Lin, Hsuan-Ying Chen, Chih-Hung Liang, Hung-Ming Wu and Kuei-Sen Hsu
    Citation: Journal of Neuroinflammation 2022 19:29
  34. Recent evidences have suggested the involvement of toll-like receptor (TLR)-4 in the pathogenesis of cerebral cavernous malformations (CCM). Elevated frequency of TLR+T-cells has been associated with neurological...

    Authors: Camilla Castro, Hugo A. A. Oyamada, Marcos Octávio S. D. Cafasso, Lana M. Lopes, Clarice Monteiro, Priscila M. Sacramento, Soniza Vieira Alves-Leon, Gustavo da Fontoura Galvão, Joana Hygino, Jorge Paes Barreto Marcondes de Souza and Cleonice A. M. Bento
    Citation: Journal of Neuroinflammation 2022 19:28
  35. Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiologica...

    Authors: Alba Sánchez-Fernández, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat and Rubèn López-Vales
    Citation: Journal of Neuroinflammation 2022 19:27
  36. Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Its molecular mechanism is still unclear, and pharmacological treatments are unsatisfactory. Transient receptor potential vanilloid 4 (TRPV...

    Authors: Na Liu, Liping Bai, Zhipeng Lu, Rou Gu, Dongdong Zhao, Fang Yan and Jie Bai
    Citation: Journal of Neuroinflammation 2022 19:26
  37. The development of morphine tolerance is a clinical challenge for managing severe pain. Studies have shown that neuroinflammation is a critical aspect for the development of analgesic tolerance. We found that ...

    Authors: Li Wan, Ru-Meng Jia, Lu-Lu Ji, Xin-Miao Qin, Liang Hu, Fan Hu, Yuan Han, Yin-Bing Pan, Chun-Yi Jiang and Wen-Tao Liu
    Citation: Journal of Neuroinflammation 2022 19:25
  38. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT

    Authors: Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu and Gang Hu
    Citation: Journal of Neuroinflammation 2022 19:23
  39. The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy may provide a therapeutic target for reduction of seizure burden in patients that are currently underserved by traditional anti-seiz...

    Authors: Charles L. Howe, Reghann G. LaFrance-Corey, Brittany L. Overlee, Renee K. Johnson, Benjamin D. S. Clarkson and Emma N. Goddery
    Citation: Journal of Neuroinflammation 2022 19:22
  40. Understanding the pathophysiology of central nervous system tuberculosis (CNS-TB) is hampered by the lack of a good pre-clinical model that mirrors the human CNS-TB infection. We developed a murine CNS-TB mode...

    Authors: Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S. L. Ding and Catherine W. M. Ong
    Citation: Journal of Neuroinflammation 2022 19:21
  41. Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological and pathological processes, including the widespread use of the Cx3cr1CreER...

    Authors: Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson…
    Citation: Journal of Neuroinflammation 2022 19:20
  42. Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far.

    Authors: Sven Jarius, Florence Pache, Peter Körtvelyessy, Ilijas Jelčić, Mark Stettner, Diego Franciotta, Emanuela Keller, Bernhard Neumann, Marius Ringelstein, Makbule Senel, Axel Regeniter, Rea Kalantzis, Jan F. Willms, Achim Berthele, Markus Busch, Marco Capobianco…
    Citation: Journal of Neuroinflammation 2022 19:19
  43. Toxoplasma gondii (T. gondii) is a highly successful parasite being able to cross all biological barriers of the body, finally reaching the central nervous system (CNS). Previous studies have highlighted the crit...

    Authors: Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Mária A. Deli, Andrea Kröger, Thomas Schüler and Ildiko Rita Dunay
    Citation: Journal of Neuroinflammation 2022 19:17
  44. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovir...

    Authors: Yuan Chao Xue, Huitao Liu, Yasir Mohamud, Amirhossein Bahreyni, Jingchun Zhang, Neil R. Cashman and Honglin Luo
    Citation: Journal of Neuroinflammation 2022 19:16
  45. Authors: S. T. Peruzzaro, M. M. M. Andrews, A. Al-Gharaibeh, O. Pupiec, M. Resk, D. Story, P. Maiti, J. Rossignol and G. L. Dunbar
    Citation: Journal of Neuroinflammation 2022 19:15

    The original article was published in Journal of Neuroinflammation 2019 16:2

  46. Authors: Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan and Jianmei Ma
    Citation: Journal of Neuroinflammation 2022 19:14

    The original article was published in Journal of Neuroinflammation 2019 16:10

  47. Postviral olfactory dysfunction (PVOD) following a viral upper respiratory tract infection (URI) is one of the most common causes of olfactory disorders, often lasting for over a year. To date, the molecular p...

    Authors: Ryoji Kagoya, Makiko Toma-Hirano, Junya Yamagishi, Naoyuki Matsumoto, Kenji Kondo and Ken Ito
    Citation: Journal of Neuroinflammation 2022 19:13

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