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  1. Content type: Research

    1-42 peptide abnormal production is associated with the development and maintenance of neuroinflammation and oxidative stress in brains from Alzheimer disease (AD) patients. Suppression of neuroinflammation may...

    Authors: Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo and Luigi M. Grimaldi

    Citation: Journal of Neuroinflammation 2019 16:44

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  2. Content type: Research

    Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protec...

    Authors: Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck and Antje Grosche

    Citation: Journal of Neuroinflammation 2019 16:43

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  3. Content type: Research

    Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis,...

    Authors: Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O’Reilly, Bhanu Priya Ganesh, Fudong Liu and Louise D. McCullough

    Citation: Journal of Neuroinflammation 2019 16:40

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  4. Content type: Research

    Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food and water intake, while pre-injection of endotoxins attenuates these responses. This phenomen...

    Authors: Shoko Morita-Takemura, Kazuki Nakahara, Sanae Hasegawa-Ishii, Ayami Isonishi, Kouko Tatsumi, Hiroaki Okuda, Tatsuhide Tanaka, Masahiro Kitabatake, Toshihiro Ito and Akio Wanaka

    Citation: Journal of Neuroinflammation 2019 16:39

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  5. Content type: Research

    Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasm...

    Authors: Christine Silwedel, Axel Haarmann, Markus Fehrholz, Heike Claus, Christian P. Speer and Kirsten Glaser

    Citation: Journal of Neuroinflammation 2019 16:38

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  6. Content type: Research

    High white blood cell (WBC) count and high blood glucose level are risk factors for mortality and pneumonia after acute ischemic stroke (AIS). We investigated the combined effect of high WBC count and high blo...

    Authors: Shoujiang You, Zhijie Ou, Wei Zhang, Danni Zheng, Chongke Zhong, Xiaofeng Dong, Chenhong Qiu, Taosheng Lu, Yongjun Cao and Chun-Feng Liu

    Citation: Journal of Neuroinflammation 2019 16:37

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  7. Content type: Research

    This study investigated whether therapeutic hypercapnia (TH) ameliorated blood–brain barrier (BBB) damage and improved the neurologic outcome in a rat model of lateral fluid percussion injury (FPI), and explor...

    Authors: Wan-Chao Yang, Qi Wang, Lai-Ting Chi, Yue-Zhen Wang, Hong-Ling Cao and Wen-Zhi Li

    Citation: Journal of Neuroinflammation 2019 16:36

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  8. Content type: Research

    Extracellular accumulation of amyloid β-peptide (Aβ) is one of pathological hallmarks of Alzheimer’s disease (AD) and contributes to the neuronal loss. Mesencephalic astrocyte-derived neurotrophic factor (MANF...

    Authors: Shengchun Xu, Zemin Di, Yufeng He, Runjie Wang, Yuyang Ma, Rui Sun, Jing Li, Tao Wang, Yujun Shen, Shengyun Fang, Lijie Feng and Yuxian Shen

    Citation: Journal of Neuroinflammation 2019 16:35

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  9. Content type: Research

    Chronic pain is a major clinical problem with limited treatment options. Previous studies have demonstrated that activation of adenosine monophosphate-activated protein kinase (AMPK) can attenuate neuropathic ...

    Authors: Hong-Chun Xiang, Li-Xue Lin, Xue-Fei Hu, He Zhu, Hong-Ping Li, Ru-Yue Zhang, Liang Hu, Wen-Tao Liu, Yi-Lin Zhao, Yang Shu, Hui-Lin Pan and Man Li

    Citation: Journal of Neuroinflammation 2019 16:34

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  10. Content type: Research

    Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survi...

    Authors: Enshan Feng, Tingyu Liang, Xiaoyong Wang, Juan Du, Kai Tang, Xiaoxuan Wang, Fang Wang and Gan You

    Citation: Journal of Neuroinflammation 2019 16:33

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  11. Content type: Research

    The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the reg...

    Authors: Alexandre D. Gimenes, Bruna F. D. Andrade, José Victor P. Pinotti, Sonia M. Oliani, Orfa Y. Galvis-Alonso and Cristiane D. Gil

    Citation: Journal of Neuroinflammation 2019 16:32

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  12. Content type: Correction

    In the version of this article that was originally published [1]; some information in the “Author’s contributions” section was omitted.

    Authors: Veronika E. Neubrand, Irene Forte-Lago, Marta Caro and Mario Delgado

    Citation: Journal of Neuroinflammation 2019 16:31

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    The original article was published in Journal of Neuroinflammation 2018 15:343

  13. Content type: Research

    Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregu...

    Authors: Huan-Huan Ding, Su-Bo Zhang, You-You Lv, Chao Ma, Meng Liu, Kui-Bo Zhang, Xiang-Cai Ruan, Jia-You Wei, Wen-Jun Xin and Shao-Ling Wu

    Citation: Journal of Neuroinflammation 2019 16:29

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  14. Content type: Research

    Traumatic brain injury remains a significant cause of death and disability in the USA. Currently, there are no effective therapies to mitigate disability except for surgical interventions necessitating a need ...

    Authors: Stephanie W. Lee, Juan Pablo de Rivero Vaccari, Jessie S. Truettner, W. Dalton Dietrich and Robert W. Keane

    Citation: Journal of Neuroinflammation 2019 16:27

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  15. Content type: Research

    Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endotheli...

    Authors: Carsten Balser, Anne Wolf, Marc Herb and Thomas Langmann

    Citation: Journal of Neuroinflammation 2019 16:26

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  16. Content type: Research

    Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low chimerism levels, blood-brain barrier disruption an...

    Authors: A. Saam Youshani, Samuel Rowlston, Claire O’Leary, Gabriella Forte, Helen Parker, Aiyin Liao, Brian Telfer, Kaye Williams, Ian D. Kamaly-Asl and Brian W. Bigger

    Citation: Journal of Neuroinflammation 2019 16:25

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  17. Content type: Research

    Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 protected brain I/R remained to be elucidated. The pr...

    Authors: Jialin Duan, Jia Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Yan Weng, Ying Yin, Yanhua Wang, Guo Wei, Boling Qiao and Aidong Wen

    Citation: Journal of Neuroinflammation 2019 16:24

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  18. Content type: Research

    Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neur...

    Authors: Yuan Yue, Milos Stanojlovic, Yifeng Lin, Gerard Karsenty and Wensheng Lin

    Citation: Journal of Neuroinflammation 2019 16:23

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  19. Content type: Research

    The incidence of traumatic brain injuries (TBIs) is on the rise in the USA. Concussions, or mild TBIs without skull fracture, account for about 75% of all TBIs. Mild TBIs (mTBIs) lead to memory and cognitive d...

    Authors: Xingjuan Chen, Natalie N. Taylor-Nguyen, Ashley M. Riley, B. Paul Herring, Fletcher A. White and Alexander G. Obukhov

    Citation: Journal of Neuroinflammation 2019 16:21

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  20. Content type: Review

    Stroke is the most common cerebrovascular disease, the second leading cause of death behind heart disease and is a major cause of long-term disability worldwide. Currently, systemic immunomodulatory therapy ba...

    Authors: Zhe Wang, Da He, Ya-Yue Zeng, Li Zhu, Chao Yang, Yong-Juan Lu, Jie-Qiong Huang, Xiao-Yan Cheng, Xiang-Hong Huang and Xiao-Jun Tan

    Citation: Journal of Neuroinflammation 2019 16:20

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  21. Content type: Research

    Intracerebral hemorrhage and ischemic stroke are increasingly recognized complications of central nervous system (CNS) infection by herpes simplex virus (HSV).

    Authors: Larissa Hauer, Slaven Pikija, Eva C. Schulte, Laszlo K. Sztriha, Raffaele Nardone and Johann Sellner

    Citation: Journal of Neuroinflammation 2019 16:19

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  22. Content type: Research

    Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining prenatal immune stimuli with disease-related geneti...

    Authors: Rebecca L. Openshaw, Jaedeok Kwon, Alison McColl, Josef M. Penninger, Jonathan Cavanagh, Judith A. Pratt and Brian J. Morris

    Citation: Journal of Neuroinflammation 2019 16:18

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  23. Content type: Research

    Inflammation is considered a hallmark of concussion pathophysiology in experimental models, yet is understudied in human injury. Despite the growing use of blood biomarkers in concussion, inflammatory biomarke...

    Authors: Alex P. Di Battista, Nathan Churchill, Shawn G. Rhind, Doug Richards and Michael G. Hutchison

    Citation: Journal of Neuroinflammation 2019 16:17

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  24. Content type: Research

    HIV-1 infects the central nervous system (CNS) shortly after transmission. This leads to a chronic intrathecal immune activation. YKL-40, a biomarker that mainly reflects activation of astroglial cells, has no...

    Authors: Linn Hermansson, Aylin Yilmaz, Markus Axelsson, Kaj Blennow, Dietmar Fuchs, Lars Hagberg, Jan Lycke, Henrik Zetterberg and Magnus Gisslén

    Citation: Journal of Neuroinflammation 2019 16:16

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  25. Content type: Review

    In this narrative review, a theoretical framework on the crosstalk between physical exercise and blood-brain barrier (BBB) permeability is presented. We discuss the influence of physical activity on the factor...

    Authors: Marta A. Małkiewicz, Arkadiusz Szarmach, Agnieszka Sabisz, Wiesław J. Cubała, Edyta Szurowska and Paweł J. Winklewski

    Citation: Journal of Neuroinflammation 2019 16:15

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  26. Content type: Review

    Neurovascular, autoimmune, and traumatic injuries of the central nervous system (CNS) all have in common an initial acute inflammatory response mediated by influx across the blood-brain barrier of activated mo...

    Authors: Arthur A. Vandenbark, Roberto Meza-Romero, Gil Benedek and Halina Offner

    Citation: Journal of Neuroinflammation 2019 16:14

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  27. Content type: Short report

    The chemokine CXCL13 is an intensively investigated biomarker in Lyme neuroborreliosis (LNB). Its role in other neuroinfections is increasingly recognized but less clear.

    Authors: Georg Pilz, Peter Wipfler, Ferdinand Otto, Wolfgang Hitzl, Shahrzad Afazel, Elisabeth Haschke-Becher, Eugen Trinka and Andrea Harrer

    Citation: Journal of Neuroinflammation 2019 16:13

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  28. Content type: Research

    Traumatic spinal cord injury (SCI) triggers a chain of events that is accompanied by an inflammatory reaction leading to necrotic cell death at the core of the injury site, which is restricted by astrogliosis ...

    Authors: Kristyna Karova, John V. Wainwright, Lucia Machova-Urdzikova, Rishikaysh V. Pisal, Meic Schmidt, Pavla Jendelova and Meena Jhanwar-Uniyal

    Citation: Journal of Neuroinflammation 2019 16:12

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  29. Content type: Research

    Microglia, the resident immune cells of the brain, exhibit various morphologies that correlate with their functions under physiological and pathological conditions. In conditions such as aging and stress, micr...

    Authors: Victoria L. DiBona, Wenxin Zhu, Mihir K. Shah, Aditi Rafalia, Hajer Ben Cheikh, David P. Crockett and Huaye Zhang

    Citation: Journal of Neuroinflammation 2019 16:11

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  30. Content type: Research

    Microglia-derived lysosomal cathepsins are important inflammatory mediators to trigger signaling pathways in inflammation-related cascades. Our previous study showed that the expression of cathepsin C (CatC) i...

    Authors: Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan and Jianmei Ma

    Citation: Journal of Neuroinflammation 2019 16:10

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  31. Content type: Research

    Phagocytosis is a key function of myeloid cells and is highly involved in brain ischemic injury. It has been scarcely studied in vivo, thus preventing a deep knowledge of the processes occurring in the ischemi...

    Authors: Stefano Fumagalli, Fabio Fiordaliso, Carlo Perego, Alessandro Corbelli, Alessandro Mariani, Massimiliano De Paola and Maria-Grazia De Simoni

    Citation: Journal of Neuroinflammation 2019 16:9

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  32. Content type: Research

    Activated microglia-mediated neuroinflammation has been regarded as an underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). The therapeutic potential of ...

    Authors: Wenchao Liu, Ran Li, Jian Yin, Shenquan Guo, Yunchang Chen, Haiyan Fan, Gancheng Li, Zhenjun Li, Xifeng Li, Xin Zhang, Xuying He and Chuanzhi Duan

    Citation: Journal of Neuroinflammation 2019 16:8

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  33. Content type: Short report

    Cerebrospinal fluid (CSF) shunt placement is frequently complicated by bacterial infection. Shunt infection diagnosis relies on bacterial culture of CSF which can often produce false-negative results. Negative...

    Authors: Gwenn L. Skar, David Synhorst, Matthew Beaver and Jessica N. Snowden

    Citation: Journal of Neuroinflammation 2019 16:7

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  34. Content type: Research

    Altered neuronal connectivity in peri-infarct tissue is an important contributor to both the spontaneous recovery of neurological function that commonly develops after stroke and improvements in recovery that ...

    Authors: Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Frederick R. Walker, Karl A. A. Roos, Timothy K. Chataway, Hakan Muyderman and Neil R. Sims

    Citation: Journal of Neuroinflammation 2019 16:6

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  35. Content type: Research

    The fetal brain is particularly vulnerable to intrauterine growth restriction (IUGR) conditions evidenced by neuronal and white matter abnormalities and altered neurodevelopment in the IUGR infant. To further ...

    Authors: Julie A. Wixey, Kah Meng Lee, Stephanie M. Miller, Kate Goasdoue, Paul B. Colditz, S. Tracey Bjorkman and Kirat K. Chand

    Citation: Journal of Neuroinflammation 2019 16:5

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  36. Content type: Research

    Microglia/macrophages (M/Ms) with multiple functions derived from distinct activation states are key surveillants maintaining brain homeostasis. However, their activation status and role during the brain metas...

    Authors: Sha Qiao, Yuan Qian, Guoqiang Xu, Qingming Luo and Zhihong Zhang

    Citation: Journal of Neuroinflammation 2019 16:4

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  37. Content type: Research

    Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer’s disease (AD), yet their role in the pathogenesis still remains poorly defined.

    Authors: Isabelle St-Amour, Cristina R. Bosoi, Isabelle Paré, Prenitha Mercy Ignatius Arokia Doss, Manu Rangachari, Sébastien S. Hébert, Renée Bazin and Frédéric Calon

    Citation: Journal of Neuroinflammation 2019 16:3

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  38. Content type: Research

    Traumatic brain injury (TBI) is a major cause for long-term disability, yet the treatments available that improve outcomes after TBI limited. Neuroinflammatory responses are key contributors to determining pat...

    Authors: S. T. Peruzzaro, M. M. M. Andrews, A. Al-Gharaibeh, O. Pupiec, M. Resk, D. Story, P. Maiti, J. Rossignol and G. L. Dunbar

    Citation: Journal of Neuroinflammation 2019 16:2

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  39. Content type: Research

    Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of chro...

    Authors: Huadong Ni, Yungong Wang, Kang An, Qianying Liu, Longsheng Xu, Chunyan Zhu, Housheng Deng, Qiuli He, Tingting Wang, Miao Xu, Ying Zheng, Bing Huang, Jianqiao Fang and Ming Yao

    Citation: Journal of Neuroinflammation 2019 16:1

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  40. Content type: Research

    Spinal reactive astrocytes and microglia are known to participate to the initiation and maintenance of neuropathic pain. However, whether reactive astrocytes and microglia in thalamic nuclei that process senso...

    Authors: Lucie Blaszczyk, Marlène Maître, Thierry Lesté-Lasserre, Samantha Clark, Daniela Cota, Stéphane H. R. Oliet and Valérie S. Fénelon

    Citation: Journal of Neuroinflammation 2018 15:349

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  41. Content type: Research

    Neuroinflammation is closely associated with functional outcome in subarachnoid hemorrhage (SAH) patients. Our recent study demonstrated that fluoxetine inhibited NLRP3 inflammasome activation and attenuated n...

    Authors: Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang and Gao Chen

    Citation: Journal of Neuroinflammation 2018 15:347

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  42. Content type: Short report

    The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain’s resident immune cells, microglia. Here we used [11C]DPA-713 and ...

    Authors: Jennifer M. Coughlin, Ting Yang, Alison W. Rebman, Kathleen T. Bechtold, Yong Du, William B. Mathews, Wojciech G. Lesniak, Erica A. Mihm, Sarah M. Frey, Erica S. Marshall, Hailey B. Rosenthal, Tristan A. Reekie, Michael Kassiou, Robert F. Dannals, Mark J. Soloski, John N. Aucott…

    Citation: Journal of Neuroinflammation 2018 15:346

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  43. Content type: Research

    Understanding the interdependencies among inflammatory mediators of tissue damage following traumatic brain injury (TBI) is essential in providing effective, patient-specific care. Activated microglia and elev...

    Authors: Leah E. Vaughan, Prerna R. Ranganathan, Raj G. Kumar, Amy K. Wagner and Jonathan E. Rubin

    Citation: Journal of Neuroinflammation 2018 15:345

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  44. Content type: Research

    Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the...

    Authors: Sarah J. Karlen, Eric B. Miller, Xinlei Wang, Emily S. Levine, Robert J. Zawadzki and Marie E. Burns

    Citation: Journal of Neuroinflammation 2018 15:344

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  45. Content type: Research

    Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate ...

    Authors: Veronika E. Neubrand, Irene Forte-Lago, Marta Caro and Mario Delgado

    Citation: Journal of Neuroinflammation 2018 15:343

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    The Correction to this article has been published in Journal of Neuroinflammation 2019 16:31

  46. Content type: Review

    Methamphetamine (METH) is an illicit psychostimulant that is subject to abuse worldwide. While the modulatory effects of METH on dopamine neurotransmission and its neurotoxicity in the central nervous system a...

    Authors: Fatemeh Shaerzadeh, Wolfgang J. Streit, Soomaayeh Heysieattalab and Habibeh Khoshbouei

    Citation: Journal of Neuroinflammation 2018 15:341

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