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  1. Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in ...

    Authors: Fu Li, Haitao Xiang, Yue Gu, Ting Ye, Xu Lu and Chao Huang
    Citation: Journal of Neuroinflammation 2022 19:12
  2. The brain vasculature plays a pivotal role in the inflammatory process by modulating the interaction between blood cells and the neurovascular unit. Argonaute-2 (Ago2) has been suggested as essential for endot...

    Authors: Marta Machado-Pereira, Cláudia Saraiva, Liliana Bernardino, Ana C. Cristóvão and Raquel Ferreira
    Citation: Journal of Neuroinflammation 2022 19:11
  3. Astrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which ...

    Authors: Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel and Luke M. Healy
    Citation: Journal of Neuroinflammation 2022 19:10
  4. Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathw...

    Authors: Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C. Daskhan, Edward N. Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S. Macauley and Simonetta Sipione
    Citation: Journal of Neuroinflammation 2022 19:9
  5. The serine protease inhibitor nafamostat has been proposed as a treatment for COVID-19, by inhibiting TMPRSS2-mediated viral cell entry. Nafamostat has been shown to have other, immunomodulatory effects, which...

    Authors: Abi G. Yates, Caroline M. Weglinski, Yuxin Ying, Isobel K. Dunstan, Tatyana Strekalova and Daniel C. Anthony
    Citation: Journal of Neuroinflammation 2022 19:8
  6. Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4+ T lymphocytes in mice. The present study aimed at identifying opioid receptor(s) expressed on nociceptive sens...

    Authors: Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac and Gilles Dietrich
    Citation: Journal of Neuroinflammation 2022 19:7
  7. Anti-aquaporin 4 (AQP4) antibody (AQP4-Ab) is involved in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). However, the mechanism involved in AQP4-Ab production remains unclear.

    Authors: Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori and Sachiko Miyake
    Citation: Journal of Neuroinflammation 2022 19:6
  8. Neurodegeneration is considered the consequence of misfolded proteins’ deposition. Little is known about external environmental effects on the neurodegenerative process. Infectious agent-derived pathogen-assoc...

    Authors: Tal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein and Tamir Ben-Hur
    Citation: Journal of Neuroinflammation 2022 19:5
  9. Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within the centr...

    Authors: Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos and Kulmira Nurgali
    Citation: Journal of Neuroinflammation 2022 19:4
  10. Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically targeting the CSF1R rece...

    Authors: Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto and Yu Luo
    Citation: Journal of Neuroinflammation 2022 19:3
  11. Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country’s mental health treatment cost. Although anxiolytic therapies are available, many pat...

    Authors: Alzahra J. Al Omran, Amy S. Shao, Saki Watanabe, Zeyu Zhang, Jifeng Zhang, Chen Xue, Junji Watanabe, Daryl L. Davies, Xuesi M. Shao and Jing Liang
    Citation: Journal of Neuroinflammation 2022 19:2
  12. Abnormal expression of long noncoding RNAs (lncRNAs) has been reported in the acute stage of acute ischemic stroke (AIS). This study aimed to explore differential lncRNA expression in the subpopulations of per...

    Authors: Huiling Sun, Shuo Li, Zhaohan Xu, Chengfang Liu, Pengyu Gong, Qiwen Deng and Fuling Yan
    Citation: Journal of Neuroinflammation 2022 19:1
  13. Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer’s disease (AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective effects of...

    Authors: Weijun Ou, Joshua Yang, Juste Simanauskaite, Matthew Choi, Demi M. Castellanos, Rudy Chang, Jiahong Sun, Nataraj Jagadeesan, Karen D. Parfitt, David H. Cribbs and Rachita K. Sumbria
    Citation: Journal of Neuroinflammation 2021 18:312
  14. Mechanical ventilation of preterm newborns causes lung injury and is associated with poor neurodevelopmental outcomes. However, the mechanistic links between ventilation-induced lung injury (VILI) and brain in...

    Authors: Laura Chavez, Julia Meguro, Shaoyi Chen, Vanessa Nunes de Paiva, Ronald Zambrano, Julia M. Eterno, Rahul Kumar, Matthew R. Duncan, Merline Benny, Karen C. Young, W. Dalton Dietrich, Roberta Brambilla, Shu Wu and Augusto F. Schmidt
    Citation: Journal of Neuroinflammation 2021 18:310
  15. Authors: Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang and Hong Ma
    Citation: Journal of Neuroinflammation 2021 18:309

    The original article was published in Journal of Neuroinflammation 2018 15:250

  16. The association of lipoprotein(a) [Lp(a)] and stroke functional outcomes was conflicting. The aim of the study was to clarify whether high Lp(a) is associated with unfavorable functional outcomes in patients w...

    Authors: Xue Jiang, Jie Xu, Xiwa Hao, Jing Xue, Ke Li, Aoming Jin, Jinxi Lin, Xia Meng, Lemin Zheng and Yongjun Wang
    Citation: Journal of Neuroinflammation 2021 18:307
  17. Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of...

    Authors: Beatriz G. Perez-Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vazquez-Villasenor, Maria Jimenez-Sanchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo and Wendy Noble
    Citation: Journal of Neuroinflammation 2021 18:306
  18. Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocyt...

    Authors: Miranda M. Standiford, Ethan M. Grund and Charles L. Howe
    Citation: Journal of Neuroinflammation 2021 18:305
  19. Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge ...

    Authors: Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa and Keisuke Yoshikawa
    Citation: Journal of Neuroinflammation 2021 18:304
  20. Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progressive apoptotic death of retinal ganglion cells (RGCs). Although the mechanisms underlyin...

    Authors: Xin Hu, Guo-Li Zhao, Meng-Xi Xu, Han Zhou, Fang Li, Yanying Miao, Bo Lei, Xiong-Li Yang and Zhongfeng Wang
    Citation: Journal of Neuroinflammation 2021 18:303
  21. Spinal cord injury elicits widespread inflammation that can exacerbate long-term neurologic deficits. Neutrophils are the most abundant immune cell type to invade the spinal cord in the early acute phase after...

    Authors: Dylan A. McCreedy, Clare L. Abram, Yongmei Hu, Sun Won Min, Madison E. Platt, Megan A. Kirchhoff, Shelby K. Reid, Frank L. Jalufka and Clifford A. Lowell
    Citation: Journal of Neuroinflammation 2021 18:302
  22. Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-de...

    Authors: Deepak Kumar Kaushik, Anindita Bhattacharya, Brian Mark Lozinski and V. Wee Yong
    Citation: Journal of Neuroinflammation 2021 18:301
  23. Atrial natriuretic peptide (ANP) secreted from atrial myocytes is shown to possess anti-inflammatory, anti-oxidant and immunomodulatory effects. The aim of this study is to assess the effect of ANP on bacteria...

    Authors: Yuming Wu, Yujing Zhang, Bing Xie, Amro Abdelgawad, Xiaoyan Chen, Mengqi Han, You Shang, Shiying Yuan and Jiancheng Zhang
    Citation: Journal of Neuroinflammation 2021 18:300
  24. The incidence of diabetes and diabetic peripheral neuropathy continues to rise, and studies have shown that macrophages play an important role in their pathogenesis. To date, macrophage tracking has largely be...

    Authors: James M. Nichols, Caitlin V. Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic and Andrew J. Shepherd
    Citation: Journal of Neuroinflammation 2021 18:299
  25. Selective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy ...

    Authors: Lijun Zhang, Lei Dai and Deyuan Li
    Citation: Journal of Neuroinflammation 2021 18:297
  26. Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct i...

    Authors: Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison and Joel S. Pachter
    Citation: Journal of Neuroinflammation 2021 18:296
  27. Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α-synuclein, chronic neuroinflammation and autopha...

    Authors: Jialong Chen, Kanmin Mao, Honglin Yu, Yue Wen, Hua She, He Zhang, Linhua Liu, Mingque Li, Wenjun Li and Fei Zou
    Citation: Journal of Neuroinflammation 2021 18:295
  28. Lysophosphatidic acid (LPA) is a pleiotropic lipid messenger that addresses at least six specific G-protein coupled receptors. Accumulating evidence indicates a significant involvement of LPA in immune cell re...

    Authors: Fabian Szepanowski, Maximilian Winkelhausen, Rebecca D. Steubing, Anne K. Mausberg, Christoph Kleinschnitz and Mark Stettner
    Citation: Journal of Neuroinflammation 2021 18:293
  29. Recent evidence has shown dopamine as a major regulator of inflammation. Accordingly, dopaminergic regulation of immune cells plays an important role in the physiopathology of inflammatory disorders. Multiple ...

    Authors: Carolina Prado, Francisco Osorio-Barrios, Paulina Falcón, Alexandra Espinoza, Juan José Saez, María Isabel Yuseff and Rodrigo Pacheco
    Citation: Journal of Neuroinflammation 2021 18:292
  30. Stress-induced neuroinflammation was considered to play a critical role in the pathogenesis of depression. Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative trea...

    Authors: Jun-ying Wang, Yue Zhang, Yu Chen, Yu Wang, Shao-yuan Li, Yi-fei Wang, Zi-xuan Zhang, Jinling Zhang and Peijing Rong
    Citation: Journal of Neuroinflammation 2021 18:291
  31. Major depressive disorder (MDD) represents a major public health concern, particularly due to its steadily rising prevalence and the poor responsiveness to standard antidepressants notably in patients afflicte...

    Authors: Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudéry, Sylvie Vancassel, Nathalie Castanon and Lucile Capuron
    Citation: Journal of Neuroinflammation 2021 18:290
  32. Current therapies targeting several neurotransmitter systems are only able to partially mitigate the symptoms of stress- and trauma-related disorder. Stress and trauma-related disorders lead to a prominent inf...

    Authors: Simantini Ghosh, Zaidan Mohammed and Itender Singh
    Citation: Journal of Neuroinflammation 2021 18:289
  33. While marked reductions in neural activity and mitochondrial function have been reported in Alzheimer’s disease (AD), the degree of mitochondrial activity in mild cognitive impairment (MCI) or early-stage AD r...

    Authors: Satoru Yamagishi, Yurika Iga, Shunsuke Ikegaya, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Daisuke Fukomoto, Masakatsu Kanazawa, Norihiro Harada, Hideo Tsukada, Kohji Sato and Yasuomi Ouchi
    Citation: Journal of Neuroinflammation 2021 18:288
  34. Previous studies have confirmed that the microglial activation and subsequent inflammatory responses in the trigeminal nucleus caudalis (TNC) are involved in the central sensitization of chronic migraine (CM)....

    Authors: Qianwen Wen, Yunfeng Wang, Qi Pan, Ruimin Tian, Dunke Zhang, Guangcheng Qin, Jiying Zhou and Lixue Chen
    Citation: Journal of Neuroinflammation 2021 18:287
  35. TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease p...

    Authors: Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Dan Can, Che-Feng Chang, Yun-wu Zhang, Huaxi Xu, Guojun Bu, Li Zhong and Xiao-Fen Chen
    Citation: Journal of Neuroinflammation 2021 18:286
  36. Authors: Yuluo Rong, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Pengyu Tang, Dongdong Jiang, Jin Fan, Guoyong Yin, Wei Liu and Weihua Cai
    Citation: Journal of Neuroinflammation 2021 18:285

    The original article was published in Journal of Neuroinflammation 2021 18:196

  37. Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a loss of motor and sensory function. Although extensive research to develop treatments for SCI has been performed, to...

    Authors: Daniel J. Hellenbrand, Charles M. Quinn, Zachariah J. Piper, Carolyn N. Morehouse, Jordyn A. Fixel and Amgad S. Hanna
    Citation: Journal of Neuroinflammation 2021 18:284
  38. Inflammation is integral to the pathophysiology of ischemic stroke and a prime target for the development of new stroke therapies. The aim of the present study is to seek out the regulatory mechanism of circCD...

    Authors: Lei Zuo, Jian Xie, Yun Liu, Shuo Leng, Zhijun Zhang and Fuling Yan
    Citation: Journal of Neuroinflammation 2021 18:283
  39. Neuroimmunology is a rapidly expanding field, and there have been recent discoveries of new antibodies and neurological syndromes. Most of the current clinical studies have focused on disorders involving one s...

    Authors: Shaohua Liao, Chuanfen Li, Xiaoying Bi, Hongwei Guo, Ying Qian, Xiaobei Liu, Shuai Miao, Huaiqiang Hu and Bingzhen Cao
    Citation: Journal of Neuroinflammation 2021 18:282
  40. Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, we aimed to reveal the regulatory roles of optineurin (OPTN) ...

    Authors: Long-Long Cao, Pei-Pei Guan, Shen-Qing Zhang, Yi Yang, Xue-Shi Huang and Pu Wang
    Citation: Journal of Neuroinflammation 2021 18:281
  41. Growing evidence indicates that inflammasome-mediated inflammation plays important roles in the pathophysiology of amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Pyroptosis induced by ...

    Authors: Wenjuan Rui, Hong Xiao, Yi Fan, Zhongxuan Ma, Ming Xiao, Sheng Li and Jingping Shi
    Citation: Journal of Neuroinflammation 2021 18:280
  42. Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modula...

    Authors: Mario Heles, Petra Mrozkova, Dominika Sulcova, Pavel Adamek, Diana Spicarova and Jiri Palecek
    Citation: Journal of Neuroinflammation 2021 18:279
  43. Diabetic individuals have increased circulating inflammatory mediators which are implicated as underlying causes of neuroinflammation and memory deficits. Tonicity-responsive enhancer-binding protein (TonEBP) ...

    Authors: Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, Jong Youl Lee, Kyung Eun Kim, Hyeong Seok An, Deok Ryong Kim, Kyu Yeong Choi, Kun Ho Lee and Gu Seob Roh
    Citation: Journal of Neuroinflammation 2021 18:278
  44. Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial injury markers (EIM) have been limited...

    Authors: Jude Savarraj, Eun S. Park, Gabriela D. Colpo, Sarah N. Hinds, Diego Morales, Hilda Ahnstedt, Atzhiry S. Paz, Andres Assing, Fudong Liu, Shivanki Juneja, Eunhee Kim, Sung-min Cho, Aaron M. Gusdon, Pramod Dash, Louise D. McCullough and H. Alex Choi
    Citation: Journal of Neuroinflammation 2021 18:277
  45. Microglia are integral mediators of innate immunity within the mammalian central nervous system. Typical microglial responses are transient, intending to restore homeostasis by orchestrating the removal of pat...

    Authors: Erskine Chu, Richelle Mychasiuk, Margaret L. Hibbs and Bridgette D. Semple
    Citation: Journal of Neuroinflammation 2021 18:276
  46. Members of the transient receptor potential canonical (TRPC) protein family are widely distributed in the hippocampus of mammals and exert respective and cooperative influences on the functions of neurons. The...

    Authors: Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li and Zhaowei Liu
    Citation: Journal of Neuroinflammation 2021 18:275

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