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  1. Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a n...

    Authors: Lu Luo, Meixi Liu, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao and Yi Wu
    Citation: Journal of Neuroinflammation 2022 19:141
  2. Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations with human IgLON5 antibodies have suggested an ant...

    Authors: You Ni, Yifan Feng, Dingding Shen, Ming Chen, Xiaona Zhu, Qinming Zhou, Yining Gao, Jun Liu, Qi Zhang, Yuntian Shen, Lisheng Peng, Zike Zeng, Dou Yin, Ji Hu and Sheng Chen
    Citation: Journal of Neuroinflammation 2022 19:140
  3. Therapeutic hypothermia significantly improves outcomes after moderate–severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although hypothermia is consistently associated with reduced ...

    Authors: Kelly Q. Zhou, Laura Bennet, Guido Wassink, Alice McDouall, Maurice A. Curtis, Blake Highet, Taylor J. Stevenson, Alistair J. Gunn and Joanne O. Davidson
    Citation: Journal of Neuroinflammation 2022 19:139
  4. Neuroinflammation-induced injury is intimately associated with poor prognosis in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase–stimulator of interferon gene (cGAS–STING) ax...

    Authors: Rui Ding, Haiyan Li, Yaqi Liu, Weiyang Ou, Xifang Zhang, Huihui Chai, Xiaofei Huang, Weijie Yang and Qiujing Wang
    Citation: Journal of Neuroinflammation 2022 19:137
  5. Spinal cord injury (SCI) induces a multitude of deleterious processes, including neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and demyelination. Recent studies have suggeste...

    Authors: Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis and Adib Zendedel
    Citation: Journal of Neuroinflammation 2022 19:134
  6. Circadian disturbance is a common nonmotor complaint in Parkinson’s disease (PD). The molecular basis underlying circadian rhythm in PD is poorly understood. Neuroinflammation has been identified as a key cont...

    Authors: Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia and Tao Wang
    Citation: Journal of Neuroinflammation 2022 19:133
  7. Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhi...

    Authors: Haixia Wang, Yi He, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang and Jian Yang
    Citation: Journal of Neuroinflammation 2022 19:132
  8. Contribution of individual and combined inflammatory markers in prognosis after stroke was still undefined. We aimed to investigate the association of systemic and local vascular inflammatory markers and recur...

    Authors: Jiejie Li, Jinxi Lin, Yuesong Pan, Mengxing Wang, Xia Meng, Hao Li, Yilong Wang, Xingquan Zhao, Haiqiang Qin, Liping Liu and Yongjun Wang
    Citation: Journal of Neuroinflammation 2022 19:131
  9. Multiple sclerosis (MS) is a neurodegenerative disease, wherein aberrant immune cells target myelin-ensheathed nerves. Conventional magnetic resonance imaging (MRI) can be performed to monitor damage to the ce...

    Authors: Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl and Jeff W. M. Bulte
    Citation: Journal of Neuroinflammation 2022 19:130
  10. Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Microglial activation in the spinal cord plays a critical role in the pathogenesis of neuropathic pain. However...

    Authors: Long-Qing Zhang, Shao-Jie Gao, Jia Sun, Dan-Yang Li, Jia-Yi Wu, Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou and Wei Mei
    Citation: Journal of Neuroinflammation 2022 19:129
  11. Vascular dementia (VAD) is the second most common type of dementia lacking effective treatments. Pentoxifylline (PTX), a nonselective phosphodiesterase inhibitor, displays protective effects in multiple cerebr...

    Authors: Lili Zheng, Junqiu Jia, Yan Chen, Renyuan Liu, Runjing Cao, Manlin Duan, Meijuan Zhang and Yun Xu
    Citation: Journal of Neuroinflammation 2022 19:128
  12. Neuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer’s disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory ...

    Authors: Christopher Clark, Jonas Richiardi, Bénédicte Maréchal, Gene L. Bowman, Loïc Dayon and Julius Popp
    Citation: Journal of Neuroinflammation 2022 19:127
  13. The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associate...

    Authors: Taylor E. Syme, Magdalena Grill, Emina Hayashida, Barney Viengkhou, Iain L. Campbell and Markus J. Hofer
    Citation: Journal of Neuroinflammation 2022 19:126
  14. Ischemic stroke is a leading cause of mortality worldwide, largely due to the inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing intensive research, there have not been any...

    Authors: Aditya Rayasam, Julie A. Kijak, Lee Kissel, Yun Hwa Choi, Taehee Kim, Martin Hsu, Dinesh Joshi, Collin J. Laaker, Peter Cismaru, Anders Lindstedt, Krisztian Kovacs, Raghu Vemuganti, Shing Yan Chiu, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor and Zsuzsanna Fabry
    Citation: Journal of Neuroinflammation 2022 19:125
  15. Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti-inflammatory properties of melatonin have att...

    Authors: Jun Huang, Zhuang Li, Yunwei Hu, Zuoyi Li, Yanyan Xie, Haixiang Huang, Qian Chen, Guanyu Chen, Wenjie Zhu, Yuxi Chen, Wenru Su, Xiaoqing Chen and Dan Liang
    Citation: Journal of Neuroinflammation 2022 19:124
  16. The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its effect on pathological pain and the cellula...

    Authors: Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu and Song Cao
    Citation: Journal of Neuroinflammation 2022 19:123
  17. Inflammation contributes to the poor prognosis of intracerebral hemorrhage (ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in multiple pathogenic processes. In the present...

    Authors: Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang and Xia Li
    Citation: Journal of Neuroinflammation 2022 19:122
  18. The complex pathophysiology of epilepsy hampers the development of effective treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on seizure control worldwide, about 30% of ...

    Authors: Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü and Weihua Yu
    Citation: Journal of Neuroinflammation 2022 19:121
  19. The danger-associated molecular patterns (DAMPs) are critical contributors to the progressive neuropathology and thereafter affect the functional outcomes following spinal cord injury (SCI). Up to now, the reg...

    Authors: Ting Yang, Haiyan Jiang, Xinye Luo, Yuxuan Hou, Aicheng Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Honghua Song, Rixin Cai, Xudong Wang, Yingjie Wang, Chun Yao, Lei Qi and Yongjun Wang
    Citation: Journal of Neuroinflammation 2022 19:120
  20. Anxiety, often seen as comorbidity in multiple sclerosis (MS), is a frequent neuropsychiatric symptom and essentially affects the overall disease burden. Here, we aimed to decipher anxiety-related networks fun...

    Authors: Erik Ellwardt, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Venkata Chaitanya Chirumamilla, Felix Luessi, Stefan Bittner, Frauke Zipp, Sergiu Groppa and Vinzenz Fleischer
    Citation: Journal of Neuroinflammation 2022 19:119
  21. The transient receptor potential vanilloid 1 (TRPV1) participates in thermosensation and inflammatory pain, but its immunomodulatory mechanisms remain enigmatic. N-Oleoyl dopamine (OLDA), an endovanilloid and end...

    Authors: Jérémie Joffre, Erika Wong, Samira Lawton, Elliot Lloyd, Nina Nguyen, Fengyun Xu, Cristina Sempio, Lester Kobzik, Ivana Zlatanova, Mark Schumacher, Jost Klawitter, Hua Su, Katalin Rabl, Kevin Wilhelmsen, Che-Chung Yeh and Judith Hellman
    Citation: Journal of Neuroinflammation 2022 19:118
  22. Agomelatine has been shown to be effective in the treatment of depression, but the molecular mechanisms underlying its antidepressant effects have yet to be elucidated. Identification of these molecular mechan...

    Authors: Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang and Shu Yan Yu
    Citation: Journal of Neuroinflammation 2022 19:117
  23. Inflammations play crucial role in the pathogenesis of Parkinson’s disease (PD), however, their possible value in the diagnosis or tracking of the progress of PD is still limited, because of discordant results...

    Authors: Yuanyuan Li, Yan Yang, Aonan Zhao, Ningdi Luo, Mengyue Niu, Wenyan Kang, Anmu Xie, Hong Lu, Lei Chen and Jun Liu
    Citation: Journal of Neuroinflammation 2022 19:116
  24. The natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to chronic mild stress (CMS) and the underlying molecu...

    Authors: Xue Jiang, Saini Yi, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao and Jinqiang Zhang
    Citation: Journal of Neuroinflammation 2022 19:115
  25. Sepsis is a potentially fatal disease characterized by acute organ failure that affects more than 30 million people worldwide. Inflammation is strongly associated with sepsis, and patients can experience impai...

    Authors: Vijayasree V. Giridharan, Jaqueline S. Generoso, Leonardo Lence, Gabriela Candiotto, Emílio Streck, Fabricia Petronilho, Anilkumar Pillai, Tarek Sharshar, Felipe Dal-Pizzol and Tatiana Barichello
    Citation: Journal of Neuroinflammation 2022 19:114
  26. The α-synuclein released by neurons activates microglia, which then engulfs α-synuclein for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease (PD), although ...

    Authors: Jia Lu, Chenfei Wang, Xin Cheng, Ruizhi Wang, Xuehan Yan, Pengju He, Hongzhuan Chen and Zhihua Yu
    Citation: Journal of Neuroinflammation 2022 19:113
  27. Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- or a...

    Authors: Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao, Yaomei Yang and Yanqin Gao
    Citation: Journal of Neuroinflammation 2022 19:112
  28. Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequenc...

    Authors: Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen and Susanne M. Kooistra
    Citation: Journal of Neuroinflammation 2022 19:111
  29. Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap of dementia subtypes is known as mixed de...

    Authors: Olivia J. Gannon, Lisa S. Robison, Abigail E. Salinero, Charly Abi-Ghanem, Febronia M. Mansour, Richard D. Kelly, Alvira Tyagi, Rebekah R. Brawley, Jordan D. Ogg and Kristen L. Zuloaga
    Citation: Journal of Neuroinflammation 2022 19:110
  30. The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition recep...

    Authors: Austin M. Jeffries, Alexander J. Suptela and Ian Marriott
    Citation: Journal of Neuroinflammation 2022 19:109
  31. The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of A...

    Authors: Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi and Jun Pan
    Citation: Journal of Neuroinflammation 2022 19:108
  32. Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. PD etiopathogenesis is multifactorial and not yet fully known, however, the scientific world advised the establishment of neuroin...

    Authors: Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Michela Campolo, Marika Lanza, Emanuela Esposito and Irene Paterniti
    Citation: Journal of Neuroinflammation 2022 19:107
  33. This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).

    Authors: Lingling Jiang, Xueli Cai, Dongxiao Yao, Jing Jing, Lerong Mei, Yingying Yang, Shan Li, Aoming Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan and Yilong Wang
    Citation: Journal of Neuroinflammation 2022 19:106
  34. The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS...

    Authors: Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter and Steven A. Sloan
    Citation: Journal of Neuroinflammation 2022 19:105
  35. Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the risk of developing cardiovascular disease and neuroinflammation. Even...

    Authors: Nathalie Obadia, Giulia Andrade, Marina Leardini-Tristão, Letícia Albuquerque, Celina Garcia, Flavia Lima, Júlio Daleprane, Hugo C. Castro-Faria-Neto, Eduardo Tibiriçá and Vanessa Estato
    Citation: Journal of Neuroinflammation 2022 19:104
  36. c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentatio...

    Authors: Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn and Patrice H. Lalive
    Citation: Journal of Neuroinflammation 2022 19:103
  37. Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. ...

    Authors: Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix and Stefanie Lemmens
    Citation: Journal of Neuroinflammation 2022 19:102
  38. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes cerebral dysfunction in the short and long term and induces disruption of the blood–brain barri...

    Authors: Nobufumi Sekino, Magdy Selim and Amjad Shehadah
    Citation: Journal of Neuroinflammation 2022 19:101
  39. Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but se...

    Authors: Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins and Brian P. Daniels
    Citation: Journal of Neuroinflammation 2022 19:100
  40. Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts nearly 400 million people worldwide. The accumulation of amyloid beta (Aβ) in the brain has historically been associated with AD...

    Authors: I. Y. Quiroga, A. E. Cruikshank, M. L. Bond, K. S. M. Reed, B. A. Evangelista, J. H. Tseng, J. V. Ragusa, R. B. Meeker, H. Won, S. Cohen, T. J. Cohen and D. H. Phanstiel
    Citation: Journal of Neuroinflammation 2022 19:99
  41. Neurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer’s disease (AD), P...

    Authors: Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu and Xueping Chen
    Citation: Journal of Neuroinflammation 2022 19:98
  42. Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However, the role of these cells has been underestimated in the context...

    Authors: Zeina Msheik, Mohamed El Massry, Amandine Rovini, Fabrice Billet and Alexis Desmoulière
    Citation: Journal of Neuroinflammation 2022 19:97
  43. Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectru...

    Authors: Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell and Markus J. Hofer
    Citation: Journal of Neuroinflammation 2022 19:96
  44. Excessively deposited fibrotic scar after spinal cord injury (SCI) inhibits axon regeneration. It has been reported that platelet-derived growth factor receptor beta (PDGFRβ), as a marker of fibrotic scar-form...

    Authors: Ziyu Li, Shuisheng Yu, Yanchang Liu, Xuyang Hu, Yiteng Li, Zhaoming Xiao, Yihao Chen, Dasheng Tian, Xinzhong Xu, Li Cheng, Meige Zheng and Juehua Jing
    Citation: Journal of Neuroinflammation 2022 19:95
  45. Development of neurodegeneration in older people has been associated with microglial cell activation triggered by systemic infection. We hypothesize that α7 nicotinic acetylcholine receptor (α7nAChR) plays an ...

    Authors: Inge C. M. Hoogland, Jutka Yik, Dunja Westhoff, Joo-Yeon Engelen-Lee, Merche Valls Seron, Wing Kit Man, Judith H. P. M. Houben-Weerts, Michael W. T. Tanck, David J. van Westerloo, Tom van der Poll, Willem A. van Gool and Diederik van de Beek
    Citation: Journal of Neuroinflammation 2022 19:94
  46. Myasthenic crisis (MC) and disease exacerbation in myasthenia gravis (MG) are associated with significant lethality and continue to impose a high disease burden on affected patients. Therefore, we sought to de...

    Authors: Christopher Nelke, Frauke Stascheit, Carmen Eckert, Marc Pawlitzki, Christina B. Schroeter, Niklas Huntemann, Philipp Mergenthaler, Ercan Arat, Menekse Öztürk, Dirk Foell, Stefanie Schreiber, Stefan Vielhaber, Asmae Gassa, Henning Stetefeld, Michael Schroeter, Benjamin Berger…
    Citation: Journal of Neuroinflammation 2022 19:89
  47. Despite rigorous confirmation with reliable assays, some individuals showing the neuromyelitis optica spectrum disorder (NMOSD) phenotype remain negative for both aquaporin-4 (AQP4) and myelin oligodendrocyte ...

    Authors: Jae-Won Hyun, Yeseul Kim, Ki Hoon Kim, Su-Hyun Kim, Mads Nikolaj Olesen, Nasrin Asgari, Sasitorn Siritho, Friedemann Paul and Ho Jin Kim
    Citation: Journal of Neuroinflammation 2022 19:86
  48. Angiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal...

    Authors: Kai-Yuan Jhan, Pi-Kai Chang, Chien-Ju Cheng, Shih-Ming Jung and Lian-Chen Wang
    Citation: Journal of Neuroinflammation 2022 19:85

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