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  1. Microglia, the mononuclear immune cells of the central nervous system (CNS), are essential for the maintenance of CNS homeostasis. BAP31, a resident and ubiquitously expressed protein of the endoplasmic reticu...

    Authors: Xia Liu, Kun Jiao, Cong-cong Jia, Guo-xun Li, Qing Yuan, Ji-kai Xu, Yue Hou and Bing Wang

    Citation: Journal of Neuroinflammation 2019 16:281

    Content type: Research

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  2. The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal menin...

    Authors: E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer and Diederik van de Beek

    Citation: Journal of Neuroinflammation 2019 16:279

    Content type: Research

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  3. Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How...

    Authors: Tian Niu, Lu Cheng, Hanying Wang, Shaopin Zhu, Xiaolu Yang, Kun Liu, Huiyi Jin and Xun Xu

    Citation: Journal of Neuroinflammation 2019 16:278

    Content type: Research

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  4. Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depend...

    Authors: Antony Cougnoux, Rebecca A. Drummond, Mason Fellmeth, Fatemeh Navid, Amanda L. Collar, James Iben, Ashok B. Kulkarni, James Pickel, Raphael Schiffmann, Christopher A. Wassif, Niamh X. Cawley, Michail S. Lionakis and Forbes D. Porter

    Citation: Journal of Neuroinflammation 2019 16:276

    Content type: Research

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  5. Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated wi...

    Authors: Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger and W. Sue T. Griffin

    Citation: Journal of Neuroinflammation 2019 16:275

    Content type: Research

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  6. Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as a “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions. Several mechan...

    Authors: Stefania Petrosino, Aniello Schiano Moriello, Roberta Verde, Marco Allarà, Roberta Imperatore, Alessia Ligresti, Ali Mokhtar Mahmoud, Alessio Filippo Peritore, Fabio Arturo Iannotti and Vincenzo Di Marzo

    Citation: Journal of Neuroinflammation 2019 16:274

    Content type: Research

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  7. Recent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes...

    Authors: Jia Lu, Fangfang Dou and Zhihua Yu

    Citation: Journal of Neuroinflammation 2019 16:273

    Content type: Research

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  8. Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and...

    Authors: Tjalf Ziemssen, Katja Akgün and Wolfgang Brück

    Citation: Journal of Neuroinflammation 2019 16:272

    Content type: Review

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  9. Neuropathic pain is one of the most debilitating of all chronic pain syndromes. Intrathecal (i.t.) bone marrow stromal cell (BMSC) injections have a favorable safety profile; however, results have been inconsi...

    Authors: Yongbo Teng, Yang Zhang, Shouwei Yue, Huanwen Chen, Yujuan Qu, Hui Wei and Xiaofeng Jia

    Citation: Journal of Neuroinflammation 2019 16:271

    Content type: Research

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  10. Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson’s disease (PD) and the toxic fibrillary α-syn binds lymphocyte-activation...

    Authors: Wenyuan Guo, Miaomiao Zhou, Jiewen Qiu, Yuwan Lin, Xiang Chen, Shuxuan Huang, Mingshu Mo, Hanqun Liu, Guoyou Peng, Xiaoqin Zhu and Pingyi Xu

    Citation: Journal of Neuroinflammation 2019 16:270

    Content type: Research

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  11. Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology...

    Authors: Samuel D. Shin, Alexandra Shin, Karina Mayagoitia, Lorraine Siebold, Marsilio Rubini, Christopher G. Wilson, Denise L. Bellinger and Salvador Soriano

    Citation: Journal of Neuroinflammation 2019 16:269

    Content type: Research

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  12. Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central neuroinflammatory responses that occur during...

    Authors: Darine Fakih, Zhanlin Zhao, Pierre Nicolle, Elodie Reboussin, Fanny Joubert, Jade Luzu, Antoine Labbé, William Rostène, Christophe Baudouin, Stéphane Mélik Parsadaniantz and Annabelle Réaux-Le Goazigo

    Citation: Journal of Neuroinflammation 2019 16:268

    Content type: Research

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  13. Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities. It is expressed in various cell types in the brain and is involved in the pa...

    Authors: Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen and Tzong-Shyuan Lee

    Citation: Journal of Neuroinflammation 2019 16:267

    Content type: Research

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  14. The involvement of microglia in neuroinflammatory responses has been extensively demonstrated. Recent animal studies have shown that exposure to either acute or chronic stress induces robust microglial activat...

    Authors: Shuei Sugama, Takato Takenouchi, Makoto Hashimoto, Hisayuki Ohata, Yasuhiro Takenaka and Yoshihiko Kakinuma

    Citation: Journal of Neuroinflammation 2019 16:266

    Content type: Research

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  15. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture (EA) is a complementary alternative medicine...

    Authors: Mudan Cai, Jun-Hwan Lee and Eun Jin Yang

    Citation: Journal of Neuroinflammation 2019 16:264

    Content type: Research

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  16. The mechanisms underlying the pathogenesis and progression of Parkinson’s disease (PD) remain elusive, but recent opinions and perspectives have focused on whether the inflammation process induced by microglia...

    Authors: Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu and Jun Liu

    Citation: Journal of Neuroinflammation 2019 16:263

    Content type: Research

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  17. HIV-1–associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells...

    Authors: Gladys Chompre, Neysha Martinez-Orengo, Myrella Cruz, James T. Porter and Richard J. Noel Jr

    Citation: Journal of Neuroinflammation 2019 16:262

    Content type: Research

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  18. Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have p...

    Authors: Fátima Rivera-Escalera, Jonathan J. Pinney, Laura Owlett, Hoda Ahmed, Juilee Thakar, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion

    Citation: Journal of Neuroinflammation 2019 16:261

    Content type: Research

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  19. Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms ...

    Authors: Shao-Hua Su, Yi-Fang Wu, Qi Lin, Da-Peng Wang and Jian Hai

    Citation: Journal of Neuroinflammation 2019 16:260

    Content type: Research

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  20. Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal...

    Authors: Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aricò, Rachel James, Carolina Cruciani, Cheryl Reeves, Federico Roncaroli, Richard Nicholas and Richard Reynolds

    Citation: Journal of Neuroinflammation 2019 16:259

    Content type: Research

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  21. Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and sepsis. Despite microglial cells being the cent...

    Authors: Andro Montoya, Daniela Elgueta, Javier Campos, Ornella Chovar, Paulina Falcón, Soledad Matus, Iván Alfaro, María Rosa Bono and Rodrigo Pacheco

    Citation: Journal of Neuroinflammation 2019 16:258

    Content type: Research

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  22. Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune syst...

    Authors: Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias and Elisabetta Mantuano

    Citation: Journal of Neuroinflammation 2019 16:257

    Content type: Research

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  23. Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroi...

    Authors: Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang and Xifa Lan

    Citation: Journal of Neuroinflammation 2019 16:256

    Content type: Research

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  24. Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate...

    Authors: Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong and Hui-Ming Gao

    Citation: Journal of Neuroinflammation 2019 16:255

    Content type: Research

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  25. Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals. Here, we characterize the CSF E...

    Authors: Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello and Dana Gabuzda

    Citation: Journal of Neuroinflammation 2019 16:254

    Content type: Research

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  26. Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with devastating consequences, including a high mortality rate and severe disabilities among survivors. Inflammation is induced following SAH,...

    Authors: Typhaine Gris, Patrick Laplante, Paméla Thebault, Romain Cayrol, Ahmed Najjar, Benjamin Joannette-Pilon, Frédéric Brillant-Marquis, Elsa Magro, Shane W. English, Réjean Lapointe, Michel Bojanowski, Charles L. Francoeur and Jean-François Cailhier

    Citation: Journal of Neuroinflammation 2019 16:253

    Content type: Research

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  27. Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic ag...

    Authors: Petri Elo, Xiang-Guo Li, Heidi Liljenbäck, Semi Helin, Jarmo Teuho, Kalle Koskensalo, Virva Saunavaara, Päivi Marjamäki, Vesa Oikonen, Jenni Virta, Qingshou Chen, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas and Anne Roivainen

    Citation: Journal of Neuroinflammation 2019 16:252

    Content type: Research

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  28. Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health an...

    Authors: Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W. Stitt, Heping Xu and Mei Chen

    Citation: Journal of Neuroinflammation 2019 16:251

    Content type: Research

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  29. Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular patt...

    Authors: Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G. Hazim and Jae-Kyung Lee

    Citation: Journal of Neuroinflammation 2019 16:250

    Content type: Short report

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  30. Inflammation can induce cognitive dysfunction in patients who undergo surgery. Previous studies have demonstrated that both acute peripheral inflammation and anaesthetic insults, especially isoflurane (ISO), a...

    Authors: Xiao-Yu Sun, Teng Zheng, Xiu Yang, Le Liu, Shen-Shen Gao, Han-Bing Xu, Yu-Tong Song, Kun Tong, Li Yang, Ya Gao, Tong Wu, Jing-Ru Hao, Chen Lu, Tao Ma and Can Gao

    Citation: Journal of Neuroinflammation 2019 16:249

    Content type: Research

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  31. Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities. Different cell typ...

    Authors: Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan…

    Citation: Journal of Neuroinflammation 2019 16:248

    Content type: Research

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  32. Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 ...

    Authors: Weilin Xu, Tao Li, Liansheng Gao, Jingwei Zheng, Jun Yan, Jianmin Zhang and Anwen Shao

    Citation: Journal of Neuroinflammation 2019 16:247

    Content type: Research

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  33. Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). Thus, the development of agents that can control neuroinflammation has been suggested as a promising therapeutic strategy...

    Authors: Yu-Young Lee, Jin-Sun Park, Yea-Hyun Leem, Jung-Eun Park, Do-Yeon Kim, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang and Hee-Sun Kim

    Citation: Journal of Neuroinflammation 2019 16:246

    Content type: Research

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  34. Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administra...

    Authors: María del Mar Fernández-Arjona, Jesús M. Grondona, Pedro Fernández-Llebrez and María Dolores López-Ávalos

    Citation: Journal of Neuroinflammation 2019 16:245

    Content type: Research

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  35. Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomo...

    Authors: Che Serguera, Lev Stimmer, Claire-Maelle Fovet, Philippe Horellou, Vanessa Contreras, Nicolas Tchitchek, Julie Massonneau, Carole Leroy, Audrey Perrin, Julien Flament, Philippe Hantraye, Joanna Demilly, Romain Marignier, Pascale Chrétien, Bert‘t Hart, Jean Boutonnat…

    Citation: Journal of Neuroinflammation 2019 16:244

    Content type: Research

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  36. Microglia are resident immune cells in the central nervous system and central to the innate immune system. Excessive activation of microglia after subarachnoid haemorrhage (SAH) contributes greatly to early br...

    Authors: Tao Tao, Guang-Jie Liu, Xuan Shi, Yan Zhou, Yue Lu, Yong-Yue Gao, Xiang-Sheng Zhang, Han Wang, Ling-Yun Wu, Chun-Lei Chen, Zong Zhuang, Wei Li and Chun-Hua Hang

    Citation: Journal of Neuroinflammation 2019 16:243

    Content type: Research

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  37. Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component of the BBB, promote BBB breakdown in ...

    Authors: Yilong Shan, Sha Tan, Yinyao Lin, Siyuan Liao, Bingjun Zhang, Xiaodong Chen, Jihui Wang, Zhezhi Deng, Qin Zeng, Lei Zhang, Yuge Wang, Xueqiang Hu, Wei Qiu, Lisheng Peng and Zhengqi Lu

    Citation: Journal of Neuroinflammation 2019 16:242

    Content type: Research

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  38. Sepsis-associated encephalopathy (SAE), a diffuse cerebral dysfunction in the absence of direct CNS infection, is associated with increased rates of mortality and morbidity in patients with sepsis. Increased c...

    Authors: Daniel S. Kikuchi, Ana Carolina P. Campos, Hongyan Qu, Steven J. Forrester, Rosana L. Pagano, Bernard Lassègue, Ruxana T. Sadikot, Kathy K. Griendling and Marina S. Hernandes

    Citation: Journal of Neuroinflammation 2019 16:241

    Content type: Research

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  39. Microglia, the resident macrophages of central nervous system, have been initially categorized into two opposite phenotypes: classical activation related to pro-inflammatory responses and alternative activatio...

    Authors: Liang Kong, Zehua Wang, Xiaohong Liang, Yue Wang, Lifen Gao and Chunhong Ma

    Citation: Journal of Neuroinflammation 2019 16:240

    Content type: Research

    Published on:

  40. Sepsis is a critical disease associated with extremely high mortality. Some severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive dysfunction. Pyroptosis is a type of cell death...

    Authors: Ruixi Zhou, Xiaoyan Yang, Xihong Li, Yi Qu, Qun Huang, Xuemei Sun and Dezhi Mu

    Citation: Journal of Neuroinflammation 2019 16:239

    Content type: Research

    Published on:

  41. Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and disability and imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays a...

    Authors: Chao Wang, Lu Zhang, Jean De La Croix Ndong, Aubryanna Hettinghouse, Guodong Sun, Changhong Chen, Chen Zhang, Ronghan Liu and Chuan-ju Liu

    Citation: Journal of Neuroinflammation 2019 16:238

    Content type: Research

    Published on:

  42. Neuroinflammation is thought to contribute to psychiatric and neurological disorders such as major depression and Alzheimer’s disease (AD). N-6 polyunsaturated fatty acids (PUFA) and molecules derived from the...

    Authors: Shoug M. Alashmali, Lin Lin, Marc-Olivier Trépanier, Giulia Cisbani and Richard P. Bazinet

    Citation: Journal of Neuroinflammation 2019 16:237

    Content type: Research

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  43. Vacuolar sorting protein 35 (VPS35), a critical component of retromer, is essential for selective endosome-to-Golgi retrieval of membrane proteins. It is highly expressed in microglial cells, in addition to ne...

    Authors: Shi-Yang Ye, Joanna E. Apple, Xiao Ren, Fu-Lei Tang, Ling-Ling Yao, Yong-Gang Wang, Lin Mei, Yuan-Guo Zhou and Wen-Cheng Xiong

    Citation: Journal of Neuroinflammation 2019 16:235

    Content type: Research

    Published on:

  44. Inflammation and apoptosis caused by intracerebral hemorrhage (ICH) are two important factors that affect patient prognosis and survival. Toll-like receptor 4 (TLR4) triggers activation of the inflammatory pat...

    Authors: Xiaowei Fei, Yeting He, Jia Chen, Weitao Man, Chen Chen, Kai Sun, Boyun Ding, Chongwu Wang and Ruxiang Xu

    Citation: Journal of Neuroinflammation 2019 16:234

    Content type: Research

    Published on:

  45. Inflammation is a critical process for the progression of neuronal death in neurodegenerative disorders. Microglia play a central role in neuroinflammation and may affect neuron vulnerability. Next generation ...

    Authors: Miguel Angel Abellanas, Marta Zamarbide, Leyre Basurco, Esther Luquin, Marta Garcia-Granero, Pedro Clavero, Patxi San Martin-Uriz, Amaia Vilas, Elisa Mengual, Sandra Hervas-Stubbs and Maria S. Aymerich

    Citation: Journal of Neuroinflammation 2019 16:233

    Content type: Research

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  46. Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main...

    Authors: Marie Wiatr, Carolin Stump-Guthier, Daniela Latorre, Stefanie Uhlig, Christel Weiss, Jorma Ilonen, Britta Engelhardt, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Tobias Tenenbaum and Henriette Rudolph

    Citation: Journal of Neuroinflammation 2019 16:232

    Content type: Research

    Published on:

  47. Multiple sclerosis (MS) is an inflammatory and autoimmune neurological disorder which leads to demyelination. Although the etiology of MS is yet to be known, it appears that regulating the immune system and su...

    Authors: Mohammad Morshedi, Reza Hashemi, Sara Moazzen, Amirhossein Sahebkar and Elaheh-Sadat Hosseinifard

    Citation: Journal of Neuroinflammation 2019 16:231

    Content type: Review

    Published on:

  48. It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolys...

    Authors: Weixing Zhao, Zhipeng Xu, Jiangbei Cao, Qiang Fu, Yishuang Wu, Xiaoying Zhang, Yue Long, Xuan Zhang, Yitian Yang, Yunfeng Li and Weidong Mi

    Citation: Journal of Neuroinflammation 2019 16:230

    Content type: Research

    Published on:

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