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  1. Content type: Research

    Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. ...

    Authors: Hassan El Hajj, Julie C. Savage, Kanchan Bisht, Martin Parent, Luc Vallières, Serge Rivest and Marie-Ève Tremblay

    Citation: Journal of Neuroinflammation 2019 16:87

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  2. Content type: Research

    Impairment of the blood–brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role...

    Authors: Diana G. Bohannon, Allen Ko, Adam R. Filipowicz, Marcelo J. Kuroda and Woong-Ki Kim

    Citation: Journal of Neuroinflammation 2019 16:86

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  3. Content type: Research

    Astrocytes have been shown to produce several pro- and anti-inflammatory cytokines to maintain homeostasis of microenvironment in response to vast array of CNS insults. Some inflammation-related cytokines are ...

    Authors: Yuxin Zhang, Yue Zhou, Shuxia Chen, Yuming Hu, Zhenjie Zhu, Yingjie Wang, Nan Du, Tiancheng Song, Yumin Yang, Aisong Guo and Yongjun Wang

    Citation: Journal of Neuroinflammation 2019 16:85

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  4. Content type: Research

    The G protein-coupled receptor 40 (GPR40), broadly expressed in various tissues such as the spinal cord, exerts multiple physiological functions including pain regulation. This study aimed to elucidate the mec...

    Authors: Xiao-Fang Mao, Hai-Yun Wu, Xue-Qi Tang, Usman Ali, Hao Liu and Yong-Xiang Wang

    Citation: Journal of Neuroinflammation 2019 16:84

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  5. Content type: Research

    Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 is an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction and maintenance...

    Authors: Danli Zhou, Siqi Zhang, Liang Hu, Yu-Feng Gu, Yimei Cai, Deqin Wu, Wen-Tao Liu, Chun-Yi Jiang, Xiangqing Kong and Guang-Qin Zhang

    Citation: Journal of Neuroinflammation 2019 16:83

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  6. Content type: Research

    Neuropathic pain is caused by sensory nerve injury, but effective treatments are currently lacking. Microglia are activated in the spinal dorsal horn after sensory nerve injury and contribute to neuropathic pa...

    Authors: Akira Sayo, Hiroyuki Konishi, Masaaki Kobayashi, Kuniyuki Kano, Hiroki Kobayashi, Hideharu Hibi, Junken Aoki and Hiroshi Kiyama

    Citation: Journal of Neuroinflammation 2019 16:82

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  7. Content type: Research

    Neuroinflammation is an essential player in many neurological diseases including traumatic brain injury (TBI). Recent studies have identified that inflammasome complexes are responsible for inflammatory respon...

    Authors: Ram Kuwar, Andrew Rolfe, Long Di, Hongyu Xu, Liu He, Yuqi Jiang, Shijun Zhang and Dong Sun

    Citation: Journal of Neuroinflammation 2019 16:81

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  8. Content type: Research

    Microglia play crucial roles in the maintenance of brain homeostasis. Activated microglia show a biphasic influence, promoting beneficial repair and causing harmful damage via M2 and M1 microglia, respectively...

    Authors: Takashi Koizumi, Katsutoshi Taguchi, Ikuko Mizuta, Hiroe Toba, Makoto Ohigashi, Okihiro Onishi, Kazuya Ikoma, Seiji Miyata, Tetsuo Nakata, Masaki Tanaka, Sébastien Foulquier, Harry W. M. Steinbusch and Toshiki Mizuno

    Citation: Journal of Neuroinflammation 2019 16:79

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  9. Content type: Research

    Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate the inflamma...

    Authors: Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yixin Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou

    Citation: Journal of Neuroinflammation 2019 16:78

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  10. Content type: Short report

    During the acute stroke phase, neutrophils from the peripheral blood are first to arrive in the ischemic brain, which then attracts other immune cells that exacerbate neuroinflammation in the ischemic tissue. ...

    Authors: Yan Wang, Haojie Jin, Weifang Wang, Feng Wang and Heng Zhao

    Citation: Journal of Neuroinflammation 2019 16:77

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  11. Content type: Review

    Viral encephalitis is still very prominent around the world, and traditional antiviral therapies still have shortcomings. Some patients cannot get effective relief or suffer from serious sequelae. At present, ...

    Authors: Zhuangzhuang Chen, Di Zhong and Guozhong Li

    Citation: Journal of Neuroinflammation 2019 16:76

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  12. Content type: Research

    Activation of microglial cells plays an important role in neuroinflammation after ischemic stroke. Inhibiting the activation of microglial cells has been suggested as a potential therapeutic approach in the tr...

    Authors: Xi Zhang, Xiao-Lei Zhu, Bi-Ying Ji, Xiang Cao, Lin-Jie Yu, Yan Zhang, Xin-Yu Bao, Yun Xu and Jia-Li Jin

    Citation: Journal of Neuroinflammation 2019 16:75

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  13. Content type: Review

    Neuroinflammation is considered one of the cardinal features of Alzheimer’s disease (AD). Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are surrounded by reactive astrocytes a...

    Authors: Dawling A. Dionisio-Santos, John A. Olschowka and M. Kerry O’Banion

    Citation: Journal of Neuroinflammation 2019 16:74

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  14. Content type: Research

    Autoantibodies against the paranodal protein contactin-1 have recently been described in patients with severe acute-onset autoimmune neuropathies and mainly belong to the IgG4 subclass that does not activate c...

    Authors: Kathrin Doppler, Yasmin Schuster, Luise Appeltshauser, Lydia Biko, Carmen Villmann, Andreas Weishaupt, Christian Werner and Claudia Sommer

    Citation: Journal of Neuroinflammation 2019 16:73

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  15. Content type: Research

    Diabetes is known to be a main risk factor of post-stroke hemorrhagic transformation following recombinant tissue plasminogen activator (rt-PA) therapy. However, the mechanism through which diabetes exacerbate...

    Authors: Yanan Xie, Yingzhe Wang, Hongyan Ding, Min Guo, Xun Wang, Qiang Dong and Mei Cui

    Citation: Journal of Neuroinflammation 2019 16:72

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  16. Content type: Research

    HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-1-positive individuals. The transactivator of transcription (Tat) produced by HIV virus elicits inflammatory process and is a major...

    Authors: Feng Zhou, Xiaomei Liu, Lin Gao, Xinxin Zhou, Qianwen Cao, Liping Niu, Jing Wang, Dongjiao Zuo, Xiangyang Li, Ying Yang, Minmin Hu, Yinghua Yu, Renxian Tang, Bong Ho Lee, Byoung Wook Choi, Yugang Wang…

    Citation: Journal of Neuroinflammation 2019 16:71

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  17. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Figure 4 as the wrong figure was used.

    Authors: Marc A. Russo, Nathan T. Fiore, Caryn van Vreden, Dominic Bailey, Danielle M. Santarelli, Helen M. McGuire, Barbara Fazekas de St Groth and Paul J. Austin

    Citation: Journal of Neuroinflammation 2019 16:70

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    The original article was published in Journal of Neuroinflammation 2019 16:63

  18. Content type: Research

    Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is u...

    Authors: Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Brandi Jefferson, Alison Thomas, Ankita Brahmaroutu and Sharon DeMorrow

    Citation: Journal of Neuroinflammation 2019 16:69

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  19. Content type: Research

    Immunity has been suggested to be important in the pathogenesis of dementia. However, the contribution of innate versus adaptive immunity in the development of dementia is not clear. In this study, we aimed to...

    Authors: Kimberly D. van der Willik, Lana Fani, Dimitris Rizopoulos, Silvan Licher, Jesse Fest, Sanne B. Schagen, M. Kamran Ikram and M. Arfan Ikram

    Citation: Journal of Neuroinflammation 2019 16:68

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  20. Content type: Research

    Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior wi...

    Authors: Masaya Yasui, Yuki Menjyo, Kyohei Tokizane, Akiko Shiozawa, Makoto Tsuda, Kazuhide Inoue and Hiroshi Kiyama

    Citation: Journal of Neuroinflammation 2019 16:67

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  21. Content type: Research

    Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the relat...

    Authors: Yi Sun, Jiangjun Ma, Dongfang Li, Pinggan Li, Xiaolin Zhou, Yu Li, Zhanwen He, Lijun Qin, Liyang Liang and Xiangyang Luo

    Citation: Journal of Neuroinflammation 2019 16:66

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  22. Content type: Research

    Neurokine signaling via the release of neurally active cytokines arises from glial reactivity and is mechanistically implicated in central nervous system (CNS) pathologies such as chronic pain, trauma, neurode...

    Authors: Lindsay M. Parker, Nima Sayyadi, Vasiliki Staikopoulos, Ashish Shrestha, Mark R. Hutchinson and Nicolle H. Packer

    Citation: Journal of Neuroinflammation 2019 16:65

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  23. Content type: Research

    Orexins (hypocretins, Hcrt) A and B are GPCR-binding hypothalamic neuropeptides known to regulate sleep/wake states and feeding behavior. A few studies have shown that orexin A exhibits anti-inflammatory and neur...

    Authors: Laurine Becquet, Catalina Abad, Mathilde Leclercq, Camille Miel, Laetitia Jean, Gaëtan Riou, Alain Couvineau, Olivier Boyer and Yossan-Var Tan

    Citation: Journal of Neuroinflammation 2019 16:64

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  24. Content type: Research

    Complex regional pain syndrome (CRPS) is a debilitating condition where trauma to a limb results in devastating persistent pain that is disproportionate to the initial injury. The pathophysiology of CRPS remai...

    Authors: Marc A. Russo, Nathan T. Fiore, Caryn van Vreden, Dominic Bailey, Danielle M. Santarelli, Helen M. McGuire, Barbara Fazekas de St Groth and Paul J. Austin

    Citation: Journal of Neuroinflammation 2019 16:63

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    The Correction to this article has been published in Journal of Neuroinflammation 2019 16:70

  25. Content type: Research

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. Urolithin A (UA), a gut-m...

    Authors: Zhuo Gong, Jingyi Huang, Biao Xu, Zhenri Ou, Le Zhang, Xiaohong Lin, Xiujuan Ye, Xuejian Kong, Dahong Long, Xiangdong Sun, Xiaosong He, Liping Xu, Qingqing Li and Aiguo Xuan

    Citation: Journal of Neuroinflammation 2019 16:62

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  26. Content type: Research

    Microglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully understood. Mice lacking multifunctional protein-2 (MFP2), ...

    Authors: Lien Beckers, Ivana Geric, Stijn Stroobants, Sander Beel, Philip Van Damme, Rudi D’Hooge and Myriam Baes

    Citation: Journal of Neuroinflammation 2019 16:61

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  27. Content type: Research

    While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory ...

    Authors: Thomas Taetzsch, Savannah Benusa, Shannon Levesque, Christen L. Mumaw and Michelle L. Block

    Citation: Journal of Neuroinflammation 2019 16:60

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  28. Content type: Research

    Long-term outcome in multiple sclerosis (MS) depends on early treatment. In patients with acute optic neuritis (ON), an early inflammatory event, we investigated markers in cerebrospinal fluid (CSF), which may...

    Authors: M. N. Olesen, K. Soelberg, B. Debrabant, A. C. Nilsson, S. T. Lillevang, J. Grauslund, I. Brandslund, J. S. Madsen, F. Paul, T. J. Smith, S. Jarius and N. Asgari

    Citation: Journal of Neuroinflammation 2019 16:59

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  29. Content type: Research

    Corticosteroids dominate in the treatment of chronic autoimmune neuropathies although long-term use is characterized by devastating side effects.

    Authors: Kalliopi Pitarokoili, Melissa Sgodzai, Thomas Grüter, Hussein Bachir, Jeremias Motte, Björn Ambrosius, Xiomara Pedreiturria, Min-Suk Yoon and Ralf Gold

    Citation: Journal of Neuroinflammation 2019 16:58

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  30. Content type: Research

    Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, ...

    Authors: Lukmanee Tradtrantip, Tianjiao Duan, Michael R. Yeaman and Alan S. Verkman

    Citation: Journal of Neuroinflammation 2019 16:57

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  31. Content type: Research

    Intracerebral hemorrhage (ICH) has a high morbidity and mortality. The peripheral immune system and cross-talk between peripheral blood and brain have been implicated in the ICH immune response. Thus, we delin...

    Authors: Marc Durocher, Bradley P. Ander, Glen Jickling, Farah Hamade, Heather Hull, Bodie Knepp, Da Zhi Liu, Xinhua Zhan, Anh Tran, Xiyuan Cheng, Kwan Ng, Alan Yee, Frank R. Sharp and Boryana Stamova

    Citation: Journal of Neuroinflammation 2019 16:56

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  32. Content type: Research

    Glia are key regulators of inflammatory responses within the central nervous system (CNS) following infection or trauma. We have previously demonstrated the ability of activated glia to rapidly produce pro-inf...

    Authors: Amanda R. Burmeister, M. Brittany Johnson, Jessica J. Yaemmongkol and Ian Marriott

    Citation: Journal of Neuroinflammation 2019 16:55

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  33. Content type: Research

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin prot...

    Authors: Laurent Kremer, Omar Taleb, Nelly Boehm, Ayikoe Guy Mensah-Nyagan, Elisabeth Trifilieff, Jérôme de Seze and Susana Brun

    Citation: Journal of Neuroinflammation 2019 16:54

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  34. Content type: Review

    Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiolog...

    Authors: Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu and Rong-Fu Wang

    Citation: Journal of Neuroinflammation 2019 16:53

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  35. Content type: Research

    Amlexanox (ALX), a TBK1 inhibitor, can modulate immune responses and has anti-inflammatory properties. To investigate its role in regulating the progression of experimental autoimmune encephalomyelitis (EAE), ...

    Authors: Mo-Yuan Quan, Xiu-Juan Song, Hui-Jia Liu, Xiao-Hong Deng, Hui-Qing Hou, Li-Ping Chen, Tian-Zhao Ma, Xu Han, Xin-Xin He, Zhen Jia and Li Guo

    Citation: Journal of Neuroinflammation 2019 16:52

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  36. Content type: Research

    Myelinoclastic diffuse sclerosis (MDS; also termed Schilder’s disease) is a rare inflammatory demyelinating disorder of the central nervous system characterised by demyelination of vast areas of the white matt...

    Authors: S. Jarius, J. Haas, F. Paul and B. Wildemann

    Citation: Journal of Neuroinflammation 2019 16:51

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  37. Content type: Research

    Inflammation and oxidative stress are recognized as important contributors to Parkinson’s disease pathogenesis. As such, genetic variability in these pathways could have a role in susceptibility for the diseas...

    Authors: Sara Redenšek, Dušan Flisar, Maja Kojović, Milica Gregorič Kramberger, Dejan Georgiev, Zvezdan Pirtošek, Maja Trošt and Vita Dolžan

    Citation: Journal of Neuroinflammation 2019 16:50

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  38. Content type: Research

    Quinoline-3-carboxamides, such as laquinimod, ameliorate CNS autoimmunity in patients and reduce tumor cell metastasis experimentally. Previous studies have focused on the immunomodulatory effect of laquinimod...

    Authors: Martina Ott, Erika Avendaño-Guzmán, Evelyn Ullrich, Carolin Dreyer, Judith Strauss, Markus Harden, Margarete Schön, Michael P. Schön, Günter Bernhardt, Christine Stadelmann, Christiane Wegner, Wolfgang Brück and Stefan Nessler

    Citation: Journal of Neuroinflammation 2019 16:49

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  39. Content type: Research

    Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their unde...

    Authors: Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder and Helga E. de Vries

    Citation: Journal of Neuroinflammation 2019 16:48

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  40. Content type: Research

    Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. T...

    Authors: Yuchun Zuo, Lei Huang, Budbazar Enkhjargal, Weilin Xu, Ocak Umut, Zachary D. Travis, Guangyu Zhang, Jiping Tang, Fei Liu and John H. Zhang

    Citation: Journal of Neuroinflammation 2019 16:47

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  41. Content type: Research

    Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer’s disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum...

    Authors: Kaja Nordengen, Bjørn-Eivind Kirsebom, Kristi Henjum, Per Selnes, Berglind Gísladóttir, Marianne Wettergreen, Silje Bøen Torsetnes, Gøril Rolfseng Grøntvedt, Knut K. Waterloo, Dag Aarsland, Lars N. G. Nilsson and Tormod Fladby

    Citation: Journal of Neuroinflammation 2019 16:46

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  42. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disease without effective treatment. The receptor for advanced glycation end products (RAGE) and the toll-like receptor ...

    Authors: John D. Lee, Ning Liu, Samantha C. Levin, Lars Ottosson, Ulf Andersson, Helena E. Harris and Trent M. Woodruff

    Citation: Journal of Neuroinflammation 2019 16:45

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  43. Content type: Research

    1-42 peptide abnormal production is associated with the development and maintenance of neuroinflammation and oxidative stress in brains from Alzheimer disease (AD) patients. Suppression of neuroinflammation may...

    Authors: Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo and Luigi M. Grimaldi

    Citation: Journal of Neuroinflammation 2019 16:44

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  44. Content type: Research

    Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protec...

    Authors: Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck and Antje Grosche

    Citation: Journal of Neuroinflammation 2019 16:43

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  45. Content type: Research

    Varicella-zoster virus (VZV) is a common viral agent causing central nervous system (CNS) infections including encephalitis, meningitis, and Ramsay Hunt syndrome. Neurological complications occur frequently de...

    Authors: Liza Lind, Kristina Eriksson and Anna Grahn

    Citation: Journal of Neuroinflammation 2019 16:42

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  46. Content type: Research

    Excessive iron contributes to oxidative stress after central nervous system injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory activation and contribute to oxidative stress...

    Authors: Young J. Yauger, Sara Bermudez, Kasey E. Moritz, Ethan Glaser, Bogdan Stoica and Kimberly R. Byrnes

    Citation: Journal of Neuroinflammation 2019 16:41

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  47. Content type: Research

    Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis,...

    Authors: Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O’Reilly, Bhanu Priya Ganesh, Fudong Liu and Louise D. McCullough

    Citation: Journal of Neuroinflammation 2019 16:40

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  48. Content type: Research

    Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food and water intake, while pre-injection of endotoxins attenuates these responses. This phenomen...

    Authors: Shoko Morita-Takemura, Kazuki Nakahara, Sanae Hasegawa-Ishii, Ayami Isonishi, Kouko Tatsumi, Hiroaki Okuda, Tatsuhide Tanaka, Masahiro Kitabatake, Toshihiro Ito and Akio Wanaka

    Citation: Journal of Neuroinflammation 2019 16:39

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  49. Content type: Research

    High white blood cell (WBC) count and high blood glucose level are risk factors for mortality and pneumonia after acute ischemic stroke (AIS). We investigated the combined effect of high WBC count and high blo...

    Authors: Shoujiang You, Zhijie Ou, Wei Zhang, Danni Zheng, Chongke Zhong, Xiaofeng Dong, Chenhong Qiu, Taosheng Lu, Yongjun Cao and Chun-Feng Liu

    Citation: Journal of Neuroinflammation 2019 16:37

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