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  1. Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term control of latent HSV-1 infection, but it is uncle...

    Authors: Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink and Georges M. G. M. Verjans
    Citation: Journal of Neuroinflammation 2022 19:249
  2. Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulatin...

    Authors: Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen and Paul M. Matthews
    Citation: Journal of Neuroinflammation 2022 19:247
  3. Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic br...

    Authors: Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen…
    Citation: Journal of Neuroinflammation 2022 19:246
  4. Stroke is associated with high disability and mortality rates and increases the incidence of organ-related complications. Research has revealed that the outcomes and prognosis of stroke are regulated by the st...

    Authors: Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu and Xiaoxing Xiong
    Citation: Journal of Neuroinflammation 2022 19:245
  5. Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pai...

    Authors: Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen and Zhong-Ya Wei
    Citation: Journal of Neuroinflammation 2022 19:244
  6. Moderate physical exercise is conducive to the brains of healthy humans and AD patients. Previous reports have suggested that treadmill exercise plays an anti-AD role and improves cognitive ability by promotin...

    Authors: Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang and Tianhui Wang
    Citation: Journal of Neuroinflammation 2022 19:243
  7. Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the innate immune sys...

    Authors: Xinli Hu, Haojie Zhang, Qianxin Zhang, Xue Yao, Wenfei Ni and Kailiang Zhou
    Citation: Journal of Neuroinflammation 2022 19:242
  8. Multiple sclerosis (MS) is a chronic, debilitating condition characterized by CNS autoimmunity stemming from a complex etiology involving both environmental and genetic factors. Our current understanding of MS...

    Authors: Patrick O’Connell, Maja K. Blake, Sarah Godbehere, Andrea Amalfitano and Yasser A. Aldhamen
    Citation: Journal of Neuroinflammation 2022 19:241
  9. Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatis...

    Authors: Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu and Ming Lu
    Citation: Journal of Neuroinflammation 2022 19:240
  10. In neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils are found in CNS lesions. We previously demonstrated that NMOSD neutr...

    Authors: Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul and Carmen Infante-Duarte
    Citation: Journal of Neuroinflammation 2022 19:239
  11. Pathophysiological consequences of traumatic brain injury (TBI) mediated secondary injury remain incompletely understood. In particular, the impact of TBI on the differentiation and maintenance of dendritic ce...

    Authors: Orest Tsymbalyuk, Volodymyr Gerzanich, J. Marc Simard and Chozha Vendan Rathinam
    Citation: Journal of Neuroinflammation 2022 19:238
  12. Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported to be associated with various inflammatory diseases....

    Authors: Guoqing Jing, Jing Zuo, Qing Fang, Min Yuan, Yun Xia, Qiyan Jin, Yuping Liu, Yanlin Wang, Zongze Zhang, Wanhong Liu, Xiaojing Wu and Xuemin Song
    Citation: Journal of Neuroinflammation 2022 19:237
  13. Alzheimer's disease (AD) is the most common neurodegenerative disease and its pathogenesis is still unclear. There is dysbiosis of gut microbiota in AD patients. More importantly, dysbiosis of the gut microbio...

    Authors: Xiao-hang Qian, Xiao-li Liu, Guang Chen, Sheng-di Chen and Hui-dong Tang
    Citation: Journal of Neuroinflammation 2022 19:236
  14. A diverse heterogeneity of microglial cells was previously described in Alzheimer’s disease (AD) pathology, including dark microglia, a state characterized by ultrastructural markers of cellular stress. To pro...

    Authors: Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Eva Šimončičová, Marie-Josée Wallman, Luc Vallières, Martin Parent and Marie-Ève Tremblay
    Citation: Journal of Neuroinflammation 2022 19:235
  15. Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic an...

    Authors: Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren and Hélène Hirbec
    Citation: Journal of Neuroinflammation 2022 19:234
  16. The spleen, a substantial reservoir of non-differentiated monocytes, may play a crucial role in the pathophysiology of post-ischemic inflammation and influence outcomes after ischemic stroke.

    Authors: Marko Sternak, Anton Glasnović, Paula Josić, Dominik Romić and Srećko Gajović
    Citation: Journal of Neuroinflammation 2022 19:233
  17. Early life stress (ELS) is associated with the development of schizophrenia later in life. The hippocampus develops significantly during childhood and is extremely reactive to stress. In rodent models, ELS can...

    Authors: Keke Hao, Huiling Wang, Yuejin Zhang, Xinhui Xie, Huan Huang, Cheng Chen, Shilin Xu, Rui Xu, Chang Shu, Zhongchun Liu, Yuan Zhou, Gavin P. Reynolds and Gaohua Wang
    Citation: Journal of Neuroinflammation 2022 19:232
  18. Radiation-induced brain injury (RIBI) is the most serious complication of radiotherapy in patients with head and neck tumors, which seriously affects the quality of life. Currently, there is no effective treat...

    Authors: Zhan Zhang, Jingru Jiang, Yong He, Jinhua Cai, Jiatian Xie, Minyi Wu, Mengdan Xing, Zhenzhen Zhang, Haocai Chang, Pei Yu, Siqi Chen, Yuhua Yang, Zhongshan Shi, Qiang Liu, Haohui Sun, Baixuan He…
    Citation: Journal of Neuroinflammation 2022 19:231
  19. Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD). Specifically, chronically activated microglia and their distu...

    Authors: Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen and Thomas Langmann
    Citation: Journal of Neuroinflammation 2022 19:229
  20. Cerebral vasospasm (CV) can contribute to significant morbidity in subarachnoid hemorrhage (SAH) patients. A key unknown is how CV induction is triggered following SAH.

    Authors: Brandon Lucke-Wold, William Dodd, Kartik Motwani, Koji Hosaka, Dimitri Laurent, Melanie Martinez, Victoria Dugan, Nohra Chalouhi, Noelle Lucke-Wold, Arnav Barpujari, Christina von Roemeling, Chenglong Li, Richard D. Johnson and Brian Hoh
    Citation: Journal of Neuroinflammation 2022 19:228
  21. Evidence from experimental and clinical studies implicates immuno-inflammatory responses as playing an important role in epilepsy-induced brain injury. Captopril, an angiotensin-converting enzyme inhibitor (AC...

    Authors: Xinyan Dong, Jianchen Fan, Donghui Lin, Xuehui Wang, Haoyu Kuang, Lifen Gong, Chen Chen, Jie Jiang, Ningxiao Xia, Dahong He, Weida Shen, Peifang Jiang, Rong Kuang, Linghui Zeng and Yicheng Xie
    Citation: Journal of Neuroinflammation 2022 19:226
  22. Early invasion of the central nervous system (CNS) by human immunodeficiency virus (HIV) (Gray et al. in Brain Pathol 6:1–15, 1996; An et al. in Ann Neurol 40:611–6172, 1996), results in neuroinflammation, pot...

    Authors: Hussein Kaddour, Marina McDew-White, Miguel M. Madeira, Malik A. Tranquille, Stella E. Tsirka, Mahesh Mohan and Chioma M. Okeoma
    Citation: Journal of Neuroinflammation 2022 19:225
  23. Chronic suppurative otitis media (CSOM) is the most common cause of permanent hearing loss in children in the developing world. A large component of the permanent hearing loss is sensory in nature and our unde...

    Authors: Anping Xia, Anthony Thai, Zhixin Cao, Xiaohua Chen, Jing Chen, Brian Bacacao, Laurent A. Bekale, Viktoria Schiel, Paul L. Bollyky and Peter L. Santa Maria
    Citation: Journal of Neuroinflammation 2022 19:224
  24. Multifactorial diseases are characterized by inter-individual variation in etiology, age of onset, and penetrance. These diseases tend to be relatively common and arise from the combined action of genetic and ...

    Authors: Rachel J. Boyd, Dimitri Avramopoulos, Lauren L. Jantzie and Andrew S. McCallion
    Citation: Journal of Neuroinflammation 2022 19:223
  25. Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles (sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal stem cell-derived sEV...

    Authors: Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin and Tao Tao
    Citation: Journal of Neuroinflammation 2022 19:221
  26. Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to one quarter of patients. Immunoadsorption is an accepted treatment fo...

    Authors: Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl and Sven G. Meuth
    Citation: Journal of Neuroinflammation 2022 19:220
  27. Triggering receptor expressed on myeloid cell 1 (Trem1) is an important regulator of cellular inflammatory responses. Neuroinflammation is a common thread across various neurological diseases. Soluble Trem1 (s...

    Authors: Xiaolei Shi, Tao Wei, Yachun Hu, Meng Wang and Yi Tang
    Citation: Journal of Neuroinflammation 2022 19:218
  28. Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components...

    Authors: Emma L. van der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Martina Bocchetta, Emily Todd, David Cash…
    Citation: Journal of Neuroinflammation 2022 19:217
  29. Retinal degenerative diseases are a group of conditions characterized by photoreceptor death and vision loss. Excessive inflammation and microglial activation contribute to the pathology of retinal degeneratio...

    Authors: Andrea Nortey, Kimberly Garces, Tal Carmy-Bennun and Abigail S. Hackam
    Citation: Journal of Neuroinflammation 2022 19:216
  30. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the most common cause of dementia. Among various pathophysiological aspects, microglia are considered to play important roles in the pa...

    Authors: Chao Gao, Xin Shen, Yuyan Tan and Shengdi Chen
    Citation: Journal of Neuroinflammation 2022 19:215
  31. Brain injury is the main cause of high mortality and disability after successful cardiopulmonary resuscitation (CPR) from sudden cardiac arrest (CA). The transient receptor potential M4 (TRPM4) channel is a no...

    Authors: Jiancong Chen, Yuan Chang, Juan Zhu, Yuqin Peng, Zheqi Li, Kunxue Zhang, Yuzhen Zhang, Chuman Lin, Zhenzhou Lin, Suyue Pan and Kaibin Huang
    Citation: Journal of Neuroinflammation 2022 19:214
  32. Chronic kidney disease (CKD), characterized as renal dysfunction, is regarded as a major public health problem which carries a high risk of cardiovascular diseases. The purpose of this study is to evaluate the...

    Authors: Hongming Sun, Xitong Li, Xin Chen, Yingquan Xiong, Yaochen Cao and Ziqiang Wang
    Citation: Journal of Neuroinflammation 2022 19:213
  33. Interleukin-27 (IL-27) can trigger both pro- and anti-inflammatory responses. This cytokine is elevated in the central nervous system (CNS) of multiple sclerosis (MS) patients, but how it influences neuroinfla...

    Authors: Florent Lemaître, Negar Farzam-kia, Ana Carmena Moratalla, Yves Carpentier Solorio, Marie-Laure Clenet, Olivier Tastet, Aurélie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Pierre Duquette, J. Marc Girard, Alexandre Prat, Catherine Larochelle and Nathalie Arbour
    Citation: Journal of Neuroinflammation 2022 19:212
  34. Local neuroinflammation secondary to spinal nerve compression in lumbar disk herniation (LDH) is a key driver contributing to neuropathic pain. Manual therapy (MT), a widely used nonsurgical therapy, can relie...

    Authors: Chongjie Yao, Jun Ren, Ruixin Huang, Cheng Tang, Yanbin Cheng, Zhizhen Lv, Lingjun Kong, Sitong Fang, Jiming Tao, Yangyang Fu, Qingguang Zhu and Min Fang
    Citation: Journal of Neuroinflammation 2022 19:211
  35. Abnormal activation of immune system is an important pathogenesis of Parkinson’s disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remain...

    Authors: Shu-Ying Liu, Hong-Wen Qiao, Tian-Bin Song, Xiu-Lin Liu, Yun-Xia Yao, Chun-Song Zhao, Olivier Barret, Sheng-Li Xu, Yan-Ning Cai, Gilles D. Tamagnan, Vesna Sossi, Jie Lu and Piu Chan
    Citation: Journal of Neuroinflammation 2022 19:209
  36. Psychological stress is one of the most important factors that trigger emotional disorders, such as depression and anxiety. Emerging evidence suggests that neuroinflammation exacerbated by bidirectional commun...

    Authors: Huiling Hu, Xue Yang, Yuqing He, Chaohui Duan and Nannan Sun
    Citation: Journal of Neuroinflammation 2022 19:208
  37. Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. However, extant investigations have mainly focused on gray matter injury within the primary injury site after ICH rather th...

    Authors: Min Yao, Jie Fang, Jiewei Li, Anson Cho Kiu Ng, Jiaxin Liu, Gilberto Ka Kit Leung, Fanglai Song, Jian Zhang and Chunqi Chang
    Citation: Journal of Neuroinflammation 2022 19:207
  38. Progressive neuronal death is the key pathological feature of Alzheimer’s disease (AD). However, the molecular mechanisms underlying the neuronal death in AD patients have not been fully elucidated. Necroptosi...

    Authors: Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu and Wei Kong
    Citation: Journal of Neuroinflammation 2022 19:205
  39. Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic inflammation associated with tumor developme...

    Authors: Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam and Andrew J. Shepherd
    Citation: Journal of Neuroinflammation 2022 19:204
  40. Diabetic retinopathy and retinal vein occlusion are vision threatening retinal vascular diseases. Current first-line therapy targets the vascular component, but many patients are treatment-resistant due to unc...

    Authors: Amrita Rajesh, Steven Droho and Jeremy A. Lavine
    Citation: Journal of Neuroinflammation 2022 19:203
  41. Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal programmed cell death via the mitochondrial pathway but also is an essential component of the signalling cascade during microglial activatio...

    Authors: Yiying Zhang, Zhangyang Wang, Rongrong Wang, Lu Xia, Yiying Cai, Fangchao Tong, Yanqin Gao, Jing Ding and Xin Wang
    Citation: Journal of Neuroinflammation 2022 19:202
  42. Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell t...

    Authors: Yongfang Zhao, Hongfeng Mu, Yichen Huang, Sicheng Li, Yangfan Wang, R. Anne Stetler, Michael V. L. Bennett, C. Edward Dixon, Jun Chen and Yejie Shi
    Citation: Journal of Neuroinflammation 2022 19:201
  43. The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigg...

    Authors: Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher and Maurice Zauderer
    Citation: Journal of Neuroinflammation 2022 19:200
  44. Cerebral edema (CE) at admission is a surrogate marker of ‘early brain injury’ (EBI) after subarachnoid hemorrhage (SAH). Only recently has the focus on the changes in CE after SAH such as delayed resolution o...

    Authors: Sung-Ho Ahn, Angela Burkett, Atzhiry Paz, Jude P. Savarraj, Sarah Hinds, Georgene Hergenroeder, Aaron M. Gusdon, Xuefeng Ren, Jeong-Ho Hong and Huimahn A. Choi
    Citation: Journal of Neuroinflammation 2022 19:199

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