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  1. Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer’s disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer’s disease. TREM2 i...

    Authors: Oliver Cousins, Julia J. Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O’Neill, David Collier…
    Citation: Journal of Neuroinflammation 2023 20:272
  2. Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathophysiological mechanisms of brain injury remain unclear, which hinders the development of drugs for SAH. We aimed to inve...

    Authors: Huaijun Chen, Chaoran Xu, Hanhai Zeng, Zhihua Zhang, Ning Wang, Yinghan Guo, Yonghe Zheng, Siqi Xia, Hang Zhou, Xiaobo Yu, Xiongjie Fu, Tianchi Tang, Xinyan Wu, Zihang Chen, Yucong Peng, Jing Cai…
    Citation: Journal of Neuroinflammation 2023 20:270
  3. Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regi...

    Authors: Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip, Jia Min Tan, Aloysius Y. T. Low, Albert I. Chen and Toh Hean Ch’ng
    Citation: Journal of Neuroinflammation 2023 20:269
  4. Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. However, as the effects of C3G on the amyloidogenic pathway, autophagy, tau phosphorylation,...

    Authors: Hana Baek, Sanjay, Miey Park and Hae-Jeung Lee
    Citation: Journal of Neuroinflammation 2023 20:268
  5. Brain pericytes participate in the regulation of cerebral blood flow and the maintenance of blood–brain barrier integrity. Because of their perivascular localization, their receptor repertoire, and their poten...

    Authors: Nina C. Teske, Susanne Dyckhoff-Shen, Paul Beckenbauer, Jan Philipp Bewersdorf, Joo-Yeon Engelen-Lee, Sven Hammerschmidt, Roland E. Kälin, Hans-Walter Pfister, Matthijs C. Brouwer, Matthias Klein, Rainer Glass, Diederik van de Beek and Uwe Koedel
    Citation: Journal of Neuroinflammation 2023 20:267
  6. Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cel...

    Authors: Muhammad Taifur Rahman, Brian J. Mostaert, Bryce Hunger, Utsow Saha, Alexander D. Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Ali Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon R. Kirk, Keiko Hirose and Marlan R. Hansen
    Citation: Journal of Neuroinflammation 2023 20:266
  7. Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the interaction between oxidatively stressed red blood cells (RBC) and cerebral en...

    Authors: Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher and Xiangmin Xu
    Citation: Journal of Neuroinflammation 2023 20:265
  8. Lipid metabolism has a crucial role in neural repair in neurodegenerative diseases. We recently revealed that lipogenesis-mediated interleukin-33 (IL-33) upregulation lead to blood–brain barrier (BBB) repair a...

    Authors: Haidong Wei, Luming Zhen, Shiquan Wang, Liufei Yang, Shuyue Zhang, Yuanyuan Zhang, Pengyu Jia, Tianyue Wang, Kui Wang, Yan Zhang, Lei Ma, Jianrui Lv and Pengbo Zhang
    Citation: Journal of Neuroinflammation 2023 20:264
  9. The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was used in combination with a Cav1.2 conditional knock-out mouse (Cav1.2KO) to study the role of astrocytic voltage-gated Ca++ chan...

    Authors: G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang and P. M. Paez
    Citation: Journal of Neuroinflammation 2023 20:263
  10. Ongoing neuroaxonal damage is a major contributor to disease progression and long-term disability in multiple sclerosis. However, spatio-temporal distribution and pathophysiological mechanisms of neuroaxonal d...

    Authors: Tobias Brummer, Miriam Schillner, Falk Steffen, Flores Kneilmann, Beatrice Wasser, Timo Uphaus, Frauke Zipp and Stefan Bittner
    Citation: Journal of Neuroinflammation 2023 20:262
  11. Subarachnoid hemorrhage (SAH) causes significant long-term neurocognitive dysfunction, which is associated with hippocampal neuroinflammation. Growing evidences have shown that astrocytes played a significant ...

    Authors: Ping Chen, Xue-Yan Liu, Mou-Hui Lin, Yu-Xi Li, De-Zhi Kang, Zu-Cheng Ye and Qing-Song Lin
    Citation: Journal of Neuroinflammation 2023 20:261
  12. Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secrete...

    Authors: Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu and Xiang Cao
    Citation: Journal of Neuroinflammation 2023 20:260
  13. Spinal cord injury (SCI) can prompt an immediate disruption to the blood–spinal cord barrier (BSCB). Restoring the integrity of this barrier is vital for the recovery of neurological function post-SCI. The UTX...

    Authors: Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang and Jianzhong Hu
    Citation: Journal of Neuroinflammation 2023 20:259
  14. Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. ...

    Authors: Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota and Masamichi Shinoda
    Citation: Journal of Neuroinflammation 2023 20:258
  15. This study investigated chronic and repeated sleep deprivation (RSD)-induced neuronal changes in hexosamine biosynthetic pathway/O-linked N-acetylglucosamine (HBP/O-GlcNAc) cycling of glucose metabolism and furth...

    Authors: Jiwon Park, Dong Yeol Kim, Geum-Sook Hwang and Inn-Oc Han
    Citation: Journal of Neuroinflammation 2023 20:257
  16. Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production o...

    Authors: Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang and Michelle H. Theus
    Citation: Journal of Neuroinflammation 2023 20:256
  17. Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric glio...

    Authors: Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C. Kalff and Sven Wehner
    Citation: Journal of Neuroinflammation 2023 20:255
  18. Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion
    Citation: Journal of Neuroinflammation 2023 20:254

    The original article was published in Journal of Neuroinflammation 2022 19:38

  19. Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have b...

    Authors: Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick and Michele D. Binder
    Citation: Journal of Neuroinflammation 2023 20:253
  20. Inflammation during pregnancy is associated with an increased risk for neurodevelopmental disorders (NDD). Increased gestational inflammation can be a result of an immune condition/disease, exposure to infecti...

    Authors: Juan M. Tamayo, Hadley C. Osman, Jared J. Schwartzer, Kent E. Pinkerton and Paul Ashwood
    Citation: Journal of Neuroinflammation 2023 20:252
  21. Disruption of the extracellular matrix at the blood–brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) ...

    Authors: Tessa Peck, Connor Davis, Georgia Lenihan-Geels, Maddie Griffiths, Sam Spijkers-Shaw, Olga V. Zubkova and Anne Camille La Flamme
    Citation: Journal of Neuroinflammation 2023 20:251
  22. Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic brain injuries (mTBI). There is also concern that repeated-mTB...

    Authors: Katie J. Neale, Hannah M. O. Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson and Brian R. Christie
    Citation: Journal of Neuroinflammation 2023 20:250
  23. Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in a...

    Authors: Qian Li, Lei Huang, Yan Ding, Prativa Sherchan, Wenjie Peng and John H. Zhang
    Citation: Journal of Neuroinflammation 2023 20:249
  24. Neuroinflammation contributes to secondary injury cascades following traumatic brain injury (TBI), with alternating waves of inflammation and resolution. Interleukin-1 (IL-1), a critical neuroinflammatory medi...

    Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan and Adam D. Bachstetter
    Citation: Journal of Neuroinflammation 2023 20:248

    The Correction to this article has been published in Journal of Neuroinflammation 2023 20:287

  25. The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human t...

    Authors: Shuo Kong, Tao-xiang Chen, Xiang-lei Jia, Xue-lei Cheng, Meng-liu Zeng, Jing-yi Liang, Xiao-hua He, Jun Yin, Song Han, Wan-hong Liu, Yuan-teng Fan, Ting Zhou, Yu-min Liu and Bi-wen Peng
    Citation: Journal of Neuroinflammation 2023 20:247
  26. Peripheral facial palsy (PFP) is a common neurologic symptom which can be triggered by pathogens, autoimmunity, trauma, tumors, cholesteatoma or further local conditions disturbing the peripheral section of th...

    Authors: Leyla Mohammad, Mathias Fousse, Gentiana Wenzel, Marina Flotats Bastardas, Klaus Faßbender, Ulrich Dillmann, Bernhard Schick, Michael Zemlin, Barbara C. Gärtner, Urban Sester, David Schub, Tina Schmidt and Martina Sester
    Citation: Journal of Neuroinflammation 2023 20:246
  27. Homozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia and recurrent strokes. Variable mutations in CD59 leading to loss of ...

    Authors: Netanel Karbian, Yael Eshed-Eisenbach, Marian Zeibak, Adi Tabib, Natasha Sukhanov, Anya Vainshtein, B. Paul Morgan, Yakov Fellig, Elior Peles and Dror Mevorach
    Citation: Journal of Neuroinflammation 2023 20:245
  28. Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) dise...

    Authors: Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi and Yanqin Gao
    Citation: Journal of Neuroinflammation 2023 20:244
  29. Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS). Resulting myelin debris hinders repair if not effectively sc...

    Authors: Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal and Shlomo Rotshenker
    Citation: Journal of Neuroinflammation 2023 20:243
  30. Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and r...

    Authors: Akhabue K. Okojie, Joseph O. Uweru, Morgan A. Coburn, Sihan Li, Vivian D. Cao-Dao and Ukpong B. Eyo
    Citation: Journal of Neuroinflammation 2023 20:242
  31. Perinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth. Despite a growing preclinical evidence base, anti-inflammatory interventio...

    Authors: Sharmony B. Kelly, Nhi T. Tran, Graeme R. Polglase, Rodney W. Hunt, Marcel F. Nold, Claudia A. Nold-Petry, David M. Olson, Sylvain Chemtob, Gregory A. Lodygensky, Sarah A. Robertson, Alistair J. Gunn and Robert Galinsky
    Citation: Journal of Neuroinflammation 2023 20:241
  32. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been reported to accelerate amyloid plaque deposition and cognitive impair...

    Authors: Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang and Li Zhu
    Citation: Journal of Neuroinflammation 2023 20:240
  33. Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including ...

    Authors: Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man and Riccardo Natoli
    Citation: Journal of Neuroinflammation 2023 20:239
  34. Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1−/− mice display alterations in non-classical monocytes and microgli...

    Authors: Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine
    Citation: Journal of Neuroinflammation 2023 20:238
  35. Glucose transporter 1 (GLUT1) is essential for glucose transport into the brain and is predominantly expressed in the cerebral microvasculature. Downregulation of GLUT1 precedes the development of cognitive im...

    Authors: Ying Chen, Jin Joo, John Man-Tak Chu, Raymond Chuen-Chung Chang and Gordon Tin-Chun Wong
    Citation: Journal of Neuroinflammation 2023 20:237
  36. The noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of neurostimulation therapies for inflammatory diseases. However, there is no real-tim...

    Authors: Ibrahim T. Mughrabi, Michael Gerber, Naveen Jayaprakash, Santhoshi P. Palandira, Yousef Al-Abed, Timir Datta-Chaudhuri, Corey Smith, Valentin A. Pavlov and Stavros Zanos
    Citation: Journal of Neuroinflammation 2023 20:236
  37. Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer’s disease (AD). The bas...

    Authors: Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila and Erika Gyengesi
    Citation: Journal of Neuroinflammation 2023 20:235
  38. Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and si...

    Authors: Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta and Jessica L. Williams
    Citation: Journal of Neuroinflammation 2023 20:234
  39. The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is a...

    Authors: Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez and Maria Dolores Ganfornina
    Citation: Journal of Neuroinflammation 2023 20:233
  40. Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury. Chronically after stroke, repair processes, including an...

    Authors: Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali, Chunfeng Tan, Julia K. Kofler, Linda Shapiro, Sean P. Marrelli and Anjali Chauhan
    Citation: Journal of Neuroinflammation 2023 20:232
  41. Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central ner...

    Authors: Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw and Hazel Hall-Roberts
    Citation: Journal of Neuroinflammation 2023 20:231
  42. Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injur...

    Authors: Maria P. Blasco Conesa, Frank W. Blixt, Pedram Peesh, Romeesa Khan, Janelle Korf, Juneyoung Lee, Gayathri Jagadeesan, Alexander Andersohn, Tushar K. Das, Chunfeng Tan, Claudia Di Gesu, Gabriela Delevati Colpo, Jose Félix Moruno-Manchón, Louise D. McCullough, Robert Bryan and Bhanu P. Ganesh
    Citation: Journal of Neuroinflammation 2023 20:230
  43. Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease affecting the white matter of the central nervous system. However, over the past two decades, increasing evidence has hig...

    Authors: Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D. Smith, Peter A. Calabresi and Pavan Bhargava
    Citation: Journal of Neuroinflammation 2023 20:229
  44. Periodontitis-related oral microbial dysbiosis is thought to contribute to Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics can modulate periodontitis/oral dysbiosis, t...

    Authors: Chuanjiang Zhao, Ryutaro Kuraji, Changchang Ye, Li Gao, Allan Radaic, Pachiyappan Kamarajan, Yoshimasa Taketani and Yvonne L. Kapila
    Citation: Journal of Neuroinflammation 2023 20:228
  45. Some patients show persistent cognitive decline for weeks, months or even years after surgery, which seriously affects their long-term prognosis and quality of life. However, most previous basic studies have f...

    Authors: Xiaowei Li, Hong Wang, Qidi Zhang, Xiaobin Sun, Mengyuan Zhang and Gongming Wang
    Citation: Journal of Neuroinflammation 2023 20:227
  46. Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakd...

    Authors: Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque and Elena González-Rey
    Citation: Journal of Neuroinflammation 2023 20:226
  47. Neuromyelitis optica spectrum disorder (NMOSD) stands out among CNS inflammatory demyelinating diseases (CIDDs) due to its unique disease characteristics, including severe clinical attacks with extensive lesio...

    Authors: Hyo Jae Kim, Jong-Eun Park, Wangyong Shin, Dayoung Seo, Seungmi Kim, Hyunji Kim, Jinsung Noh, Yonghee Lee, Hyunjin Kim, Young-Min Lim, Hyori Kim and Eun-Jae Lee
    Citation: Journal of Neuroinflammation 2023 20:225
  48. The inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to profile a broad range of inflammation-relat...

    Authors: Annelie Angerfors, Cecilia Brännmark, Cecilia Lagging, Kara Tai, Robert Månsby Svedberg, Björn Andersson, Christina Jern and Tara M. Stanne
    Citation: Journal of Neuroinflammation 2023 20:224
  49. Microglia are so versatile that they not only provide immune surveillance for central nervous system, but participate in neural circuitry development, brain blood vessels formation, blood–brain barrier archite...

    Authors: Hongrui Zhu, Ao Guan, Jiayuan Liu, Li Peng, Zhi Zhang and Sheng Wang
    Citation: Journal of Neuroinflammation 2023 20:223

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