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  1. Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet...

    Authors: Antonio Heras-Garvin, Violetta Refolo, Markus Reindl, Gregor K. Wenning and Nadia Stefanova

    Citation: Journal of Neuroinflammation 2020 17:35

    Content type: Research

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  2. In cerebral ischemia, microglia have a dichotomous role in keeping the balance between pro- and anti-inflammatory mediators to avoid deleterious chronic inflammation and to leverage repair processes.

    Authors: Monika Rabenstein, Sabine Ulrike Vay, Stefan Blaschke, Helene Luise Walter, Anne Ladwig, Gereon Rudolf Fink, Maria Adele Rueger and Michael Schroeter

    Citation: Journal of Neuroinflammation 2020 17:33

    Content type: Research

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  3. Autoantibodies against ribosomal P proteins (anti-P antibodies) are strongly associated with the neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE). The present study was designed to asses...

    Authors: Xuejiao Wang, Yingzhuo Li, Zijie Li, Jinhong Li, Jingyi Xu, Pingting Yang and Ling Qin

    Citation: Journal of Neuroinflammation 2020 17:31

    Content type: Research

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  4. Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory sys...

    Authors: Yongwoo Jang, Minseok Kim and Sun Wook Hwang

    Citation: Journal of Neuroinflammation 2020 17:30

    Content type: Review

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  5. Metabolic syndrome, the development of which is associated with high-caloric Western diet (HCD) intake, represent a risk factor for mild cognitive impairment (MCI) and dementia including Alzheimer’s disease (A...

    Authors: Nadezda Ivanova, Qingfan Liu, Cansu Agca, Yuksel Agca, Earl G. Noble, Shawn Narain Whitehead and David Floyd Cechetto

    Citation: Journal of Neuroinflammation 2020 17:29

    Content type: Research

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  6. Accumulating evidence has documented that microRNA-7 (miR-7) plays an important role in the pathology of various diseases. However, the potential role of miR-7 in brain tissue inflammation (BTI) remains unclear.

    Authors: Dongxu Yue, Juanjuan Zhao, Huizi Chen, Mengmeng Guo, Chao Chen, Ya Zhou and Lin Xu

    Citation: Journal of Neuroinflammation 2020 17:28

    Content type: Research

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  7. Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by Toll-like receptor (TLR) activation, ethanol, stress, and ...

    Authors: Leon G. Coleman Jr, Jian Zou and Fulton T. Crews

    Citation: Journal of Neuroinflammation 2020 17:27

    Content type: Research

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  8. Recent findings describe microglia as modulators of neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are thought to adopt a neurotrophic phenotype after ischemic stroke. Early post...

    Authors: Urs Fisch, Catherine Brégère, Florian Geier, Laurie Chicha and Raphael Guzman

    Citation: Journal of Neuroinflammation 2020 17:26

    Content type: Research

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  9. There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system....

    Authors: Sibo Zhu, Yanfeng Jiang, Kelin Xu, Mei Cui, Weimin Ye, Genming Zhao, Li Jin and Xingdong Chen

    Citation: Journal of Neuroinflammation 2020 17:25

    Content type: Review

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  10. Individuals with impaired immunity are more susceptible to infections than immunocompetent subjects. No vaccines are currently available to induce protection against E. coli meningoencephalitis. This study evalua...

    Authors: Sandra Ribes, Christa Arcilla, Martina Ott, Sandra Schütze, Uwe-Karsten Hanisch, Stefan Nessler and Roland Nau

    Citation: Journal of Neuroinflammation 2020 17:24

    Content type: Research

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  11. Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Bra...

    Authors: Li-Li Qiu, Wei Pan, Dan Luo, Guang-Fen Zhang, Zhi-Qiang Zhou, Xiao-Yun Sun, Jian-Jun Yang and Mu-Huo Ji

    Citation: Journal of Neuroinflammation 2020 17:23

    Content type: Research

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  12. The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulate...

    Authors: Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins and Eva Carro

    Citation: Journal of Neuroinflammation 2020 17:22

    Content type: Research

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  13. There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury.

    Authors: Jennifer Rusiecki, Lynn I. Levin, Li Wang, Celia Byrne, Jayasree Krishnamurthy, Ligong Chen, Zygmunt Galdzicki and Louis M. French

    Citation: Journal of Neuroinflammation 2020 17:20

    Content type: Research

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  14. Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation of the sp...

    Authors: Honglu Ding, Jialiang Chen, Minzhi Su, Zhijun Lin, Hailun Zhan, Fei Yang, Wenbiao Li, Juncong Xie, Yong Huang, Xianguo Liu, Bolong Liu and Xiangfu Zhou

    Citation: Journal of Neuroinflammation 2020 17:19

    Content type: Research

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  15. Microglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be pr...

    Authors: Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue and Jingyu Yang

    Citation: Journal of Neuroinflammation 2020 17:18

    Content type: Research

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  16. Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation in Alzheimer’s disease and traumatic brain injury. The present study was designed to investig...

    Authors: Xin-Chun Ye, Qi Hao, Wei-Jing Ma, Qiu-Chen Zhao, Wei-Wei Wang, Han-Han Yin, Tao Zhang, Miao Wang, Kun Zan, Xin-Xin Yang, Zuo-Hui Zhang, Hong-Juan Shi, Jie Zu, Hafiz Khuram Raza, Xue-Ling Zhang, De-Qin Geng…

    Citation: Journal of Neuroinflammation 2020 17:17

    Content type: Research

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  17. The potential roles and mechanisms of pericytes in maintaining blood–brain barrier (BBB) integrity, which would be helpful for the development of therapeutic strategies for subarachnoid hemorrhage (SAH), remai...

    Authors: Pengyu Pan, Hengli Zhao, Xuan Zhang, Qiang Li, Jie Qu, Shilun Zuo, Fan Yang, Guobiao Liang, John H. Zhang, Xin Liu, Haiyang He, Hua Feng and Yujie Chen

    Citation: Journal of Neuroinflammation 2020 17:16

    Content type: Research

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  18. Microglial mediated neuroinflammation in the rostral ventrolateral medulla (RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that autophagy influenced inflammation via im...

    Authors: Shutian Zhang, Li Hu, Jialun Jiang, Hongji Li, Qin Wu, Kokwin Ooi, Jijiang Wang, Yi Feng, Danian Zhu and Chunmei Xia

    Citation: Journal of Neuroinflammation 2020 17:15

    Content type: Research

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  19. Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients. Uncontrolled neuroinflammation and ischemic...

    Authors: Chao Ren, Ren-qi Yao, Hui Zhang, Yong-wen Feng and Yong-ming Yao

    Citation: Journal of Neuroinflammation 2020 17:14

    Content type: Review

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  20. Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-infla...

    Authors: Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi and Tiantai Zhang

    Citation: Journal of Neuroinflammation 2020 17:13

    Content type: Research

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  21. Dickkopf-3 (Dkk-3) is implicated in the progression of atherosclerosis. This study aimed to investigate the association between serum Dkk-3 and the prognosis of ischemic stroke.

    Authors: Zhengbao Zhu, Daoxia Guo, Chongke Zhong, Aili Wang, Tan Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang and Jiang He

    Citation: Journal of Neuroinflammation 2020 17:12

    Content type: Research

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  22. Emerging evidence indicates that inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Several proteins including α-synuclein trigger the activation of NLRP3 i...

    Authors: Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma and Xiao-Min Wang

    Citation: Journal of Neuroinflammation 2020 17:11

    Content type: Research

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  23. Alzheimer’s disease is associated with the accumulation of intracellular Tau tangles within neurons and extracellular amyloid-β plaques in the brain parenchyma, which altogether results in synaptic loss and ne...

    Authors: Rashmi Das, Abhishek Ankur Balmik and Subashchandrabose Chinnathambi

    Citation: Journal of Neuroinflammation 2020 17:10

    Content type: Research

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  24. The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunom...

    Authors: Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese and Andrew Chan

    Citation: Journal of Neuroinflammation 2020 17:9

    Content type: Short report

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  25. Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critic...

    Authors: Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn and Amy F. T. Arnsten

    Citation: Journal of Neuroinflammation 2020 17:8

    Content type: Research

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  26. Inflammation is associated with poor outcome after stroke. A relationship between ex vivo cytokine synthesis and stroke outcome remains unclear. We explored an association between ex vivo cytokine release, cir...

    Authors: Elzbieta Klimiec-Moskal, Marcin Piechota, Joanna Pera, Kazimierz Weglarczyk, Agnieszka Slowik, Maciej Siedlar and Tomasz Dziedzic

    Citation: Journal of Neuroinflammation 2020 17:7

    Content type: Research

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  27. The circumventricular organs (CVOs) are blood-brain-barrier missing structures whose activation through lipopolysaccharide (LPS) is a starting point for TLR-driven (Toll-like receptors) neuroinflammation. The ...

    Authors: Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Montaña, Javier R. Caso, José L. M. Madrigal, Borja García-Bueno and Juan C. Leza

    Citation: Journal of Neuroinflammation 2020 17:6

    Content type: Research

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  28. Bacterial meningitis is a devastating central nervous system (CNS) infection with acute and long-term neurological consequences, including cognitive impairment. The aim of this study was to understand the asso...

    Authors: Vijayasree V. Giridharan, Allan Collodel, Jaqueline S. Generoso, Giselli Scaini, Rico Wassather, Sudhakar Selvaraj, Rodrigo Hasbun, Felipe Dal-Pizzol, Fabricia Petronilho and Tatiana Barichello

    Citation: Journal of Neuroinflammation 2020 17:5

    Content type: Research

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  29. Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage ...

    Authors: Yan Liu, John Man Tak Chu, Tim Yan, Yan Zhang, Ying Chen, Raymond Chuen Chung Chang and Gordon Tin Chun Wong

    Citation: Journal of Neuroinflammation 2020 17:4

    Content type: Research

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  30. Diabetes mellitus (DM) and chronic cerebral hypoperfusion(CCH)are both risk factors for cognitive impairment. However, whether DM and CCH can synergistically promote cognitive impairment and the related pathol...

    Authors: Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang and Jianliang Fu

    Citation: Journal of Neuroinflammation 2020 17:2

    Content type: Research

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  31. Age-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived I...

    Authors: Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Valérie Forster, Nour Barmo, Sébastien Augustin, Serge Picaud, José-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Florian Sennlaub…

    Citation: Journal of Neuroinflammation 2020 17:1

    Content type: Research

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  32. Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer’s disease (AD); however, VCID is commonly found as a co-morbidity with sporadic...

    Authors: Erica M. Weekman, Tiffany L. Sudduth, Brittani R. Price, Abigail E. Woolums, Danielle Hawthorne, Charles E. Seaks and Donna M. Wilcock

    Citation: Journal of Neuroinflammation 2019 16:284

    Content type: Research

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  33. The prognosis of spinal cord injury (SCI) is closely related to secondary injury, which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates after SCI and that inhibition of α-synuc...

    Authors: Hong Zeng, Nan Liu, Yan-yan Yang, Hua-yi Xing, Xiao-xie Liu, Fang Li, Gao-yan La, Meng-jie Huang and Mou-wang Zhou

    Citation: Journal of Neuroinflammation 2019 16:283

    Content type: Research

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  34. Recent studies have demonstrated that natural killer (NK) cells can modulate other immune components and are involved in the development or progression of several autoimmune diseases. However, the roles and me...

    Authors: Chun-Lin Yang, Peng Zhang, Ru-Tao Liu, Na Zhang, Min Zhang, Heng Li, Tong Du, Xiao-Li Li, Ying-Chun Dou and Rui-Sheng Duan

    Citation: Journal of Neuroinflammation 2019 16:282

    Content type: Research

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  35. Microglia, the mononuclear immune cells of the central nervous system (CNS), are essential for the maintenance of CNS homeostasis. BAP31, a resident and ubiquitously expressed protein of the endoplasmic reticu...

    Authors: Xia Liu, Kun Jiao, Cong-cong Jia, Guo-xun Li, Qing Yuan, Ji-kai Xu, Yue Hou and Bing Wang

    Citation: Journal of Neuroinflammation 2019 16:281

    Content type: Research

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  36. The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal menin...

    Authors: E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer and Diederik van de Beek

    Citation: Journal of Neuroinflammation 2019 16:279

    Content type: Research

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  37. Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How...

    Authors: Tian Niu, Lu Cheng, Hanying Wang, Shaopin Zhu, Xiaolu Yang, Kun Liu, Huiyi Jin and Xun Xu

    Citation: Journal of Neuroinflammation 2019 16:278

    Content type: Research

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  38. Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physica...

    Authors: Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal and Shlomo Rotshenker

    Citation: Journal of Neuroinflammation 2019 16:277

    Content type: Research

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  39. Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depend...

    Authors: Antony Cougnoux, Rebecca A. Drummond, Mason Fellmeth, Fatemeh Navid, Amanda L. Collar, James Iben, Ashok B. Kulkarni, James Pickel, Raphael Schiffmann, Christopher A. Wassif, Niamh X. Cawley, Michail S. Lionakis and Forbes D. Porter

    Citation: Journal of Neuroinflammation 2019 16:276

    Content type: Research

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  40. Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated wi...

    Authors: Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger and W. Sue T. Griffin

    Citation: Journal of Neuroinflammation 2019 16:275

    Content type: Research

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  41. Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as a “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions. Several mechan...

    Authors: Stefania Petrosino, Aniello Schiano Moriello, Roberta Verde, Marco Allarà, Roberta Imperatore, Alessia Ligresti, Ali Mokhtar Mahmoud, Alessio Filippo Peritore, Fabio Arturo Iannotti and Vincenzo Di Marzo

    Citation: Journal of Neuroinflammation 2019 16:274

    Content type: Research

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  42. Recent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes...

    Authors: Jia Lu, Fangfang Dou and Zhihua Yu

    Citation: Journal of Neuroinflammation 2019 16:273

    Content type: Research

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  43. Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and...

    Authors: Tjalf Ziemssen, Katja Akgün and Wolfgang Brück

    Citation: Journal of Neuroinflammation 2019 16:272

    Content type: Review

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  44. Neuropathic pain is one of the most debilitating of all chronic pain syndromes. Intrathecal (i.t.) bone marrow stromal cell (BMSC) injections have a favorable safety profile; however, results have been inconsi...

    Authors: Yongbo Teng, Yang Zhang, Shouwei Yue, Huanwen Chen, Yujuan Qu, Hui Wei and Xiaofeng Jia

    Citation: Journal of Neuroinflammation 2019 16:271

    Content type: Research

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  45. Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson’s disease (PD) and the toxic fibrillary α-syn binds lymphocyte-activation...

    Authors: Wenyuan Guo, Miaomiao Zhou, Jiewen Qiu, Yuwan Lin, Xiang Chen, Shuxuan Huang, Mingshu Mo, Hanqun Liu, Guoyou Peng, Xiaoqin Zhu and Pingyi Xu

    Citation: Journal of Neuroinflammation 2019 16:270

    Content type: Research

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  46. Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central neuroinflammatory responses that occur during...

    Authors: Darine Fakih, Zhanlin Zhao, Pierre Nicolle, Elodie Reboussin, Fanny Joubert, Jade Luzu, Antoine Labbé, William Rostène, Christophe Baudouin, Stéphane Mélik Parsadaniantz and Annabelle Réaux-Le Goazigo

    Citation: Journal of Neuroinflammation 2019 16:268

    Content type: Research

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