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  1. Neuropathic pain (NP) is characterized by abnormal activation of pain conducting pathways and manifests as mechanical allodynia and thermal hypersensitivity. Peripheral nerve stimulation is used for treatment ...

    Authors: Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu and Jung-Shun Lee
    Citation: Journal of Neuroinflammation 2022 19:153
  2. Postoperative neurocognitive dysfunction remains a significant problem in vulnerable groups such as the elderly. While experimental data regarding its possible pathogenic mechanisms accumulate, therapeutic opt...

    Authors: Yan Liu, John Man Tak Chu, You Ran, Yan Zhang, Raymond Chuen Chung Chang and Gordon Tin Chun Wong
    Citation: Journal of Neuroinflammation 2022 19:150
  3. Neonatal stroke is a devastating insult that can lead to life-long impairments. In response to hypoxic–ischaemic injury, there is loss of neurons and glia as well as a neuroinflammatory response mediated by re...

    Authors: Clara Bourget, Kelsey V. Adams and Cindi M. Morshead
    Citation: Journal of Neuroinflammation 2022 19:146
  4. Exposure to sunlight may decrease the risk of developing Alzheimer’s disease (AD), and visible and near infrared light have been proposed as a possible therapeutic strategy for AD. Here, we investigated the ef...

    Authors: Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Cao, Shuling Peng, Zhiyi Zuo and Zhi Wang
    Citation: Journal of Neuroinflammation 2022 19:145
  5. The adaption of brain region is fundamental to the development and maintenance of nervous system disorders. The prelimbic cortex (PrL) participates in the affective components of the pain sensation. However, w...

    Authors: Yu-Ting Zhao, Jie Deng, He-Ming Liu, Jia-You Wei, Hai-Ting Fan, Meng Liu, Ting Xu, Ting-Feng Chen, Jing-Yi He, Wei-Ming Sun, Tao-Yu Jia, Xue-Qin Zhang and Wen-Jun Xin
    Citation: Journal of Neuroinflammation 2022 19:144
  6. Trimethyltin (TMT) is a potent neurotoxicant that leads to hippocampal neurodegeneration. Regulatory T cells (Tregs) play an important role in maintaining the immune balance in the central nervous system (CNS)...

    Authors: Seon-Young Park, HyeJin Yang, Minsook Ye, Xiao Liu, Insop Shim, Young-Tae Chang and Hyunsu Bae
    Citation: Journal of Neuroinflammation 2022 19:143
  7. It has been demonstrated that reactive astrocytes can be polarized into pro-inflammatory A1 phenotype or anti-inflammatory A2 phenotype under neurotoxic and neurodegenerative conditions. Microglia have been su...

    Authors: Yeonggwang Hwang, Hyoung-Chun Kim and Eun-Joo Shin
    Citation: Journal of Neuroinflammation 2022 19:142
  8. Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a n...

    Authors: Lu Luo, Meixi Liu, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao and Yi Wu
    Citation: Journal of Neuroinflammation 2022 19:141
  9. Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations with human IgLON5 antibodies have suggested an ant...

    Authors: You Ni, Yifan Feng, Dingding Shen, Ming Chen, Xiaona Zhu, Qinming Zhou, Yining Gao, Jun Liu, Qi Zhang, Yuntian Shen, Lisheng Peng, Zike Zeng, Dou Yin, Ji Hu and Sheng Chen
    Citation: Journal of Neuroinflammation 2022 19:140
  10. Therapeutic hypothermia significantly improves outcomes after moderate–severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although hypothermia is consistently associated with reduced ...

    Authors: Kelly Q. Zhou, Laura Bennet, Guido Wassink, Alice McDouall, Maurice A. Curtis, Blake Highet, Taylor J. Stevenson, Alistair J. Gunn and Joanne O. Davidson
    Citation: Journal of Neuroinflammation 2022 19:139
  11. Inflammation and coagulation are linked and pathogenic in neuroinflammatory diseases. Protease-activated receptor 1 (PAR1) can be activated both by thrombin, inducing increased inflammation, and activated prot...

    Authors: Valery Golderman, Marina Ben-Shimon, Nicola Maggio, Amir Dori, Shany Guly Gofrit, Shani Berkowitz, Lamis Qassim, Avital Artan-Furman, Talya Zeimer, Joab Chapman and Efrat Shavit-Stein
    Citation: Journal of Neuroinflammation 2022 19:138
  12. Neuroinflammation-induced injury is intimately associated with poor prognosis in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase–stimulator of interferon gene (cGAS–STING) ax...

    Authors: Rui Ding, Haiyan Li, Yaqi Liu, Weiyang Ou, Xifang Zhang, Huihui Chai, Xiaofei Huang, Weijie Yang and Qiujing Wang
    Citation: Journal of Neuroinflammation 2022 19:137
  13. Spinal cord injury (SCI) induces a multitude of deleterious processes, including neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and demyelination. Recent studies have suggeste...

    Authors: Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis and Adib Zendedel
    Citation: Journal of Neuroinflammation 2022 19:134
  14. Circadian disturbance is a common nonmotor complaint in Parkinson’s disease (PD). The molecular basis underlying circadian rhythm in PD is poorly understood. Neuroinflammation has been identified as a key cont...

    Authors: Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia and Tao Wang
    Citation: Journal of Neuroinflammation 2022 19:133
  15. Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhi...

    Authors: Haixia Wang, Yi He, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang and Jian Yang
    Citation: Journal of Neuroinflammation 2022 19:132
  16. Contribution of individual and combined inflammatory markers in prognosis after stroke was still undefined. We aimed to investigate the association of systemic and local vascular inflammatory markers and recur...

    Authors: Jiejie Li, Jinxi Lin, Yuesong Pan, Mengxing Wang, Xia Meng, Hao Li, Yilong Wang, Xingquan Zhao, Haiqiang Qin, Liping Liu and Yongjun Wang
    Citation: Journal of Neuroinflammation 2022 19:131
  17. Multiple sclerosis (MS) is a neurodegenerative disease, wherein aberrant immune cells target myelin-ensheathed nerves. Conventional magnetic resonance imaging (MRI) can be performed to monitor damage to the ce...

    Authors: Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl and Jeff W. M. Bulte
    Citation: Journal of Neuroinflammation 2022 19:130
  18. Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Microglial activation in the spinal cord plays a critical role in the pathogenesis of neuropathic pain. However...

    Authors: Long-Qing Zhang, Shao-Jie Gao, Jia Sun, Dan-Yang Li, Jia-Yi Wu, Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou and Wei Mei
    Citation: Journal of Neuroinflammation 2022 19:129
  19. Vascular dementia (VAD) is the second most common type of dementia lacking effective treatments. Pentoxifylline (PTX), a nonselective phosphodiesterase inhibitor, displays protective effects in multiple cerebr...

    Authors: Lili Zheng, Junqiu Jia, Yan Chen, Renyuan Liu, Runjing Cao, Manlin Duan, Meijuan Zhang and Yun Xu
    Citation: Journal of Neuroinflammation 2022 19:128
  20. Neuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer’s disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory ...

    Authors: Christopher Clark, Jonas Richiardi, Bénédicte Maréchal, Gene L. Bowman, Loïc Dayon and Julius Popp
    Citation: Journal of Neuroinflammation 2022 19:127
  21. The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associate...

    Authors: Taylor E. Syme, Magdalena Grill, Emina Hayashida, Barney Viengkhou, Iain L. Campbell and Markus J. Hofer
    Citation: Journal of Neuroinflammation 2022 19:126
  22. Ischemic stroke is a leading cause of mortality worldwide, largely due to the inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing intensive research, there have not been any...

    Authors: Aditya Rayasam, Julie A. Kijak, Lee Kissel, Yun Hwa Choi, Taehee Kim, Martin Hsu, Dinesh Joshi, Collin J. Laaker, Peter Cismaru, Anders Lindstedt, Krisztian Kovacs, Raghu Vemuganti, Shing Yan Chiu, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor and Zsuzsanna Fabry
    Citation: Journal of Neuroinflammation 2022 19:125
  23. Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti-inflammatory properties of melatonin have att...

    Authors: Jun Huang, Zhuang Li, Yunwei Hu, Zuoyi Li, Yanyan Xie, Haixiang Huang, Qian Chen, Guanyu Chen, Wenjie Zhu, Yuxi Chen, Wenru Su, Xiaoqing Chen and Dan Liang
    Citation: Journal of Neuroinflammation 2022 19:124
  24. The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its effect on pathological pain and the cellula...

    Authors: Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu and Song Cao
    Citation: Journal of Neuroinflammation 2022 19:123
  25. Inflammation contributes to the poor prognosis of intracerebral hemorrhage (ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in multiple pathogenic processes. In the present...

    Authors: Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang and Xia Li
    Citation: Journal of Neuroinflammation 2022 19:122
  26. The complex pathophysiology of epilepsy hampers the development of effective treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on seizure control worldwide, about 30% of ...

    Authors: Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü and Weihua Yu
    Citation: Journal of Neuroinflammation 2022 19:121
  27. The danger-associated molecular patterns (DAMPs) are critical contributors to the progressive neuropathology and thereafter affect the functional outcomes following spinal cord injury (SCI). Up to now, the reg...

    Authors: Ting Yang, Haiyan Jiang, Xinye Luo, Yuxuan Hou, Aicheng Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Honghua Song, Rixin Cai, Xudong Wang, Yingjie Wang, Chun Yao, Lei Qi and Yongjun Wang
    Citation: Journal of Neuroinflammation 2022 19:120
  28. Anxiety, often seen as comorbidity in multiple sclerosis (MS), is a frequent neuropsychiatric symptom and essentially affects the overall disease burden. Here, we aimed to decipher anxiety-related networks fun...

    Authors: Erik Ellwardt, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Venkata Chaitanya Chirumamilla, Felix Luessi, Stefan Bittner, Frauke Zipp, Sergiu Groppa and Vinzenz Fleischer
    Citation: Journal of Neuroinflammation 2022 19:119
  29. The transient receptor potential vanilloid 1 (TRPV1) participates in thermosensation and inflammatory pain, but its immunomodulatory mechanisms remain enigmatic. N-Oleoyl dopamine (OLDA), an endovanilloid and end...

    Authors: Jérémie Joffre, Erika Wong, Samira Lawton, Elliot Lloyd, Nina Nguyen, Fengyun Xu, Cristina Sempio, Lester Kobzik, Ivana Zlatanova, Mark Schumacher, Jost Klawitter, Hua Su, Katalin Rabl, Kevin Wilhelmsen, Che-Chung Yeh and Judith Hellman
    Citation: Journal of Neuroinflammation 2022 19:118
  30. Agomelatine has been shown to be effective in the treatment of depression, but the molecular mechanisms underlying its antidepressant effects have yet to be elucidated. Identification of these molecular mechan...

    Authors: Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang and Shu Yan Yu
    Citation: Journal of Neuroinflammation 2022 19:117
  31. Inflammations play crucial role in the pathogenesis of Parkinson’s disease (PD), however, their possible value in the diagnosis or tracking of the progress of PD is still limited, because of discordant results...

    Authors: Yuanyuan Li, Yan Yang, Aonan Zhao, Ningdi Luo, Mengyue Niu, Wenyan Kang, Anmu Xie, Hong Lu, Lei Chen and Jun Liu
    Citation: Journal of Neuroinflammation 2022 19:116
  32. The natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to chronic mild stress (CMS) and the underlying molecu...

    Authors: Xue Jiang, Saini Yi, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao and Jinqiang Zhang
    Citation: Journal of Neuroinflammation 2022 19:115
  33. Sepsis is a potentially fatal disease characterized by acute organ failure that affects more than 30 million people worldwide. Inflammation is strongly associated with sepsis, and patients can experience impai...

    Authors: Vijayasree V. Giridharan, Jaqueline S. Generoso, Leonardo Lence, Gabriela Candiotto, Emílio Streck, Fabricia Petronilho, Anilkumar Pillai, Tarek Sharshar, Felipe Dal-Pizzol and Tatiana Barichello
    Citation: Journal of Neuroinflammation 2022 19:114
  34. The α-synuclein released by neurons activates microglia, which then engulfs α-synuclein for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease (PD), although ...

    Authors: Jia Lu, Chenfei Wang, Xin Cheng, Ruizhi Wang, Xuehan Yan, Pengju He, Hongzhuan Chen and Zhihua Yu
    Citation: Journal of Neuroinflammation 2022 19:113
  35. Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- or a...

    Authors: Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao, Yaomei Yang and Yanqin Gao
    Citation: Journal of Neuroinflammation 2022 19:112
  36. Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequenc...

    Authors: Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen and Susanne M. Kooistra
    Citation: Journal of Neuroinflammation 2022 19:111
  37. Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap of dementia subtypes is known as mixed de...

    Authors: Olivia J. Gannon, Lisa S. Robison, Abigail E. Salinero, Charly Abi-Ghanem, Febronia M. Mansour, Richard D. Kelly, Alvira Tyagi, Rebekah R. Brawley, Jordan D. Ogg and Kristen L. Zuloaga
    Citation: Journal of Neuroinflammation 2022 19:110
  38. The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition recep...

    Authors: Austin M. Jeffries, Alexander J. Suptela and Ian Marriott
    Citation: Journal of Neuroinflammation 2022 19:109
  39. The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of A...

    Authors: Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi and Jun Pan
    Citation: Journal of Neuroinflammation 2022 19:108
  40. Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. PD etiopathogenesis is multifactorial and not yet fully known, however, the scientific world advised the establishment of neuroin...

    Authors: Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Michela Campolo, Marika Lanza, Emanuela Esposito and Irene Paterniti
    Citation: Journal of Neuroinflammation 2022 19:107
  41. This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).

    Authors: Lingling Jiang, Xueli Cai, Dongxiao Yao, Jing Jing, Lerong Mei, Yingying Yang, Shan Li, Aoming Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan and Yilong Wang
    Citation: Journal of Neuroinflammation 2022 19:106
  42. The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS...

    Authors: Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter and Steven A. Sloan
    Citation: Journal of Neuroinflammation 2022 19:105
  43. Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the risk of developing cardiovascular disease and neuroinflammation. Even...

    Authors: Nathalie Obadia, Giulia Andrade, Marina Leardini-Tristão, Letícia Albuquerque, Celina Garcia, Flavia Lima, Júlio Daleprane, Hugo C. Castro-Faria-Neto, Eduardo Tibiriçá and Vanessa Estato
    Citation: Journal of Neuroinflammation 2022 19:104
  44. c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentatio...

    Authors: Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn and Patrice H. Lalive
    Citation: Journal of Neuroinflammation 2022 19:103
  45. Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. ...

    Authors: Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix and Stefanie Lemmens
    Citation: Journal of Neuroinflammation 2022 19:102
  46. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes cerebral dysfunction in the short and long term and induces disruption of the blood–brain barri...

    Authors: Nobufumi Sekino, Magdy Selim and Amjad Shehadah
    Citation: Journal of Neuroinflammation 2022 19:101
  47. Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but se...

    Authors: Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins and Brian P. Daniels
    Citation: Journal of Neuroinflammation 2022 19:100
  48. Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts nearly 400 million people worldwide. The accumulation of amyloid beta (Aβ) in the brain has historically been associated with AD...

    Authors: I. Y. Quiroga, A. E. Cruikshank, M. L. Bond, K. S. M. Reed, B. A. Evangelista, J. H. Tseng, J. V. Ragusa, R. B. Meeker, H. Won, S. Cohen, T. J. Cohen and D. H. Phanstiel
    Citation: Journal of Neuroinflammation 2022 19:99

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