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  1. Clinical and animal studies show that alcohol consumption during pregnancy produces lasting behavioral disturbances in offspring, including increased alcohol drinking, which are linked to inflammation in the b...

    Authors: Guo-Qing Chang, Olga Karatayev, Devi Sai Sri Kavya Boorgu and Sarah F. Leibowitz

    Citation: Journal of Neuroinflammation 2020 17:207

    Content type: Research

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  2. Progressive multifocal leukoencephalopathy (PML) caused by JC virus (JCV) is a rare but serious complication of some disease-modifying drugs used to treat multiple sclerosis (MS). Japanese MS patients treated ...

    Authors: Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Yuji Kawano, Ryo Yamasaki, Takuya Matsushita and Jun-ichi Kira

    Citation: Journal of Neuroinflammation 2020 17:206

    Content type: Research

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  3. Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as posttraumatic stress disorder (PTSD) and anxiety disorder. Despite the...

    Authors: Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou, Zengqiang Yuan and Jinbo Cheng

    Citation: Journal of Neuroinflammation 2020 17:205

    Content type: Research

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  4. Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia. It mediates multiple pathophysiological processes in various diseases. Recently, TREM2 has b...

    Authors: Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng and Zhentao Zhang

    Citation: Journal of Neuroinflammation 2020 17:204

    Content type: Review

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  5. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu and Kan Xu

    Citation: Journal of Neuroinflammation 2020 17:203

    Content type: Correction

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    The original article was published in Journal of Neuroinflammation 2020 17:46

  6. Spinal cord injury (SCI) triggers the primary mechanical injury and secondary inflammation-mediated injury. Neuroinflammation-mediated insult causes secondary and extensive neurological damage after SCI. Micro...

    Authors: Wen-Kai Chen, Lin-Juan Feng, Qiao-Dan Liu, Qing-Feng Ke, Pei-Ya Cai, Pei-Ru Zhang, Li-Quan Cai, Nian-Lai Huang and Wen-Ping Lin

    Citation: Journal of Neuroinflammation 2020 17:202

    Content type: Research

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  7. Recent clinical and basic research implicated a strong correlation between NAFLD/NASH phenotypes with ectopic manifestations including neuroinflammation and neurodegeneration, but the mediators and critical pa...

    Authors: Ayan Mondal, Dipro Bose, Punnag Saha, Sutapa Sarkar, Ratanesh Seth, Diana Kimono, Muayad Albadrani, Mitzi Nagarkatti, Prakash Nagarkatti and Saurabh Chatterjee

    Citation: Journal of Neuroinflammation 2020 17:201

    Content type: Research

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  8. Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear. Here, we stu...

    Authors: He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu and Xiao-Xia Jiang

    Citation: Journal of Neuroinflammation 2020 17:200

    Content type: Research

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  9. Research on the brain-gut-microbiota axis has led to accumulating interest in gut microbiota dysbiosis and intestinal barrier dysfunction in Alzheimer’s disease (AD). Our previous studies have demonstrated neu...

    Authors: Ying Wang, Yu An, Weiwei Ma, Huiyan Yu, Yanhui Lu, Xiaona Zhang, Yushan Wang, Wen Liu, Tao Wang and Rong Xiao

    Citation: Journal of Neuroinflammation 2020 17:199

    Content type: Research

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  10. Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on t...

    Authors: Ye Gong, Ya-ling Zhang, Zhen Wang, Huan-huan Song, Yuan-chu Liu, Ao-wei Lv, Li-li Tian, Wen-li Zhu, Ying Fu, Xiao-li Ding, Lang-jun Cui and Ya-ping Yan

    Citation: Journal of Neuroinflammation 2020 17:198

    Content type: Research

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  11. Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages...

    Authors: Syed Faaiz Enam, Sajidur Rahman Kader, Nicholas Bodkin, Johnathan G. Lyon, Mark Calhoun, Cesar Azrak, Pooja Munnilal Tiwari, Daryll Vanover, Haichen Wang, Philip J. Santangelo and Ravi Venkat Bellamkonda

    Citation: Journal of Neuroinflammation 2020 17:197

    Content type: Research

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  12. Neurological manifestations and the co-occurrence of multiple sclerosis (MS) have been reported in patients with autoinflammatory diseases (AID) and variants of the NLRP3-, MEFV-, or TNFRSF1A gene. However, type ...

    Authors: Elisabeth Mulazzani, Danny Wagner, Joachim Havla, Miriam Schlüter, Ingrid Meinl, Lisa-Ann Gerdes and Tania Kümpfel

    Citation: Journal of Neuroinflammation 2020 17:196

    Content type: Research

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  13. A growing body of evidence shows that hypothalamic inflammation is an important factor in the initiation of obesity. In particular, reactive gliosis accompanied by inflammatory responses in the hypothalamus ar...

    Authors: Sungho Jin, Kwang Kon Kim, Byong Seo Park, Dong Hee Kim, Bora Jeong, Dasol Kang, Tae Hwan Lee, Jeong Woo Park, Jae Geun Kim and Byung Ju Lee

    Citation: Journal of Neuroinflammation 2020 17:195

    Content type: Research

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  14. Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients...

    Authors: Natalia Kolosowska, Maria Gotkiewicz, Hiramani Dhungana, Luca Giudice, Rosalba Giugno, Daphne Box, Mikko T. Huuskonen, Paula Korhonen, Flavia Scoyni, Katja M. Kanninen, Seppo Ylä-Herttuala, Tiia A. Turunen, Mikko P. Turunen, Jari Koistinaho and Tarja Malm

    Citation: Journal of Neuroinflammation 2020 17:194

    Content type: Research

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  15. Traumatic brain injury (TBI) occurs in as many as 64–74 million people worldwide each year and often results in one or more post-traumatic syndromes, including depression, cognitive, emotional, and behavioral ...

    Authors: Sanjib Mukherjee, Gabriel M. Arisi, Kaley Mims, Gabriela Hollingsworth, Katherine O’Neil and Lee A. Shapiro

    Citation: Journal of Neuroinflammation 2020 17:193

    Content type: Review

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  16. Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators o...

    Authors: Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul and Wenjie Luo

    Citation: Journal of Neuroinflammation 2020 17:192

    Content type: Research

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  17. The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a...

    Authors: Sichen Li, Yuan Shi, Peixi Liu, Yaying Song, Yingjun Liu, Lingwen Ying, Kai Quan, Guo Yu, Zhiyuan Fan and Wei Zhu

    Citation: Journal of Neuroinflammation 2020 17:191

    Content type: Research

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  18. Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease. Some children with OMS also have neuroblastoma (NB). We and others have previously documented that serum IgG from children with OMS and NB in...

    Authors: Xu Ding, Wei Yang, Qinghua Ren, Jiajian Hu, Shen Yang, Wei Han, Jing Wang, Xu Wang and Huanmin Wang

    Citation: Journal of Neuroinflammation 2020 17:190

    Content type: Research

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  19. To characterize long-term repopulation of peripheral immune cells following alemtuzumab-induced lymphopenia in relapsing-remitting MS (RRMS), with a focus on regulatory cell types, and to explore associations ...

    Authors: Wendy Gilmore, Brett T. Lund, Peili Li, Alex M. Levy, Eve E. Kelland, Omid Akbari, Susan Groshen, Steven Yong Cen, Daniel Pelletier, Leslie P. Weiner, Adil Javed, Jeffrey E. Dunn and Anthony L. Traboulsee

    Citation: Journal of Neuroinflammation 2020 17:189

    Content type: Research

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  20. Aucubin (Au), an iridoid glycoside from natural plants, has antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain injury (TBI) model remain unknown. We explored the poten...

    Authors: Han Wang, Xiao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu, Wei-Dong Xu, Xiang-Sheng Zhang, Yong-Yue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chu-Lei Deng, Zong Zhuang, Chun-Hua Hang and Wei Li

    Citation: Journal of Neuroinflammation 2020 17:188

    Content type: Research

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  21. Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly from the lateral hypothalamus, which exert a wide range of physiological effects by activating two types of receptors (orexin recept...

    Authors: Tao Li, Weilin Xu, Jinsong Ouyang, Xiaoyang Lu, Prativa Sherchan, Cameron Lenahan, Giselle Irio, John H. Zhang, Jianhua Zhao, Yongfa Zhang and Jiping Tang

    Citation: Journal of Neuroinflammation 2020 17:187

    Content type: Research

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  22. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by inflammatory and neurodegenerative processes. Despite demyelination being a hallmark of the disease, how i...

    Authors: Manuela Cerina, Muthuraman Muthuraman, Marco Gallus, Nabin Koirala, Andre Dik, Lydia Wachsmuth, Petra Hundehege, Patrick Schiffler, Jan-Gerd Tenberge, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Venu Narayanan, Julia Krämer, Cornelius Faber, Thomas Budde, Sergiu Groppa…

    Citation: Journal of Neuroinflammation 2020 17:186

    Content type: Research

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  23. Inflammation is a common pathophysiological trait found in both hypertension and cardiac vascular disease. Recent evidence indicates that fractalkine (FKN) and its receptor CX3CR1 have been linked to inflammat...

    Authors: Chiu-Yi Ho, Yu-Te Lin, Hsin-Hung Chen, Wen-Yu Ho, Gwo-Ching Sun, Michael Hsiao, Pei-Jung Lu, Pei-Wen Cheng and Ching-Jiunn Tseng

    Citation: Journal of Neuroinflammation 2020 17:185

    Content type: Research

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  24. In early autoimmune neuroinflammation, interferon (IFN)γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Althou...

    Authors: Brandon C. Smith, Maksim Sinyuk, Julius E. Jenkins III, Morgan W. Psenicka and Jessica L. Williams

    Citation: Journal of Neuroinflammation 2020 17:184

    Content type: Research

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  25. Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. T...

    Authors: Mohammed Shaqura, Li Li, Doaa M. Mohamed, Xiongjuan Li, Sascha Treskatsch, Constanze Buhrmann, Mehdi Shakibaei, Antje Beyer, Shaaban A. Mousa and Michael Schäfer

    Citation: Journal of Neuroinflammation 2020 17:183

    Content type: Research

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  26. Hypoxic-ischemic encephalopathy (HIE) is a life-threatening cerebrovascular disease. Neuroinflammation plays an important role in the pathogenesis of HIE, in which microglia are key cellular mediators in the r...

    Authors: Xiao Hu, Shirong Li, Desislava Met Doycheva, Lei Huang, Cameron Lenahan, Rui Liu, Juan Huang, Shucai Xie, Jiping Tang, Gang Zuo and John H. Zhang

    Citation: Journal of Neuroinflammation 2020 17:182

    Content type: Research

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  27. A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is ...

    Authors: Xiao-Hui Tang, Guang-Fen Zhang, Ning Xu, Gui-Fang Duan, Min Jia, Ru Liu, Zhi-Qiang Zhou and Jian-Jun Yang

    Citation: Journal of Neuroinflammation 2020 17:181

    Content type: Research

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  28. Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseas...

    Authors: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca and Mark D. Mannie

    Citation: Journal of Neuroinflammation 2020 17:180

    Content type: Research

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  29. Though it is well-known that a high-salt diet (HSD) is associated with many chronic diseases, the effects of long-term high-salt intake on physiological functions and homeostasis remain elusive. In this study,...

    Authors: Anni Fan, Oladayo Oladiran, Xiang Qun Shi and Ji Zhang

    Citation: Journal of Neuroinflammation 2020 17:179

    Content type: Research

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  30. Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, and inflammation has been considered crucial components of the pathogenesis of depression. NLRP1 inflammasome-driven inflammatory res...

    Authors: Ao-Qi Song, Bo Gao, Jun-Juan Fan, Ya-Jing Zhu, Jun Zhou, Yu-Ling Wang, Li-Zhong Xu and Wen-Ning Wu

    Citation: Journal of Neuroinflammation 2020 17:178

    Content type: Research

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  31. Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced by several proinflammatory mediators and p...

    Authors: Tsong-Hai Lee, Jiun-Liang Chen, Pei-Shan Liu, Ming-Ming Tsai, Su-Jane Wang and Hsi-Lung Hsieh

    Citation: Journal of Neuroinflammation 2020 17:177

    Content type: Research

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  32. Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration. Activation of the kynurenine pathway (KP) r...

    Authors: Gayathri Sundaram, Chai K. Lim, Bruce J. Brew and Gilles J. Guillemin

    Citation: Journal of Neuroinflammation 2020 17:176

    Content type: Research

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  34. Interleukin-33 is a cytokine endowed with pro- and anti-inflammatory properties that plays a still poorly defined role in the pathogenesis of a number of central nervous system (CNS) conditions including Alzhe...

    Authors: Marina Saresella, Ivana Marventano, Federica Piancone, Francesca La Rosa, Daniela Galimberti, Chiara Fenoglio, Elio Scarpini and Mario Clerici

    Citation: Journal of Neuroinflammation 2020 17:174

    Content type: Research

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  35. Inflammation is a general pathological phenomenon during severe disturbances to the homeostasis. Forsythiaside A (FA) and forsythiaside B (FB), isolated from the dried fruit of Forsythia suspensa (Thunb.) Vahl, a...

    Authors: Lihong Gong, Linyuan Yu, Xiaohong Gong, Cheng Wang, Naihua Hu, Xuyang Dai, Cheng Peng and Yunxia Li

    Citation: Journal of Neuroinflammation 2020 17:173

    Content type: Research

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  36. Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammat...

    Authors: Elisabeth G. Vichaya, Sajida Malik, Luba Sominsky, Bianca G. Ford, Sarah J. Spencer and Robert Dantzer

    Citation: Journal of Neuroinflammation 2020 17:172

    Content type: Research

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  37. Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism underlying spontaneous recovery and identifying...

    Authors: Hao Sun, Xinran He, Xia Tao, Tingting Hou, Mingming Chen, Meijun He and Hong Liao

    Citation: Journal of Neuroinflammation 2020 17:171

    Content type: Research

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  38. The autoimmune disease rheumatoid arthritis (RA) affects approximately 1% of the global population. RA is characterized with chronic joint inflammation and often associated with chronic pain. The imbalance of ...

    Authors: Shih-Ping Dai, Wei-Shan Hsieh, Chien-Hua Chen, Yueh-Hao Lu, Hsu-Shan Huang, Der-Ming Chang, Shir-Ly Huang and Wei-Hsin Sun

    Citation: Journal of Neuroinflammation 2020 17:170

    Content type: Research

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  39. Sepsis-associated encephalopathy (SAE) increases the mortality of septic patients, but its mechanism remains unclear. The present study aimed to investigate the roles of T lymphocytes, proBDNF, and their inter...

    Authors: Ru-Yi Luo, Cong Luo, Feng Zhong, Wei-Yun Shen, Hui Li, Zhao-Lan Hu and Ru-Ping Dai

    Citation: Journal of Neuroinflammation 2020 17:169

    Content type: Research

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  40. Neuroinflammation is an important host defense response to secondary brain injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective e...

    Authors: Shengpan Chen, Jianhua Peng, Prativa Sherchan, Yongjie Ma, Sishi Xiang, Feng Yan, Hao Zhao, Yong Jiang, Ning Wang, John H. Zhang and Hongqi Zhang

    Citation: Journal of Neuroinflammation 2020 17:168

    Content type: Research

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  41. Exposure to inflammation during pregnancy can predispose to brain injury in premature infants. In the present study, we investigated the effects of prolonged exposure to inflammation on the cerebrovasculature ...

    Authors: Clémence Disdier, Fares Awa, Xiaodi Chen, Simerdeep K. Dhillon, Robert Galinsky, Joanne O. Davidson, Christopher A. Lear, Laura Bennet, Alistair J. Gunn and Barbara S. Stonestreet

    Citation: Journal of Neuroinflammation 2020 17:167

    Content type: Research

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  42. Recently, depression has been identified as a prevalent and severe mental disorder. However, the mechanisms underlying the depression risk remain elusive. The neuroinflammation and NLRP3 inflammasome activatio...

    Authors: Hetao Bian, Gaohua Wang, Junjie Huang, Liang Liang, Yage Zheng, Yanyan Wei, Hui Wang, Ling Xiao and Huiling Wang

    Citation: Journal of Neuroinflammation 2020 17:166

    Content type: Research

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  43. Neuroinflammation is closely associated with the poor prognosis in subarachnoid hemorrhage (SAH) patients. This study was aimed to determine the role of stimulator of IFN genes (STING), an essential regulator ...

    Authors: Yucong Peng, Jianfeng Zhuang, Guangyu Ying, Hanhai Zeng, Hang Zhou, Yang Cao, Huaijun Chen, Chaoran Xu, Xiongjie Fu, Hangzhe Xu, Jianru Li, Shenglong Cao, Jingyin Chen, Chi Gu, Feng Yan and Gao Chen

    Citation: Journal of Neuroinflammation 2020 17:165

    Content type: Research

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  44. Farnesoid X receptor (FXR) is a nuclear receptor that plays a critical role in controlling cell apoptosis in diverse diseases. Previous studies have shown that knocking out FXR improved cardiac function by reduci...

    Authors: Hui-Min Shan, Minhua Zang, Qi Zhang, Ru-Bing Shi, Xiao-Jing Shi, Muyassar Mamtilahun, Chang Liu, Long-long Luo, Xiaoying Tian, Zhijun Zhang, Guo-Yuan Yang, Yaohui Tang, Jun Pu and Yongting Wang

    Citation: Journal of Neuroinflammation 2020 17:164

    Content type: Research

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  45. Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to stimulate the activation of astrocytes and microglia ...

    Authors: Hui-Ting Huang, Po-See Chen, Yu-Min Kuo and Shun-Fen Tzeng

    Citation: Journal of Neuroinflammation 2020 17:163

    Content type: Research

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  46. Complex regional pain syndrome type-I (CRPS-I) is a progressive and devastating pain condition. The mechanisms of CRPS-I still remain poorly understood. We aim to explore expression profiles of genes relevant ...

    Authors: Ruixiang Chen, Chengyu Yin, Qimiao Hu, Boyu Liu, Yan Tai, Xiaoli Zheng, Yuanyuan Li, Jianqiao Fang and Boyi Liu

    Citation: Journal of Neuroinflammation 2020 17:162

    Content type: Research

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  47. Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...

    Authors: Ana Zabalza, Andrea Vera, Elisenda Alari-Pahissa, Elvira Munteis, Antía Moreira, Jose Yélamos, Mireia Llop, Miguel López-Botet and Jose E. Martínez-Rodríguez

    Citation: Journal of Neuroinflammation 2020 17:161

    Content type: Short report

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  48. Risk of stroke-related morbidity and mortality increases significantly with age. Aging is associated with chronic, low-grade inflammation, which is thought to contribute to the poorer outcomes after stroke see...

    Authors: Maria Pilar Blasco, Anjali Chauhan, Pedram Honarpisheh, Hilda Ahnstedt, John d’Aigle, Arunkumar Ganesan, Sriram Ayyaswamy, Frank Blixt, Susan Venable, Angela Major, David Durgan, Anthony Haag, Julia Kofler, Robert Bryan, Louise D. McCullough and Bhanu Priya Ganesh

    Citation: Journal of Neuroinflammation 2020 17:160

    Content type: Research

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  49. Cosmic radiation exposures have been found to elicit cognitive impairments involving a wide-range of underlying neuropathology including elevated oxidative stress, neural stem cell loss, and compromised neuron...

    Authors: Barrett D. Allen, Amber R. Syage, Mattia Maroso, Al Anoud D. Baddour, Valerie Luong, Harutyun Minasyan, Erich Giedzinski, Brian L. West, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch and Munjal M. Acharya

    Citation: Journal of Neuroinflammation 2020 17:159

    Content type: Research

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  50. Neuroinflammation plays an important role in pathogenesis of germinal matrix hemorrhage (GMH). Neurotrophin-4 (NT-4) is a member of the neurotrophin family and interacts with the tropomyosin receptor kinase B ...

    Authors: Tianyi Wang, Junyi Zhang, Peng Li, Yan Ding, Jiping Tang, Gang Chen and John H. Zhang

    Citation: Journal of Neuroinflammation 2020 17:158

    Content type: Research

    Published on:

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Journal of Neuroinflammation

ISSN: 1742-2094