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  1. Content type: Research

    Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence suggest that endomorphins, the endogenous mu-opioid agonis...

    Authors: Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen and Quan Fang

    Citation: Journal of Neuroinflammation 2018 15:320

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  2. Content type: Research

    The development of intracranial hemorrhage (ICH) in acute ischemic stroke is associated with a higher neutrophil to lymphocyte ratio (NLR) in peripheral blood. Here, we studied whether the predictive value of ...

    Authors: Slaven Pikija, Laszlo K. Sztriha, Monika Killer-Oberpfalzer, Friedrich Weymayr, Constantin Hecker, Christian Ramesmayer, Larissa Hauer and Johann Sellner

    Citation: Journal of Neuroinflammation 2018 15:319

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  3. Content type: Research

    Varicella zoster virus (VZV) is a ubiquitous alphaherpesvirus that produces varicella and zoster. VZV can infect multiple cell types in the spinal cord and brain, including astrocytes, producing myelopathy and...

    Authors: Andrew N. Bubak, Christina N. Como, Anna M. Blackmon, Dallas Jones and Maria A. Nagel

    Citation: Journal of Neuroinflammation 2018 15:318

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  4. Content type: Research

    The intermediate-conductance Ca2+-activated K+ channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer’s disease (AD).

    Authors: Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou and Hongzhuan Chen

    Citation: Journal of Neuroinflammation 2018 15:316

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  5. Content type: Research

    La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper underst...

    Authors: Brian E. Dawes, Junling Gao, Colm Atkins, Jacob T. Nelson, Kendra Johnson, Ping Wu and Alexander N. Freiberg

    Citation: Journal of Neuroinflammation 2018 15:315

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  6. Content type: Research

    Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes,...

    Authors: Marloes H. J. Hagens, Sandeep V. Golla, Martijn T. Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D. Steenwijk, Patrick Schober, John J. P. Brevé, Robert C. Schuit, Tristan A. Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D. Windhorst, Joep Killestein, Frederik Barkhof, Bart N. M. van Berckel…

    Citation: Journal of Neuroinflammation 2018 15:314

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  7. Content type: Research

    Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the infl...

    Authors: Mohammad Harun-Or-Rashid and Denise M. Inman

    Citation: Journal of Neuroinflammation 2018 15:313

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  8. Content type: Research

    TDP-43 has been identified as a disease-associated protein in several chronic neurodegenerative disorders and increasing evidence suggests its potentially pathogenic role following brain injuries. Normally exp...

    Authors: Sai Sampath Thammisetty, Jordi Pedragosa, Yuan Cheng Weng, Frédéric Calon, Anna Planas and Jasna Kriz

    Citation: Journal of Neuroinflammation 2018 15:312

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  9. Content type: Research

    Activation of inflammation pathways in the brain occurs in Alzheimer’s disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify h...

    Authors: Rachel E. Bennett, Annie Bryant, Miwei Hu, Ashley B. Robbins, Sarah C. Hopp and Bradley T. Hyman

    Citation: Journal of Neuroinflammation 2018 15:311

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  10. Content type: Research

    Enhancing autophagy after traumatic brain injury (TBI) may decrease the expression of neuronal apoptosis-related molecules. Autophagy-mediated neuronal survival is regulated by the sirtuin family of proteins (...

    Authors: Xiangrong Chen, Zhigang Pan, Zhongning Fang, Weibin Lin, Shukai Wu, Fuxing Yang, Yasong Li, Huangde Fu, Hongzhi Gao and Shun Li

    Citation: Journal of Neuroinflammation 2018 15:310

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  11. Content type: Research

    Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase...

    Authors: Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick and Mohammad F. Kiani

    Citation: Journal of Neuroinflammation 2018 15:309

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  12. Content type: Research

    Inflammation plays a critical role in accelerating the progression of neurodegenerative diseases, such as Alzheimer’s disease (AD) and ataxia telangiectasia (A-T). In A-T mouse models, LPS-induced neuroinflamm...

    Authors: Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen and Karl Herrup

    Citation: Journal of Neuroinflammation 2018 15:308

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  13. Content type: Research

    Causal associations between microglia activation and β-amyloid (Aβ) accumulation during the progression of Alzheimer’s disease (AD) remain a matter of controversy. Therefore, we used longitudinal dual tracer i...

    Authors: Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L. Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms and Matthias Brendel

    Citation: Journal of Neuroinflammation 2018 15:307

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  14. Content type: Research

    Neuroinflammation has been established to be part of the neuropathological changes in Parkinson’s disease (PD) and atypical parkinsonism (APD). Activated microglia play a key role in neuroinflammation by relea...

    Authors: C. Starhof, K. Winge, N. H. H. Heegaard, K. Skogstrand, S. Friis and A. Hejl

    Citation: Journal of Neuroinflammation 2018 15:305

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  15. Content type: Research

    Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dement...

    Authors: Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N. G. Nilsson and Leiv Otto Watne

    Citation: Journal of Neuroinflammation 2018 15:304

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  16. Content type: Research

    HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage. Pro-inflammatory factors and neurotoxins from activated a...

    Authors: Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya…

    Citation: Journal of Neuroinflammation 2018 15:303

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  17. Content type: Research

    Key clinical features of chronic relapsing inflammatory optic neuropathy (CRION) include relapsing inflammatory optic neuritis (ON) and steroid dependency, both of which have been reported among patients with ...

    Authors: Haeng-Jin Lee, Boram Kim, Patrick Waters, Mark Woodhall, Sarosh Irani, Sohyun Ahn, Seong-Joon Kim and Sung-Min Kim

    Citation: Journal of Neuroinflammation 2018 15:302

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  18. Content type: Research

    Neonatal brain injury is increasingly understood to be linked to inflammatory processes that involve specialised CNS and peripheral immune interactions. However, the role of peripheral myeloid cells in neonata...

    Authors: Peter L. P. Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, Joakim Ek and Carina Mallard

    Citation: Journal of Neuroinflammation 2018 15:301

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  19. Content type: Research

    Regulatory B cells (Bregs), which protect from autoimmunity, are deficient in multiple sclerosis (MS). Novel regulatory B cell subsets CD19+CD24hiCD38hi cells and CD19+PD-L1hi cells, with disparate regulatory mec...

    Authors: Yeseul Kim, Gayoung Kim, Hyun-June Shin, Jae-Won Hyun, Su-Hyun Kim, Eunjig Lee and Ho Jin Kim

    Citation: Journal of Neuroinflammation 2018 15:300

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  20. Content type: Research

    Although studies have reported an increased risk for mood disorders in Hashimoto’s thyroiditis (HT) patients even in the euthyroid state, the mechanisms involved remain unclear. Neuroinflammation may play a ke...

    Authors: Yao-Jun Cai, Fen Wang, Zhang-Xiang Chen, Li Li, Hua Fan, Zhang-Bi Wu, Jin-Fang Ge, Wen Hu, Qu-Nan Wang and De-Fa Zhu

    Citation: Journal of Neuroinflammation 2018 15:299

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  21. Content type: Research

    The end-organ effects of alcohol span throughout the entire body, from the gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use changes the microbiome composition and incre...

    Authors: Patrick P. Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Yeonhee Cho, Aditya Ambade and Gyongyi Szabo

    Citation: Journal of Neuroinflammation 2018 15:298

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  22. Content type: Research

    Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons durin...

    Authors: Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco and Elisa Greggio

    Citation: Journal of Neuroinflammation 2018 15:297

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  23. Content type: Research

    Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), suggest an involvement of the histone methyltransferase enhancer of zeste 2 polycomb repressive complex ...

    Authors: Sunny Malhotra, Luisa M. Villar, Carme Costa, Luciana Midaglia, Marta Cubedo, Silvia Medina, Nicolás Fissolo, Jordi Río, Joaquín Castilló, José C. Álvarez-Cermeño, Alex Sánchez, Xavier Montalban and Manuel Comabella

    Citation: Journal of Neuroinflammation 2018 15:296

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  24. Content type: Research

    Polyriboinosinic-polyribocytidylic acid (polyI:C) triggers a strong innate immune response that mimics immune activation by viral infections. Induction of interferon-induced transmembrane protein 3 (Ifitm3) in...

    Authors: Shinnosuke Yamada, Norimichi Itoh, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima and Kiyofumi Yamada

    Citation: Journal of Neuroinflammation 2018 15:295

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  25. Content type: Research

    High-fat feeding and hyperglycemia, key risk factors for the development of metabolic syndrome (MetS), are emerging to associate with increased risk of developing dementia and cognitive decline. Despite this, ...

    Authors: Brooke J. Wanrooy, Kathryn Prame Kumar, Shu Wen Wen, Cheng Xue Qin, Rebecca H. Ritchie and Connie H. Y. Wong

    Citation: Journal of Neuroinflammation 2018 15:293

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  26. Content type: Research

    Bortezomib is a frequently used chemotherapeutic drug for the treatment of multiple myeloma and other nonsolid malignancies. Accumulating evidence has demonstrated that bortezomib-induced persistent pain serve...

    Authors: Kun Chen, Jing Fan, Zhao-Fan Luo, Ying Yang, Wen-Jun Xin and Cui-Cui Liu

    Citation: Journal of Neuroinflammation 2018 15:292

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  27. Content type: Research

    Bacterial meningitis remains a big threat to the integrity of the central nervous system (CNS), despite the advancements in antimicrobial reagents. Escherichia coli is a bacterial pathogen that can disrupt the CN...

    Authors: Wen-Tong Liu, Yu-Jin Lv, Rui-Cheng Yang, Ji-Yang Fu, Lu Liu, Huan Wang, Qi Cao, Chen Tan, Huan-Chun Chen and Xiang-Ru Wang

    Citation: Journal of Neuroinflammation 2018 15:291

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  28. Content type: Research

    PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking inflammatory response and conspiring tumor immune evasion. H...

    Authors: Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu and Yiwei Chu

    Citation: Journal of Neuroinflammation 2018 15:290

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  29. Content type: Research

    The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that l...

    Authors: Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr, Elspeth A. Foran, Timothy J. Kopper, John C. Gensel and Keith R. Pennypacker

    Citation: Journal of Neuroinflammation 2018 15:288

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  30. Content type: Research

    Even in the antiretroviral treatment (ART) era, HIV-1-infected patients suffer from milder forms of HIV-1-associated neurocognitive disorders (HAND). While the viral proteins Tat and gp120 have been shown to i...

    Authors: Raj Putatunda, Yonggang Zhang, Fang Li, Xiao-Feng Yang, Mary F Barbe and Wenhui Hu

    Citation: Journal of Neuroinflammation 2018 15:287

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  31. Content type: Research

    Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer’s disease (AD). Thus, modulating the neuroinflammatory response represents a potential therapeutic strategy for treating neu...

    Authors: Ju-Young Lee, Jin Han Nam, Youngpyo Nam, Hye Yeon Nam, Gwangho Yoon, Eunhwa Ko, Sang-Bum Kim, Mahealani R Bautista, Christina C Capule, Takaoki Koyanagi, Geoffray Leriche, Hwan Geun Choi, Jerry Yang, Jeongyeon Kim and Hyang-Sook Hoe

    Citation: Journal of Neuroinflammation 2018 15:286

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  32. Content type: Research

    The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the co...

    Authors: Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser and Pamela E Knapp

    Citation: Journal of Neuroinflammation 2018 15:285

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  33. Content type: Research

    The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S...

    Authors: Bhakta Prasad Gaire, Mi-Ryoung Song and Ji Woong Choi

    Citation: Journal of Neuroinflammation 2018 15:284

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  34. Content type: Research

    Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a systemic inflammatory response is considered a possible et...

    Authors: Mattias Danielson, Björn Reinsfelt, Anne Westerlind, Henrik Zetterberg, Kaj Blennow and Sven-Erik Ricksten

    Citation: Journal of Neuroinflammation 2018 15:283

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  35. Content type: Research

    Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal c...

    Authors: Taraneh Ebrahimi, Marcus Rust, Sarah Nele Kaiser, Alexander Slowik, Cordian Beyer, Andreas Rembert Koczulla, Jörg B. Schulz, Pardes Habib and Jan Philipp Bach

    Citation: Journal of Neuroinflammation 2018 15:282

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  36. Content type: Research

    To identify the vulnerable areas associated with systemic oxidative stress and further disruption of these vulnerable areas by measuring the associated morphology and functional network alterations in Parkinso...

    Authors: Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Yueh-Sheng Chen, Kun-Hsien Chou, Tun-Wei Hsu, Meng-Hsiang Chen, Nai-Wen Tsai, Shau-Hsuan Li and Wei-Che Lin

    Citation: Journal of Neuroinflammation 2018 15:281

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  37. Content type: Research

    Neuropathic pain is caused by damage to the nervous system, resulting in aberrant pain, which is associated with gene expression changes in the sensory pathway. However, the molecular mechanisms are not fully ...

    Authors: Hui Du, Juan Shi, Ming Wang, Shuhong An, Xingjing Guo and Zhaojin Wang

    Citation: Journal of Neuroinflammation 2018 15:280

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  38. Content type: Research

    While brain asymmetry has been a fascinating issue in neuroscience, the critical mechanism remains to be elucidated. Based on some index cases with asymmetric 18F-fluoro-2-deoxy-d-glucose positron emission tomogr...

    Authors: Yoonhyuk Jang, Soon-Tae Lee, Ji-Yeon Bae, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Sarosh R. Irani, Kon Chu and Sang Kun Lee

    Citation: Journal of Neuroinflammation 2018 15:279

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  39. Content type: Research

    Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. ...

    Authors: Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb and Kiran Bhaskar

    Citation: Journal of Neuroinflammation 2018 15:278

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  40. Content type: Research

    Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal mod...

    Authors: Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry and Mark S. Kindy

    Citation: Journal of Neuroinflammation 2018 15:277

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  41. Content type: Review

    Alzheimer’s disease (AD) is a neurodegenerative disorder, most cases of which lack a clear causative event. This has made the disease difficult to characterize and, thus, diagnose. Although some cases are gene...

    Authors: Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat and Rodrigo Medeiros

    Citation: Journal of Neuroinflammation 2018 15:276

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  42. Content type: Research

    Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER str...

    Authors: Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang and Zhenhua Zheng

    Citation: Journal of Neuroinflammation 2018 15:275

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  43. Content type: Research

    Undoubtedly, neuroinflammation is a major contributor to Alzheimer’s disease (AD) progression. Neuroinflammation is characterized by the activity of brain resident glial cells, in particular microglia, but als...

    Authors: M. S. Unger, P. Schernthaner, J. Marschallinger, H. Mrowetz and L. Aigner

    Citation: Journal of Neuroinflammation 2018 15:274

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  44. Content type: Research

    Complex mechanisms participate in microglial activation after a traumatic brain injury (TBI). TBI can induce autophagy and apoptosis in neurons and glial cells, and moderate hypothermia plays a protective role...

    Authors: Fengchen Zhang, Haiping Dong, Tao Lv, Ke Jin, Yichao Jin, Xiaohua Zhang and Jiyao Jiang

    Citation: Journal of Neuroinflammation 2018 15:273

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  45. Content type: Research

    Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson’s disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegenerati...

    Authors: Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter Serrano, John Babich and Maria E. Figueiredo-Pereira

    Citation: Journal of Neuroinflammation 2018 15:272

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  46. Content type: Research

    The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton’s tyrosine kinase (BTK), a kinase involved in B c...

    Authors: Hye Yeon Nam, Jin Han Nam, Gwangho Yoon, Ju-Young Lee, Youngpyo Nam, Hye-Jin Kang, Hyun-Ji Cho, Jeongyeon Kim and Hyang-Sook Hoe

    Citation: Journal of Neuroinflammation 2018 15:271

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  47. Content type: Research

    Axonal degeneration and neuronal loss have been described as the major causes of irreversible clinical disability in multiple sclerosis (MS). The aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) protei...

    Authors: Tissa Rahim, Pierre Becquart, Maria-Elizabeth Baeva and Jacqueline Quandt

    Citation: Journal of Neuroinflammation 2018 15:270

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