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  1. Neovascular age-related macular degeneration (nAMD) commonly causes vision loss from aberrant angiogenesis, termed choroidal neovascularization (CNV). Macrophages are heterogeneous cells that are necessary for...

    Authors: Steven Droho, Benjamin R. Thomson, Hadijat M. Makinde, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine

    Citation: Journal of Neuroinflammation 2020 17:341

    Content type: Research

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  2. Interferon α (IFNα) is a cytokine whose production is increased endogenously in response to viral infection and in autoimmune diseases such as systemic lupus erythematosus (SLE). An elevated IFNα signature has...

    Authors: Ernest Aw, Yingying Zhang and Michael Carroll

    Citation: Journal of Neuroinflammation 2020 17:340

    Content type: Research

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  3. Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against se...

    Authors: Susan A. Farr, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo, Michael L. Niehoff, Timothy M. Doyle and Daniela Salvemini

    Citation: Journal of Neuroinflammation 2020 17:339

    Content type: Research

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  4. This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relati...

    Authors: Jeppe Sillesen Matzen, Charlotte Loumann Krogh, Julie Lyng Forman, Peter Garred, Kirsten Møller and Søren Bache

    Citation: Journal of Neuroinflammation 2020 17:338

    Content type: Research

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  5. Intermittent hypoxia (IH) caused by obstructive sleep apnea (OSA) leads to neuroinflammation. Pinocembrin has been shown to have neuroprotective effects, while the therapeutic functions under IH condition are ...

    Authors: Lin-Jing Gong, Xin-Yuan Wang, Wen-Yu Gu and Xu Wu

    Citation: Journal of Neuroinflammation 2020 17:337

    Content type: Research

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  6. The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioa...

    Authors: Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John and Gareth R. Howell

    Citation: Journal of Neuroinflammation 2020 17:336

    Content type: Research

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  7. Perioperative neurocognitive disorders (PNDs) occur frequently after surgery and worsen patient outcome. How C-X-C motif chemokine (CXCL) 13 and its sole receptor CXCR5 contribute to PNDs remains poorly unders...

    Authors: Yanan Shen, Yuan Zhang, Lihai Chen, Jiayue Du, Hongguang Bao, Yan Xing, Mengmeng Cai and Yanna Si

    Citation: Journal of Neuroinflammation 2020 17:335

    Content type: Research

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  8. Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying the clinical association between air pollution, n...

    Authors: Andrea Cortese, Luca Lova, Patrizia Comoli, Elisabetta Volpe, Silvia Villa, Giulia Mallucci, Sabrina La Salvia, Alfredo Romani, Diego Franciotta, Valentina Bollati, Sabrina Basso, Ilaria Guido, Giuseppe Quartuccio, Luca Battistini, Cristina Cereda and Roberto Bergamaschi

    Citation: Journal of Neuroinflammation 2020 17:334

    Content type: Research

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  9. Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss.

    Authors: Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu and Dai-Shi Tian

    Citation: Journal of Neuroinflammation 2020 17:333

    Content type: Research

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  10. After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known etiology. Adding to the myriad of different pathways involved, bacterial neu...

    Authors: Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas and Sandra M. Cardoso

    Citation: Journal of Neuroinflammation 2020 17:332

    Content type: Research

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  11. Periodontopathic bacteria such as Porphyromonas gingivalis produce several metabolites, including lipopolysaccharide (LPS) and n-butyric acid (BA). Past work suggested that periodontal infection may cause cogniti...

    Authors: Takamitsu Tsukahara, Atsushi Toyoda, Takahiro Kawase, Shin-ichi Nakamura and Kuniyasu Ochiai

    Citation: Journal of Neuroinflammation 2020 17:331

    Content type: Research

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  12. Inflammatory response has been recognized as a pivotal pathophysiological process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation of inflammatory cascade, can simultaneously lea...

    Authors: Rui Sun, Mengna Peng, Pengfei Xu, Feihong Huang, Yi Xie, Juanji Li, Ye Hong, Hongquan Guo, Qian Liu and Wusheng Zhu

    Citation: Journal of Neuroinflammation 2020 17:330

    Content type: Research

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  13. Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype, which act as a critical me...

    Authors: Tingting He, Wanlu Li, Yaying Song, Zongwei Li, Yaohui Tang, Zhijun Zhang and Guo-Yuan Yang

    Citation: Journal of Neuroinflammation 2020 17:329

    Content type: Research

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  14. Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These ...

    Authors: Aftab Alam, Eric P. Thelin, Tamara Tajsic, Danyal Z. Khan, Abdelhakim Khellaf, Rickie Patani and Adel Helmy

    Citation: Journal of Neuroinflammation 2020 17:328

    Content type: Review

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  16. Repetitive, mild traumatic brain injuries (RmTBIs) are increasingly common in adolescents and encompass one of the largest neurological health concerns in the world. Adolescence is a critical period for brain ...

    Authors: Eric Eyolfson, Asher Khan, Richelle Mychasiuk and Alexander W. Lohman

    Citation: Journal of Neuroinflammation 2020 17:326

    Content type: Review

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  17. Bacterial meningitis is still a cause of severe neurological disability. The brain is protected from penetrating pathogens by the blood-brain barrier and the innate immune system. The invading pathogens are re...

    Authors: Marvin Rüger, Eugenia Kipp, Nadine Schubert, Nicole Schröder, Thomas Pufe, Matthias B. Stope, Markus Kipp, Christian Blume, Simone C. Tauber and Lars-Ove Brandenburg

    Citation: Journal of Neuroinflammation 2020 17:325

    Content type: Research

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  18. Multiple sclerosis is an immune-mediated disease of the central nervous system (CNS) characterized by inflammation, oligodendrocytes loss, demyelination, and damaged axons. Tyro3, Axl, and MerTK belong to a fa...

    Authors: Juwen C. DuBois, Alex K. Ray, Peter Davies and Bridget Shafit-Zagardo

    Citation: Journal of Neuroinflammation 2020 17:324

    Content type: Research

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  19. The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immun...

    Authors: Kristina Berve, Brian L. West, Rudolf Martini and Janos Groh

    Citation: Journal of Neuroinflammation 2020 17:323

    Content type: Research

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  20. In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression, abnormal excessive opening of Cx43 hemich...

    Authors: Hailong Yu, Xiang Cao, Wei Li, Pinyi Liu, Yuanyuan Zhao, Lilong Song, Jian Chen, Beilei Chen, Wenkui Yu and Yun Xu

    Citation: Journal of Neuroinflammation 2020 17:322

    Content type: Research

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  21. Microglia have been implicated in the pathogenesis of radiation-induced brain injury (RIBI), which severely influences the quality of life during long-term survival. Recently, irradiated microglia were specula...

    Authors: Anan Xu, Rong Li, Anbang Ren, Haifeng Jian, Zhong Huang, Qingxing Zeng, Baiyao Wang, Jieling Zheng, Xiaoyu Chen, Naiying Zheng, Ronghui Zheng, Yunhong Tian, Mengzhong Liu, Zixu Mao, Aimin Ji and Yawei Yuan

    Citation: Journal of Neuroinflammation 2020 17:321

    Content type: Research

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  22. Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determini...

    Authors: Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao and Yan Xing

    Citation: Journal of Neuroinflammation 2020 17:320

    Content type: Research

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  23. Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide...

    Authors: Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan and Sujatha Kannan

    Citation: Journal of Neuroinflammation 2020 17:319

    Content type: Research

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  24. We previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency (CIRCI) and mortality in rats with traumatic brain injury (TBI), whereas l...

    Authors: Bin Zhang, Miao Bai, Xiaojian Xu, Mengshi Yang, Fei Niu, Fei Gao and Baiyun Liu

    Citation: Journal of Neuroinflammation 2020 17:318

    Content type: Research

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  25. The peri-menopause or menopausal transition—the time period that surrounds the final years of a woman’s reproductive life—is associated with profound reproductive and hormonal changes in a woman’s body and exp...

    Authors: Micheline McCarthy and Ami P. Raval

    Citation: Journal of Neuroinflammation 2020 17:317

    Content type: Review

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  26. Neuroinflammation is a critical feature of sensitisation of spinal nociceptive processing in chronic pain states. We hypothesised that the resolvin pathways, a unique endogenous control system, may ameliorate ...

    Authors: Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu and Victoria Chapman

    Citation: Journal of Neuroinflammation 2020 17:316

    Content type: Research

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  27. Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. JEV infection of mice and humans can lead to an uncontrolled inflammatory response in the central nervous system (CNS), res...

    Authors: Valerie Redant, Herman W. Favoreel, Kai Dallmeier, Willem Van Campe and Nick De Regge

    Citation: Journal of Neuroinflammation 2020 17:315

    Content type: Research

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  28. Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that s...

    Authors: Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel and Daniela Salvemini

    Citation: Journal of Neuroinflammation 2020 17:314

    Content type: Short report

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  29. Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration of POL1 inhibitor RAM-589.555, which is characterized by high perm...

    Authors: Rina Zilkha-Falb, Tatyana Rachutin-Zalogin, Lakota Cleaver, Michael Gurevich and Anat Achiron

    Citation: Journal of Neuroinflammation 2020 17:313

    Content type: Research

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  30. The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mech...

    Authors: Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi and Koichi Iwata

    Citation: Journal of Neuroinflammation 2020 17:312

    Content type: Research

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  31. Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggeri...

    Authors: Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan and Wen Wu

    Citation: Journal of Neuroinflammation 2020 17:311

    Content type: Research

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  32. The major dose-limiting toxicity of paclitaxel, one of the most commonly used drugs to treat solid tumor, is painful neuropathy. However, the molecular mechanisms underlying paclitaxel-induced painful neuropat...

    Authors: Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin and Dai Li

    Citation: Journal of Neuroinflammation 2020 17:310

    Content type: Research

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  33. Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer’s disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated from Verbascum sinuatum (the wavyleaf mu...

    Authors: Chunyue Wang, Xueying Cai, Ruochen Wang, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang and Di Wang

    Citation: Journal of Neuroinflammation 2020 17:309

    Content type: Research

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  34. The aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET...

    Authors: Kuo-Lun Huang, Ing-Tsung Hsiao, Meng-Yang Ho, Jung-Lung Hsu, Yeu-Jhy Chang, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Yi-Ming Wu, Kuan-Yi Wu, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Tsong-Hai Lee and Kun-Ju Lin

    Citation: Journal of Neuroinflammation 2020 17:308

    Content type: Research

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  35. Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was p...

    Authors: Young-Hee Jin, Bongsu Kang, Hyun S. Kang, Chang-Sung Koh and Byung S. Kim

    Citation: Journal of Neuroinflammation 2020 17:307

    Content type: Research

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  37. Neuroinflammation is a principal element in Alzheimer’s disease (AD) pathogenesis, so anti-inflammation may be a promising therapeutic strategy. Forsythoside B (FTS•B), a phenylethanoid glycoside isolated from Fo...

    Authors: Fan’ge Kong, Xue Jiang, Ruochen Wang, Siyu Zhai, Yizhi Zhang and Di Wang

    Citation: Journal of Neuroinflammation 2020 17:305

    Content type: Research

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  38. Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune ence...

    Authors: Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Kevin Aguilar, Anna Escrig, Mercedes Giralt, Richard D. Palmiter and Juan Hidalgo

    Citation: Journal of Neuroinflammation 2020 17:304

    Content type: Research

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  39. Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against...

    Authors: Rahat Ullah, Myeung Hoon Jo, Muhammad Riaz, Sayed Ibrar Alam, Kamran Saeed, Waqar Ali, Inayat Ur Rehman, Muhammad Ikram and Myeong Ok Kim

    Citation: Journal of Neuroinflammation 2020 17:303

    Content type: Research

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  40. Glial activation and neuroinflammation play a crucial role in the pathogenesis and development of Alzheimer’s disease (AD). The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is...

    Authors: Bo Ding, Chengheng Lin, Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma and Weina Yang

    Citation: Journal of Neuroinflammation 2020 17:302

    Content type: Research

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  41. Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads t...

    Authors: Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero Jr and Manoocher Soleimani

    Citation: Journal of Neuroinflammation 2020 17:301

    Content type: Research

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  42. Non-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide valuable insights not only into pathogenesis of neuro-inflammatory and...

    Authors: Wissam Beaino, Bieneke Janssen, Esther Kooijman, Ricardo Vos, Robert C. Schuit, James O’Brien-Brown, Michael Kassiou, Bert van het Hof, Danielle J. Vugts, Helga E. de Vries and Albert D. Windhorst

    Citation: Journal of Neuroinflammation 2020 17:300

    Content type: Research

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  43. Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with ...

    Authors: Shinrye Lee, Seyeon Kim, Ha-Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu-Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha, Seongsoo Lee and Hyung-Jun Kim

    Citation: Journal of Neuroinflammation 2020 17:299

    Content type: Research

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  44. Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive degeneration and loss of neurons in specific regions of the central nervous system. Chronic activation of the immune c...

    Authors: Chiara Burgaletto, Antonio Munafò, Giulia Di Benedetto, Cettina De Francisci, Filippo Caraci, Rosaria Di Mauro, Claudio Bucolo, Renato Bernardini and Giuseppina Cantarella

    Citation: Journal of Neuroinflammation 2020 17:298

    Content type: Review

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  45. MicroRNAs (miRNAs) belong to a class of evolutionary conserved, non-coding small RNAs with regulatory functions on gene expression. They negatively affect the expression of target genes by promoting either RNA...

    Authors: Qin Ma, Atsuko Matsunaga, Brenda Ho, Jorge R. Oksenberg and Alessandro Didonna

    Citation: Journal of Neuroinflammation 2020 17:297

    Content type: Research

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  46. Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...

    Authors: Patrick P. Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, Yeonhee Cho, Benedek Gyongyosi, Donna Catalano, Eric Lefebvre, Laurent Fischer, Star Seyedkazemi, Dorothy P. Schafer and Gyongyi Szabo

    Citation: Journal of Neuroinflammation 2020 17:296

    Content type: Research

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  47. Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms co...

    Authors: Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang, Yu Jiang, Tao Li, Cai-Feng Yang, Xiao-Ya Wang, Xia Li, Sheng-Xi Wu and Gui-Lian Zhang

    Citation: Journal of Neuroinflammation 2020 17:295

    Content type: Research

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  48. Myasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. The thymus is the effector organ, and its removal ...

    Authors: Mélanie A. Cron, Cloé A. Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston and Rozen Le Panse

    Citation: Journal of Neuroinflammation 2020 17:294

    Content type: Research

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  49. Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cereb...

    Authors: Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Jens Kuhle, David Leppert and Stephen L. Leib

    Citation: Journal of Neuroinflammation 2020 17:293

    Content type: Research

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  50. Sepsis-associated encephalopathy (SAE) is an early and frequent event of infection-induced systemic inflammatory response syndrome. Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and inflam...

    Authors: Guang-Ping Lang, Bernadin Ndongson-Dongmo, Trim Lajqi, Michael Brodhun, Yingying Han, Reinhard Wetzker, Martin G. Frasch and Reinhard Bauer

    Citation: Journal of Neuroinflammation 2020 17:292

    Content type: Research

    Published on:

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Journal of Neuroinflammation

ISSN: 1742-2094