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  1. The primary progressive aphasias (PPA) represent a group of usually sporadic neurodegenerative disorders with three main variants: the nonfluent or agrammatic variant (nfvPPA), the semantic variant (svPPA), an...

    Authors: Aitana Sogorb-Esteve, Imogen J. Swift, Ione O. C. Woollacott, Jason D. Warren, Henrik Zetterberg and Jonathan D. Rohrer
    Citation: Journal of Neuroinflammation 2021 18:224
  2. The complex pathophysiology of Alzheimer’s disease (AD) hampers the development of effective treatments. Attempts to prevent neurodegeneration in AD have failed so far, highlighting the need for further clarif...

    Authors: Gonzalo Ruiz-Pérez, Samuel Ruiz de Martín Esteban, Sharai Marqués, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Rosa M. Tolón, María Posada-Ayala, Benjamin F. Cravatt, José A. Esteban, Julián Romero and Rocío Palenzuela
    Citation: Journal of Neuroinflammation 2021 18:223
  3. During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through ol...

    Authors: Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, Konstantinos Kambas, Lida Iliopoulou, Roman Fischer, Roland E. Kontermann, Maria C. Denis, George Kollias, Hans Lassmann and Lesley Probert
    Citation: Journal of Neuroinflammation 2021 18:222
  4. Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary injury development; however, how systemic inflammatory mediators affect this is not fully understood. The...

    Authors: Philipp Lassarén, Caroline Lindblad, Arvid Frostell, Keri L. H. Carpenter, Mathew R. Guilfoyle, Peter J. A. Hutchinson, Adel Helmy and Eric Peter Thelin
    Citation: Journal of Neuroinflammation 2021 18:221
  5. Homozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson’s disease. In h...

    Authors: Electra Brunialti, Alessandro Villa, Marianna Mekhaeil, Federica Mornata, Elisabetta Vegeto, Adriana Maggi, Donato A. Di Monte and Paolo Ciana
    Citation: Journal of Neuroinflammation 2021 18:220
  6. Despite widespread acceptance that neuroinflammation contributes to age-related cognitive decline, studies comparing protein expression of cytokines in the young versus old brains are surprisingly limited in t...

    Authors: Latarsha Porcher, Sophie Bruckmeier, Steven D. Burbano, Julie E. Finnell, Nicole Gorny, Jennifer Klett, Susan K. Wood and Michy P. Kelly
    Citation: Journal of Neuroinflammation 2021 18:219
  7. The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocamp...

    Authors: Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E. Sundstrom and William P. Gray
    Citation: Journal of Neuroinflammation 2021 18:218
  8. The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the ...

    Authors: Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Huen-Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez and Claire H. Mitchell
    Citation: Journal of Neuroinflammation 2021 18:217
  9. Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which has been demonstrated to have neuroprotective effects in different neurological disease models. However, the effect and underlying...

    Authors: Yonghui Hou, Jiyao Luan, Taida Huang, Tiancheng Deng, Xing Li, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Yu Hou, Liangliang Xu and Dingkun Lin
    Citation: Journal of Neuroinflammation 2021 18:216
  10. Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the str...

    Authors: Peipei Zhang, Anja Schlecht, Julian Wolf, Stefaniya Boneva, Yannik Laich, Jana Koch, Franziska Ludwig, Myriam Boeck, Adrian Thien, Carmen Härdtner, Katrin Kierdorf, Hansjürgen Agostini, Günther Schlunck, Marco Prinz, Ingo Hilgendorf, Peter Wieghofer…
    Citation: Journal of Neuroinflammation 2021 18:215
  11. APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and obesity is a strong environmental risk factor for AD. These factors result in multiple central nervous system (CNS) disturbances and si...

    Authors: Nahdia S. Jones, Katarina Q. Watson and G. William Rebeck
    Citation: Journal of Neuroinflammation 2021 18:214
  12. Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential rol...

    Authors: Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow…
    Citation: Journal of Neuroinflammation 2021 18:213
  13. Binge ethanol exposure during adolescence reduces hippocampal neurogenesis, a reduction which persists throughout adulthood despite abstinence. This loss of neurogenesis, indicated by reduced doublecortin+ imm...

    Authors: Victoria Macht, Ryan Vetreno, Natalie Elchert and Fulton Crews
    Citation: Journal of Neuroinflammation 2021 18:212
  14. Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic pain syndrome following a cerebral vascular insult, which negatively impacts the quality of life of stroke survivors but currently lacks...

    Authors: Tongtong Liu, Ting Li, Xuhui Chen, Zuofan Li, Miaomiao Feng, Wenlong Yao, Li Wan, Chuanhan Zhang and Yue Zhang
    Citation: Journal of Neuroinflammation 2021 18:211
  15. Neuroinflammation and oxidative stress plays an important role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study is the first to show that activation of autophagy ...

    Authors: Hanhai Zeng, Huaijun Chen, Min Li, Jianfeng Zhuang, Yucong Peng, Hang Zhou, Chaoran Xu, Qian Yu, Xiongjie Fu, Shenglong Cao, Jing Cai, Feng Yan and Gao Chen
    Citation: Journal of Neuroinflammation 2021 18:210
  16. Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7 agonists al...

    Authors: Becky J. Proskocil, Karol Wai, Katherine M. Lebold, Mason A. Norgard, Katherine A. Michaelis, Ubaldo De La Torre, Madeline Cook, Daniel L. Marks, Allison D. Fryer, David B. Jacoby and Matthew G. Drake
    Citation: Journal of Neuroinflammation 2021 18:209
  17. Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD+) shows ant...

    Authors: Yao Zhao, Jiawei Zhang, Yaling Zheng, Yaxuan Zhang, Xiao Jie Zhang, Hongmei Wang, Yu Du, Jian Guan, Xiuzhe Wang and Jianliang Fu
    Citation: Journal of Neuroinflammation 2021 18:207
  18. Glaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible vision loss. Neuroinflammation is recognized as one of the causes of glauco...

    Authors: Francesca Lazzara, Rosario Amato, Chiara Bianca Maria Platania, Federica Conti, Tsung-Han Chou, Vittorio Porciatti, Filippo Drago and Claudio Bucolo
    Citation: Journal of Neuroinflammation 2021 18:206
  19. Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge at the lesion sites following spinal cord injury (SCI). A1 astrocytes are known to be neurotoxic that participate in neuropathogene...

    Authors: Lilan Li, Yu Li, Bingqiang He, Hui Li, Huiyuan Ji, Yingjie Wang, Zhenjie Zhu, Yuming Hu, Yue Zhou, Ting Yang, Chunshuai Sun, Ying Yuan and Yongjun Wang
    Citation: Journal of Neuroinflammation 2021 18:205
  20. Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND is unclear, and no effective therapies are currently availabl...

    Authors: Wenqiang Zuo, Jianshuai Zhao, Jinming Zhang, Zongping Fang, Jiao Deng, Ze Fan, Yaru Guo, Jing Han, Wugang Hou, Hailong Dong, Feifei Xu and Lize Xiong
    Citation: Journal of Neuroinflammation 2021 18:204
  21. We have recently showed that atorvastatin (ATO) combined with low dose of dexamethasone (DEX) was more efficacious in treating patients with chronic subdural haematoma (CSDH) than ATO monotherapy. This study w...

    Authors: Zhitao Gong, Daqiang Zhan, Meng Nie, Xiaochun Li, Chuang Gao, Xuanhui Liu, Tangtang Xiang, Jiangyuan Yuan, Weiwei Jiang, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Hengjie Yuan, Jianning Zhang and Rongcai Jiang
    Citation: Journal of Neuroinflammation 2021 18:203
  22. Increasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many asp...

    Authors: Minghuan Zhu, Zhenjing Liu, Yanhong Guo, Mst. Sadia Sultana, Kang Wu, Xiaoe Lang, Qinyu Lv, Xiao Huang, Zhenghui Yi and Zezhi Li
    Citation: Journal of Neuroinflammation 2021 18:202
  23. Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local ...

    Authors: Xue Ma, Chuan Qin, Man Chen, Hai-Han Yu, Yun-Hui Chu, Ting-Jun Chen, Dale B. Bosco, Long-Jun Wu, Bi-Tao Bu, Wei Wang and Dai-Shi Tian
    Citation: Journal of Neuroinflammation 2021 18:201
  24. Treatment-resistant depression (TRD) and pain frequently coexist clinically. Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes ...

    Authors: Yanling Zhou, Chengyu Wang, Xiaofeng Lan, Hanqiu Li, Ziyuan Chao and Yuping Ning
    Citation: Journal of Neuroinflammation 2021 18:200
  25. Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and deme...

    Authors: Sarah E. Barnes, Kristy A. Zera, Geoffrey T. Ivison, Marion S. Buckwalter and Edgar G. Engleman
    Citation: Journal of Neuroinflammation 2021 18:199
  26. The cortico-cerebellar-thalamic-cortical circuit has been implicated in the emergence of psychotic symptoms in schizophrenia (SZ). The kynurenine pathway (KP) has been linked to alterations in glutamatergic an...

    Authors: Amira Ben Afia, Èlia Vila, Karina S. MacDowell, Aida Ormazabal, Juan C. Leza, Josep M. Haro, Rafael Artuch, Belén Ramos and Borja Garcia-Bueno
    Citation: Journal of Neuroinflammation 2021 18:198
  27. Microglia-mediated neuroinflammation plays an important role in Parkinson’s disease (PD), and it exerts proinflammatory or anti-inflammatory effects depending on the M1/M2 polarization phenotype. Hence, promot...

    Authors: Xiaodong Yang, Yi Zhang, Yimeng Chen, Xiaoqin He, Yiwei Qian, Shaoqing Xu, Chao Gao, Chengjun Mo, Shengdi Chen and Qin Xiao
    Citation: Journal of Neuroinflammation 2021 18:197
  28. Spinal cord injury (SCI) is a severe traumatic disease which causes high disability and mortality rates. The molecular pathological features after spinal cord injury mainly involve the inflammatory response, m...

    Authors: Yuluo Rong, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Pengyu Tang, Dongdong Jiang, Jin Fan, Guoyong Yin, Wei Liu and Weihua Cai
    Citation: Journal of Neuroinflammation 2021 18:196

    The Correction to this article has been published in Journal of Neuroinflammation 2021 18:285

  29. Timely endovascular thrombectomy (EVT) significantly improves outcomes in patients with acute ischemic stroke (AIS) with large vessel occlusion type. However, whether certain central nervous system-specific pl...

    Authors: Chih-Hao Chen, Hai-Jui Chu, Yi-Ting Hwang, Yen-Heng Lin, Chung-Wei Lee, Sung-Chun Tang and Jiann-Shing Jeng
    Citation: Journal of Neuroinflammation 2021 18:195
  30. Past experiments studying innate immunity in the central nervous system (CNS) utilized microglia obtained from neonatal mouse brain, which differ developmentally from adult microglia. These differences might i...

    Authors: James A. Carroll, Brent Race, Katie Williams, James F. Striebel and Bruce Chesebro
    Citation: Journal of Neuroinflammation 2021 18:194
  31. The neuroimmune system is required for normal neural processes, including modulation of cognition, emotion, and adaptive behaviors. Aberrant neuroimmune activation is associated with dysregulation of memory an...

    Authors: Caitlin K. Posillico, Rosa E. Garcia-Hernandez and Natalie C. Tronson
    Citation: Journal of Neuroinflammation 2021 18:193
  32. Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure. In the hippocampus, so...

    Authors: Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso and Eliana P. Araujo
    Citation: Journal of Neuroinflammation 2021 18:192
  33. Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD). Here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal ...

    Authors: Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang and Dong Soo Lee
    Citation: Journal of Neuroinflammation 2021 18:190
  34. Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antago...

    Authors: Sharmony B. Kelly, Vanesa Stojanovska, Valerie A. Zahra, Alison Moxham, Suzanne L. Miller, Timothy J. M. Moss, Stuart B. Hooper, Marcel F. Nold, Claudia A. Nold-Petry, Justin M. Dean, Laura Bennet, Graeme R. Polglase, Alistair J. Gunn and Robert Galinsky
    Citation: Journal of Neuroinflammation 2021 18:189
  35. Innate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate extracellular immune responses by promoting secretion ...

    Authors: Pengfei Xu, Chunrong Tao, Yuyou Zhu, Guoping Wang, Lingqi Kong, Wenyu Li, Rui Li, Juanji Li, Chao Zhang, Li Wang, Xinfeng Liu, Wen Sun and Wei Hu
    Citation: Journal of Neuroinflammation 2021 18:188
  36. Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation ...

    Authors: Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He and Dandan Sun
    Citation: Journal of Neuroinflammation 2021 18:187
  37. Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammat...

    Authors: Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng-mao Lin, Dejuan Kong, Heather Hager, Xuwen Liu and David A. Antonetti
    Citation: Journal of Neuroinflammation 2021 18:186
  38. Efforts to understand genetic variability involved in an individual’s susceptibility to chronic pain support a role for upstream regulation by epigenetic mechanisms.

    Authors: Kimberly E. Stephens, Weiqiang Zhou, Zachary Renfro, Zhicheng Ji, Hongkai Ji, Yun Guan and Sean D. Taverna
    Citation: Journal of Neuroinflammation 2021 18:185
  39. White matter injury (WMI) is a major neuropathological event associated with intracerebral hemorrhage (ICH). P2X purinoreceptor 4 (P2X4R) is a member of the P2X purine receptor family, which plays a crucial ro...

    Authors: Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang and Feng Yan
    Citation: Journal of Neuroinflammation 2021 18:184
  40. Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, par...

    Authors: Nada El Mahmoudi, Guillaume Rastoldo, Emna Marouane, David Péricat, Isabelle Watabe, Alain Tonetto, Charlotte Hautefort, Christian Chabbert, Francesca Sargolini and Brahim Tighilet
    Citation: Journal of Neuroinflammation 2021 18:183
  41. Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here...

    Authors: Shuo Cheng, Hong-Ning Wang, Lin-Jie Xu, Fang Li, Yanying Miao, Bo Lei, Xinghuai Sun and Zhongfeng Wang
    Citation: Journal of Neuroinflammation 2021 18:182
  42. Intractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of NMOSD pain remains to be elucidated. In this study, we focused on ATP, w...

    Authors: Teruyuki Ishikura, Makoto Kinoshita, Mikito Shimizu, Yoshiaki Yasumizu, Daisuke Motooka, Daisuke Okuzaki, Kazuya Yamashita, Hisashi Murata, Shohei Beppu, Toru Koda, Satoru Tada, Naoyuki Shiraishi, Yasuko Sugiyama, Katsuichi Miyamoto, Susumu Kusunoki, Tomoyuki Sugimoto…
    Citation: Journal of Neuroinflammation 2021 18:181
  43. Exposure to general anesthesia (GA) during the postnatal period is associated with neuroinflammation and long-term neurocognitive impairment in preclinical and clinical settings. Pyroptosis is a novel type of ...

    Authors: Jing Dai, Xue Li, Cai Wang, Shuxin Gu, Lei Dai, Jingyun Zhang, Yunxia Fan and Jing Wu
    Citation: Journal of Neuroinflammation 2021 18:180
  44. Intracerebral hemorrhage (ICH) results in a cascade of inflammatory cell activation with recruitment of peripheral leukocytes to the brain parenchyma and surrounding the hematoma. We hypothesized that in patie...

    Authors: Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley and Wendy C. Ziai
    Citation: Journal of Neuroinflammation 2021 18:179
  45. Zika virus (ZIKV) has been associated with several neurological complications in adult patients.

    Authors: William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay and Guy Boivin
    Citation: Journal of Neuroinflammation 2021 18:178
  46. Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has p...

    Authors: Emil Gregersen, Cristine Betzer, Woojin S. Kim, Gergo Kovacs, Lasse Reimer, Glenda M. Halliday, Steffen Thiel and Poul Henning Jensen
    Citation: Journal of Neuroinflammation 2021 18:177
  47. Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells including dendritic cells, macrophages, and microglia. We ...

    Authors: Junjun Ni, Juan Zhao, Xinwen Zhang, Thomas Reinheckel, Vito Turk and Hiroshi Nakanishi
    Citation: Journal of Neuroinflammation 2021 18:176
  48. Diabetes has been recognized as a risk factor contributing to the incidence and progression of Parkinson’s disease (PD). Although several hypotheses suggest a number of different mechanisms underlying the aggr...

    Authors: Osama F. Elabi, João Paulo M. C. M. Cunha, Abderahim Gaceb, Malin Fex and Gesine Paul
    Citation: Journal of Neuroinflammation 2021 18:175

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