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  1. Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There is increasing evidence that environmental factors are important in the developm...

    Authors: Solenne Vigne, Donovan Duc, Benjamin Peter, Jessica Rebeaud, Yannick Yersin, Florian Ruiz, Valentine Bressoud, Tinh-Hai Collet and Caroline Pot
    Citation: Journal of Neuroinflammation 2022 19:42
  2. The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including...

    Authors: Ruozhi Dang, Mingyang Wang, Xinhui Li, Haiyang Wang, Lanxiang Liu, Qingyuan Wu, Jianting Zhao, Ping Ji, Lianmei Zhong, Julio Licinio and Peng Xie
    Citation: Journal of Neuroinflammation 2022 19:41
  3. Zika virus (ZIKV) is a mosquito-transmitted flavivirus that affects many regions of the world. Infection, in utero, causes microcephaly and later developmental and neurologic impairments. The impact of ZIKV in...

    Authors: Denise C. Hsu, Kesara Chumpolkulwong, Michael J. Corley, Taweewun Hunsawong, Dutsadee Inthawong, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Panupat Nadee, Jumpol Sopanaporn, Yuwadee Phuang-Ngern, Chonticha Klungthong, Matthew Reed, Stefan Fernandez, Lishomwa C. Ndhlovu, Robert Paul…
    Citation: Journal of Neuroinflammation 2022 19:40
  4. Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and rece...

    Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion
    Citation: Journal of Neuroinflammation 2022 19:38
  5. Paediatric traumatic brain injury (TBI) is recognised to have significant longer-term neurocognitive effects. Childhood is a time of high risk for head injury. Functional recovery is variable with a combinatio...

    Authors: Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger and Eleanor J. Molloy
    Citation: Journal of Neuroinflammation 2022 19:36
  6. Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive ability. Exosomes derived from bone-marrow mesenchymal stem cells (BMSC-exos) are extracellular vesic...

    Authors: Sen Liu, Min Fan, Jing-Xian Xu, Long-Jun Yang, Cong-Cong Qi, Qing-Rong Xia and Jin-Fang Ge
    Citation: Journal of Neuroinflammation 2022 19:35
  7. The role of physical exercise in the prevention of Alzheimer’s disease (AD) has been widely studied. Microglia play an important role in AD. Triggering receptor expressed in myeloid cells 2 (TREM2) is expresse...

    Authors: Shan-shan Zhang, Lin Zhu, Yan Peng, Lei Zhang, Feng-lei Chao, Lin Jiang, Qian Xiao, Xin Liang, Jing Tang, Hao Yang, Qi He, Yi-jing Guo, Chun-ni Zhou and Yong Tang
    Citation: Journal of Neuroinflammation 2022 19:34
  8. Previous studies have shown that vagus nerve stimulation (VNS) can attenuate inflammatory responses in peripheral tissues and also improve some neurological disorders and cognitive function in the brain. Howev...

    Authors: Uk Namgung, Ki-Joong Kim, Byung-Gon Jo and Jong-Min Park
    Citation: Journal of Neuroinflammation 2022 19:33

    The Correction to this article has been published in Journal of Neuroinflammation 2022 19:175

  9. Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective treatments for PNI are still limited...

    Authors: Jinhuan Wei, Wenfeng Su, Yayu Zhao, Zhongya Wei, Yuchen Hua, Peng Xue, Xiang Zhu, Ying Chen and Gang Chen
    Citation: Journal of Neuroinflammation 2022 19:32
  10. The neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson’s disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger–W...

    Authors: Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi and Balázs Gaszner
    Citation: Journal of Neuroinflammation 2022 19:31
  11. Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpop...

    Authors: Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman and Alberto Serrano-Pozo
    Citation: Journal of Neuroinflammation 2022 19:30
  12. Systemic inflammation is a potent contributor to increased seizure susceptibility. However, information regarding the effects of systemic inflammation on cerebral vascular integrity that influence neuron excit...

    Authors: Wan-Yu Huang, Yen-Ling Lai, Ko-Hung Liu, Shankung Lin, Hsuan-Ying Chen, Chih-Hung Liang, Hung-Ming Wu and Kuei-Sen Hsu
    Citation: Journal of Neuroinflammation 2022 19:29
  13. Recent evidences have suggested the involvement of toll-like receptor (TLR)-4 in the pathogenesis of cerebral cavernous malformations (CCM). Elevated frequency of TLR+T-cells has been associated with neurological...

    Authors: Camilla Castro, Hugo A. A. Oyamada, Marcos Octávio S. D. Cafasso, Lana M. Lopes, Clarice Monteiro, Priscila M. Sacramento, Soniza Vieira Alves-Leon, Gustavo da Fontoura Galvão, Joana Hygino, Jorge Paes Barreto Marcondes de Souza and Cleonice A. M. Bento
    Citation: Journal of Neuroinflammation 2022 19:28
  14. Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiologica...

    Authors: Alba Sánchez-Fernández, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat and Rubèn López-Vales
    Citation: Journal of Neuroinflammation 2022 19:27
  15. Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Its molecular mechanism is still unclear, and pharmacological treatments are unsatisfactory. Transient receptor potential vanilloid 4 (TRPV...

    Authors: Na Liu, Liping Bai, Zhipeng Lu, Rou Gu, Dongdong Zhao, Fang Yan and Jie Bai
    Citation: Journal of Neuroinflammation 2022 19:26
  16. The development of morphine tolerance is a clinical challenge for managing severe pain. Studies have shown that neuroinflammation is a critical aspect for the development of analgesic tolerance. We found that ...

    Authors: Li Wan, Ru-Meng Jia, Lu-Lu Ji, Xin-Miao Qin, Liang Hu, Fan Hu, Yuan Han, Yin-Bing Pan, Chun-Yi Jiang and Wen-Tao Liu
    Citation: Journal of Neuroinflammation 2022 19:25
  17. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT

    Authors: Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu and Gang Hu
    Citation: Journal of Neuroinflammation 2022 19:23
  18. The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy may provide a therapeutic target for reduction of seizure burden in patients that are currently underserved by traditional anti-seiz...

    Authors: Charles L. Howe, Reghann G. LaFrance-Corey, Brittany L. Overlee, Renee K. Johnson, Benjamin D. S. Clarkson and Emma N. Goddery
    Citation: Journal of Neuroinflammation 2022 19:22
  19. Understanding the pathophysiology of central nervous system tuberculosis (CNS-TB) is hampered by the lack of a good pre-clinical model that mirrors the human CNS-TB infection. We developed a murine CNS-TB mode...

    Authors: Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S. L. Ding and Catherine W. M. Ong
    Citation: Journal of Neuroinflammation 2022 19:21

    The Correction to this article has been published in Journal of Neuroinflammation 2022 19:197

  20. Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological and pathological processes, including the widespread use of the Cx3cr1CreER...

    Authors: Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson…
    Citation: Journal of Neuroinflammation 2022 19:20
  21. Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far.

    Authors: Sven Jarius, Florence Pache, Peter Körtvelyessy, Ilijas Jelčić, Mark Stettner, Diego Franciotta, Emanuela Keller, Bernhard Neumann, Marius Ringelstein, Makbule Senel, Axel Regeniter, Rea Kalantzis, Jan F. Willms, Achim Berthele, Markus Busch, Marco Capobianco…
    Citation: Journal of Neuroinflammation 2022 19:19
  22. Toxoplasma gondii (T. gondii) is a highly successful parasite being able to cross all biological barriers of the body, finally reaching the central nervous system (CNS). Previous studies have highlighted the crit...

    Authors: Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Mária A. Deli, Andrea Kröger, Thomas Schüler and Ildiko Rita Dunay
    Citation: Journal of Neuroinflammation 2022 19:17
  23. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovir...

    Authors: Yuan Chao Xue, Huitao Liu, Yasir Mohamud, Amirhossein Bahreyni, Jingchun Zhang, Neil R. Cashman and Honglin Luo
    Citation: Journal of Neuroinflammation 2022 19:16
  24. Authors: S. T. Peruzzaro, M. M. M. Andrews, A. Al-Gharaibeh, O. Pupiec, M. Resk, D. Story, P. Maiti, J. Rossignol and G. L. Dunbar
    Citation: Journal of Neuroinflammation 2022 19:15

    The original article was published in Journal of Neuroinflammation 2019 16:2

  25. Authors: Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan and Jianmei Ma
    Citation: Journal of Neuroinflammation 2022 19:14

    The original article was published in Journal of Neuroinflammation 2019 16:10

  26. Postviral olfactory dysfunction (PVOD) following a viral upper respiratory tract infection (URI) is one of the most common causes of olfactory disorders, often lasting for over a year. To date, the molecular p...

    Authors: Ryoji Kagoya, Makiko Toma-Hirano, Junya Yamagishi, Naoyuki Matsumoto, Kenji Kondo and Ken Ito
    Citation: Journal of Neuroinflammation 2022 19:13
  27. Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in ...

    Authors: Fu Li, Haitao Xiang, Yue Gu, Ting Ye, Xu Lu and Chao Huang
    Citation: Journal of Neuroinflammation 2022 19:12
  28. The brain vasculature plays a pivotal role in the inflammatory process by modulating the interaction between blood cells and the neurovascular unit. Argonaute-2 (Ago2) has been suggested as essential for endot...

    Authors: Marta Machado-Pereira, Cláudia Saraiva, Liliana Bernardino, Ana C. Cristóvão and Raquel Ferreira
    Citation: Journal of Neuroinflammation 2022 19:11
  29. Astrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which ...

    Authors: Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel and Luke M. Healy
    Citation: Journal of Neuroinflammation 2022 19:10
  30. Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathw...

    Authors: Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C. Daskhan, Edward N. Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S. Macauley and Simonetta Sipione
    Citation: Journal of Neuroinflammation 2022 19:9
  31. The serine protease inhibitor nafamostat has been proposed as a treatment for COVID-19, by inhibiting TMPRSS2-mediated viral cell entry. Nafamostat has been shown to have other, immunomodulatory effects, which...

    Authors: Abi G. Yates, Caroline M. Weglinski, Yuxin Ying, Isobel K. Dunstan, Tatyana Strekalova and Daniel C. Anthony
    Citation: Journal of Neuroinflammation 2022 19:8
  32. Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4+ T lymphocytes in mice. The present study aimed at identifying opioid receptor(s) expressed on nociceptive sens...

    Authors: Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac and Gilles Dietrich
    Citation: Journal of Neuroinflammation 2022 19:7
  33. Anti-aquaporin 4 (AQP4) antibody (AQP4-Ab) is involved in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). However, the mechanism involved in AQP4-Ab production remains unclear.

    Authors: Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori and Sachiko Miyake
    Citation: Journal of Neuroinflammation 2022 19:6
  34. Neurodegeneration is considered the consequence of misfolded proteins’ deposition. Little is known about external environmental effects on the neurodegenerative process. Infectious agent-derived pathogen-assoc...

    Authors: Tal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein and Tamir Ben-Hur
    Citation: Journal of Neuroinflammation 2022 19:5
  35. Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within the centr...

    Authors: Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos and Kulmira Nurgali
    Citation: Journal of Neuroinflammation 2022 19:4
  36. Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically targeting the CSF1R rece...

    Authors: Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto and Yu Luo
    Citation: Journal of Neuroinflammation 2022 19:3
  37. Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country’s mental health treatment cost. Although anxiolytic therapies are available, many pat...

    Authors: Alzahra J. Al Omran, Amy S. Shao, Saki Watanabe, Zeyu Zhang, Jifeng Zhang, Chen Xue, Junji Watanabe, Daryl L. Davies, Xuesi M. Shao and Jing Liang
    Citation: Journal of Neuroinflammation 2022 19:2
  38. Abnormal expression of long noncoding RNAs (lncRNAs) has been reported in the acute stage of acute ischemic stroke (AIS). This study aimed to explore differential lncRNA expression in the subpopulations of per...

    Authors: Huiling Sun, Shuo Li, Zhaohan Xu, Chengfang Liu, Pengyu Gong, Qiwen Deng and Fuling Yan
    Citation: Journal of Neuroinflammation 2022 19:1
  39. Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer’s disease (AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective effects of...

    Authors: Weijun Ou, Joshua Yang, Juste Simanauskaite, Matthew Choi, Demi M. Castellanos, Rudy Chang, Jiahong Sun, Nataraj Jagadeesan, Karen D. Parfitt, David H. Cribbs and Rachita K. Sumbria
    Citation: Journal of Neuroinflammation 2021 18:312
  40. Mechanical ventilation of preterm newborns causes lung injury and is associated with poor neurodevelopmental outcomes. However, the mechanistic links between ventilation-induced lung injury (VILI) and brain in...

    Authors: Laura Chavez, Julia Meguro, Shaoyi Chen, Vanessa Nunes de Paiva, Ronald Zambrano, Julia M. Eterno, Rahul Kumar, Matthew R. Duncan, Merline Benny, Karen C. Young, W. Dalton Dietrich, Roberta Brambilla, Shu Wu and Augusto F. Schmidt
    Citation: Journal of Neuroinflammation 2021 18:310
  41. Authors: Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang and Hong Ma
    Citation: Journal of Neuroinflammation 2021 18:309

    The original article was published in Journal of Neuroinflammation 2018 15:250

  42. The association of lipoprotein(a) [Lp(a)] and stroke functional outcomes was conflicting. The aim of the study was to clarify whether high Lp(a) is associated with unfavorable functional outcomes in patients w...

    Authors: Xue Jiang, Jie Xu, Xiwa Hao, Jing Xue, Ke Li, Aoming Jin, Jinxi Lin, Xia Meng, Lemin Zheng and Yongjun Wang
    Citation: Journal of Neuroinflammation 2021 18:307
  43. Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of...

    Authors: Beatriz G. Perez-Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vazquez-Villasenor, Maria Jimenez-Sanchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo and Wendy Noble
    Citation: Journal of Neuroinflammation 2021 18:306
  44. Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocyt...

    Authors: Miranda M. Standiford, Ethan M. Grund and Charles L. Howe
    Citation: Journal of Neuroinflammation 2021 18:305
  45. Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge ...

    Authors: Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa and Keisuke Yoshikawa
    Citation: Journal of Neuroinflammation 2021 18:304
  46. Spinal cord injury elicits widespread inflammation that can exacerbate long-term neurologic deficits. Neutrophils are the most abundant immune cell type to invade the spinal cord in the early acute phase after...

    Authors: Dylan A. McCreedy, Clare L. Abram, Yongmei Hu, Sun Won Min, Madison E. Platt, Megan A. Kirchhoff, Shelby K. Reid, Frank L. Jalufka and Clifford A. Lowell
    Citation: Journal of Neuroinflammation 2021 18:302

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