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  1. Content type: Research

    Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia...

    Authors: Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu and Gang Hu

    Citation: Journal of Neuroinflammation 2018 15:193

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  2. Content type: Research

    Neuroinflammation accompanies neural trauma and most neurological diseases. Axotomy in the peripheral nervous system (PNS) leads to dramatic changes in the injured neuron: the cell body expresses a distinct se...

    Authors: Jane A. Lindborg, Jon P. Niemi, Madeline A. Howarth, Kevin W. Liu, Christian Z. Moore, Deepti Mahajan and Richard E. Zigmond

    Citation: Journal of Neuroinflammation 2018 15:192

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  3. Content type: Case study

    The perinatal period carries the highest risk for stroke in childhood; however, the pathophysiology is poorly understood and preventive, prognostic, and therapeutic strategies are not available. A new pathophy...

    Authors: Anna Bajnok, László Berta, Csaba Orbán, Tivadar Tulassay and Gergely Toldi

    Citation: Journal of Neuroinflammation 2018 15:191

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  4. Content type: Research

    Chronic noise exposure is associated with neuroinflammation and gut microbiota dysregulation and increases the risk of Alzheimer’s disease (AD). Environmental hazards are also thought to be associated with gen...

    Authors: Bo Cui, Donghong Su, Wenlong Li, Xiaojun She, Ming Zhang, Rui Wang and Qingfeng Zhai

    Citation: Journal of Neuroinflammation 2018 15:190

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  5. Content type: Research

    Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential f...

    Authors: Afrânio Ferreira Evangelista, Marcos André Vannier-Santos, Gessica Sabrina de Assis Silva, Daniela Nascimento Silva, Paulo José Lima Juiz, Carolina Kymie Vasques Nonaka, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares and Cristiane Flora Villarreal

    Citation: Journal of Neuroinflammation 2018 15:189

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  6. Content type: Research

    At low levels, carbon monoxide (CO) has been shown to have beneficial effects on multiple organs and tissues through its potential anti-inflammatory, anti-apoptotic, and anti-proliferative properties. However,...

    Authors: Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang and Jian Wang

    Citation: Journal of Neuroinflammation 2018 15:188

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  7. Content type: Research

    Management of neuropathic pain is a real clinical challenge. Despite intense investigation, the mechanisms of neuropathic pain remain substantially unidentified. Matrix metalloproteinase (MMP)-9 and MMP-2 have...

    Authors: Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wen-Tao Liu, Liang Hu and Yinbing Pan

    Citation: Journal of Neuroinflammation 2018 15:187

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  8. Content type: Research

    Neonatal hypoxic-ischemic brain damage, characterized by tissue loss and neurologic dysfunction, is a leading cause of mortality and a devastating disease of the central nervous system. We have previously show...

    Authors: Wen-di Luo, Jia-wei Min, Wen-Xian Huang, Xin Wang, Yuan-yuan Peng, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He and Bi-Wen Peng

    Citation: Journal of Neuroinflammation 2018 15:186

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  9. Content type: Research

    Amplified inflammation is important for the progression of Parkinson’s disease (PD). However, how this enhanced inflammation is regulated remains largely unknown. Deletion of DICER leads to progressive dopamin...

    Authors: Qing Wang, Qian He, Yifei Chen, Wei Shao, Chao Yuan and Yizheng Wang

    Citation: Journal of Neuroinflammation 2018 15:184

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  10. Content type: Research

    The oral immunomodulatory agent laquinimod is currently evaluated for multiple sclerosis (MS) treatment. Phase II and III studies demonstrated a reduction of degenerative processes. In addition to anti-inflamm...

    Authors: Anna T. Wilmes, Sabrina Reinehr, Sandra Kühn, Xiomara Pedreiturria, Laura Petrikowski, Simon Faissner, Ilya Ayzenberg, Gesa Stute, Ralf Gold, H. Burkhard Dick, Ingo Kleiter and Stephanie C. Joachim

    Citation: Journal of Neuroinflammation 2018 15:183

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  11. Content type: Research

    Alzheimer’s disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molec...

    Authors: J. Vérité, T. Janet, D. Chassaing, B. Fauconneau, H. Rabeony and G. Page

    Citation: Journal of Neuroinflammation 2018 15:182

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  12. Content type: Research

    Since its inception in 2001, in utero electroporation (IUE) has been widely used by the neuroscience community. IUE is a technique developed to introduce plasmid DNA into embryonic mouse brains without permane...

    Authors: Jessica M. Rosin and Deborah M. Kurrasch

    Citation: Journal of Neuroinflammation 2018 15:181

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  13. Content type: Research

    Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms l...

    Authors: Jing Sun, Xiaoyu Pan, Line I. Christiansen, Xiao-Long Yuan, Kerstin Skovgaard, Dereck E. W. Chatterton, Sanne S. Kaalund, Fei Gao, Per T. Sangild and Stanislava Pankratova

    Citation: Journal of Neuroinflammation 2018 15:180

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  14. Content type: Research

    microRNA-146a-5p (miRNA-146a-5p) is a key molecule in the negative regulation pathway of TLRs and IL-1 receptor (TIR) signaling. Our recent study demonstrated that MyD88-dependent signaling pathway of TIR in t...

    Authors: Zhiyao Wang, Fan Liu, Min Wei, Yue Qiu, Chao Ma, Le Shen and Yuguang Huang

    Citation: Journal of Neuroinflammation 2018 15:179

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  15. Content type: Research

    Neuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely related to patient prognosis. Recently, angiogeni...

    Authors: Qiquan Zhu, Budbazar Enkhjargal, Lei Huang, Tongyu Zhang, Chengmei Sun, Zhiyi Xie, Pei Wu, Jun Mo, Jiping Tang, Zongyi Xie and John H. Zhang

    Citation: Journal of Neuroinflammation 2018 15:178

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  16. Content type: Research

    Interleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the vicious cycle of inflammation by inducing the expression of various other pro-inflammatory cy...

    Authors: Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha and Anirban Basu

    Citation: Journal of Neuroinflammation 2018 15:177

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    The Correction to this article has been published in Journal of Neuroinflammation 2018 15:317

  17. Content type: Research

    Diabetic neuropathic pain (DNP) is a common and distressing complication in patients with diabetes, and the underlying mechanism remains unclear. Tricyclic antidepressants (TCAs) and serotonin and norepinephri...

    Authors: Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye and You-Zhi Zhang

    Citation: Journal of Neuroinflammation 2018 15:176

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  18. Content type: Research

    Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the resistance of the CNS against infections. We studie...

    Authors: Catharina Diesselberg, Sandra Ribes, Jana Seele, Annika Kaufmann, Sandra Redlich, Stephanie Bunkowski, Uwe-Karsten Hanisch, Uwe Michel, Roland Nau and Sandra Schütze

    Citation: Journal of Neuroinflammation 2018 15:175

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  19. Content type: Research

    Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative functions, may facilitate research towards curing neurode...

    Authors: Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts and Mathias Hoehn

    Citation: Journal of Neuroinflammation 2018 15:174

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  20. Content type: Research

    Cerebral malaria (CM) is the most lethal outcome of Plasmodium infection. There are clear correlations between expression of inflammatory cytokines, severe coagulopathies, and mortality in human CM. However, the ...

    Authors: Kyle D. Wilson, Lorenzo F. Ochoa, Olivia D. Solomon, Rahul Pal, Sandra M. Cardona, Victor H. Carpio, Philip H. Keiser, Astrid E. Cardona, Gracie Vargas and Robin Stephens

    Citation: Journal of Neuroinflammation 2018 15:173

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  21. Content type: Research

    Chronic neuroinflammation is a hallmark of Parkinson’s disease (PD) pathophysiology, associated with increased levels of pro-inflammatory factors in PD brain tissues. The pro-inflammatory mediator and highly a...

    Authors: Istvan Horvath, Igor A. Iashchishyn, Roman A. Moskalenko, Chao Wang, Sebastian K. T. S. Wärmländer, Cecilia Wallin, Astrid Gräslund, Gabor G. Kovacs and Ludmilla A. Morozova-Roche

    Citation: Journal of Neuroinflammation 2018 15:172

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  22. Content type: Research

    Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examinati...

    Authors: John D. Lee, Samantha C. Levin, Emily F. Willis, Rui Li, Trent M. Woodruff and Peter G. Noakes

    Citation: Journal of Neuroinflammation 2018 15:171

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  23. Content type: Research

    While most patients with Alzheimer’s disease (AD) present with memory complaints, 30% of patients with early disease onset present with non-amnestic symptoms. This atypical presentation is thought to be caused...

    Authors: Baayla D. C. Boon, Jeroen J. M. Hoozemans, Boaz Lopuhaä, Kristel N. Eigenhuis, Philip Scheltens, Wouter Kamphorst, Annemieke J. M. Rozemuller and Femke H. Bouwman

    Citation: Journal of Neuroinflammation 2018 15:170

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  24. Content type: Correction

    After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats of the manuscript as Luke D. Fisher.

    Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf and Caryl E. Sortwell

    Citation: Journal of Neuroinflammation 2018 15:169

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    The original article was published in Journal of Neuroinflammation 2018 15:129

  25. Content type: Research

    Activated microglia play an essential role in inflammatory responses elicited in the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are suggested to be involved in propagation of ...

    Authors: Yiyi Yang, Antonio Boza-Serrano, Christopher J. R. Dunning, Bettina Hjelm Clausen, Kate Lykke Lambertsen and Tomas Deierborg

    Citation: Journal of Neuroinflammation 2018 15:168

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  26. Content type: Research

    Remote ischemic preconditioning (RIPC) of a limb has been reported to protect against ischemic stroke. Our previous results demonstrated that the RIPC-mediated neuroprotection is associated with alterations in...

    Authors: Chen Chen, Wei Jiang, Zongjian Liu, Fengwu Li, Jian Yang, Yanlong Zhao, Yuanyuan Ran, Yan Meng, Xunming Ji, Xiaokun Geng, Huishan Du and Xiaoming Hu

    Citation: Journal of Neuroinflammation 2018 15:167

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  27. Content type: Research

    A wealth of evidence implicates both central and peripheral immune changes as contributing to the pathogenesis of Parkinson’s disease (PD). It is critical to better understand this aspect of PD given that it i...

    Authors: C. H. Williams-Gray, R. S. Wijeyekoon, K. M. Scott, S. Hayat, R. A. Barker and J. L. Jones

    Citation: Journal of Neuroinflammation 2018 15:166

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  28. Content type: Research

    In contrast to mammals, zebrafish have the capacity to regenerate retinal neurons following a variety of injuries. Two types of glial cells, Müller glia (MG) and microglia, are known to exist in the zebrafish ...

    Authors: Diana M. Mitchell, Anna G. Lovel and Deborah L. Stenkamp

    Citation: Journal of Neuroinflammation 2018 15:163

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  29. Content type: Research

    Over the past 30 years, evidence has been accumulating for an immunological component to schizophrenia etiology, including genetic links to the major histocompatibility complex, microglia activation, and dysre...

    Authors: Tyler A. Lesh, Milo Careaga, Destanie R. Rose, A. Kimberley McAllister, Judy Van de Water, Cameron S. Carter and Paul Ashwood

    Citation: Journal of Neuroinflammation 2018 15:165

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  30. Content type: Research

    Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA). Interleukin-1β (IL-1β), a master regulator of...

    Authors: Laura Facci, Massimo Barbierato, Morena Zusso, Stephen D. Skaper and Pietro Giusti

    Citation: Journal of Neuroinflammation 2018 15:164

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  31. Content type: Research

    Parkinson’s disease (PD) is characterized by dopaminergic cell loss and inflammation in the substantia nigra (SN) leading to motor deficits but also to hippocampus-associated non-motor symptoms such as spatial...

    Authors: Elisabeth G. Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz and Barbara Steiner

    Citation: Journal of Neuroinflammation 2018 15:162

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  32. Content type: Research

    Microglia-mediated neuroinflammation is recognized to mainly contribute to the pathogenesis of Parkinson’s disease (PD). Tetrahydroxystilbene glucoside (TSG) has been proved to be beneficial for health with a ...

    Authors: Yanzhen Zhou, Guoqing Wang, Daidi Li, Yanying Wang, Qin Wu, Jingshan Shi and Feng Zhang

    Citation: Journal of Neuroinflammation 2018 15:161

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  33. Content type: Research

    The gold standard in cerebrospinal fluid (CSF) cell immunophenotyping is flow cytometry. Nevertheless, the small amount of CSF cells and the invasive character of lumbar puncture limit the spectrum of possible...

    Authors: Martin W. Hümmert, Sascha Alvermann, Stefan Gingele, Catharina C. Gross, Heinz Wiendl, Anja Mirenska, Christian Hennig and Martin Stangel

    Citation: Journal of Neuroinflammation 2018 15:160

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  34. Content type: Research

    Pyrethroids, such as bifenthrin (BF), are among the most widely used class of insecticides that pose serious risks to human and wildlife health. Pyrethroids are proposed to affect astrocytic functions and to c...

    Authors: Brahim Gargouri, Nizar M. Yousif, Michèle Bouchard, Hamadi Fetoui and Bernd L. Fiebich

    Citation: Journal of Neuroinflammation 2018 15:159

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  35. Content type: Research

    Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially releva...

    Authors: Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard and Julián Romero

    Citation: Journal of Neuroinflammation 2018 15:158

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  36. Content type: Research

    Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and by degrading tight junctions. Acute severe hypoglycemia induces a proinflammatory environment that may contribute to a ...

    Authors: Fei Zhao, Jiangshan Deng, Xiaofeng Xu, Fengya Cao, Kaili Lu, Dawei Li, Xiaojuan Cheng, Xiuzhe Wang and Yuwu Zhao

    Citation: Journal of Neuroinflammation 2018 15:157

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  37. Content type: Research

    Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and m...

    Authors: Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann and Kirsten Glaser

    Citation: Journal of Neuroinflammation 2018 15:156

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  38. Content type: Research

    Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two s...

    Authors: Shun Xu, Wei Zhu, Minghao Shao, Fan Zhang, Ji Guo, Haocheng Xu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia, Xiuling Zhi, Ping Zhou and Feizhou Lu

    Citation: Journal of Neuroinflammation 2018 15:155

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  39. Content type: Research

    Traumatic brain injury (TBI) begins with the application of mechanical force to the head or brain, which initiates systemic and cellular processes that are hallmarks of the disease. The pathological cascade of...

    Authors: Rachel K. Rowe, Jordan L. Harrison, Hongtao Zhang, Adam D. Bachstetter, David P. Hesson, Bruce F. O’Hara, Mark I. Greene and Jonathan Lifshitz

    Citation: Journal of Neuroinflammation 2018 15:154

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  40. Content type: Research

    Microglia play key roles in neuron–glia interaction, neuroinflammation, neural repair, and neurotoxicity. Currently, various microglial in vitro models including primary microglia derived from distinct isolati...

    Authors: Yingbo He, Xiang Yao, Natalie Taylor, Yuchen Bai, Timothy Lovenberg and Anindya Bhattacharya

    Citation: Journal of Neuroinflammation 2018 15:153

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  41. Content type: Research

    Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine ...

    Authors: Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang and Wen-Ning Wu

    Citation: Journal of Neuroinflammation 2018 15:152

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  42. Content type: Case report

    Rheumatoid meningitis (RM) is a rare disorder that often develops during a remission phase of rheumatoid arthritis (RA). This is the first study to demonstrate differences in regard to immunological disturbanc...

    Authors: Miki Oono, Yoshimasa Fujita, Nobuaki Uchida, Ukichiro Kawai, Michiyo Fujita-Nakata, Megumi Nakanishi, Mitsuru Sanada, Shigemi Nagayama and Makoto Matsui

    Citation: Journal of Neuroinflammation 2018 15:151

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  43. Content type: Research

    Microglial polarization with M1/M2 phenotype shifts and the subsequent neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI)-induced secondary injury. Nuclear factor-κB (NF-κB...

    Authors: Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu and Shun Li

    Citation: Journal of Neuroinflammation 2018 15:150

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  44. Content type: Research

    Activation of transforming growth factor-β-activated kinase 1 (TAK1) occurs after stroke and leads to an exacerbation of brain injury. TAK1 is involved in innate and adaptive immune responses, but it has diver...

    Authors: Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C. Koellhoffer, Anthony Patrizz, Rodney M. Ritzel, Bhanu P. Ganesh and Louise D. McCullough

    Citation: Journal of Neuroinflammation 2018 15:148

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  45. Content type: Research

    Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without ...

    Authors: Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong and Raymond Chuen Chung Chang

    Citation: Journal of Neuroinflammation 2018 15:147

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  46. Content type: Review

    Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites ...

    Authors: Yang-Wuyue Liu, Song Li and Shuang-Shuang Dai

    Citation: Journal of Neuroinflammation 2018 15:146

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  47. Content type: Research

    Immune checkpoint inhibitors have been shown to promote antitumor immunity and achieve durable tumor remissions. However, certain tumors are refractory to current immunotherapy. These negative results encourag...

    Authors: Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li and Chang-Xiang Yan

    Citation: Journal of Neuroinflammation 2018 15:145

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