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  1. Based on their potent anti-inflammatory properties and a preliminary clinical trial, statins (HMG-CoA reductase inhibitors) are being studied as possible candidates for multiple sclerosis (MS) therapy. The pat...

    Authors: Esther Zeinstra, Nadine Wilczak, Daniel Chesik, Lisa Glazenburg, Frans GM Kroese and Jacques De Keyser
    Citation: Journal of Neuroinflammation 2006 3:16
  2. The cytokines IL-1α and IL-1β are induced rapidly after insults to the CNS, and their subsequent signaling through the type 1 IL-1 receptor (IL-1R1) has been regarded as essential for a normal astroglial and m...

    Authors: Hsiao-Wen Lin, Anirban Basu, Charles Druckman, Michael Cicchese, J Kyle Krady and Steven W Levison
    Citation: Journal of Neuroinflammation 2006 3:15
  3. Immunotherapy for Alzheimer's disease (AD) is emerging as a potential treatment. However, a clinical trial (AN1792) was halted after adverse effects occurred in a small subset of subjects, which may have been ...

    Authors: Timothy J Seabrook, Liying Jiang, Katelyn Thomas and Cynthia A Lemere
    Citation: Journal of Neuroinflammation 2006 3:14
  4. Multiple sclerosis (MS) is a central nervous system-specific autoimmune, demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive, myelin-specific CD4+Th1 cells correlates with cl...

    Authors: Dusanka S Skundric, Juan Cai, William W Cruikshank and Djordje Gveric
    Citation: Journal of Neuroinflammation 2006 3:13
  5. Stroke is one of the leading causes of death worldwide and a major cause of morbidity and mortality in the United States of America. Brain ischemia-reperfusion (IR) triggers a complex series of biochemical eve...

    Authors: Manu Jatana, Shailendra Giri, Mubeen A Ansari, Chinnasamy Elango, Avtar K Singh, Inderjit Singh and Mushfiquddin Khan
    Citation: Journal of Neuroinflammation 2006 3:12
  6. Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune ac...

    Authors: Niki C Carty, Donna M Wilcock, Arnon Rosenthal, Jan Grimm, Jaume Pons, Victoria Ronan, Paul E Gottschall, Marcia N Gordon and Dave Morgan
    Citation: Journal of Neuroinflammation 2006 3:11
  7. Inheritance of the three different alleles of the human apolipoprotein (apo) E gene (APOE) are associated with varying risk or clinical outcome from a variety of neurologic diseases. ApoE isoform-specific modulat...

    Authors: Izumi Maezawa, Nobuyo Maeda, Thomas J Montine and Kathleen S Montine
    Citation: Journal of Neuroinflammation 2006 3:10
  8. C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological activities through interaction with two G protein-coupled receptors named C3aR and...

    Authors: Anne-christine Jauneau, Alexander Ischenko, Alexandra Chatagner, Magalie Benard, Philippe Chan, Marie-therese Schouft, Christine Patte, Hubert Vaudry and Marc Fontaine
    Citation: Journal of Neuroinflammation 2006 3:8
  9. Alzheimer's disease is a neurodegenerative disorder characterized by a progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately the death of neurons. The amyloid hypothesis prop...

    Authors: Clive Bate, Sarah Kempster, Victoria Last and Alun Williams
    Citation: Journal of Neuroinflammation 2006 3:7
  10. Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specificall...

    Authors: Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V Nguyen, Randy L Hunter and Guoying Bing
    Citation: Journal of Neuroinflammation 2006 3:6
  11. Clinical and neuropathological overlap between Alzheimer's (AD) and Parkinson's disease (PD) is now well recognized. Such cases of concurrent AD and Lewy body disease (AD/LBD) show neuropathological changes th...

    Authors: W Sue T Griffin, Ling Liu, Yuekui Li, Robert E Mrak and Steven W Barger
    Citation: Journal of Neuroinflammation 2006 3:5
  12. Oxidative stress is believed to be an early event and a key factor in Alzheimer's disease (AD) pathogenesis and progression. In spite of an intensive search for surrogate markers to monitor changes related to ...

    Authors: Luisa Minghetti, Anita Greco, Maria Puopolo, Marc Combrinck, Donald Warden and A David Smith
    Citation: Journal of Neuroinflammation 2006 3:4
  13. We have previously shown that transgenic mice carrying a mutant human APP but deficient in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower amount of deposited Aβ. Furthermore...

    Authors: Vincent Laporte, Ghania Ait-Ghezala, Claude-Henry Volmar and Michael Mullan
    Citation: Journal of Neuroinflammation 2006 3:3
  14. Detailed study of glial inflammation has been hindered by lack of cell culture systems that spontaneously demonstrate the "neuroinflammatory phenotype". Mice expressing a glycine → alanine substitution in cyto...

    Authors: Kenneth Hensley, Haitham Abdel-Moaty, Jerrod Hunter, Molina Mhatre, Shenyun Mou, Kim Nguyen, Tamara Potapova, Quentin N Pye, Min Qi, Heather Rice, Charles Stewart, Katharine Stroukoff and Melinda West
    Citation: Journal of Neuroinflammation 2006 3:2
  15. Evidence exists suggesting that the immune system may contribute to the severity of idiopathic Parkinson's disease (IPD). The data presented here demonstrates that antibodies in the sera of patients with IPD h...

    Authors: Victor C Huber, Tapan Mondal, Stewart A Factor, Richard F Seegal and David A Lawrence
    Citation: Journal of Neuroinflammation 2006 3:1
  16. Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), and HIV dementia. It is well known that inflammatory med...

    Authors: Jared Ehrhart, Demian Obregon, Takashi Mori, Huayan Hou, Nan Sun, Yun Bai, Thomas Klein, Francisco Fernandez, Jun Tan and R Douglas Shytle
    Citation: Journal of Neuroinflammation 2005 2:29
  17. Alzheimer's disease, a common dementia of the elder, is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic poss...

    Authors: Jun Zhou, Maria I Fonseca, Rakez Kayed, Irma Hernandez, Scott D Webster, Ozkan Yazan, David H Cribbs, Charles G Glabe and Andrea J Tenner
    Citation: Journal of Neuroinflammation 2005 2:28
  18. Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein e...

    Authors: Jeroen JM Hoozemans, Elise S van Haastert, Robert Veerhuis, Thomas Arendt, Wiep Scheper, Piet Eikelenboom and Annemieke JM Rozemuller
    Citation: Journal of Neuroinflammation 2005 2:27
  19. The aim of the present study was to examine inflammatory responses during Wallerian degeneration in rat peripheral nerve when the regrowth of axons was prevented by suturing.

    Authors: Saku Ruohonen, Mohsen Khademi, Maja Jagodic, Hanna-Stiina Taskinen, Tomas Olsson and Matias Röyttä
    Citation: Journal of Neuroinflammation 2005 2:26
  20. Propagated tissue degeneration, especially during aging, has been shown to be enhanced through potentiation of innate immune responses. Neurodegenerative diseases and a wide variety of inflammatory conditions ...

    Authors: Jari Huuskonen, Tiina Suuronen, Riitta Miettinen, Thomas van Groen and Antero Salminen
    Citation: Journal of Neuroinflammation 2005 2:25
  21. Alzheimer's disease is a complex neurodegenerative disorder characterized pathologically by a temporal and spatial progression of beta-amyloid (Aβ) deposition, neurofibrillary tangle formation, and synaptic de...

    Authors: Michelle C Janelsins, Michael A Mastrangelo, Salvatore Oddo, Frank M LaFerla, Howard J Federoff and William J Bowers
    Citation: Journal of Neuroinflammation 2005 2:23
  22. Inflammation is suspected to contribute to the progression and severity of neurodegeneration in Alzheimer's disease (AD). Transgenic mice overexpressing the london mutant of amyloid precursor protein, APP [V71...

    Authors: Michael T Heneka, Magdalena Sastre, Lucia Dumitrescu-Ozimek, Ilse Dewachter, Jochen Walter, Thomas Klockgether and Fred Van Leuven
    Citation: Journal of Neuroinflammation 2005 2:22
  23. Alzheimer's disease (AD) pathology shows characteristic 'plaques' rich in amyloid beta (Aβ) peptide deposits. Inflammatory process-related proteins such as pro-inflammatory cytokines have been detected in AD b...

    Authors: Kamesh R Ayasolla, Shailendra Giri, Avtar K Singh and Inderjit Singh
    Citation: Journal of Neuroinflammation 2005 2:21
  24. Inflammation-activated glia are seen in many CNS pathologies and may kill neurons through the release of cytotoxic mediators, such as nitric oxide from inducible NO synthase (iNOS), and possibly superoxide fro...

    Authors: Palwinder Mander and Guy C Brown
    Citation: Journal of Neuroinflammation 2005 2:20
  25. Inflammation and oxidative stress play a critical role in neurodegeneration associated with acute and chronic insults of the nervous system. Notably, affected neurons are often responsive to and dependent on t...

    Authors: Michael S Thomas, WenRu Zhang, Paivi M Jordan, H Uri Saragovi and Giulio Taglialatela
    Citation: Journal of Neuroinflammation 2005 2:19
  26. Recent studies have suggested that passive or active immunization with anti-amyloid β peptide (Aβ) antibodies may enhance microglial clearance of Aβ deposits from the brain. However, in a human clinical trial,...

    Authors: Ronald Strohmeyer, Carl J Kovelowski, Diego Mastroeni, Brian Leonard, Andrew Grover and Joseph Rogers
    Citation: Journal of Neuroinflammation 2005 2:18
  27. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). It is associated with local activation of microglia and astroglia, infiltration of activated macrophages and T cel...

    Authors: Dan Sunnemark, Sana Eltayeb, Maria Nilsson, Erik Wallström, Hans Lassmann, Tomas Olsson, Anna-Lena Berg and Anders Ericsson-Dahlstrand
    Citation: Journal of Neuroinflammation 2005 2:17
  28. There is evidence that the kynurenine pathway (KP) and particularly one of its end products, quinolinic acid (QUIN) play a role in the pathogenesis of several major neuroinflammatory diseases, and more particu...

    Authors: Gilles J Guillemin, Lily Wang and Bruce J Brew
    Citation: Journal of Neuroinflammation 2005 2:16
  29. Interleukin 1 (IL-1) is a key mediator of immune responses in health and disease. Although classically the function of IL-1 has been studied in the systemic immune system, research in the past decade has revea...

    Authors: Jeffrey M Craft, D Martin Watterson, Emmet Hirsch and Linda J Van Eldik
    Citation: Journal of Neuroinflammation 2005 2:15
  30. The role of both microglial activation and alpha-synuclein deposition in Parkinson's disease remain unclear. We have tested the hypothesis that if microglia play a primary role in Parkinson's disease pathogene...

    Authors: Emilie Croisier, Linda B Moran, David T Dexter, Ronald KB Pearce and Manuel B Graeber
    Citation: Journal of Neuroinflammation 2005 2:14

    The Research to this article has been published in Journal of Neuroinflammation 2006 3:9

  31. In the nervous system, as in other organs, Cu/Zn superoxide dismutase (Cu/Zn SOD) is a key antioxidant enzyme involved in superoxide detoxification in normal cellular metabolism and after cell injury. Although...

    Authors: Hugo Peluffo, Laia Acarin, Maryam Faiz, Bernardo Castellano and Berta Gonzalez
    Citation: Journal of Neuroinflammation 2005 2:12
  32. Calcium-sensitive fluorescence microscopy and molecular biology analysis have been used to study the effects of platelet-activating factor (PAF) on intracellular calcium [Ca2+]i and IL-6 expression in human micro...

    Authors: Prasongchai Sattayaprasert, Hyun B Choi, Sukumal Chongthammakun and James G McLarnon
    Citation: Journal of Neuroinflammation 2005 2:11
  33. Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogene...

    Authors: Kuriko Kagitani-Shimono, Ikuko Mohri, Yasushi Fujitani, Kinuko Suzuki, Keiichi Ozono, Yoshihiro Urade and Masako Taniike
    Citation: Journal of Neuroinflammation 2005 2:10
  34. Inflammation is believed to play an important role in the pathology of Alzheimer's disease (AD) and cytokine production is a key pathologic event in the progression of inflammatory cascades. The current study ...

    Authors: Nikunj S Patel, Daniel Paris, Venkatarajan Mathura, Amita N Quadros, Fiona C Crawford and Michael J Mullan
    Citation: Journal of Neuroinflammation 2005 2:9
  35. In neuropathological processes associated with neutrophilic infiltrates, such as experimental allergic encephalitis and traumatic injury of the brain, the CXC chemokine, macrophage inflammatory protein-2 (MIP-...

    Authors: Michiyo Tomita, Brita J Holman, Christopher P Santoro and Thomas J Santoro
    Citation: Journal of Neuroinflammation 2005 2:8
  36. Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. T...

    Authors: David R Harding, Sukhbir Dhamrait, David Devadason, Steve E Humphries, Andrew Whitelaw, Neil Marlow and Hugh E Montgomery
    Citation: Journal of Neuroinflammation 2005 2:6
  37. Subventricular microglia (SVMs) are positioned at the interface of the cerebrospinal fluid and brain parenchyma and may play a role in periventricular inflammatory reactions. However, SVMs have not been previo...

    Authors: W Shawn Carbonell, Shin-Ichi Murase, Alan F Horwitz and James W Mandell
    Citation: Journal of Neuroinflammation 2005 2:5
  38. Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system. However, the α...

    Authors: Roberta De Simone, Maria Antonietta Ajmone-Cat, Daniela Carnevale and Luisa Minghetti
    Citation: Journal of Neuroinflammation 2005 2:4
  39. Previous studies suggest that the cyclooxygenase-2 (COX-2) inhibitor nimesulide has a remarkable protective effect against different types of brain injury including ischemia. Since there are no reports on the ...

    Authors: Eduardo Candelario-Jalil, Noël H Mhadu, Armando González-Falcón, Michel García-Cabrera, Eduardo Muñoz, Olga Sonia León and Bernd L Fiebich
    Citation: Journal of Neuroinflammation 2005 2:3
  40. Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well pa...

    Authors: Donna M Wilcock, Amyn Rojiani, Arnon Rosenthal, Sangeetha Subbarao, Melissa J Freeman, Marcia N Gordon and Dave Morgan
    Citation: Journal of Neuroinflammation 2004 1:24
  41. Recent studies suggest that hypercholesterolemia, an established risk factor for atherosclerosis, is also a risk factor for Alzheimer's disease. The myeloid scavenger receptor CD36 binds oxidized lipoproteins ...

    Authors: Vidya V Kunjathoor, Anita A Tseng, Lea A Medeiros, Tayeba Khan and Kathryn J Moore
    Citation: Journal of Neuroinflammation 2004 1:23
  42. Mental fatigue, with decreased concentration capacity, is common in neuroinflammatory and neurodegenerative diseases, often appearing prior to other major mental or physical neurological symptoms. Mental fatig...

    Authors: Lars Rönnbäck and Elisabeth Hansson
    Citation: Journal of Neuroinflammation 2004 1:22
  43. An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimer's disease (AD). The relevance of their interaction in vivo, however, is unknown. Previous...

    Authors: Yuemang Yao, Cinzia Chinnici, Hanguan Tang, John Q Trojanowski, Virginia MY Lee and Domenico Praticò
    Citation: Journal of Neuroinflammation 2004 1:21
  44. The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate...

    Authors: Dejan Milatovic, Snjezana Zaja-Milatovic, Kathleen S Montine, Feng-Shiun Shie and Thomas J Montine
    Citation: Journal of Neuroinflammation 2004 1:20

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