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  1. Dimethyl fumarate (DMF) is a fumaric acid ester that exhibits immunoregulatory and anti-inflammatory properties. However, the function of DMF in autoimmune uveitis (AU) is incompletely understood, and studies ...

    Authors: Lei Zhu, He Li, Xuening Peng, Zhaohuai Li, Sichen Zhao, Dongting Wu, Jialing Chen, Si Li, Renbing Jia, Zuohong Li and Wenru Su
    Citation: Journal of Neuroinflammation 2024 21:112
  2. It is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier (BBB) breakdown. However, whether the bone-brain axis participates in this...

    Authors: Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qingrong Lin, Yanjun Hu, Nan Jiang and Bin Yu
    Citation: Journal of Neuroinflammation 2024 21:111
  3. Identifying individuals with intracranial injuries following mild traumatic brain injury (mTBI), i.e. complicated mTBI cases, is important for follow-up and prognostication. The main aims of our study were (1)...

    Authors: Gerard Janez Brett Clarke, Turid Follestad, Toril Skandsen, Henrik Zetterberg, Anne Vik, Kaj Blennow, Alexander Olsen and Asta Kristine Håberg
    Citation: Journal of Neuroinflammation 2024 21:109
  4. Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressiv...

    Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk and Caryl E. Sortwell
    Citation: Journal of Neuroinflammation 2024 21:108
  5. Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic protein neurogranin (Nrgn) is significantly reduced in the f...

    Authors: Roberta S. dos Reis, Marc C. E. Wagner, Savannah McKenna and Velpandi Ayyavoo
    Citation: Journal of Neuroinflammation 2024 21:107
  6. Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these p...

    Authors: Xiangyang Deng, Junwei Ren, Kezhu Chen, Jin Zhang, Quan Zhang, Jun Zeng, Tianwen Li, Qisheng Tang, Jian Lin and Jianhong Zhu
    Citation: Journal of Neuroinflammation 2024 21:106
  7. NADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity of the blood-retinal barrier. Abnormalities in neurovascular-coupled im...

    Authors: Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li and Verena Prokosch
    Citation: Journal of Neuroinflammation 2024 21:105
  8. Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as a hallmark of POCD. However, safe and e...

    Authors: Xiangyi Kong, Wenyuan Lyu, Xiaojie Lin, Chunlong Lin, Hao Feng, Lin Xu, Kaiyue Shan, Penghui Wei and Jianjun Li
    Citation: Journal of Neuroinflammation 2024 21:104
  9. Colony stimulating factor 1 receptor (CSF1R) signaling is crucial for the maintenance and function of various myeloid subsets. CSF1R antagonism was previously shown to mitigate clinical severity in experimenta...

    Authors: Marilyn Wang, Sofia E. Caryotakis, Glendalyn G. Smith, Alan V. Nguyen, David E. Pleasure and Athena M. Soulika
    Citation: Journal of Neuroinflammation 2024 21:103
  10. The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous...

    Authors: Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng and Yujie Chen
    Citation: Journal of Neuroinflammation 2024 21:102
  11. Increased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both human and animal studies suggests a link between hypertension and gut mic...

    Authors: Xiaopeng Yin, Changhao Duan, Lin Zhang, Yufang Zhu, Yueyao Qiu, Kaiyi Shi, Sen Wang, Xiaoguang Zhang, Huaxing Zhang, Yinchao Hao, Fang Yuan and Yanming Tian
    Citation: Journal of Neuroinflammation 2024 21:101
  12. Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangl...

    Authors: Kevin Budding, Jeroen W. Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Eva M. Zekveld, Ewout J.N. Groen, Bart C. Jacobs, Ruth Huizinga, H. Stephan Goedee, Elisabeth A. Cats, Jeanette H.W. Leusen, Leonard H. van den Berg, C. Erik Hack and W. Ludo van der Pol
    Citation: Journal of Neuroinflammation 2024 21:100
  13. The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ ...

    Authors: Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu and Chan Chen
    Citation: Journal of Neuroinflammation 2024 21:99
  14. The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regu...

    Authors: Ruiyi Zhang, Emily Wuerch, V. Wee Yong and Mengzhou Xue
    Citation: Journal of Neuroinflammation 2024 21:97
  15. Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynam...

    Authors: Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu and Xiao-Ping Gu
    Citation: Journal of Neuroinflammation 2024 21:96
  16. Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom ...

    Authors: Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox and Ukpong B. Eyo
    Citation: Journal of Neuroinflammation 2024 21:95
  17. Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inf...

    Authors: Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou and Jae Kyu Ryu
    Citation: Journal of Neuroinflammation 2024 21:94
  18. The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS...

    Authors: Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman and Eliezer Masliah
    Citation: Journal of Neuroinflammation 2024 21:93
  19. Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Si...

    Authors: Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Hervás-Stubbs and Maria S. Aymerich
    Citation: Journal of Neuroinflammation 2024 21:92
  20. Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis.

    Authors: Maria T. Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M. Villar, José I. Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Nicholas Mazarakis, Richard Reynolds, Richard Nicholas…
    Citation: Journal of Neuroinflammation 2024 21:91
  21. Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE’s pathogenesis has not been fully elucidated, clinical imaging studies ...

    Authors: Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting and Chaim Putterman
    Citation: Journal of Neuroinflammation 2024 21:89
  22. Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central nervous system (CNS) injury. Microglia, a crucial cellular component of the glial scar, fa...

    Authors: Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing and Li Cheng
    Citation: Journal of Neuroinflammation 2024 21:88
  23. Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption o...

    Authors: Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi and Hong Liao
    Citation: Journal of Neuroinflammation 2024 21:86
  24. Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of ...

    Authors: Xiaowei Fei, Li Wang, Ya-nan Dou, Fei Fei, Yanyu Zhang, Weihao Lv, Xin He, Xiuquan Wu, Wangshu Chao, Hongqing Chen, Jialiang Wei, Dakuan Gao and Zhou Fei
    Citation: Journal of Neuroinflammation 2024 21:85
  25. Alzheimer’s disease (AD) is recognized as the predominant cause of dementia, and neuroimmune processes play a pivotal role in its pathological progression. The involvement of long non-coding RNAs (lncRNAs) in ...

    Authors: Hanyou Liu, Jingying Li, Xue Wang, Shiqi Luo, Dan Luo, Wei Ge and Chao Ma
    Citation: Journal of Neuroinflammation 2024 21:84
  26. It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neur...

    Authors: Rodney M. Ritzel, Yun Li, Yun Jiao, Sarah J. Doran, Niaz Khan, Rebecca J. Henry, Kavitha Brunner, David J. Loane, Alan I. Faden, Gregory L. Szeto and Junfang Wu
    Citation: Journal of Neuroinflammation 2024 21:83
  27. Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in shape and morphology depending...

    Authors: Alexandra O. Strohm, Carl Johnston, Eric Hernady, Brian Marples, M. Kerry O’Banion and Ania K. Majewska
    Citation: Journal of Neuroinflammation 2024 21:82
  28. Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuro...

    Authors: Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma and Ren-Hong Du
    Citation: Journal of Neuroinflammation 2024 21:81
  29. Neuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells in the brain, ...

    Authors: Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei and Fang Huang
    Citation: Journal of Neuroinflammation 2024 21:80
  30. Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of the IR, offeri...

    Authors: Milena Rodriguez Alvarez, Hussam Alkaissi, Aja M. Rieger, Guillem R. Esber, Manuel E. Acosta, Stacy I. Stephenson, Allison V. Maurice, Laura Melissa Rodríguez Valencia, Christopher A. Roman and Juan Marcos Alarcon
    Citation: Journal of Neuroinflammation 2024 21:79
  31. Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role...

    Authors: Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký and Andrej Kováč
    Citation: Journal of Neuroinflammation 2024 21:78
  32. Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by...

    Authors: Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E. Alexander, Aimin Xu and Koon-Ho Chan
    Citation: Journal of Neuroinflammation 2024 21:77
  33. Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV in neurons lead to extensive neuronal damage and inflammati...

    Authors: Ling’en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao and Jing Ye
    Citation: Journal of Neuroinflammation 2024 21:76
  34. Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr...

    Authors: Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu and Jingfa Zhang
    Citation: Journal of Neuroinflammation 2024 21:75
  35. The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several mon...

    Authors: Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager and David N Zacks
    Citation: Journal of Neuroinflammation 2024 21:74
  36. Guillain–Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Pu...

    Authors: Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang and Xiuju Chen
    Citation: Journal of Neuroinflammation 2024 21:73
  37. Blood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit ne...

    Authors: Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij…
    Citation: Journal of Neuroinflammation 2024 21:72
  38. Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells have been rarely investiga...

    Authors: Mahesh Chandra Kodali, Jerry Antone, Eric Alsop, Rojashree Jayakumar, Khushi Parikh, Aude Chiot, Paula Sanchez-Molina, Bahareh Ajami, Steven E. Arnold, Kendall Jensen, Sudeshna Das and Marc S. Weinberg
    Citation: Journal of Neuroinflammation 2024 21:71
  39. Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia–reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility gr...

    Authors: Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng and Jiangang Shen
    Citation: Journal of Neuroinflammation 2024 21:70
  40. Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stroke brains. To explore underlying mechanisms, we conducted single cell RNA-seq transcriptom...

    Authors: Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash and Dandan Sun
    Citation: Journal of Neuroinflammation 2024 21:69
  41. Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of r...

    Authors: Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt and Volker Enzmann
    Citation: Journal of Neuroinflammation 2024 21:68
  42. Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchy...

    Authors: Rui Sun and Haowu Jiang
    Citation: Journal of Neuroinflammation 2024 21:67
  43. Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. D...

    Authors: Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby and Michelle E. Ehrlich
    Citation: Journal of Neuroinflammation 2024 21:66
  44. Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retin...

    Authors: Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha and Abdelrahman Y. Fouda
    Citation: Journal of Neuroinflammation 2024 21:65
  45. Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell ...

    Authors: Alice Brandli, Kirstan A. Vessey and Erica L. Fletcher
    Citation: Journal of Neuroinflammation 2024 21:64
  46. Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cor...

    Authors: Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen and Marc J. Ruitenberg
    Citation: Journal of Neuroinflammation 2024 21:63

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