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  1. There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like b...

    Authors: Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong and Shao-Ming Wang
    Citation: Journal of Neuroinflammation 2024 21:61
  2. We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l-arginine. Arginine is implicated in infl...

    Authors: Ian D. Gaudet, Hongyuan Xu, Emily Gordon, Gianna A. Cannestro, Michael L. Lu and Jianning Wei
    Citation: Journal of Neuroinflammation 2024 21:59
  3. Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ effl...

    Authors: Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger and Christian Madry
    Citation: Journal of Neuroinflammation 2024 21:58
  4. Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP remains a complicated issue for pain management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2...

    Authors: Chenglong Wang, Yitong Xu, Miao Xu, Cong Sun, Xiaojiao Zhang, Xueshu Tao and Tao Song
    Citation: Journal of Neuroinflammation 2024 21:57
  5. Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic va...

    Authors: Josef Biber, Yassin Jabri, Sarah Glänzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly and Antje Grosche
    Citation: Journal of Neuroinflammation 2024 21:56
  6. Neuroinflammation substantially contributes to the pathology of Alzheimer’s disease (AD), the most common form of dementia. Studies have reported that nuclear factor erythroid 2-related factor 2 (Nrf2) attenua...

    Authors: Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C. Saido, Takashi Saito and Koji Yamanaka
    Citation: Journal of Neuroinflammation 2024 21:55
  7. Parkinson’s disease (PD) is a common age-related neurodegenerative disorder characterized by the aggregation of α-Synuclein (αSYN) building up intraneuronal inclusions termed Lewy pathology. Mounting evidence ...

    Authors: Cansu Yildirim-Balatan, Alexis Fenyi, Pierre Besnault, Lina Gomez, Julia E. Sepulveda-Diaz, Patrick P. Michel, Ronald Melki and Stéphane Hunot
    Citation: Journal of Neuroinflammation 2024 21:54
  8. Parkinson’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need...

    Authors: Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon and Sang Myun Park
    Citation: Journal of Neuroinflammation 2024 21:53
  9. Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised that a combination of biomarkers would increase the accurac...

    Authors: Eleftheria Kodosaki, W. John Watkins, Sam Loveless, Karim L. Kreft, Aidan Richards, Valerie Anderson, Lisa Hurler, Neil P. Robertson, Wioleta M. Zelek and Emma C. Tallantyre
    Citation: Journal of Neuroinflammation 2024 21:52
  10. Thyroid eye disease (TED) is highly correlated with dysregulated immunoendocrine status. The insular cortex was found to regulate peripheral inflammation and immunomodulation in mice. This study aimed to explo...

    Authors: Haiyang Zhang, Yuting Liu, Duojin Xia, Mengda Jiang, Yinwei Li, Jing Sun, Haixia Guan, Ling Zhu, Xuefei Song, Jue Wang, Xianqun Fan and Huifang Zhou
    Citation: Journal of Neuroinflammation 2024 21:51
  11. Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clin...

    Authors: Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White and Hazel Quek
    Citation: Journal of Neuroinflammation 2024 21:50

    The Correction to this article has been published in Journal of Neuroinflammation 2024 21:90

  12. Myeloid-derived suppressor cells (MDSCs) constitute a recently discovered bone-marrow-derived cell type useful for dealing with neuroinflammatory disorders. However, these cells are only formed during inflamma...

    Authors: Carlos del Pilar, Lucía Garrido-Matilla, Lucía del Pozo-Filíu, Rafael Lebrón-Galán, Raúl F. Arias, Diego Clemente, José Ramón Alonso, Eduardo Weruaga and David Díaz
    Citation: Journal of Neuroinflammation 2024 21:49
  13. Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. ...

    Authors: Carla Rodriguez-Mogeda, Chaja M. J. van Ansenwoude, Lennart van der Molen, Eva M. M. Strijbis, Reina E. Mebius and Helga E. de Vries
    Citation: Journal of Neuroinflammation 2024 21:48
  14. Progranulin (PGRN) haploinsufficiency due to progranulin gene (GRN) variants can cause frontotemporal dementia (FTD) with aberrant TAR DNA-binding protein 43 (TDP-43) accumulation. Despite microglial burden with ...

    Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim and Seung Hyun Kim
    Citation: Journal of Neuroinflammation 2024 21:47
  15. Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (...

    Authors: Suzan van Amerongen, Surya V. Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D. Cherry, Charles Bernick, Yonas E. Geda, Jennifer V. Wethe, Douglas I. Katz, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H. Daneshvar…
    Citation: Journal of Neuroinflammation 2024 21:46
  16. Sepsis has a high mortality rate due to multiple organ failure. However, the influence of peripheral inflammation on brainstem autonomic and respiratory circuits in sepsis is poorly understood. Our working hyp...

    Authors: Gjinovefa Kola, Caitlyn W. Clifford, Cara K. Campanaro, Rishi R. Dhingra, Mathias Dutschmann, Frank J. Jacono and Thomas E. Dick
    Citation: Journal of Neuroinflammation 2024 21:45
  17. Stroke is a clinical syndrome characterized by an acute, focal neurological deficit, primarily caused by the occlusion or rupture of cerebral blood vessels. In stroke, neuroinflammation emerges as a pivotal ev...

    Authors: Ling Gao, Li Peng, Jian Wang, John H. Zhang and Ying Xia
    Citation: Journal of Neuroinflammation 2024 21:44
  18. Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig...

    Authors: Chong He, Kun Peng, Xiong Zhu, Zuo Wang, Wenbo Xiu, Gao Zhang, Yang Chen, Chaonan Sun, Xiao Xiao, Donghua Liu, An Li, Yanping Gao, Jinxia Wang, Ping Shuai, Yilian Chen, Ling Yu…
    Citation: Journal of Neuroinflammation 2024 21:43
  19. Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promot...

    Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash and Astrid E. Cardona
    Citation: Journal of Neuroinflammation 2024 21:42
  20. Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct...

    Authors: Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen and Michelle H. Theus
    Citation: Journal of Neuroinflammation 2024 21:41
  21. Children born to obese mothers are at increased risk of developing mood disorders and cognitive impairment. Experimental studies have reported structural changes in the brain such as the gliovascular unit as w...

    Authors: Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Pernilla Svedin, Thomas Jansson, Carina Mallard and Maryam Ardalan
    Citation: Journal of Neuroinflammation 2024 21:39
  22. Herpes simplex virus (HSV) encephalitis (HSE) is a serious and potentially life-threatening disease, affecting both adults and newborns. Progress in understanding the virus and host factors involved in neonata...

    Authors: Ahmad S. Rashidi, Diana N. Tran, Caithlin R. Peelen, Michiel van Gent, Werner J. D. Ouwendijk and Georges M. G. M. Verjans
    Citation: Journal of Neuroinflammation 2024 21:38
  23. Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform b...

    Authors: Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate and Jonathan M. Levenson
    Citation: Journal of Neuroinflammation 2024 21:37
  24. Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the...

    Authors: Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li and Wenjie Jin
    Citation: Journal of Neuroinflammation 2024 21:36
  25. Microglia is the major contributor of post-stroke neuroinflammation cascade and the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous mechanism underlying microglial activ...

    Authors: Yi Qian, Lixuan Yang, Jian Chen, Chao Zhou, Ningning Zong, Yang Geng, Shengnan Xia, Haiyan Yang, Xinyu Bao, Yan Chen and Yun Xu
    Citation: Journal of Neuroinflammation 2024 21:35
  26. Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. Many immune aspects of the disease are understood through studies in the experimental...

    Authors: Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M. Delgado-García, Lesley Probert and Vasiliki Kyrargyri
    Citation: Journal of Neuroinflammation 2024 21:34
  27. Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal neurovascular unit and play a critical role in DR. We therefore in...

    Authors: Anna M. Pfaller, Lew Kaplan, Madalena Carido, Felix Grassmann, Nundehui Díaz-Lezama, Farhad Ghaseminejad, Kirsten A. Wunderlich, Sarah Glänzer, Oliver Bludau, Thomas Pannicke, Bernhard H. F. Weber, Susanne F. Koch, Boyan Bonev, Stefanie M. Hauck and Antje Grosche
    Citation: Journal of Neuroinflammation 2024 21:33
  28. Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and sym...

    Authors: Wendy Balestri, Ruchi Sharma, Victor A. da Silva, Bianca C. Bobotis, Annabel J. Curle, Vandana Kothakota, Farnoosh Kalantarnia, Maria V. Hangad, Mina Hoorfar, Joanne L. Jones, Marie-Ève Tremblay, Jehan J. El-Jawhari, Stephanie M. Willerth and Yvonne Reinwald
    Citation: Journal of Neuroinflammation 2024 21:32
  29. The only validated treatment to prevent brain damage associated with hypoxia–ischemia (HI) encephalopathy of the newborn is controlled hypothermia with limited benefits. Additional putative neuroprotective dru...

    Authors: Pansiot Julien, Manuela Zinni, Natacha Bonnel, Marina El Kamouh, Felipe Odorcyk, Lea Peters, Emilie-Fleur Gautier, Marjorie Leduc, Cédric Broussard and Olivier Baud
    Citation: Journal of Neuroinflammation 2024 21:31
  30. 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding...

    Authors: Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis…
    Citation: Journal of Neuroinflammation 2024 21:30
  31. Demyelination and failure of remyelination in the central nervous system (CNS) characterize a number of neurological disorders. Spontaneous remyelination in demyelinating diseases is limited, as oligodendrocyt...

    Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang and Xing Li
    Citation: Journal of Neuroinflammation 2024 21:29
  32. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis o...

    Authors: Peng-Fei Wang, Fei Jiang, Qiu-Ming Zeng, Wei-Fan Yin, Yue-Zi Hu, Qiao Li and Zhao-Lan Hu
    Citation: Journal of Neuroinflammation 2024 21:28
  33. Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center,...

    Authors: Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang and Chunsheng Wang
    Citation: Journal of Neuroinflammation 2024 21:27
  34. Experimental autoimmune encephalomyelitis (EAE) induced in inbred rodents, i.e., genetically identical animals kept under identical environmental conditions, shows variable clinical outcomes. We investigated s...

    Authors: Milica Lazarević, Goran Stegnjaić, Bojan Jevtić, Sanja Despotović, Đurđica Ignjatović, Suzana Stanisavljević, Neda Nikolovski, Miljana Momčilović, Graeme L. Fraser, Mirjana Dimitrijević and Đorđe Miljković
    Citation: Journal of Neuroinflammation 2024 21:26
  35. Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis...

    Authors: Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi and Hiroshi Kiyama
    Citation: Journal of Neuroinflammation 2024 21:25
  36. Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that V...

    Authors: Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra and Robyn S. Klein
    Citation: Journal of Neuroinflammation 2024 21:24
  37. Complex regional pain syndrome (CRPS) develops after injury and is characterized by disproportionate pain, oedema, and functional loss. CRPS has clinical signs of neuropathy as well as neurogenic inflammation....

    Authors: Beate Hartmannsberger, Sabrina Scriba, Carolina Guidolin, Juliane Becker, Katharina Mehling, Kathrin Doppler, Claudia Sommer and Heike L. Rittner
    Citation: Journal of Neuroinflammation 2024 21:23
  38. Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial ...

    Authors: Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Michel Paques, Torben Lykke Sørensen, Olaf Strauss…
    Citation: Journal of Neuroinflammation 2024 21:22
  39. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration. Considering the increasing prevalence amon...

    Authors: Jelle Y. Broos, Rianne T. M. van der Burgt, Julia Konings, Merel Rijnsburger, Oliver Werz, Helga E. de Vries, Martin Giera and Gijs Kooij
    Citation: Journal of Neuroinflammation 2024 21:21
  40. Authors: Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte and Ramon Velazquez
    Citation: Journal of Neuroinflammation 2024 21:20

    The original article was published in Journal of Neuroinflammation 2022 19:193

  41. Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activiti...

    Authors: Izhar Livne-Bar, Shubham Maurya, Karsten Gronert and Jeremy M. Sivak
    Citation: Journal of Neuroinflammation 2024 21:18
  42. Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Accumulating evidence sugge...

    Authors: Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson and Alon Monsonego
    Citation: Journal of Neuroinflammation 2024 21:17
  43. Preterm birth is often associated with chorioamnionitis and leads to increased risk of neurodevelopmental disorders, such as autism. Preterm birth can lead to cerebellar underdevelopment, but the mechanisms of...

    Authors: Josef Newman, Xiaoying Tong, April Tan, Toni Yeasky, Vanessa Nunes De Paiva, Pietro Presicce, Paranthaman S. Kannan, Kevin Williams, Andreas Damianos, Marione Tamase Newsam, Merline K. Benny, Shu Wu, Karen C. Young, Lisa A. Miller, Suhas G. Kallapur, Claire A. Chougnet…
    Citation: Journal of Neuroinflammation 2024 21:16
  44. Hepcidin is the master regulator of iron homeostasis. Hepcidin downregulation has been demonstrated in the brains of Alzheimer’s disease (AD) patients. However, the mechanism underlying the role of hepcidin do...

    Authors: Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang and Guofen Gao
    Citation: Journal of Neuroinflammation 2024 21:15
  45. Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological respons...

    Authors: Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun and Sandy R. Shultz
    Citation: Journal of Neuroinflammation 2024 21:14
  46. Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be downregulated in epilep...

    Authors: Xueying Li, Pusheng Quan, Yao Si, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Han Liu, Shuo Huang, Linlin Sun, Fan Yang and Lifen Yao
    Citation: Journal of Neuroinflammation 2024 21:13
  47. Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, de...

    Authors: Yue Hao, Yinchun Su, Yifan He, Wenyuan Zhang, Yang Liu, Yu Guo, Xingfan Chen, Chunhan Liu, Siyu Han, Buyi Wang, Yushuang Liu, Wei Zhao, Lili Mu, Jinghua Wang, Haisheng Peng, Junwei Han…
    Citation: Journal of Neuroinflammation 2024 21:10
  48. Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyri...

    Authors: Ya-Jing Zhu, Jing Huang, Ru Chen, Yu Zhang, Xin He, Wen-Xin Duan, Yuan-Lei Zou, Meng-Mei Sun, Hui-Li Sun, Si-Min Cheng, Hao-Chuan Wang, Hao Zhang and Wen-Ning Wu
    Citation: Journal of Neuroinflammation 2024 21:6

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