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The original article was published in Journal of Neuroinflammation 2020 17:155
Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT
Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However ... the CNS insult—acute versus chronic—influences ...
Reactive astrogliosis is a ubiquitous but poorly understood hallmark of central nervous system pathologies such as trauma and neurodegenerative diseases. In vitro and in vivo...studies have identified proinflamma...
We aimed to investigate whether double seronegative NMOSD (DN-NMOSD) and NMOSD with AQP4 antibody (AQP4–NMOSD) share the same pathophysiological basis, astrocytopathy, by measurement of cerebrospinal fluid (CSF) ...
In neuropathological processes associated with neutrophilic infiltrates, such as experimental allergic encephalitis and traumatic injury of the brain, the CXC chemokine, macrophage inflammatory protein-2 (MIP-2) ...
Older-age individuals are at the highest risk for disability from a traumatic brain injury (TBI). Astrocytes are the most numerous glia in the ... there is little known about unique responses of astrocytes in the...
The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigger ...
The brain HI model was established in neonatal C57BL/6 mice by left common carotid artery occlusion with 90 min hypoxia and treated with IL-33 at a dose of 0.2 μg/day i.p. for 3 days. TTC staining and neurobehavi...
Citrobacter koseri (C. koseri) is a Gram-negative bacterium that can cause a highly aggressive form of neonatal meningitis, which often progresses to establish multi-focal brain abscesses. The roles of Toll-like...
Despite extensive astrocyte activation in patients suffering from HIV-associated ... , little is known about the contribution of astrocytes to HAND neuropathology. Here, we report that the robust activation of ne...
Hypoxic-ischemic encephalopathy (HIE) has a high morbidity rate and involves severe neurologic deficits, including cerebral palsy. Therapeutic hypothermia (TH) has been shown to decrease the mortality rate and pr...
It has been demonstrated that reactive astrocytes can be polarized into pro-inflammatory A1 ... been suggested to play a critical role in astrocyte phenotype polarization by releasing pro- and anti ... examined w...
Senescent astrocytes play crucial roles in age-associated neurodegenerative ... and neuroprotective activities. However, its effect on astrocyte senescence in PD remains to be defined.
The new mouse model, called 5xFAD TAU, shows accelerated cognitive impairment at 2 months of age, increased number of Aβ depositions at 4 months and neuritic plaques at 6 months of age. An expression of human mut...
Senescent astrocytes have been implicated in the aging brain ... and neuroprotective activities. However, its effect on astrocyte senescence in PD remains to be defined.
Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative...
Neuroinflammation is a vital pathophysiological process during ischemic stroke. Activated astrocytes play a major role in inflammation. Lipocalin-2 (LCN2), secreted by activated astrocytes, promotes neuroinflamma...
Expression of chemokine CCL2 in the normal central nervous system (CNS) is nearly undetectable, but is significantly upregulated and drives neuroinflammation during experimental autoimmune encephalomyelitis (EAE)...
Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive oxygen species (ROS) that may subsequently cause severe white matter injury. The process of oligodendrocyte progenitor cell (OPC) diffe...
The interaction between astrocytes and microglia plays a vital role in...
A growing body of evidence shows that hypothalamic inflammation is an important factor in the initiation of obesity. In particular, reactive gliosis accompanied by inflammatory responses in the hypothalamus are p...
The glial reactivation and neuronal activities in emotion-related brain regions were analyzed among normal diet mice (ND), HFD mice, wild-type mice, and ob/ob mice. To further activate or inhibit astrocytes in me...
The astrocytes in the central nervous system (CNS) ... region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human temporal lobe ... cases, meanwhile the neuroinflammation...
The accumulation of astrocytes around senile plaques is one of the ... , we demonstrate the role of SAA in astrocyte migration.
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic biomar...
Astrocyte over-activation and extensive neuron loss are ... has never been determined whether HSPA8 participates in astrocyte activation and thus mediated neuroinflammation associated with...
Helicobacter pylori (Hp)...infects the stomach of 50% of the world’s population. Importantly, chronic infection by this bacterium correlates with the appearance of several extra-gastric pathologies, including neu...
The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role i...
During cerebral inflammation uracil nucleotides leak to the extracellular medium and activate glial pyrimidine receptors contributing to the development of a reactive phenotype. Chronically activated microglia ac...
During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X7...receptors. In animal models of amyotrophic lateral sclerosis (ALS),...
Traumatic brain injury (TBI) is a leading cause of death and disability that lacks neuroprotective therapies. Following a TBI, secondary injury response pathways are activated and contribute to ongoing neurodegen...
Inflammatory responses in brain are primarily mediated by microglia, but growing evidence suggests a crucial importance of astrocytes. S100B, a calcium-binding protein secreted by astrocytes, has properties of a ...
Primary monocultures of microglia or astrocytes, co-cultures containing microglia and astrocytes, and mixed glial cultures consisting of microglia, astrocytes and oligodendrocytes were stimulated with poly(I:...L...
Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the ef...
Ischemic stroke is the second leading cause of death globally. The narrow time window for administering effective thrombolytic therapy motivates the search for alternative prevention strategies. Microglia and astrocyte
In early autoimmune neuroinflammation, interferon (IFN)γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Although ...
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and signi...
Interactions between neurons, astrocytes, and microglia critically influence neuroinflammatory responses to ... in the central nervous system. In vitro astrocyte and microglia cultures are powerful tools to...
The Correction to this article has been published in Journal of Neuroinflammation 2022 19:49
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a 20 ... originally derived from a rat mesencephalic type-1 astrocyte cell line. MANF belongs to a novel...in vivo or in vitro.... However, the characte...
There is increasing interest in astrocyte biology because astrocytes have been demonstrated to play prominent roles ... central nervous system, including neuroinflammation. To understand astrocyte biology, primar...
Astrocyte activation is a hallmark of traumatic brain ... Sirt1 upregulation and MAPK pathway pharmacological inhibition on astrocyte activation in vitro and in vivo. Moreover ... underlying interactions between ...
CCAAT enhancer-binding protein (C/EBP)β regulates gene expression in multiple organ systems and cell types, including astrocytes in the central nervous system (CNS). ... immunodeficiency virus (HIV)-1 and lipopol...
Increased physical exercise improves cognitive function and reduces pathology associated with Alzheimer’s disease (AD). However, the mechanisms underlying the beneficial effects of exercise in AD on the level of ...
We established two chronic stress models, including chronic unpredictable mild stress (CUMS), and chronic social defeat stress (CSDS), to complementarily recapitulate depression-like behaviors. Then, hippocampal ...
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acute p...
Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in t...
Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity an...
The brain is unique and the most complex organ of the body, containing neurons and several types of glial cells of different origins and properties that protect and ensure normal brain structure and function. Neu...
Astrocytes contribute to chronic neuroinflammation in a variety ... movement disorder. However, the precise role of astrocytes in neuroinflammation remains incompletely understood. Herein,...Rgs5 in astrocytes ca...
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