Figure 10

Relationships between cognitive performances, amyloidosis and LRP-1 expression in APP mouse brain. (A) Relationship between Aβ plaque load and cognitive score (see Material and Methods). (B) Relationship between Aβ plaque load and LRP-1 immunoreactivity (left, % area; right, intensity). Illustration for the 10-week treatment, but similar relationships were obtained after the 5-week treatment. Error bars represent SEM. N = 5/group (▲ APP; Δ APP treated). Aβ, amyloid-beta; APP, amyloid precursor protein; C, cortex; H, hippocampus; DG, dentate gyrus; LRP-1, lipoprotein receptor-related protein.