Figure 4

Prophylaxis with palmitoylethanolamide (PEA) conferred protection against E. coli K1 infection. Kaplan-Meier survival curves of mice pre-treated intraperitoneally with 0.1 mg/kg PEA (250 μl, containing 0.3% DMSO in 0.9% NaCl) 12 hours and 30 minutes before infection (n = 39) and control mice (n = 39) (250 μl, 0.3% DMSO in 0.9% NaCl) after ip infection with E. coli K1 (a) and of mice pre-treated with 0.1 mg/kg PEA (250 μl containing 0.3% DMSO in 0.9% NaCl) 12 hours and 30 minutes before infection (n = 29) and control mice (250 μl 0.3% DMSO in 0.9% NaCl) (n = 28) after intracerebral infection with E. coli K1 (b). The respective groups were compared by log-rank test.