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Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
Journal of Neuroinflammation volume 21, Article number: 20 (2024)
Correction: Journal of Neuroinflammation (2022) 19:193 https://doi.org/10.1186/s12974-022-02544-5
Following publication of the original article [1], the authors identified an error in the notation of units used in the publication.
All glyphosate and AMPA measurements reported for brain tissue should have been reported as ng/g, instead of ng/mg. This change impacts the axis labels on Fig. 1B, C, E, F, Fig. 3A, B, Supplemental Figure S1A and S1B and two statements in the method section of the publication.
These changes do not impact any findings or conclusions made in this publication. All authors agree to this correction.
Following statements in the methods should be updated as follow:
“Homogenates corresponding to 5 mg of tissue were aliquoted and spiked with 10 ng/g isotopically labeled internal standards of glyphosate (13C215N Glyphosate, Sigma-Aldrich, St. Louis, MO) and AMPA (D213C15N AMPA, Sigma-Aldrich).”
“The limit of detection (LOD) (LOD = t(n − 1, t − α = 0.99) * Ss, where Ss is standard deviation from replicate measurements of a spiked-in standard and t(n−1, t − α = 0.99 represents Student’s t-value at 99% confidence with n − 1 degrees of freedom) was 0.189 ng/g and 0.122 ng/g for Glyphosate and AMPA, respectively, and limit of quantitation (LOQ) was 0.5 ng/g and 0.4 ng/g for glyphosate and AMPA, respectively.”
All figures noted above have been updated in this correction.
The original article has been corrected.
Reference
Winstone JK, Pathak KV, Winslow W, Piras IS, White J, Sharma R, Huentelman MJ, Pirrotte P, Velazquez R. Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders. J Neuroinflamm. 2022;19:193. https://doi.org/10.1186/s12974-022-02544-5.
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Additional file 1
: Figure S1. Linearity of A. glyphosate and B. AMPA over a concentration range of 0–50 ng/g in brain. The area ratio depicts ratio of variable concentrations of glyphosate or AMPA to their respective internal standards (13C215N-Glyphosate or D213C15N-AMPA) with a constant concentration of 10 ng/g. C–F. Representative MS2 extracted ion chromatograms (EIC) of glyphosate in mice fed at 0 mg/kg, 125 mg/kg, 250 mg/kg, and 500 mg/kg glyphosate.
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Winstone, J.K., Pathak, K.V., Winslow, W. et al. Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders. J Neuroinflammation 21, 20 (2024). https://doi.org/10.1186/s12974-023-02990-9
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DOI: https://doi.org/10.1186/s12974-023-02990-9