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Table 2 IL-1 family cytokine and receptor levels in CSF and serum of sALS patients

From: Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

Cytokine/Receptor

CSF

Serum

ALS

Controls

ALS

Controls

IL-1β

<7.8

<7.8

<7.8 (n = 1; 47.2)

<7.8 (n = 1; 26.6)

IL-1Ra

<78.1

<78.1 (n = 1; 101.7)

<78.1 (n = 1; 547.4)

<78.1

sIL-1R2

<312.5

<312.5 (n = 1; 325.7)

5673.4 ± 2771.5

5575.0 ± 1359.5

IL-33

<30.0 (n = 3; 72.9 ± 32.3)

<30.0 (n = 3; 54.8 ± 27.1)

625.4 ± 1570.5

536.3 ± 1166.3

sIL-1R4

<62.5 (n = 4; 85.1 ± 13.2)

<62.5(n = 2; 85.5 ± 3.9)

72.4 ± 16.4

79.9 ± 28.3

IL-37

<46.8

<46.8

<46.8

<46.8 (n = 1; 74.7)

IL-36

NT

NT

888.3 ± 729.3

1531.7 ± 1843.2

  1. Values are given as mean pg/ml ± SD rather than in nM since the MW of the mature forms of the cytokines and of the natural soluble receptors are not yet precisely defined.
  2. CSF, Cerebrospinal fluid; n, Number of samples above the detection limit; NT, Not tested; sALS, sporadic amyotrophic lateral sclerosis.