Hardiman O, van den Berg LH, Kiernan MC: Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol. 2011, 7: 639-649. 10.1038/nrneurol.2011.153.
Article
CAS
PubMed
Google Scholar
Troost D, van den Oord JJ, de Jong JM, Swaab DF: Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. Clin Neuropathol. 1989, 8: 289-294.
CAS
PubMed
Google Scholar
Zhang R, Gascon R, Miller RG, Gelinas DF, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS: Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol. 2005, 159: 215-224. 10.1016/j.jneuroim.2004.10.009.
Article
CAS
PubMed
Google Scholar
Engelhardt JI, Appel SH: IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol. 1990, 47: 1210-1216. 10.1001/archneur.1990.00530110068019.
Article
CAS
PubMed
Google Scholar
Kawamata T, Akiyama H, Yamada T, McGeer PL: Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol. 1992, 140: 691-707.
PubMed Central
CAS
PubMed
Google Scholar
Hayashi S, Sakurai A, Amari M, Okamoto K: Pathological study of the diffuse myelin pallor in the anterolateral columns of the spinal cord in amyotrophic lateral sclerosis. J Neurol Sci. 2001, 188: 3-7. 10.1016/S0022-510X(01)00531-7.
Article
CAS
PubMed
Google Scholar
Baron P, Bussini S, Cardin V, Corbo M, Conti G, Galimberti D, Scarpini E, Bresolin N, Wharton SB, Shaw PJ, Silani V: Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis. Muscle Nerve. 2005, 32: 541-544. 10.1002/mus.20376.
Article
CAS
PubMed
Google Scholar
Sekizawa T, Openshaw H, Ohbo K, Sugamura K, Itoyama Y, Niland JC: Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci. 1998, 154: 194-199. 10.1016/S0022-510X(97)00228-1.
Article
CAS
PubMed
Google Scholar
Ono S, Hu J, Shimizu N, Imai T, Nakagawa H: Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis. J Neurol Sci. 2001, 187: 27-34. 10.1016/S0022-510X(01)00514-7.
Article
CAS
PubMed
Google Scholar
Poloni M, Facchetti D, Mai R, Micheli A, Agnoletti L, Francolini G, Mora G, Camana C, Mazzini L, Bachetti T: Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci Lett. 2000, 287: 211-214. 10.1016/S0304-3940(00)01177-0.
Article
CAS
PubMed
Google Scholar
Pasinelli P, Houseweart MK, Brown RH, Cleveland DW: Caspase-1 and −3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2000, 97: 13901-13906. 10.1073/pnas.240305897.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li M, Ona VO, Guégan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM: Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science. 2000, 288: 335-339. 10.1126/science.288.5464.335.
Article
CAS
PubMed
Google Scholar
Meissner F, Molawi K, Zychlinsky A: Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis. Proc Natl Acad Sci U S A. 2010, 107: 13046-13050. 10.1073/pnas.1002396107.
Article
PubMed Central
CAS
PubMed
Google Scholar
Garlanda C, Dinarello CA, Mantovani A: The interleukin-1 family: back to the future. Immunity. 2013, 39: 1003-1018. 10.1016/j.immuni.2013.11.010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dinarello CA, Arend W, Sims J, Smith D, Blumberg H, O’Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A: IL-1 family nomenclature. Nat Immunol. 2010, 11: 973-10.1038/ni1110-973.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boraschi D, Tagliabue A: The interleukin-1 receptor family. Semin Immunol. 2013, 25: 394-407. 10.1016/j.smim.2013.10.023.
Article
CAS
PubMed
Google Scholar
Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G: The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 2009, 10: 241-247.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bulau AM, Nold MF, Li S, Nold-Petry CA, Fink M, Mansell A, Schwerd T, Hong J, Rubartelli A, Dinarello CA, Bufler P: Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci U S A. 2014, 111: 2650-2655. 10.1073/pnas.1324140111.
Article
PubMed Central
CAS
PubMed
Google Scholar
Garlanda C, Riva F, Bonavita E, Gentile S, Mantovani A: Decoys and regulatory ‘receptors’ of the IL-1/Toll-Like receptor superfamily. Front Immunol. 2013, 4: 180.
PubMed Central
PubMed
Google Scholar
Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fukuda S, Kurimoto M: Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995, 378: 88-91. 10.1038/378088a0.
Article
CAS
PubMed
Google Scholar
Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H: Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 2001, 12: 53-72. 10.1016/S1359-6101(00)00015-0.
Article
CAS
PubMed
Google Scholar
Zorrilla EP, Sanchez-Alavez M, Sugama S, Brennan M, Fernandez R, Bartfai T, Conti B: Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A. 2007, 104: 11097-11102. 10.1073/pnas.0611523104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW: Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med. 2006, 12: 650-656. 10.1038/nm1415.
Article
CAS
PubMed
Google Scholar
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011, 145: 745-757. 10.1016/j.cell.2011.04.022.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D, Oostingh GJ, Pfaller T, Pixner C, Posselt G, Italiani P, Nold MF, Nold-Petry CA, Bufler P, Dinarello CA: IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw. 2011, 22: 127-147.
CAS
PubMed
Google Scholar
Arend WP, Palmer G, Gabay C: IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 2008, 223: 20-38. 10.1111/j.1600-065X.2008.00624.x.
Article
CAS
PubMed
Google Scholar
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005, 23: 479-490. 10.1016/j.immuni.2005.09.015.
Article
CAS
PubMed
Google Scholar
Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A: The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999, 169: 13-21. 10.1016/S0022-510X(99)00210-5.
Article
CAS
PubMed
Google Scholar
Novick D, Schwartsburd B, Pinkus R, Suissa D, Belzer I, Sthoeger Z, Keane WF, Chvatchko Y, Kim SH, Fantuzzi G, Dinarello CA, Rubinstein M: A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 2001, 14: 334-342. 10.1006/cyto.2001.0914.
Article
CAS
PubMed
Google Scholar
Migliorini P, Anzilotti C, Pratesi F, Quattroni P, Bargagna M, Dinarello CA, Boraschi D: Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur Cytokine Netw. 2010, 21: 264-271.
CAS
PubMed
Google Scholar
Kim SH, Eisenstein M, Reznikov L, Fantuzzi G, Novick D, Rubinstein M, Dinarello CA: Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A. 2000, 97: 1190-1195. 10.1073/pnas.97.3.1190.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bufler P, Azam T, Gamboni-Robertson F, Reznikov LL, Kumar S, Dinarello CA, Kim SH: A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci U S A. 2002, 99: 13723-13728. 10.1073/pnas.212519099.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boraschi D, Dinarello CA: IL-18 and autoimmunity. Eur Cytokine Netw. 2006, 17: 224-252.
CAS
PubMed
Google Scholar
Dinarello CA: Interleukin-18 and the pathogenesis of inflammatory diseases. Semin Nephrol. 2007, 27: 98-114. 10.1016/j.semnephrol.2006.09.013.
Article
CAS
PubMed
Google Scholar
Troseid M, Seljeflot I, Arnesen H: The role of interleukin-18 in the metabolic syndrome. Cardiovasc Diabetol. 2010, 9: 11-10.1186/1475-2840-9-11.
Article
PubMed Central
PubMed
Google Scholar
Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K: IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A. 1999, 96: 13962-13966. 10.1073/pnas.96.24.13962.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pizarro TT, Michie MH, Bentz M, Woraratanadharm J, Smith MF, Foley E, Moskaluk CA, Bickston SJ, Cominelli F: IL-18, a novel immunoregulatory cytokine, is upregulated in Crohn’s disease: expression and localization in intestinal mucosal cells. J Immunol. 1999, 162: 6829-6835.
CAS
PubMed
Google Scholar
Kanai T, Kamada N, Hisamatsu T: Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases. Curr Drug Targets. 2013, 14: 1392-1399. 10.2174/13894501113149990006.
Article
CAS
PubMed
Google Scholar
Martinon F, Burns K, Tschopp J: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-1β. Mol Cell. 2002, 10: 417-426. 10.1016/S1097-2765(02)00599-3.
Article
CAS
PubMed
Google Scholar
Nguyen MD, Julien J-P, Rivest S: Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1β in neurodegeneration. Ann Neurol. 2001, 50: 630-639. 10.1002/ana.1256.
Article
CAS
PubMed
Google Scholar
Hensley K, Fedynyshyn J, Ferrel S, Floyd RA, Gordon B, Grammas P, Hamdheydari L, Mhatre M, Mou S, Pye QN, Stewart C, West M, West S, Williamson KS: Message and protein level elevations of tumor necrosis factor alpha (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis. 2003, 14: 74-80. 10.1016/S0969-9961(03)00087-1.
Article
CAS
PubMed
Google Scholar
Hensley K, Abdel-Moaty H, Hunter J, Mhatre M, Mou S, Nguyen K, Potapova T, Pye QN, Qi M, Rice H, Stewart C, Stroukoff K, West M: Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. J Neuroinflammation. 2006, 3: 2-10.1186/1742-2094-3-2.
Article
PubMed Central
PubMed
Google Scholar
Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O’Regan JP, Deng HX: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993, 362: 59-62. 10.1038/362059a0.
Article
CAS
PubMed
Google Scholar
Schymick JC, Talbot K, Traynor BJ: Genetics of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2007, 16: R233-R242. 10.1093/hmg/ddm215.
Article
CAS
PubMed
Google Scholar
Dinarello CA, Bufler P: Interleukin-37. Semin Immunol. 2013, 25: 466-468. 10.1016/j.smim.2013.10.004.
Article
CAS
PubMed
Google Scholar
Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y, Andoh A: Epithelial expression of interleukin-37b in inflammatory bowel disease. Clin Exp Immunol. 2013, 172: 410-416. 10.1111/cei.12061.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stamatovic SM, Shakui P, Keep RF, Moore BB, Kunkel SL, van Rooijen N, Andjelkovic AV: Monocyte chemoattractant protein-1 regulation of blood–brain barrier permeability. J Cereb Blood Flow Metab. 2005, 25: 593-606. 10.1038/sj.jcbfm.9600055.
Article
CAS
PubMed
Google Scholar
Gupta PK, Prabhakar S, Sharma S, Anand A: Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients. J Neuroinflammation. 2011, 8: 47-10.1186/1742-2094-8-47.
Article
PubMed Central
CAS
PubMed
Google Scholar
Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, Khalili-Shirazi A, Lowdell MW, Brundin P, Bates GP, Leavitt BR, Möller T, Tabrizi SJ: A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington’s disease. J Exp Med. 2008, 205: 1869-1877. 10.1084/jem.20080178.
Article
PubMed Central
PubMed
Google Scholar
Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA, Piccini P: Microglial activation in regions related to cognitive function predicts disease onset in Huntington’s disease: a multimodal imaging study. Hum Brain Mapp. 2011, 32: 258-270. 10.1002/hbm.21008.
Article
PubMed
Google Scholar
Bettcher BM, Kramer JH: Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase. 2013, 19: 182-200. 10.1080/13554794.2011.654227.
Article
PubMed Central
PubMed
Google Scholar