Role of platelets in neuroinflammation: a wide-angle perspective

Table 1 Main Constituents of Platelet Secretory Granules

Dense Granules
Solutes	5HT, ADP, ATP, GDP, GTP, Ca, Mg, PyroPi, histamine
Membrane	CD62P, CD63, GP's Ib & IIb/IIIa, LAMP2, Src, Ral-1
Alpha Granules
Adhesive glycoproteins	fibronectin, vitronectin, vWF, TSP
Proteoglycans	PF4, ßTG, serglycin, HRGP & ßTG Ag's: PBT, CTAP-III, NAP-2
Mitogens:	PDGF, TGFß, ECGF, EGF, VEGF, VPE, IGF, IL-ß
Protease inhib's	TFPI, PAI-1, PDCI, α₂-antiplasmin, C1 inhibitor, α₂-antitrypsin, α₂-macroglobulin
Coagulation:	Factors V, XI, XIII, HMWK, fibrinogen, PAI-1, protein C, protein S, protein C inhibitor, TSP-1, TSP-2
Membrane*	CD9, CD31, CD36, CD62P, CD144, GLUT-3,
* Not including several GP's found also on plasma membrane
Misc.	IgG, IgM, IgA, albumin, GP Ia/multimerin, osteonectin, clusterin, angiostatin, endostatin, plasminogen
Lysosomal Granules (Lysosomes)
Acid proteases	cathepsins D & E, carboxypeptidases A & B, collagenase, acid phosphatase, aryl sulfatase
Glycohydrolases	heparinase, b-galactosidase, b-glucuronidase, b-N-acetyl-glucosaminodase, b-glycerophosphatse, b-D-glucosidase, a-D-glucosidase, a-L-fucosidase, b-D-fucosidase, a-L-arabinosidase, a-D-mannosidase
Membrane	LIMP-1, LAMP-1, -2
Dense Tubules	Principal Ca store for internal secretion

Contents of the three main granules (dense, alpha, lysosomal) and the "dense tubules" are listed in Table 1.

ISSN: 1742-2094