Figure 8
From: Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
PARP-1 modulates trophic factor release in Aβ-treated microglia. Microglial release of VEGF and TGFβ were reduced during 24 hours of Aβ exposure. This reduction was attenuated in PARP-1 -/- microglia and in wt microglia treated with by inhibitors of PARP-1 (PJ34, 400 nM) or NF-κB (BAY 11-7082, 5 μM). Data are presented as a fold increase or decrease from control levels. Release from wt and PARP-1 -/- microglia was not significantly different under control conditions. * p < 0.005 vs. Aβ, # p < 0.05 vs. control. n = 3-4.