Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

Table 2 Cytokine levels in mouse brain

	wt	PARP-1 ^-/-	hAPP	hAPP/PARP-1 ^-/-
IP-10	38.2 ± 2.5	62.5 ± 7.7 *	48.9 ± 6.7	87.0 ± 27.1 * #
KC	32.8 ± 3.1	43.6 ± 4.8 *	28.1 ± 2.5	36.6 ± 4.6
MCP-1	69.3 ± 5.3	85.3 ± 7.4	69.2 ± 7.4	85.6 ± 9.3
MIP-1α	18.5 ± 1.5	20.9 ± 2.7	20.6 ± 1.6	18.9 ± 1.8
IFNγ	1.8 ± 0.4	2.7 ± 0.6	1.9 ± 0.7	2.3 ± 0.5
IL-1β	6.6 ± 0.7	8.4 ± 1.1	7.6 ± 0.8	9.0 ± 1.1
IL-6	13.5 ± 4.9	8.9 ± 2.4	13.2 ± 9.0	11.3 ± 5.9
TNFα	3.0 ± 0.2	3.6 ± 0.4	3.1 ± 0.2	3.2 ± 0.3
IL-4	0.5 ± 0.3	1.1 ± 0.4	0.8 ± 0.4	2.0 ± 1.1
IL-10	7.0 ± 1.1	9.2 ± 1.0	7.1 ± 1.4	8.2 ± 1.3
IL-13	3.2 ± 1.7	11.7 ± 3.9 *	4.5 ± 1.7	6.9 ± 3.0
VEGF	7.8 ± 1.5	8.4 ± 2.1	10.9 ± 2.4	9.5 ± 2.8

Data presented as pg/mg protein, mean ± SEM. n = 8-12. * p < 0.05 for comparison against wt, # p < 0.05 for comparisons between hAPP vs. hAPP/PARP-1 ^-/- (ANOVA with Bonferroni correction). Differences were not statistically significant when corrected for comparisons between the 12 cytokines analyzed. RANTES and TGFβ were also measured, but values were below calibration limits.

ISSN: 1742-2094