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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes

Fig. 4

Different effects of endothelial-activated versus astrocyte-activated microglia on the neurons. a MTT assays of neuronal cell viability. Conditioned media from endothelial-activated microglia were moderately neurotoxic. In contrast, conditioned media from astrocyte-activated microglia did not affect neuronal viability. p = 0.0272 (one-way ANOVA). b Representative hippocampal neurons transfected with pEGFP-C1 vector. c Graph of dendritogenesis. Astrocyte-activated microglia significantly increased dendritic complexity. Data were expressed as mean ± SD. *p < 0.05 compared to the control (one-way ANOVA). n = 21 to 23 individual neurons

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Journal of Neuroinflammation

ISSN: 1742-2094