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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes

Fig. 5

Potential roles of transcription factors in microglial phenotypic switching. a Expression of IRFs and STATs were detected by real-time PCR. Endo-CM treatment significantly downregulated IRF4 expression and upregulated IRF7 expression in microglia, but astro-CM treatment did not significantly change the expression levels of IRFs and STATs. Data were expressed as mean ± SD. *p < 0.05 compared to the control (t test). n = 3 independent experiments. b Bar graph of the ratio of IRF5/IRF4. Endo-CM treatment significantly raised the ratio of IRF5/IRF4 in microglia compared with astro-CM treatment. Data were expressed as mean ± SD. *p < 0.05 (t test). n = 3 independent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094