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Table 1 Maternal characteristics

From: Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure

Variable

C/TD (n = 15)

C/ND (n = 12)

A/TD (n = 15)

A/ND (n = 17)

p value

Maternal age at enrollment (years)

27.5 ± 1.3

27.8 ± 1.5

27.3 ± 2.2

30.2 ± 1.7

0.7581

Recruitment site

Khmelnytsky

67.7% (10)

41.7% (5)

53.3% (8)

82.4% (14)

0.1262

Rivne

33.3% (5)

58.3% (7)

46.7% (7)

17.6% (3)

Marital status

Married or cohabitating

93.3% (14)

100.0% (12)

93.3% (14)

88.2% (15)

0.8992

Single/separated

6.7% (1)

0.0% (0)

6.7% (1)

11.8% (2)

Maternal education level

Incomplete high school diploma

0.0% (0)

8.3% (1)

0.0% (0)

17.6% (3)

0.2632

High school diploma/vocational school

40.0% (6)

33.3% (4)

40.0% (6)

58.8% (10)

Some college (college degree or unfinished university education)

13.3% (2)

8.3% (1)

26.7% (4)

5.9% (1)

University graduate

46.7% (7)

50.0% (6)

33.3% (5)

17.6% (3)

Socio-economic status category (Hollingshead score)

1 (high), 55–66

33.3% (5)

16.7% (2)

6.7% (1)

0.0% (0)

0.2262

2, 40–54

33.3% (5)

25.0% (3)

26.7% (4)

29.4% (5)

3, 30–39

13.3% (2)

25.0% (3)

40.0% (6)

23.5% (4)

4, 20–29

12.5% (2)

33.3% (4)

13.3% (2)

17.6% (3)

5 (low), 8–19

6.7% (1)

0.0% (0)

13.3% (2)

29.4% (5)

Gravidity

> 1

46.7% (7)

75.0% (9)

73.3% (11)

64.7% (11)

0.3822

1

53.3% (8)

25.0% (3)

26.7% (4)

35.3% (6)

Parity

> 0

46.7% (7)

66.7% (8)

60.0% (9)

52.9% (9)

0.7423

0

53.3% (8)

33.3.3% (4)

40.0% (6)

47.1% (8)

Pre-pregnancy body mass index (BMI)

23.6 ± 1.1

23.3 ± 1.1

23.3 ± 0.9

25.0 ± 1.1

0.6481

Smoking status

Current smoker

6.7% (1)

0.0% (0)

33.3% (5)

43.8% (7)

0.0142

Never smoked

86.7% (13)

91.7% (11)

53.3% (8)

43.8% (7)

Quit after realized pregnant

6.7% (1)

0.0% (0)

6.7% (1)

12.5% (2)

Quit before pregnancy

0.0% (0)

8.3% (1)

6.7% (1)

0.0% (0)

Ounces of alcohol/day at time of conception (AAD0)

0.02 ± 0.02

0.01 ± 0.01

0.69 ± 0.19a,b

1.91 ± 0.42a,b,c

< 0.0011

Ounces of alcohol/drinking day at conception (AADD0)

0.06 ± 0.05

0.10 ± 0.10

1.73 ± 0.41a,b

4.03 ± 0.89a,b

< 0.0011

Ounces of alcohol/day 2 weeks prior to enrollment (AADXP)

0.00 ± 0.00

0.004 ± 0.00

0.31 ± 0.13a,b

0.65 ± 0.23a,b

< 0.0011

Ounces of alcohol/drinking day 2 weeks prior to enrollment (AADDXP)

0.00 ± 0.00

0.05 ± 0.05

0.96 ± 0.30a,b

1.38 ± 0.47a,b

< 0.0011

  1. Abbreviations: C/TD control mother (low to no alcohol), typically developing child; C/ND control mother (low to no alcohol), neurodevelopmental delay in the child; A/TD alcohol-consuming mother, typically developing child; A/ND alcohol-consuming mother, neurodevelopmental delay in the child. Continuous variables are reported as the average value ± the standard error of the mean (SEM). Categorical variables are reported as percentage of group followed by the N in parentheses. Note: One subject in the A/ND group failed to report their smoking status. 1Kruskal-Wallis rank sum test. 2Fisher’s exact test. 3Chi-square test. p values in italics are statistically significant; post hoc testing—a> C/TD; b> C/ND; c> A/TD