Skip to main content

Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

The Original Article was published on 02 December 2017

Correction to: Journal of Neuroinflammation (2017) 14:234 https://doi.org/10.1186/s12974-017-1007-2

Following the publication of the original article [1], it was noted that the authors identified an error in Figs. 2 and 9.

  1. 1.

    The representative western blot image for α7AchR protein expression in Fig. 2b was incorrect by mistake. The corrected version of Fig. 2 (JPG file) is given below.

  2. 2.

    CRS21d image in Fig. 9a, CRS 21d + DMXBA image in Fig. 9b are incorrect. During the preparation of figures, we inadvertently provided an incorrect image, and are updated with correct images, Con group image in Fig. 9a was also updated for more accuracy. The corrected version of Fig. 9 is given below.

  3. 3.

    We would like to add in the correction that "the authors clarify that this work was not financially supported by the NIH grants or by the Johns Hopkins University."

Fig. 2
figure 2

Chronic restraint stress (CRS)-induced alterations in components of central cholinergic signaling in hippocampus. a Doubleimmunolabeling showed that α7nAChR colocalized primarily with NeuN+ neurons and to a lesser extent with GFAP + astrocytes and Iba-1+ microglia in the hippocampus; scale bar, 30 μm. b Representative immunoblots and relative levels of α7nAChR protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. c Representative immunoblots and relative levels of choline acetyltransferase (ChAT) protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. d Acetylcholinesterase (AChE) activity in hippocampus at different time points of CRS. e Representative immunoblots and relative levels of STAT3 protein in hippocampus. Results are shown as fold change relative to histone1 protein level. Con, control group. Data are expressed as mean ± SEM. n = 8 per group; *P < 0.05, **P < 0.01 vs. control group

Fig. 9
figure 9

Chronic DMXBA treatment reverses chronic restraint stress (CRS)-induced reductions in T regulatory (Treg) cells in mouse periphery and hippocampus. a Representative flow cytometry profiles and statistics of Foxp3+-expressing cells among CD4+ CD25+ splenocytes on days 7, 14, and 21 of CRS. b Representative flow cytometry profiles and statistics of Treg cells among splenocytes from mice treated with vehicle or DMXBA. c Representative immunoblots and relative levels of Foxp3 protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. Con, control group. All data are expressed as mean ± SEM. n = 8; *P < 0.05 vs. control group; #P < 0.05, ##P < 0.01 vs. CRS 21d + Veh group; ++P < 0.01 vs. CRS 21d + DMXBA group

The corrections did not affect the overall conclusions and we hope to make the corrigendum as soon as possible. We apologize for this mistake due to our carelessness.

Reference

  1. Zhao D, Xu X, Pan L, Zhu W, Fu X, Guo L, Lu Q, Wang J. Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress. J Neuroinflammation. 2017;14:234. https://doi.org/10.1186/s12974-017-1007-2.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Qing Lu.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhao, D., Xu, X., Pan, L. et al. Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress. J Neuroinflammation 19, 227 (2022). https://doi.org/10.1186/s12974-022-02577-w

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/s12974-022-02577-w