Fig. 11

TREM2 depletion finally abolished the protective effects of COG1410 on neurological functions. A Representative images of the trajectory of mice in different groups in the open field test at 14 d after CCI. B, C Quantitative analysis of centre time (B) and total distance travelled by the mice in the open field test (C). *p < 0.05 vs. WT CCI + COG1410; ^#p < 0.05 vs. WT CCI + Vehicle; ns p > 0.05 KO CCI + Vehicle vs. KO CCI + COG1410, n = 6 per group. D Representative images of the trajectory of mice in different groups in the Morris water maze. E–G Quantitative analysis of latency in the learning test (E), target quadrant time in the memory test (F), and average swimming speed in the memory test (G). *p < 0.05 vs. WT CCI + COG1410; ^#p < 0.05 vs. WT CCI + Vehicle; ns p > 0.05 KO CCI + Vehicle vs. KO CCI + COG1410, n = 6 per group