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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

Fig. 7

The Akt/CREB/BDNF axis participated in the neuroprotective effects of TREM2 activation. A Representative images of BDNF (green) surrounding the lesion sites at 3 d after CCI. Scale bar = 50 μm. B Quantitative analysis of the relative BDNF fluorescence intensity surrounding the lesion sites after CCI. *p < 0.05 vs. Sham; #p < 0.05 vs. CCI + Vehicle, n = 6 per group. C Representative Western blot bands of TREM2, p-Akt, Akt, p-CREB, CREB, BDNF, and β-Actin at the lesion sites after CCI. D–G Quantitative analysis of TREM2 (D), p-Akt (E), p-CREB (F), and BDNF (G) density at the lesion sites after CCI. *p < 0.05 vs. Sham; #p < 0.05 vs. CCI + Vehicle, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094