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  1. Neuroinflammation is one of the most important processes in secondary injury after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to exert neuroprotectiv...

    Authors: Jin Yan, Yuan Zhang, Lin Wang, Zhao Li, Shuang Tang, Yingwen Wang, Nina Gu, Xiaochuan Sun and Lin Li
    Citation: Journal of Neuroinflammation 2022 19:289
  2. Adverse pathophysiological and behavioral outcomes related to mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and chronic pain are common following blast exposure and contribute to de...

    Authors: Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook and Abigail. G. Schindler
    Citation: Journal of Neuroinflammation 2022 19:288
  3. Inflammation and increases in inflammatory cytokines are common findings in psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Meta-analyses of studi...

    Authors: Heather K. Hughes, Houa Yang, Tyler A. Lesh, Cameron S. Carter and Paul Ashwood
    Citation: Journal of Neuroinflammation 2022 19:287
  4. The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astr...

    Authors: T. L. Stephen, B. Breningstall, S. Suresh, C. J. McGill and C. J. Pike
    Citation: Journal of Neuroinflammation 2022 19:286
  5. Aicardi–Goutières syndrome (AGS) is a severe neurodegenerative disease with clinical features of early-onset encephalopathy and progressive loss of intellectual abilities and motor control. Gene mutations in s...

    Authors: Xinfeng Guo, Richard A. Steinman, Yi Sheng, Guodong Cao, Clayton A. Wiley and Qingde Wang
    Citation: Journal of Neuroinflammation 2022 19:285
  6. Due to the complexity of the mechanisms involved in epileptogenesis, the available antiseizure drugs (ASDs) do not meet clinical needs; hence, both the discovery of new ASDs and the elucidation of novel molecu...

    Authors: Yan Hu, Buliang Meng, Saige Yin, Meifeng Yang, Yilin Li, Naixin Liu, Shanshan Li, Yixiang Liu, Dandan Sun, Siyu Wang, Yinglei Wang, Zhe Fu, Yutong Wu, Ailan Pang, Jun Sun, Ying Wang…
    Citation: Journal of Neuroinflammation 2022 19:284
  7. Neuronal injury is considered a critical risk factor in the pathogenesis of most neurological and neuropsychiatric diseases. However, the underlying molecular mechanisms and identification of potential therape...

    Authors: Changmin Wang, Ye Li, Yuhang Yi, Guiyu Liu, Ruojing Guo, Liyan Wang, Tian Lan, Wenjing Wang, Xiao Chen, Shihong Chen and Shu Yan Yu
    Citation: Journal of Neuroinflammation 2022 19:283
  8. Plasma gelsolin (pGSN) is an important part of the blood actin buffer that prevents negative consequences of possible F-actin deposition in the microcirculation and has various functions during host immune res...

    Authors: Łukasz Suprewicz, Kiet A. Tran, Ewelina Piktel, Krzysztof Fiedoruk, Paul A. Janmey, Peter A. Galie and Robert Bucki
    Citation: Journal of Neuroinflammation 2022 19:282
  9. Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions. To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anor...

    Authors: Stéphanie Gaige, Rym Barbouche, Manon Barbot, Sarah Boularand, Michel Dallaporta, Anne Abysique and Jean-Denis Troadec
    Citation: Journal of Neuroinflammation 2022 19:280
  10. Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or hypoexcitability. Nuclear calcium signaling pathways are involved in tran...

    Authors: Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading and Francesco Roselli
    Citation: Journal of Neuroinflammation 2022 19:279
  11. Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The most common tauopathy is Alzheimer’s disease (AD), but chronic trauma...

    Authors: Jonathan D. Cherry, Zach H. Baucom, Kaleb G. Eppich, Daniel Kirsch, Erin R. Dixon, Yorghos Tripodis, Kevin F. Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F. Crary, Dennis Dickson and Ann C. McKee
    Citation: Journal of Neuroinflammation 2022 19:278
  12. The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medi...

    Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega and Diego Clemente
    Citation: Journal of Neuroinflammation 2022 19:277
  13. Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only radiation therapy provides m...

    Authors: Casper J. Pachocki and Elly M. Hol
    Citation: Journal of Neuroinflammation 2022 19:276
  14. Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain ch...

    Authors: Elham Poonaki, Ulf Dietrich Kahlert, Sven G. Meuth and Ali Gorji
    Citation: Journal of Neuroinflammation 2022 19:275
  15. Cerebral infection with the protozoan Toxoplasma gondii (T. gondii) is responsible for inflammation of the central nervous system (CNS) contributing to subtle neuronal alterations. Albeit essential for brain para...

    Authors: Caio Andreeta Figueiredo, Henning Peter Düsedau, Johannes Steffen, Stefanie Ehrentraut, Miklos P. Dunay, Gabor Toth, Dora Reglödi, Markus M. Heimesaat and Ildiko Rita Dunay
    Citation: Journal of Neuroinflammation 2022 19:274
  16. Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can...

    Authors: Larissa M. G. Cassiano, Marina S. Oliveira, Jeanne Pioline, Anna C. M. Salim and Roney S. Coimbra
    Citation: Journal of Neuroinflammation 2022 19:272
  17. Brachial plexus root avulsion (BPRA) is frequently caused by high-energy trauma including traffic accident and birth trauma, which will induces massive motoneurons (MNs) death as well as loss of motor and sens...

    Authors: Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng and Lihua Zhou
    Citation: Journal of Neuroinflammation 2022 19:271
  18. Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of...

    Authors: Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege…
    Citation: Journal of Neuroinflammation 2022 19:270
  19. The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TBI), but the underlying mechanism of microglial activation is unclear.

    Authors: Pengzhan Zhao, Yutian Wei, Guangchi Sun, Lei Xu, Tian Wang, Yufei Tian, Honglu Chao, Yiming Tu and Jing Ji
    Citation: Journal of Neuroinflammation 2022 19:269
  20. The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is...

    Authors: Diogo Dominguini, Monique Michels, Leticia B. Wessler, Emilio L. Streck, Tatiana Barichello and Felipe Dal-Pizzol
    Citation: Journal of Neuroinflammation 2022 19:268
  21. Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infec...

    Authors: Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh and Cornelia C. Bergmann
    Citation: Journal of Neuroinflammation 2022 19:267
  22. Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies. We leveraged single-cell observa...

    Authors: Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill and Thomas R. Kiehl
    Citation: Journal of Neuroinflammation 2022 19:266
  23. Encephalopathy of prematurity (EoP) affects approximately 30% of infants born < 32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of montelukast, a cys...

    Authors: Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton…
    Citation: Journal of Neuroinflammation 2022 19:265
  24. People with spinal cord injury (SCI) frequently develop neuropathic pain (NP) that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently incurable due to poor understanding of unde...

    Authors: Lei Wang, Mehmet A. Gunduz, Ana T. Semeano, Enis C. Yılmaz, Feras A. H. Alanazi, Ozan B. Imir, Ulas Yener, Christian A. Arbelaez, Esteban Usuga and Yang D. Teng
    Citation: Journal of Neuroinflammation 2022 19:264
  25. Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function,...

    Authors: Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga and Toshihide Yamashita
    Citation: Journal of Neuroinflammation 2022 19:263
  26. Glaucoma, the major cause of irreversible blindness worldwide, is characterized by progressive degeneration of retinal ganglion cells (RGCs). Current treatments for glaucoma only slow or partially prevent the ...

    Authors: Mengyuan Liu, Haibo Li, Rongliang Yang, Dan Ji and Xiaobo Xia
    Citation: Journal of Neuroinflammation 2022 19:262
  27. The aim of this study was to establish a complete retinal cell atlas of ischemia–reperfusion injury by single-cell RNA sequencing, and to explore the underlying mechanism of retinal ischemia–reperfusion injury...

    Authors: Yangyang Li, Yuwen Wen, Xiuxing Liu, Zhuang Li, Bingying Lin, Caibin Deng, Ziyu Yu, Yingting Zhu, Ling Zhao, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2022 19:261
  28. Forkhead-Box-Protein P3 (FoxP3) is a transcription factor and marker of regulatory T cells, converting naive T cells into Tregs that can downregulate the effector function of other T cells. We previously detec...

    Authors: Ahmad Samir Alfaar, Lucas Stürzbecher, Maria Diedrichs-Möhring, Marion Lam, Christophe Roubeix, Julia Ritter, Kathrin Schumann, Balasubramaniam Annamalai, Inga-Marie Pompös, Bärbel Rohrer, Florian Sennlaub, Nadine Reichhart, Gerhild Wildner and Olaf Strauß
    Citation: Journal of Neuroinflammation 2022 19:260
  29. Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies. Rituximab is a second-line choice for the treatment for AE with NSAbs, which...

    Authors: Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao and Wei Zhang
    Citation: Journal of Neuroinflammation 2022 19:259
  30. The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely understood. Axonal stress signals arising from white matter lesions has been suggested to play a role in initiating this ...

    Authors: Benjamin D. S. Clarkson, Ethan Grund, Kenneth David, Renee K. Johnson and Charles L. Howe
    Citation: Journal of Neuroinflammation 2022 19:258
  31. Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and effici...

    Authors: Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte and Tim Magnus
    Citation: Journal of Neuroinflammation 2022 19:256
  32. Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play key roles in the activation and ...

    Authors: Adriana Fernanda K. Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos and Carlos Alberto Gonçalves
    Citation: Journal of Neuroinflammation 2022 19:255
  33. Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy a...

    Authors: Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin I. Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger and Marco Sisignano
    Citation: Journal of Neuroinflammation 2022 19:254
  34. The immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's disease (AD). However, there were few studies on improving the niche microenvironment of neural st...

    Authors: Xiaolei Wu, Qi Shen, Haocai Chang, Junyu Li and Da Xing
    Citation: Journal of Neuroinflammation 2022 19:253
  35. Despite widespread searches, there are currently no validated biofluid markers for the detection of subclinical neuroinflammation in multiple sclerosis (MS). The dynamic nature of human metabolism in response ...

    Authors: Tianrong Yeo, Halwan Bayuangga, Marcus Augusto-Oliveira, Megan Sealey, Timothy D. W. Claridge, Rachel Tanner, David Leppert, Jacqueline Palace, Jens Kuhle, Fay Probert and Daniel C. Anthony
    Citation: Journal of Neuroinflammation 2022 19:252
  36. The adaptive immune system and associated inflammation are vital in surveillance and host protection against internal and external threats, but can secondarily damage host tissues. The central nervous system i...

    Authors: Alexa DeMaio, Shikhar Mehrotra, Kumar Sambamurti and Shahid Husain
    Citation: Journal of Neuroinflammation 2022 19:251
  37. Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly...

    Authors: Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa, Sean Ott, Blythe P. Durbin-Johnson, Ashok R. Dinasarapu, Andrea Gompers, John H. Morrison and Smita S. Iyer
    Citation: Journal of Neuroinflammation 2022 19:250
  38. Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term control of latent HSV-1 infection, but it is uncle...

    Authors: Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink and Georges M. G. M. Verjans
    Citation: Journal of Neuroinflammation 2022 19:249
  39. Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulatin...

    Authors: Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen and Paul M. Matthews
    Citation: Journal of Neuroinflammation 2022 19:247
  40. Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic br...

    Authors: Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen…
    Citation: Journal of Neuroinflammation 2022 19:246
  41. Stroke is associated with high disability and mortality rates and increases the incidence of organ-related complications. Research has revealed that the outcomes and prognosis of stroke are regulated by the st...

    Authors: Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu and Xiaoxing Xiong
    Citation: Journal of Neuroinflammation 2022 19:245
  42. Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pai...

    Authors: Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen and Zhong-Ya Wei
    Citation: Journal of Neuroinflammation 2022 19:244
  43. Moderate physical exercise is conducive to the brains of healthy humans and AD patients. Previous reports have suggested that treadmill exercise plays an anti-AD role and improves cognitive ability by promotin...

    Authors: Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang and Tianhui Wang
    Citation: Journal of Neuroinflammation 2022 19:243
  44. Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the innate immune sys...

    Authors: Xinli Hu, Haojie Zhang, Qianxin Zhang, Xue Yao, Wenfei Ni and Kailiang Zhou
    Citation: Journal of Neuroinflammation 2022 19:242
  45. Multiple sclerosis (MS) is a chronic, debilitating condition characterized by CNS autoimmunity stemming from a complex etiology involving both environmental and genetic factors. Our current understanding of MS...

    Authors: Patrick O’Connell, Maja K. Blake, Sarah Godbehere, Andrea Amalfitano and Yasser A. Aldhamen
    Citation: Journal of Neuroinflammation 2022 19:241
  46. Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatis...

    Authors: Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu and Ming Lu
    Citation: Journal of Neuroinflammation 2022 19:240

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