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  1. Multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) are debilitating neuroinflammatory diseases mediated by lymphocyte entry into the central nervous system (CNS). While it ...

    Authors: Jeffrey H Mills, Leah M Alabanza, Deeqa A Mahamed and Margaret S Bynoe
    Citation: Journal of Neuroinflammation 2012 9:193
  2. Inheritance of the human ϵ4 allele of the apolipoprotein (apo) E gene (APOE) significantly increases the risk of developing Alzheimer’s disease (AD), in addition to adversely influencing clinical outcomes of othe...

    Authors: Eiron Cudaback, Xianwu Li, Yue Yang, Thomas Yoo, Kathleen S Montine, Suzanne Craft, Thomas J Montine and Christopher Dirk Keene
    Citation: Journal of Neuroinflammation 2012 9:192
  3. Using a live imaging approach, we have previously shown that microglia activation after stroke is characterized by marked and long-term induction of the Toll-like receptor (TLR) 2 biophotonic signals. However,...

    Authors: Ivan Bohacek, Pierre Cordeau, Mélanie Lalancette–Hébert, Dunja Gorup, Yuan-Cheng Weng, Srecko Gajovic and Jasna Kriz
    Citation: Journal of Neuroinflammation 2012 9:191
  4. To perform their functions during development and after central nervous system injury, the brain’s immune cells (microglia) must migrate through dense neuropil and extracellular matrix (ECM), but it is not kno...

    Authors: Catherine Vincent, Tamjeed A Siddiqui and Lyanne C Schlichter
    Citation: Journal of Neuroinflammation 2012 9:190
  5. Inflammation or nerve injury-induced upregulation and release of chemokine CC chemokine ligand 2 (CCL2) within the dorsal root ganglion (DRG) is believed to enhance the activity of DRG nociceptive neurons and ...

    Authors: Der-Jang Kao, Allen H Li, Jin-Chung Chen, Ro-Sun Luo, Ying-Ling Chen, Juu-Chin Lu and Hung-Li Wang
    Citation: Journal of Neuroinflammation 2012 9:189
  6. Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at ...

    Authors: Valerio Pisani, Alessandro Stefani, Mariangela Pierantozzi, Silvia Natoli, Paolo Stanzione, Diego Franciotta and Antonio Pisani
    Citation: Journal of Neuroinflammation 2012 9:188
  7. Cerebrospinal fluid (CSF) has been considered as a preferential pathway of circulation for immune cells during neuroimmune surveillance. In order to evaluate the involvement of CSF-filled spaces in the pathoge...

    Authors: Charlotte Schmitt, Nathalie Strazielle and Jean-François Ghersi-Egea
    Citation: Journal of Neuroinflammation 2012 9:187
  8. This study evaluated whether GM2 ganglioside storage is necessary for neurodegeneration and neuroinflammation by performing β-hexosaminidase rescue experiments in neurons of HexB−/− mice. We developed a novel mou...

    Authors: Stephanos Kyrkanides, Sabine M Brouxhon, Ross H Tallents, Jen-nie H Miller, John A Olschowka and M Kerry O’Banion
    Citation: Journal of Neuroinflammation 2012 9:186
  9. A global health problem, traumatic brain injury (TBI) is especially prevalent in the current era of ongoing world military conflicts. Its pathological hallmark is one or more primary injury foci, followed by a...

    Authors: Brian Giunta, Demian Obregon, Renuka Velisetty, Paul R Sanberg, Cesar V Borlongan and Jun Tan
    Citation: Journal of Neuroinflammation 2012 9:185
  10. Status epilepticus induces subcellular changes that may lead to neuronal cell death in the hippocampus. However, the mechanism of seizure-induced neuronal cell death remains unclear. The mitochondrial uncoupli...

    Authors: Yao-Chung Chuang, Tsu-Kung Lin, Hsuan-Ying Huang, Wen-Neng Chang, Chia-Wei Liou, Shang-Der Chen, Alice YW Chang and Samuel HH Chan
    Citation: Journal of Neuroinflammation 2012 9:184
  11. In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcircula...

    Authors: Stanka Mihaylova, Anke Killian, Konstantin Mayer, Soni Savai Pullamsetti, Ralph Schermuly and Bernhard Rosengarten
    Citation: Journal of Neuroinflammation 2012 9:183
  12. Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes. Although mild or moderate hypoglycemia is not life-threatening, if recurrent, it may cause cognitive impairment. In the present study, we sou...

    Authors: Seok Joon Won, Byung Hoon Yoo, Tiina M Kauppinen, Bo Young Choi, Jin Hee Kim, Bong Geom Jang, Min Woo Lee, Min Sohn, Jialing Liu, Raymond A Swanson and Sang Won Suh
    Citation: Journal of Neuroinflammation 2012 9:182
  13. Tibia fracture in rats followed by cast immobilization leads to nociceptive, trophic, vascular and bone-related changes similar to those seen in Complex Regional Pain Syndrome (CRPS). Substance P (SP) mediated...

    Authors: Tzuping Wei, Tian-Zhi Guo, Wen-Wu Li, Saiyun Hou, Wade S Kingery and John David Clark
    Citation: Journal of Neuroinflammation 2012 9:181
  14. High-mobility group box-1 protein (HMGB1) is a nuclear protein that regulates gene expression throughout the body. It can also become cytoplasmic and function as a neuromodulatory cytokine after tissue damage ...

    Authors: Polina Feldman, Michael R Due, Matthew S Ripsch, Rajesh Khanna and Fletcher A White
    Citation: Journal of Neuroinflammation 2012 9:180
  15. This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD).

    Authors: David H Cribbs, Nicole C Berchtold, Victoria Perreau, Paul D Coleman, Joseph Rogers, Andrea J Tenner and Carl W Cotman
    Citation: Journal of Neuroinflammation 2012 9:179
  16. Emerging evidence indicates that reactive microglia-initiated inflammatory responses are responsible for secondary damage after primary traumatic spinal cord injury (SCI); epidermal growth factor receptor (EGF...

    Authors: Wen-sheng Qu, Dai-shi Tian, Zhi-bao Guo, Jun Fang, Qiang Zhang, Zhi-yuan Yu, Min-jie Xie, Hua-qiu Zhang, Jia-gao Lü and Wei Wang
    Citation: Journal of Neuroinflammation 2012 9:178
  17. The activation of the immune system in neurodegeneration has detrimental as well as beneficial effects. Which aspects of this immune response aggravate the neurodegenerative breakdown and which stimulate regen...

    Authors: Elke Ydens, Anje Cauwels, Bob Asselbergh, Sofie Goethals, Lieve Peeraer, Guillaume Lornet, Leonardo Almeida-Souza, Jo A Van Ginderachter, Vincent Timmerman and Sophie Janssens
    Citation: Journal of Neuroinflammation 2012 9:176
  18. White matter injury is the major form of brain damage in very preterm infants. Selective white matter injury in the immature brain can be induced by lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) in...

    Authors: Lan-Wan Wang, Yi-Fang Tu, Chao-Ching Huang and Chien-Jung Ho
    Citation: Journal of Neuroinflammation 2012 9:175
  19. Deletion of some Toll-like receptors (TLRs) affords protection against cerebral ischemia, but disruption of their known major downstream adaptors does not. To determine whether compensation in the production o...

    Authors: Famakin Bolanle, Mou Yongshan, Spatz Maria, Lawal Modinat and John Hallenbeck
    Citation: Journal of Neuroinflammation 2012 9:174
  20. CD137 (4-1BB, TNFRSF9), a member of the tumor necrosis factor (TNF) receptor family, is a potent T cell co-stimulatory molecule. CD137 ligand (CD137L) is expressed by antigen presenting cells (APC) as a transm...

    Authors: Yee Andy Yeo, Julia M Martínez Gómez, J Ludovic Croxford, Stephan Gasser, Eng-Ang Ling and Herbert Schwarz
    Citation: Journal of Neuroinflammation 2012 9:173
  21. The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from u...

    Authors: Ying-mei Lu, Rong-rong Tao, Ji-yun Huang, Li-tao Li, Mei-hua Liao, Xiao-ming Li, Kohji Fukunaga, Ze-Hui Hong and Feng Han
    Citation: Journal of Neuroinflammation 2012 9:172
  22. Production of the chemokine CCL2 by cells of the neurovascular unit (NVU) drives critical aspects of neuroinflammation. Suppression of CCL2 therefore holds promise in treating neuroinflammatory disease. Accord...

    Authors: Shujun Ge, Bandana Shrestha, Debayon Paul, Carolyn Keating, Robert Cone, Angelo Guglielmotti and Joel S Pachter
    Citation: Journal of Neuroinflammation 2012 9:171
  23. Secreted phospholipase A2-IIA (sPLA2-IIA) is an inducible enzyme released under several inflammatory conditions. It has been shown that sPLA2-IIA is released from rat brain astrocytes after inflammatory stimulus,...

    Authors: Guansong Wang, Pin Qian, Zhi Xu, Jiqiang Zhang, Yaoli Wang, Saiyu Cheng, Wenqin Cai, Guisheng Qian, Changzheng Wang and Mark A DeCoster
    Citation: Journal of Neuroinflammation 2012 9:170
  24. Traumatic spinal cord injury (SCI) induces secondary tissue damage that is associated with astrogliosis and inflammation. We previously reported that acute upregulation of a cluster of cell-cycle-related genes...

    Authors: Junfang Wu, Ahdeah Pajoohesh-Ganji, Bogdan A Stoica, Michael Dinizo, Kelsey Guanciale and Alan I Faden
    Citation: Journal of Neuroinflammation 2012 9:169
  25. Physical exercise has been shown to increase neurogenesis, to decrease neuronal injury and to improve memory in animal models of stroke and head trauma. Therefore, we investigated the effect of voluntary wheel...

    Authors: David Liebetanz, Joachim Gerber, Christina Schiffner, Sandra Schütze, Florian Klinker, Hubertus Jarry, Roland Nau and Simone C Tauber
    Citation: Journal of Neuroinflammation 2012 9:168
  26. Expression of inflammatory cytokines in cerebrospinal fluid (CSF) has led to the hypothesis of intrathecal chronic inflammation to explain the denervation observed in post-polio syndrome (PPS). It has been sho...

    Authors: Henrik Gonzalez, Mohsen Khademi, Kristian Borg and Tomas Olsson
    Citation: Journal of Neuroinflammation 2012 9:167
  27. Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis. Clearance of degenerated myelin by...

    Authors: Smadar Hadas, Maya Spira, Uwe-Karsten Hanisch, Fanny Reichert and Shlomo Rotshenker
    Citation: Journal of Neuroinflammation 2012 9:166
  28. In physiological conditions, it is postulated that neurons control microglial reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent, soluble-factor-dependent or neurotra...

    Authors: Guido Dentesano, Marco Straccia, Aroa Ejarque-Ortiz, Josep M Tusell, Joan Serratosa, Josep Saura and Carme Solà
    Citation: Journal of Neuroinflammation 2012 9:165
  29. Therapeutic hypothermia is one of the neuroprotective strategies that improve neurological outcomes after brain damage in ischemic stroke and traumatic brain injury. Microglial cells become activated following...

    Authors: Jung-Wan Seo, Jong-Heon Kim, Jae-Hong Kim, Minchul Seo, Hyung Soo Han, Jaechan Park and Kyoungho Suk
    Citation: Journal of Neuroinflammation 2012 9:164
  30. Neuropathic pain in the trigeminal system is frequently observed in clinic, but the mechanisms involved are largely unknown. In addition, the function of immune cells and related chemicals in the mechanism of ...

    Authors: Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, Su Cao, Zhi-Qi Zhao and Yong-Jing Gao
    Citation: Journal of Neuroinflammation 2012 9:136
  31. Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate is a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with...

    Authors: Philipp Albrecht, Imane Bouchachia, Norbert Goebels, Nadine Henke, Harald H Hofstetter, Andrea Issberner, Zsuzsa Kovacs, Jan Lewerenz, Dmitrij Lisak, Pamela Maher, Anne-Kathrin Mausberg, Kim Quasthoff, Corinna Zimmermann, Hans-Peter Hartung and Axel Methner
    Citation: Journal of Neuroinflammation 2012 9:163
  32. Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorp...

    Authors: Nan Zhao, Xin Liu, Yongqin Wang, Xiaoqiu Liu, Jiana Li, Litian Yu, Liyuan Ma, Shuyu Wang, Hongye Zhang, Lisheng Liu, Jingbo Zhao and Xingyu Wang
    Citation: Journal of Neuroinflammation 2012 9:162
  33. (−)-Epigallocatechin gallate (EGCG) is a major polyphenol component of green tea that has antioxidant activities. Lipopolysaccharide (LPS) induces inflammatory cytokine production and impairs blood–brain barri...

    Authors: Jieliang Li, Li Ye, Xu Wang, Jinping Liu, Yizhong Wang, Yu Zhou and Wenzhe Ho
    Citation: Journal of Neuroinflammation 2012 9:161
  34. Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative propert...

    Authors: Bernhard T Baune, Carsten Konrad, Dominik Grotegerd, Thomas Suslow, Eva Birosova, Patricia Ohrmann, Jochen Bauer, Volker Arolt, Walter Heindel, Katharina Domschke, Sonja Schöning, Astrid V Rauch, Christina Uhlmann, Harald Kugel and Udo Dannlowski
    Citation: Journal of Neuroinflammation 2012 9:125
  35. Lipoteichoic acid (LTA) is a component of gram-positive bacterial cell walls and may be elevated in the cerebrospinal fluid of patients suffering from meningitis. Among matrix metalloproteinases (MMPs), MMP-9 ...

    Authors: Hsi-Lung Hsieh, Chih-Chung Lin, Ruey-Horng Shih, Li-Der Hsiao and Chuen-Mao Yang
    Citation: Journal of Neuroinflammation 2012 9:110
  36. It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial ce...

    Authors: Vanessa Coelho-Santos, Joana Gonçalves, Carlos Fontes-Ribeiro and Ana Paula Silva
    Citation: Journal of Neuroinflammation 2012 9:103
  37. Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-indu...

    Authors: Yun-Li Peng, Yu-Ning Liu, Lei Liu, Xia Wang, Chun-Lei Jiang and Yun-Xia Wang
    Citation: Journal of Neuroinflammation 2012 9:75
  38. The purpose of this paper is to report a patient with otherwise unexplained cerebellar ataxia with serum antibodies against contactin-associated protein-2 (CASPR-2) and provide a detailed description of the co...

    Authors: Nico Melzer, Kristin S Golombeck, Catharina C Gross, Sven G Meuth and Heinz Wiendl
    Citation: Journal of Neuroinflammation 2012 9:160
  39. The T-helper (Th)1/Th2 dichotomy dominated the field of immune regulation until interleukin (IL)-17-expressing T cells (Th17) were proposed to be a third lineage of helper T cells, the key players in the patho...

    Authors: Laila Yousef AL-Ayadhi and Gehan Ahmed Mostafa
    Citation: Journal of Neuroinflammation 2012 9:158
  40. Estradiol has been shown to exert neuroprotective effects in several neurodegenerative conditions, including cerebral ischemia. The presence of this hormone prior to ischemia attenuates the damage associated w...

    Authors: Maria Jose Pérez-Álvarez, Maria del Carmen Maza, Marta Anton, Lara Ordoñez and Francisco Wandosell
    Citation: Journal of Neuroinflammation 2012 9:157
  41. In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The a...

    Authors: Jack van Horssen, Shailender Singh, Susanne van der Pol, Markus Kipp, Jamie L Lim, Laura Peferoen, Wouter Gerritsen, Evert-Jan Kooi, Maarten E Witte, Jeroen JG Geurts, Helga E de Vries, Regina Peferoen-Baert, Peter J van den Elsen, Paul van der Valk and Sandra Amor
    Citation: Journal of Neuroinflammation 2012 9:156
  42. Activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease (AD) and other pathol...

    Authors: Rubén Martín, Claudia Cordova and Maria L Nieto
    Citation: Journal of Neuroinflammation 2012 9:154
  43. Gastrointestinal symptoms and altered blood phospholipid profiles have been reported in patients with autism spectrum disorders (ASD). Most of the phospholipid analyses have been conducted on the fatty acid co...

    Authors: Raymond H Thomas, Melissa M Meeking, Jennifer R Mepham, Lisa Tichenoff, Fred Possmayer, Suya Liu and Derrick F MacFabe
    Citation: Journal of Neuroinflammation 2012 9:153
  44. Endothelin-1 (ET-1) is elevated and participates in the regulation of several brain inflammatory disorders. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated throug...

    Authors: Hsi-Lung Hsieh, Chih-Chung Lin, Hui-Ju Chan, Caleb M Yang and Chuen-Mao Yang
    Citation: Journal of Neuroinflammation 2012 9:152
  45. Alzheimer’s disease (AD) is the most prevalent form of age-related dementia, and its effect on society increases exponentially as the population ages. Accumulating evidence suggests that neuroinflammation, med...

    Authors: Dimitrije Krstic, Amrita Madhusudan, Jana Doehner, Prisca Vogel, Tina Notter, Claudine Imhof, Abigail Manalastas, Martina Hilfiker, Sandra Pfister, Cornelia Schwerdel, Carsten Riether, Urs Meyer and Irene Knuesel
    Citation: Journal of Neuroinflammation 2012 9:151
  46. Microglial activation is an important histologic characteristic of the pathology of Alzheimer’s disease (AD). One hypothesis is that amyloid beta (Aβ) peptide serves as a specific stimulus for tyrosine kinase-...

    Authors: Gunjan Dhawan and Colin K Combs
    Citation: Journal of Neuroinflammation 2012 9:117

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