Ashwood P, Wills S, Van de Water J: The immune response in autism: a new frontier for autism research.
J Leukoc Biol 2006, 80:1–15.
Article
CAS
PubMed
Google Scholar
Atladottir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW, Parner ET: Association of family history of autoimmune diseases and autism spectrum disorders.
Pediatrics 2009, 124:687–694.
Article
PubMed
Google Scholar
Theoharides TC, Kempuraj D, Redwood L: Autism: an emerging ’neuroimmune disorder’ in search of therapy.
Exp Opinion on Pharmacotherapy 2009, 10:2127–2143.
Article
CAS
Google Scholar
Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D: Differential release of mast cell mediators and the pathogenesis of inflammation.
Immunol Rev 2007, 217:65–78.
Article
CAS
PubMed
Google Scholar
Gurney JG, McPheeters ML, Davis MM: Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health.
Arch Pediatr Adolesc Med 2006, 160:825–830.
Article
PubMed
Google Scholar
Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H: Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study.
J Neuroinflammation 2008, 5:52.
Article
PubMed
PubMed Central
Google Scholar
Bakkaloglu B, Anlar B, Anlar FY, Oktem F, Pehlivanturk B, Unal F, Ozbesler C, Gokler B: Atopic features in early childhood autism.
Eur J Paediatr Neurol 2008, 12:476–479.
Article
PubMed
Google Scholar
Magalhaes ES, Pinto-Mariz F, Bastos-Pinto S, Pontes AT, Prado EA, Deazevedo LC: Immune allergic response in Asperger syndrome.
J Neuroimmunol 2009, 216:108–112.
Article
CAS
PubMed
Google Scholar
Angelidou A, Alysandratos KD, Asadi S, Zhang B, Francis K, Vasiadi M, Kalogeromitros D, Theoharides TC: Brief report: “allergic symptoms” in children with autism spectrum disorders. more than meets the eye?
J Autism Dev Disord 2011, 41:1579–1585.
Article
PubMed
Google Scholar
White SW, Oswald D, Ollendick T, Scahill L: Anxiety in children and adolescents with autism spectrum disorders.
Clin Psychol Rev 2009, 29:216–229.
Article
PubMed
PubMed Central
Google Scholar
Cao J, Papadopoulou N, Kempuraj D, Boucher WS, Sugimoto K, Cetrulo CL, Theoharides TC: Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor.
J Immunol 2005, 174:7665–7675.
Article
CAS
PubMed
Google Scholar
Angelidou A, Francis K, Vasiadi M, Alysandratos K-D, Zhang B, Theoharides A, Lykouras L, Kalogeromitros D, Theoharides TC: Neurotensin is increased in serum of young children with autistic disorder.
J Neuroinflammation 2010, 7:48.
Article
PubMed
PubMed Central
Google Scholar
Fassio A, Evans G, Grisshammer R, Bolam JP, Mimmack M, Emson PC: Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody.
Neuropharmacology 2000, 39:1430–1442.
Article
CAS
PubMed
Google Scholar
Boucher J: Research Review: Structural language in autistic spectrum disorder - characteristics and causes.
J Child Psychol Psychiatry 2012, 53:219–233.
Article
PubMed
Google Scholar
Zhang B, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi S, Theoharides A, Sideri K, Lykouras L, Kalogeromitros D, Theoharides TC: Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children.
J Neuroinflammation 2010, 7:80.
Article
PubMed
PubMed Central
Google Scholar
Kempuraj D, Tagen M, Iliopoulou BP, Clemons A, Vasiadi M, Boucher W, House M, Wolferg A, Theoharides TC: Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells.
Br J Pharmacol 2008, 155:1076–1084.
Article
CAS
PubMed
PubMed Central
Google Scholar
Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC: Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells.
Int J Immunopathol Pharmacol 2010, 23:1015–1020.
CAS
PubMed
Google Scholar
Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H, Tomikawa M, Tachimoto H, Ebisawa M, Akasawa A, Miyagi T, Kimura H, Nakajima T, Tsuji K, Nakahata T: Characterization of mast cell-committed progenitors present in human umbilical cord blood.
Blood 1999, 93:3338–3346.
CAS
PubMed
Google Scholar
McCary C, Tancowny BP, Catalli A, Grammer LC, Harris KE, Schleimer RP, Kulka M: Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.
J Neuroimmunol 2010, 220:17–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kirshenbaum AS, Swindle E, Kulka M, Wu Y, Metcalfe DD: Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC Immunol 2008, 9:45.
Article
PubMed
PubMed Central
Google Scholar
Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D: Mast cell activation and autism.
Biochim Biophys Acta 2012,1822(1):34–41.
Article
CAS
PubMed
Google Scholar
Donelan J, Boucher W, Papadopoulou N, Lytinas M, Papaliodis D, Theoharides TC: Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.
Proc Natl Acad Sci USA 2006, 103:7759–7764.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gillott A, Standen PJ: Levels of anxiety and sources of stress in adults with autism.
J Intellect Disabil 2007, 11:359–370.
Article
PubMed
Google Scholar
Ercan F, San T, Cavdar S: The effects of cold-restraint stress on urinary bladder wall compared with interstitial cystitis morphology.
Urol Res 1999, 27:454–461.
Article
CAS
PubMed
Google Scholar
Esposito P, Chandler N, Kandere-Grzybowska K, Basu S, Jacobson S, Connolly R, Tutor D, Theoharides TC: Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood–brain-barrier permeability induced by acute stress.
J Pharmacol Exp Ther 2002, 303:1061–1066.
Article
CAS
PubMed
Google Scholar
Theoharides TC, Konstantinidou A: Corticotropin-releasing hormone and the blood–brain-barrier.
Front Biosci 2007, 12:1615–1628.
Article
CAS
PubMed
Google Scholar
Esposito P, Gheorghe D, Kandere K, Pang X, Conally R, Jacobson S, Theoharides TC: Acute stress increases permeability of the blood–brain-barrier through activation of brain mast cells.
Brain Res 2001, 888:117–127.
Article
CAS
PubMed
Google Scholar
Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E, Chrousos G: Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its pro-inflammatory effects.
Endocrinology 1998, 139:403–413.
CAS
PubMed
Google Scholar
Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.
FASEB J 2008, 22:3264–3275.
Article
CAS
PubMed
PubMed Central
Google Scholar
Palmieri L, Persico AM: Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?
Biochim Biophys Acta 2010, 1797:1130–1137.
Article
CAS
PubMed
Google Scholar
Weissman JR, Kelley RI, Bauman ML, Cohen BH, Murray KF, Mitchell RL, Kern RL, Natowicz MR: Mitochondrial disease in autism spectrum disorder patients: A cohort analysis.
PLoS One 2008, 3:e3815.
Article
PubMed
PubMed Central
Google Scholar
Frye RE, Rossignol DA: Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.
Pediatr Res 2011, 69:41R-47R.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chan DC: Mitochondria: dynamic organelles in disease, aging, and development.
Cell 2006, 125:1241–1252.
Article
CAS
PubMed
Google Scholar
Twig G, Hyde B, Shirihai OS: Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view.
Biochim Biophys Acta 2008, 1777:1092–1097.
Article
CAS
PubMed
Google Scholar
Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ: Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Nature 2010, 464:104–107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goines P, Van de Water J: The immune system’s role in the biology of autism.
Curr Opin Neurol 2010, 23:111–117.
Article
PubMed
PubMed Central
Google Scholar
Middleton E, Kandaswami C, Theoharides TC: The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer.
Pharmacol Rev 2000, 52:673–751.
CAS
PubMed
Google Scholar
Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC: Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells.
Br J Pharmacol 2005, 145:934–944.
Article
CAS
PubMed
PubMed Central
Google Scholar
Franco JL, Posser T, Missau F, Pizzolatti MG, Dos Santos AR, Souza DO, Aschner M, Rocha JB, Dafre AL, Farina M: Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction.
Environ Toxicol Pharmacol 2010, 30:272–278.
Article
CAS
PubMed
PubMed Central
Google Scholar
Theoharides TC: Luteolin as a therapeutic option for multiple sclerosis.
J Neuroinflammation 2009, 6:29.
Article
PubMed
PubMed Central
Google Scholar
Theoharides TC, Asadi S, Panagiotou JP: Effect of a luteolin formulation (NeuroProtek) on autism spectrum disorders-A case series.
Int J Immunopathol and Pharmacol 2012,:. In press
CAS
Google Scholar
Theoharides TC, Zhang B: Neuro-inflammation, blood–brain barrier.
Seizures and Autism J Neuroinflammation. 2011, 8:168.
Article
PubMed
Google Scholar
Theoharides TC, Doyle R, Francis K, Conti P, Kalogeromitros D: Novel therapeutic targets for autism.
Trends Pharmacol Sci 2008, 29:375–382.
Article
CAS
PubMed
Google Scholar
Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D: Mast cell activation and autism.
Biochim Biophys Acta 1822, 2012:34–41.
Google Scholar
Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M: How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis.
Neurotoxicology 2008, 29:190–201.
Article
CAS
Google Scholar
Herbert MR: Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders.
Curr Opin Neurol 2010, 23:103–110.
Article
PubMed
Google Scholar
Hamilton MJ, Hornick JL, Akin C, Castells MC, Greenberger NJ: Mast cell activation syndrome: a newly recognized disorder with systemic clinical manifestations.
J Allergy Clin Immunol 2011, 128:147–152.
Article
PubMed
Google Scholar